xxx

Luis,

Please shoot me an email so I can send you the latest update to the anti-inflammatory regimen CH preventative treatment protocol.  My email address is pete.batcheller@verizon.net.  The file is too large to send over this website.

You can find the posted version of this treatment protocol at the following link: 

http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708

The supplements to pick up by brand and take by dose are illustrated in the following photo of the supplements I take.  You can order all of them over amazon.com

Take care and please keep me posted.

V/R, Batch

Hey Randy,

Thanks for the update and names.  Please see my last on the Coimbra Protocol and Autism.

Take care,

V/R, Batch

OK Fire...  gotta name?

You've raised the bar on Nicole's treatment.  That said, the initial goal of preventing her CH still stands.  Treating her autism is the next step if you're up for it.

My daughter Gretchen, took a two-year hiatus from her masters studies to take care of two kids with ASD.  I learned a lot from my daughter regarding autism.  The most important lesson was positive gains (improvements) are few and far between.  I also had the opportunity to work with a naturopath treating a child with autism.  He is the son of a high school classmate of Gretchen's.  Although the naturopath and I were in agreement as to the course of treatment with vitamin D3 and the cofactors, the child's mother was unwilling to have her son's 25(OH)D3 elevated above the normal reference range of 100 ng/mL.  As a consequence,  the improvement was minor.

As Nicole's care giver and mother, I suspect you've developed a keen sense of her well being and reading her nonverbal communication.

I'll cut to the chase as Nicole's autism is nothing new to you.  Have you had a CP-MS - Mineral and Heavy Metal Elemental Hair Analysis done on Nicole?  The incidence of magnesium and zinc deficiencies among ASD patients is high as is the burdens created by excessive cadmium, aluminum, lead and mercury.  All these are treatable.  In fact, the anti-inflammatory regimen will take care of any magnesium and/or zinc deficiencies.  Chelation therapy can address the heavy metals.   

Treating Nicole's autism with vitamin D3 therapy will require you to take her to a physician trained in the Coimbra Protocol. This protocol is very similar to the anti-inflammatory regimen in preventing CH with the major exception that vitamin D3 doses and resulting 25(OH)D3 serum concentrations are significantly higher, there also are a few extra supplements and dietary conciderations. 

Where the average vitamin D3 dose for CH is between 10,000 IU/day and 20,000 IU/day, The vitamin D3 dose for autism using the Coimbra Protocol is around 1000 IU/Kg Body Weight/day ( 50,000 to 75,000 IU/day vitamin D3) and possibly higher depending on BMI and 25(OH)D3 response.  The Coimbra Protocol was developed by Dr. Cicero Coimbra, MD, PhD, a neurologist in Sao Paulo, Brazil. He has an amazing track record effective in treating patients with MS and autoimmune neurological conditions with a 95% complete remission rate.  I've exchanged email and survey data with Dr. Coimbra since 2013.  He has also trained several physicians residing here in the US.  There may be one near you.  See the following link for the location of doctors trained in the Coimbra Protocol here in the US: https://www.google.com/maps/d/viewer?mid=1fATZJUEhOsYYJdBY41h48FBkLaQ&ll=27.189497398872252%2C-82.03850906531966&z=8

I've been in contact with Dr. Barrett Ginsberg, MD in Naples, FL for several years and sent a few CHers his way.

Dr. Barrett R. Ginsberg, M.D.
77 8th Street South
Naples, 34102, FL
(239) 325-2015
Website: http://www.vitamindprotocol.org/home.html

What is the degree of difficulty in taking Nicole on travel and to a phlebotomist for blood draws?  She will need labs every 30 to 90 days until she's at a stable vitamin D3 dose.

Here's the most recent info on treating autism with the Coimbra Protocol.  I suspect you'll find more about the Coimbra Protocol and Autism on Facebook at the following link:  https://www.facebook.com/coimbraprotocol/photos/a.1548144692151907.1073741828.1546797872286589/1791336131166094/

Hey Fire,

Thanks for the feedback about your daughter's CH and headzup she's started the anti-inflammatory regimen.  You and your wife made an important decision starting your daughter on this regimen.

