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Showing content with the highest reputation on 02/19/2021 in all areas

  1. Hey John, CH Father's, Spiny's and Pebles' comments all hit the mark debunking the article in question. There are studies and then there are articles about studies. While well designed studies/clinical trials as well as their published results and conclusions must conform to accepted standards, good science and format, articles do not. This article was a POS. While the cited study at PLoS provides what appears to be consistent results from their study of oxygen therapy breathing 95% O2 and 5% CO2 resulting in "normalized" cerebral blood flow and that hyperoxia breathing normobaric 100% oxygen results hypocapnia (too little blood CO2) with attendant vasoconstriction and reduced cerebral blood flow, it fails to tell the "rest of the story" as Paul Harvey used to say. This study fails to point out that even with the reduced cerebral blood flow the authors opined would result in hypoxia (too little oxygen delivered to the brain) and the release of potentially threatening enzymes, hormones and other peptides, the actual oxygen content of the cerebral blood flow through the brain was more than sufficiently high to prevent ischemia. So where does that leave CHers who have read this article and who need to use oxygen therapy as a CH abortive? If you disregard the junk science in this article, and use the most effective oxygen therapy procedure available to abort your CH rapidly, you're in great shape. The topic of oxygen therapy as a CH abortive is near and dear to my heart. From 2005 when Dx'd as a Chronic CHer, until 2010 when I developed the anti-inflammatory regimen to prevent my CH very effectively, oxygen therapy was my only CH intervention. I developed a very effective method of rapidly aborting my CH in 2005 that uses oxygen flow rates of 25 yo 40 liters/minute. This method of oxygen therapy essentially allows the CHer to hyperventilate with 100% oxygen to a safe and effective rapid abort. As a patent holder of the Demand Valve Method of Oxygen Therapy issued by the USPTO in 2010, I spent the better part of a year reading through hundreds of studies and RCTs involving the inhalation of 100% oxygen in developing the patent application. The following link provides the abstract for one of these studies titled, The Influence of Arterial Oxygenation on Cerebral Venous Oxygen Saturation During Hyperventilation, by Matta, et al., published in 1994. It concluded oxygen therapy at flow rates that support hyperventilation were not only safe, but it resulted in venous blood flow measured at the Jugular vein, indicated blood flow from the brain had twice the oxygen content of normobaric oxygenation. https://link.springer.com/article/10.1007/BF03015651 By the way, this is the very same principle of respiratory physiology that makes aborting CH using a oxygen demand valve with oxygen flow rates that support hyperventilation so safe and effective with average abort times of 7 minutes. You can achieve the same rapid abort times (7 minutes) by repeating the following sequence seven times. Each sequence involves hyperventilating with room air for 30 seconds at forced vital capacity tidal volumes followed by inhaling a lungful of 100% oxygen and holding it for 30 seconds. The only difference between this method of oxygen therapy and the demand valve method is this method consumes one tenth the volume of oxygen or an average of 28 liters per CH abort where the demand valve method consumes an average of 280 liters of oxygen per abort. Regarding oxygen safety. It's very safe. I was flying Navy fighters on and off aircraft carriers before they started Top Gun. I have over 3000 hours flying Navy fighters and all of that flight time was spent breathing 100% oxygen from engine start through cat shot, missions lasting 1.8 hours or more in duration to landing back aboard ship chocked and tied down. Then I took off the oxygen mask and turned off the oxygen. I would also note that during high G-force maneuvering in aerial combat, I routinely sucked down 100% oxygen at flow rates above 40 liters/minute. I passed my annual flight physicals every year of my 24 years of Naval Service. Moreover I'm still here at 76 and in very good health having used oxygen therapy daily for 5 years and I still pass my annual physicals. Several hundred thousand Navy and Marine Corps pilots flying tactical fighter and attack aircraft have been breathing 100% oxygen on all missions since 1943 when US and UK engineers cockroached (copied) the oxygen regulator design from a German bF-109 Messerschmidt that crash landed in the UK. It took only a few months to retrofit this new design into Naval aircraft. Bottom line, all these Navy and Marine Corps pilots have passed their annual physicals yearly since then with PA and lateral chest X-Rays indicating no adverse effects. Finally, think about the following. Navy and Marine Corps Pilots are required to breath 100% oxygen on all flights. NASA requires Astronauts breath 100% oxygen during suited EVA operations as well as during launch and reentry. Would they do this if breathing 100% oxygen was inherently unsafe? Let that sink in for a while. Take care, V/R, Batch
    3 points
  2. Heading back up for another round with this study. https://clinicaltrials.gov/ct2/show/NCT02981173 Might not help me much but it will make things a little better for the future.
    2 points
  3. Hi Kat, I was also in cycle when I tried Aimovig without any relief, but also without any side effects. This year I tried Emgality, again in full cycle, to no avail/side effects, just like Pebbles. These anti-CGRP meds may not work, or maybe are not strong enough to cancel out a cycle, but from what I read and hear is that it is intended as an preventive med. While I was in cycle my neuro and I actually hoped it could also work as an abortive to get me out of cycle, but in hindsight we both believe it is not designed that way. In the trail groups I was in, 4 out of 10 experienced the real benefits from it, preventing CH with just one round of shots every month. If there are no financial obligations, I would certainly participate in the trail, and hopefully you are out of cycle when you start. Alex
    1 point
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