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Lots of good comments on when to dose. The basic rule is take these supplements with the largest meal of the day. This is particularly important for the mineral supplements as large meals trigger the release of more stomach acid and this helps dissolve the mineral supplements. The oil based supplements can be taken at any time. That said, taking everything with the largest meal is the best way to go. As far as the labs go, obtaining them before start of treatment with the supplements establishes a baseline to help measure progress. In simple terms, your assay for 25(OH)D3 should increase by at least 60 ng/mL (150 nmol/L) by day 30. Don't be concerned if your serum 25(OH)D3 concentration goes over 100 ng/mL (250 nmol/L). I've run my serum 25(OH)D3 concentration up as high as 272 ng/mL. I'm still here at 79, CH pain free and doing just fine. My PCP did go into fibrillation the first time he saw it that high, but calmed down when he saw my serum calcium was within its normal reference range and all my other annual physical labs were in the green. The calcium assay may rise to the top if its normal reference range but not over.. PTH should start dropping towards its minimum level within the normal reference range. A drop in PTH is the second best indication vitamin D3 is doing its thing properly. Stopping the CH is the best indication. For CHers new to this treatment protocol, I and many other CHers who use the Bio-Tech D3-50 50,000 IU water soluble capsules have found loading vitamin D3 at 100,000 IU/day for six days gets us CH pain free a lot faster. There's a lot more info in the Quick Start Guide. Take care and please keep us posted if you've just started this treatment protocol. V/R, Batch, a.k.a. XXX

Hi Elia, While it is somewhat rare to switch sides it does happen sometimes. I've never had the same pattern that you speak of but I have had occasional random spikes on the "wrong" (non cluster) side. I have also had cycles that start after having pain on the wrong side. The CH attack seems to always go back to my normal side when full blown though.

M-Philly Let me see if I can get in contact with Dr Young and get you a number to call for an appointment. I know his scheduling is booked out a few months but it does not hurt to give it a try to get in to see him or someone from his team.