How old is your daughter and has she had the lab test of her 25(OH)D3 serum concentration?  This baseline lab test before stating this regimen is an important, but not essential..  It's important because data I've collected over the last 8 years from thousands of CHers indicate a clear inverse relationship between the frequency of CH and 25(OH)D3 concentration. 

It's also important for her to see the family PCP/GP to discuss this regimen and and have lab orders written for her serum vitamin D3, calcium and PTH.  Make sure she takes a copy of the anti-inflammatory regimen.  It will help her PCP/GP understand the treatment protocol and that it is very safe.  You want her PCP/GP to be a team member as she takes this regimen to prevent her CH/

In simple terms, when a CHer realizes the frequency of his or her CH is high when serum 25(OH)D3 concentration is low (< 40 ng/mL) and CH pain free when 25(OH)D3 concentration is higher (> 80 ng/mL), has just learned a measurable factor about controlling CH.  It's an "Ah Ha" and binary learning moment a CHer is not likely to forget.  Take this regimen and there's no CH.  Don't take it and the CH beast jumps ugly with terrible pain.  It's also important for your daughter's PCP/GP to see this binary relationship.  That will help her PCP/GP become a team player and an advocate of taking this regimen to prevent CH.

What may appear to be a shotgun approach with this regimen with all the supplements has been carefully researched.  Each supplement (vitamin D3 cofactor) plays an important role in vitamin D3 pharmacokinetics (what the body does to vitamin D3) and vitamin D3 pharmacodynamics (what vitamin D3 does to the body).  From the second morning (10 October, 2010) after the second 10,000 IU dose of vitamin D3 the night before waking up realizing I'd just slept the entire night CH pain free then realizing the horrors of the previous five years of chronic daily CH hitting 3 to 5 times a day/night and all too frequently up to 8 times a night, had ended, I began researching how and why this regimen was so effective in preventing my CH.

I'd been experimenting with a variety of minerals and vitamins at different doses in the hopes of improving my CH abort times with oxygen therapy for nearly a year with minimal but measurable results.  Then I looked at my headache log and realized there were three CH pain free periods of two to six weeks over the previous five years and all occurred in mid August while I was out in the sun clad in shorts with no shirt.  At that point, I realized it was cutaneous vitamin D3 that was making the difference, so I drove to Costco and purchased a bottle of 5,000 IU vitamin D3.  It worked too well...  Two doses at 10,000 IU/day added to my clutch of other vitamins and minerals and I was CH pain free.

I've a degree in Chemistry with lots of P-Chem, Bio-Chem, Zoology, and Genetics so I took a disciplined approach in documenting my research of vitamin D3 and its cofactors as they relate to preventing CH. I'm also no stranger to researching CH.  I developed a method of oxygen therapy that involves flow rates (40 liters/minute) that support hyperventilation to abort my CH in 2005 shortly after being diagnosed with chronic CH.  I patented this method of oxygen therapy with an oxygen demand valve in 2009. 

Over the last 12 years, I've had the opportunity to  meet with several of the world's top neurologists expert in treating patients with CH and also doctors and scientists expert in vitamin D3 therapy. I've shared my research with them and all have concluded the anti-inflammatory regimen is very safe and likely to be the best and most effective CH preventative we can take.  It's so safe I've had my family and close friends taking it since 2011.  That includes my daughter and niece who have taken it through three pregnancies, deliveries and while breast feeding. 

In short, I have three grand kids who were bathed in maternal vitamin D3 from conception through breastfeeding as their mothers were taking 10,000 IU/day vitamin D3 plus the cofactors the entire time and continue to do so today and they don't have CH. After that they take 50 IU per pound of body weight per day as a vitamin D3 maintenance dose along with a multi vitamin and mineral chew.  These three grand kids are vitamin D3 poster children.  They have remarkable physical and mental development with T-Rex immune systems.  They don't get sick.  They are also budding Einsteins.  My grand daughter Fred, a.k.a., Winefred was speaking fluent Hochdeutch at age 2 and completed pre-kindergarten in Heidelberg Germany where only Hochdeutch was spoken.  She is now 5 and attending Kindergarten, but spinning her wheels...  She comes home, completes first and second grade reading assignments, writes short stories, then does simple math addition and subtraction...   I'm the old goat in the cowboy getup.  I grew up on a horse.

