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Showing content with the highest reputation on 11/29/2015 in all areas

  1. I mentioned this in another post here, but figured it was worth putting here, since it seems like maybe another new thing we might have learned. In the abstract I have pasted below, it says that triptan use is a characteristic of some people for whom oxygen is ineffective. I can't tell how effective the oxygen system used in the study was (flow rate, mask, etc.). What I think is interesting is that we often tell people that oxygen seems to work more effectively during busting. I think we have attributed that to the busting, but it seems possible that maybe (so many ifs and maybes, but you all understand that) it's the detox, being off triptans, that makes the O2 more effective. Or not. Cluster headache and oxygen: is it possible to predict which patients will be relieved? A prospective cross-sectional correlation study. Haane DY1, de Ceuster LM, Geerlings RP, Dirkx TH, Koehler PJ. Author information AbstractResponse to 100 % oxygen as acute treatment for cluster headache is relative low considering certain subgroups or predictors. The primary purpose of the present study was to find prospectively which factors differ between responders and non-responders to oxygen therapy. The second goal was to find whether any of these differences would clarify the mechanism of pain reduction by oxygen and cluster headache pathophysiology. Patients diagnosed with cluster headache according to the ICHD-II criteria, who started on oxygen therapy (n = 193), were recruited from 51 outpatient clinics and via patient websites in The Netherlands. Patients had to return two questionnaires around the start of oxygen therapy (n = 120). Eventually, 94 patients were included. Clear non- plus moderate responders had ever used pizotifen more often (p = 0.03). Clear non-responders more often had photophobia or phonophobia during cluster headache attacks (p = 0.047) and more often had used triptans in the same active phase as the phase in which they had used oxygen for the first time (p = 0.02). Using correction for multiple testing, we could only confirm a statistically significant difference in triptan use. We were unable to locate the level of action of oxygen in the thalamus and cortex or confirm the sites of its action presently known, solely based on current knowledge of photophobia circuits. However, we conclude that particularly the higher frequency of photophobia or phonophobia in clear non-responders deserves further study to understand the mechanism of pain reduction by oxygen and cluster headache pathophysiology.
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  2. Thanks CHfather, I hope you are doing well too. I'll try to write a bit in the general board. Been away for too long.
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