Enough about me and on to the more important stuff.  If you haven't already picked them up, the following photo illustrates the "Go to" supplements of choice by brand and doses my wife and I take.  We switched to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 capsules in July of 2018.  We've taken the rest for over 8 years.  Many CHers have made this same switch as we've all found this form of vitamin D3 is faster acting with a higher bioequivalence than the same dose of the oil-based liquid softgel vitamin D3 formulations.  In simple terms, stick with these brands for the best results.

Over the last few years we've found it's best to start this regimen with the accelerated 12-Day vitamin D3 loading schedule taking 50,000 IU/day for 12 days then drop back to an initial vitamin D3 maintenance dose of 10,000 IU/day.  If you have the Bio-Tech D3-50, all you need is one (1) D3-50 a week,  This works out to an average dose of 7,000 IU/day.  However, given the higher bioavailability, the effective dose with the D3-50 at one capsule a week, is more effective than 10,000 IU/day.  Your daughter will need to double the magnesium dose from 400 mg/day to 800 mg/day split 400 mg with breakfast and 400 mg with the evening meal.  Splitting the magnesium dose like this helps prevent osmotic diarrhea.

When your daughter has been on this regimen for at least 30 days, take her to the family PCP/GP to discuss this regimen and to request lab orders for her serum 25(OH)D3, calcium and PTH.  Have her PCP write the lab orders to Quest Diagnostics using the following:

Quest Diagnostics Test Name: 92888-QuestAssureD 25-OH Vitamin D (Total), LC/MS/MS. Parathyroid Hormone (PTH) Intact and Total Calcium. CPT codes 83970, 82310. 

As long as your daughter's serum calcium remains within its normal reference range, there's no hypercalcemia, a.k.a., vitamin D3 intoxication/toxicity.  You can also open a MyQuest account  for your daughter at the following link to see her lab results once her PCP has seen them.  https://myquest.questdiagnostics.com/web/home

I've used MyQuest for the last 4 years.  It's the best way to track progress with this regimen.  The following chart illustrates my lab results for 25(OH)D3, calcium and PTH over the last three years.  As you'll see I've run my 25(OH)D3 up as high as 188 ng/mL due to an allergic reaction to mold spores in June of 2018.  You'll also note my serum calcium remained in the green (within its normal reference range) the entire time so there was no hypercalcemia.  My PCP understands why I take this much vitamin D3 and has no problem with my 25(OH)D3 serum concentrations this high, as long as my serum calcium remains normal...  and it has.

When you have your daughter's lab test results in hand, have her take the online survey of CHers taking the anti-inflammatory regimen.  To start this survey, click on the following link:
http://www.esurveyspro.com/Survey.aspx?id=fb8a2415-629f-4ebc-907c-c5ce971022f6

Data from this survey is the only thing most physicians will understand and more importantly, suggest to their patients with CH.

If you want a warm fuzzy about your daughter taking this regimen to prevent her CH, you, your wife and daughter need to watch the following video by Dr. Michael Hollick. 

https://www.youtube.com/watch?v=hiGBVDcbFVk

This is an informative and humorous presentation on vitamin D3 and calcium needed to build strong bones.  Just understand that the vitamin D3 doses Dr. Hollick suggests are for otherwise healthy people.  CHers are not otherwise healthy people.  They need higher therapeutic doses of vitamin D3 plus the cofactors to prevent their CH.I know you'll have lots of questions so fire away as they come up.  If you'll shoot me an email or PM me your email address, I'll send you the latest version of the anti-inflammatory regimen.  My email address is pete.batcheller@verizon.net.

Take care and please keep me posted on your daughter's progress with this regimen.  I'm here to help.

V/R, Batch

Don,

Good question.  I've tapered the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 dose down to one capsule a week, an average vitamin D3 dose of 7,000 IU/day.  I take the rest of the cofactors daily.  I've found the Bio-Tech D3-50 water soluble vitamin D3 to be faster acting with a higher bioequivalence than the same dose of oil-based liquid softgel vitamin D3 formulations in terms of elevating serum 25(OH)D3.

In simple terms, one Bio-Tech D3-50 a week has kept my 25(OH)D3 serum concentration steady at 150 ±4 ng/mL for the last 9 months measured with lab tests for 25(OH)D3 every 3 months.

Hope this helps.

Take care and please keep me posted.

V/R, Batch

Hey JSD,

Thanks for the status uipdate.  I would bite the bullet and take the full loading dose at 50,000 IU/day for 3 to 5 days.  If your 25(OH)D has yet to reach a therapeutic level, the loading doses should help.   If the CH beast is still jumping ugly, load for a few more days.  I just read a case history of a 22 year old male who presented with seizures.

Serum Chemistry:

Calcium 1.30 mmol/L

Phosphate 0.65 mmol>L

25(OH)D < 10 nmol/L

DX: Hypocalcemia secondary to Vitamin D Deficiency

He was treated with 500,000 IU/day vitamin D3 for four days (2 million IU) and IV calcium.  He walked out of the hospital in great shape/

My wife is a 115 pounder and eats like a bird.  She took 15,000 IU/day from her start on this regimen and that has kept her migraine pain free since 2010.  She dropped back to a maintenance dose at an average of 7,000 IU/day alternating between 10,000 IU/day and 5,000 IU/day two years ago and has remained migjraine free..  Her serum 25(OH)D stayed constant at 120 ng/mL at a maintenance dose of 15,000 IU/day and is now down to 97 ng/mL at an average maintenance dose of 7,000 IU/day.

As to where to go for your lab tests of your serum 25(OH)D, calcium and PTH.  I would start with your husband's flight surgeon or the nearest military medical facility.

If push comes to shove, the magic word to get these lab tests. is "Hypervitaminosis D". Tell the doctors you've been taking 50,000 IU/day vitamin D3 and want to make sure your serum calcium is still within its normal reference range.  This works every time...

Take care and please keep me posted.

V/R, Batch

Hey JDS,

Howzit?  Have you started the anti-inflammatory regimen.  Did you start it with the 12-Day accelerated vitamin D3 loading schedule at 50,000 IU/day vitamin D3 for 12 days?

Take care and hugs,

Peter

Skyler,

If you're taking the suggested Kirkland brand Adult 50+ Mature Multi, you're getting the right amount of calcium at 230 mg/day.

I'll need your email address to send you the latest draft version of the anti-inflammatory regimen.  It's too big to attach in this blog.  It should provide what you're looking for, but it's still a work in progress and not ready for prime time so don't pass it on or post.  You can also shoot me an email at pete.batcheller@verizon.net.

Take care and please keep me posted

V/R, Batch

Skyler,

Your doctor is playing a CYA in response to your higher labs for serum calcium concentrations.  This is a "normal" response by physicians so they can't be accused of malpractice.  Acknowledge, your physician's warning and tell him you plan to continue vitamin D3 dosing to prevent your CH.  Doing this takes him off the malpractice hook.

A serum calcium concentration at the top of its normal reference range, but not over,  indicates normal calcium homeostasis, the mechanism by which the body controls blood calcium concentrations.  There's nothing alarming about calcium levels this high and it's no reason to stop vitamin D3. 

To answer your question about needing a higher 25(OH)D serum concentration than 120 ng/mL to prevent your CH, the answer is YES.  Many CHers will need a higher 25(OH)D serum concentration to prevent their CH, particularly if they're experiencing an allergic reaction to airborne or food borne allergens.  For reference, see my labs for 25(OH)D3, calcium and PTH over the last three years.  I was taking an average of 40,000 IU/day vitamin D3 when my serum 25(OH)D3 and calcium where highest.

As you can see, my calcium serum concentration was up near the top of its normal reference range, but not over it.  You can also see where my PTH goes lower in response to the higher serum calcium and 25(OH)D3 concentrations.  This is also a good indication of a normal calcium homeostasis.  Please feel free to share my labs with your doctor.

I needed to increase my vitamin D3 dose between 25,000 IU/day and 40,000 IU/day and resulting serum 25(OH)D3 due to allergic reactions to airborne allergens (pollen, mold spores) in order to remain CH pain free.  The allergic reactions triggered a flood of histamine that reduced vitamin D3 effectiveness in preventing CH.  There are two courses of action to take if you're experiencing an allergic reaction (they can be subclinical with no outward or obvious symptoms):

1. Start a week to 10-day course of Benadryl (Diphenhydramine HCL) at 25 mg every 4 hours during the day.  If there's no response with a reduction in CH frequency after 5 days, discontinue.

2. Titrate the vitamin D3 dose - increasing the maintenance dose every 3 to 4 days until you experience a reduction in CH frequency.  The best way to do this is to take a 50,000 IU vitamin D3 loading dose for two days then drop back to a new vitamin D3 maintenance dose of 15,000 IU/day.  If there's no change in CH frequency after four days, load for another two days, but continue the maintenance dose of 15,000 IU/day.  If there's still no change in CH patterns after another 3 to 4 days, repeat the 2-day loading schedule then drop back to a maintenance dose of 20,000 IU/day.  Be sure to take all the cofactors daily and double the magnesium dose to 800 mg/day while loading.  Split the magnesium dose by taking 400 mg with breakfast and 400 mg with the evening meal.  This will help avoid osmotic diarrhea. 

Once you've been at a stable maintenance dose of vitamin D3 that keeps you CH pain free for 30 days, see your PCP/GP for another set of labs for your 25(OH)D, calcium and PTH.  It's very unlikely your serum calcium will go over its normal reference range.  That said, should this happen, it is not a medical emergency.  However, you will need to stop vitamin D3 intake for at least two weeks then resume at a lower vitamin D3 maintenance dose.  Test again 30 days later.

Take care and please keep me posted,

V/R, Batch

Hey JSD,

Sorry you're having such a rough time.  I know all too well what you've been going through and the good news is it doesn't need to be that way.  You're very likely vitamin D3 deficient.  Solve that deficiency and get on an Atkins-Ketogenic diet drinking 2.5 liters of water a day and you'll be right as rain with no CH in short order.

You're off to a good start picking up the needed supplements.  Did you pick up the following by brand?  If not, please let me know what you do have or send me a photo.  Over the last 8 years, CHers who stuck with the suggested brands below had the best response.  I'm a chronic CHer and have taken this clutch of vitamins and minerals since 2011 and have been CH pain free ever since

Your next step is to see your PCP/GP.  As your husband is a military pilot, the squadron flight surgeon would be a good start.  What Service and type aircraft?  I'm a retired Navy fighter pilot except the F-8 Crusader and F-4 Phantom jets I used to fly are either on pedestals or in the bone yard at DM.

Here are the following steps you need to follow:

The high level protocol is simple.

1. You'll need to start an Atkins - Ketogenic diet. This is very important as most CHers and migraineurs have subclinical allergic reactions to wheat products.  Start this diet plan with a 24 to 36 hour fast drinking only water. 

After the fast, it's zero sugars (no fruit juices either - too high in fructose). Zero wheat products, i.e., no bread, pasta, cakes, pastries, cookies, crackers or pizza.  No grain oils like Mazola or Canola.  Good oils/fats are organic butter, extra virgin olive oil, avocado oil and my favorite, extra virgin coconut oil.  You can eat all the free range organic meats, poultry and eggs you want.  A serving to two a week of wild caught fish like Sockeye salmon is great.  You can also eat all the organic Non-GMO green and colored veggies you want.  Limit fruit to a handful a day of dark berries like blackberries, blueberries, boysenberries or raspberries.  Super foods are onions, garlic, ginger, and nuts like Non-GMO almonds and walnuts.

2. See your PCP/GP (or husband's flight surgeon) to discuss this regimen and have him or her order lab tests of your serum 25(OH)D, calcium and PTH.  There are a few medical conditions where the anti-inflammatory regimen is contraindicated such as hypercalcemia, hyperparathyroidism and sarcoidosis.  Your PCP/GP should know if you've any of these conditions.  This is an important step as it's best to have your PCP/GP and even your neurologist in some cases, as a team player while starting this regimen as your PCP/GP will need to order these same labs 30 days after starting this treatment protocol.  If possible have your PCP/GP write a single order for both sets of these labs.  It's important to specify Quest Diagnostics for these lab tests as their LC-MS/MS assay for 25(OH)D3 is good to 512 ng/mL where the DiaSorin chemiluminescent immunoassay (CLIA) is only good to 117.4 ng/mL.

3. Once the blood draw for these labs is complete, start this regimen with a 10-day accelerated vitamin D3 loading schedule taking one (1) of the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 capsules a day for 10 days.  You'll need to double the magnesium dose while loading to 800 mg/day split 400 mg with breakfast and 400 mg with the evening meal. Doing this will help avoid osmotic diarrhea.  Take all the other cofactors daily.  If you've only the oil-based liquid softgel vitamin D3 formulations, you'll still need the 10-day accelerated vitamin D3 loading schedule at 50,000 IU/day for 10 days. When complete, drop back to an initial maintenance dose of 10,000 IU/day vitamin D3 plus all the cofactors.

4. At completion of the accelerated loading schedule, drop back to an initial vitamin D3 maintenance dose of one (1) Bio-Tech D3-50 a week. Note: This maintenance dose will likely be too high, but that's OK as long as it prevents your CH.  You'll know once you get the results back from your second set of labs for serum 25(OH)D, calcium and PTH 30 days after start of regimen.

5. Thirty (30) days after start of regimen, get the second set of labs for your serum 25(OH)D, calcium and PTH.  The critical parameter in these lab tests is your serum calcium concentration.  As long as your serum calcium concentration is within its normal reference range, you're good to go.  If your serum calcium concentration is above its normal reference range, this is not a medical crisis, but you will need to stop all vitamin D3 supplementation for at least a week or two and limit high calcium food types like all dairy products, then restart the vitamin D3 at half the previous dose, i.e., one (1) Bio-Tech D3-50 capsule every two weeks.

a. If your serum 25(OH)D is over 150 ng/mL, as long as your serum calcium is within its normal reference range and you're CH pain free, drop the maintenance dose to one (1) Bio-Tech D3-50 capsule every 10 days. You'll need to mark your calendar to make sure when to take this dose.  you'll be taking the Omega-3 fish oil and all the other vitamin D3 cofactors daily. As long as this new maintenance dose is keeping you CH pain free, have these three lab tests done again 3 months later.

b. If your serum 25(OH)D is between 100 ng/mL and 149 ng/mL, your serum calcium is within its normal reference range and you're CH pain free, don't change a thing.  Have these three tests done again 3 months later.  If there's no significant change in these labs, have them done at your annual physical.

6.  There are a few speed bumps in getting started on this regimen.  I've seen most of them and they're not show stoppers.  We can handle these contingencies by phone. 

Please call me.  The home phone here in Tracyton, WA, 20 miles West of Seattle across Puget Sound, is (360) 377-6266.  We've an anti-ROBO troll answering system that will tell you to take this number off your calling list.  Just stay on the line and you'll hear the ring-tone.  The best cell number is my wife, Joyce's iPhone at (703) 906-0702, with the back up number (703) 906-0701 being my old flip phone.  If you have an iPhone or iPad you can FaceTime me at pete.batcheller@verizon.net.

If you've an android phone, you can use WhatsApp and the same email address or (703) 906-0702.

Once you're up on this regimen and have your CH under control, you'll want to get your kids and husband on this regimen too.  This regimen is so safe and healthy, I've had my entire family and close friends taking it since 2011.  My three youngest grand kids were bathed in maternal vitamin D3 since conception through breastfeeding.  After that they get 50 IU of vitamin D3 per pound of body weight per day.

Fred, a.k.a.Winefred was the first.

Fred and baby brother Orrin are never sick.  Both have a remarkable growth rate and neuromotor development.  They're also budding Einsteins. Fred was speaking fluent hochdeutsch at 2.  She just completed kindergarten at a local school in Heidelberg, Germany.

Take care and please keep me posted.

Hugs, Peter

SECA,

Thanks for the update.  I just replied to your post over at CH.com.

Take care,

V/R, Batch

Dreamer,

It was the vitamin D3.  The dirty little secret Big Pharma doesn't want you to know is the anti-CGRP monoclonal antibodies are too larger to pass through the blood brain barrier so cannot go to the site of action within the nuclei of neurons within the trigeminal ganglia.  If the Aimovig provided anything, it was to reduce serum CGRP.  Unfortunately that is after the fact as CGRP is experssed from within the sensory neurons creating the pain of CH....

Hugs, Peter

Hey Dreamer,

Thank you for the back-brief.  I'm always happy to hear another CHer has found the anti-inflammatory regimen effective in preventing their CH.  Your serum 25(OH)D is Spot On at 80 ng/mL.  All you need to do is stay on the complete anti-inflammatory regimen at 10,000 IU/day vitamin D3 plus all the cofactors year round! 

The normal range of 25(OH)D serum concentrations among 257 CHers responding to this regimen are illustrated in the following normal distribution curve.  This data comes from the study that's been running since December of 2011.  This is the longest running study of its kind in assessing the effectiveness of vitamin D3 as a CH prophylaxis.

As you can see, the mean 25(OH)D serum concentration among the 209 CHers experiencing a favorable response is 80.1 ng/mL where they experienced an 80% reduction in the frequency of their CH from an average of 3 CH/day down to 3 CH/week in the first 30 days and the 50% of CHers taking this regimen who experienced a complete cessation of all CH symptoms in the first 30 days.

It's best to stay on this regimen year round even if you're an episodic CHer.  Your serum 25(OH)D will drop by 14 ng/mL each month you don't take the 10,000 IU/day vitamin D3.  As you're episodic and you've stopped taking this regimen after your last cycle, your 25(OH)D serum concentration will have dropped below the pain free threshold when your next cycle comes around.  When that happens, the CH beast will jump ugly again...  CCHers don't have a choice so take this regimen year round.  We call taking this regimen daily a way of life...  A very good and healthy way of life at that.

Unless you've already done so, be sure to take the online survey of CHers taking this regimen to prevent their CH.  To start this survey, click on the following link:
http://www.esurveyspro.com/Survey.aspx?id=fb8a2415-629f-4ebc-907c-c5ce971022f6
I do have a question for you.  Are you still taking the Amovig?   As a member of the American Academy of Neurology, I stay abreast of all the anti-CGRP monoclonal antibody (mAb) studies.  I've spoken to a molecular biologist about these mAbs and he just laughed...  There's no way these mAbs can pass through the blood brain barrier (BBB).  Its windows are only 400 Daltons in size, a measure of molecular mass. 

All of the anti-CGRP mAbs have a molecular mass of 15,000 Daltons so are 37 times too big to pass through the BBB.  That means these anti-CGRP mAbs cannot get to neurons within the trigeminal ganglia where CGRP is expressed in the brain and the leading cause of the neurogenic inflammation and pain we know as CH.  That also means any therapeutic effect (and it's not all that great) from taking these mAbs is due to a reduction of serum CGRP concentration. 

Vitamin D3 has a molecular mass of 385 Daltons and 25-Hydroxy Vitamin D3, a.k.a., 25(OH)D has a molecular mass of 400 Daltons.  Accordingly, both pass through the BBB and into neurons within the trigeminal ganglia where they are hydroxylated to 1,25(OH)2D3, the genetically active vitamin D3 metabolite that down-regulates the expression of CGRP to prevent our CH.

So much for your lesson in molecular biology...  Thank you again for the update.

Take care and please keep me posted.

Hugs. Peter

CHWife,

My pleasure...

To start this survey, click on the following link:
http://www.esurveyspro.com/Survey.aspx?id=fb8a2415-629f-4ebc-907c-c5ce971022f6

Take care and hugs,

Peter

Hey CHWife,

Thanks for the feedback.  I'm always glad to hear another CHer has found this regimen keeps them CH pain free.   In regards to your question, I estimate at least 2000 CHers have started this regimen since December of 2010.  The online survey of CHers taking this regimen has recorded a little over 300 completed and submitted surveys out of 600 surveys started.  That works out to roughly 30% who started this survey and 15% who completed it.

One of the important lessons learned over the last 8 years is if the CHers is still experiencing a few CH... the vitamin D3 dose and resulting 25(OH)D serum concentration isn't high enough.  The following chart from this survey illustrates favorable responses up to 150 ng/mL.  To have a 25(OH)D serum concentration that high requires a daily vitamin D3 intake between 30,000 and 40,000 IU/day.

It's still not too late to take this survey.  They all help.

Take care and please keep me posted.

V/R., Batch

Jonathan,

You should have my email response to your request by now.  I think I answered all your questions, but just in case, shoot me an email if I've missed something or you've another question.

I'm well aware doing battle with cancer is a full time dedicated team effort between you and your doctors.  I'm shy one kidney and several square inches of scalp due to cancer... most likely caused by a year on a monoclonal antibody called daclizumab.  That said, I've managed through all this without chemo or radiation therapy... just lots of vitamin D3, the vitamin D3 Cofactors and lots of Vitamin C.

I haven't found any open source data on adverse interactions between vitamin D3 and ibrutinib.  There are some links suggesting Omega-3 fish oil can be a problem but no technical or clinical data to back that up.  What I do know is the anti-inflammatory regimen with 10,000 IU/day vitamin D3 works wonders building a healthy immune system.

I'm here to help... and learn.

Take care and please keep me posted.

V/R, Batch

Hey BCB,

I get PMs just fine.  Pick up the supplements shown in the photo below with the exception of the Nature's Bounty D3 5,000 IU vitamin D3 soft gels.

Replace the Nature's Bounty D3 5,000 IU soft gels with the Bio-Tech D3-50 water soluble 50,000 IU capsules shown in the Amazon photo below. You can pick up the Nature Made high potency 400 mg Magnesium, Nature Made 1200 mg Omega-3 Fish Oil and Adult 50+ Mature multi at Costco, Sam's, Wallyworld, and most super markets.

Add the Super K with advanced K2 Complex to your amazon order for the Bio-Tech D3-50.  While you're waiting for the deliveries from amazon, see your PCP/GP for lab tests of your serum 25(OH)D, calcium and PTH.  If you're in a pinch, the lab for 25(OH)D will do.

Start this regimen with the 12-Day Accelerated Vitamin D3 Loading Schedule taking 50,000 IU/day vitamin D3 for 12 days (Take one [1] of the Bio-Tech D3s-50 capsules daily for 12 days) then drop the vitamin D3 dose to one (1) Bio-Tech D3-50 capsule every five (5) days for an average of 10,000 IU/day vitamin D3.  During this accelerated vitamin D3 loading schedule double the magnesium dose to 800 mg/day split 400 mg with breakfast and the other 400 mg with the evening meal.  Take the rest of the supplements as shown by capsule count in the first photo daily.

If you've not experienced a favorable change in your CH patterns by the end of the first week on the vitamin D3 loading schedule, start a week to 10 day course of Benadryl (Diphenhydramine HCL) at 25 mg every four hours throughout the day and at bedtime.   If that doesn't help, you have questions or problems, shoot me an email at pete.batcheller@verizon.net as there are other steps that have worked for others with this problem.

Be careful and not drive while taking the Benadryl as this much Diphenhydramine will make you drowsy.  If you need to drive during the day, wait until you're home for the day then take 50 mg of Benadryl (Diphenhydramine HCL) as you walk through the door and another 50 mg at bedtime.

30 days after the start of this regimen, see your PCP/GP for labs of your serum 25(OH)D, calcium and PTH.  Please let me know when you get the results.  Your 25(OH)D serum concentration should be up around 80 ng/mL, your serum calcium within its normal reference range, and your PTH in the lower third of its normal reference range.

Once you have the lab data in hand, please take the online survey of CHers taking this regimen to prevent their CH.  To start this survey, click on the following link:
http://www.esurveyspro.com/Survey.aspx?id=fb8a2415-629f-4ebc-907c-c5ce971022f6

Take care and please keep me posted.  I'm here to help.

V/R, Batch

You only need the Benadryl (Diphenhydramine HCL) if you haven't experienced a favorable change in CH patterns by the end of the first week of the accelerated vitamin D3 loading schedule or... if you think you're experiencing an allergic reaction like allergic rhinitis.  Nothing wrong taking melatonin with this regimen.

Hey HCH,

Thank you for the wonderful feedback on your experience with the anti-inflammatory regimen.

Sorry for the delay in responding.  I had to do some additional research to confirm my initial response to your question regarding accutane (Isotretinoin).   Isotretinoin is a man-made drug with a molecular function similar to vitamin A, hence the warning not to take vitamin A along with accutane due to the risk of toxicity. 

Isotretinoin is also a teratogen highly likely to cause birth defects if taken by women during pregnancy or even a short time before conception.

When people ask me questions like this, as I'm not a doctor, I don't diagnose, treat or prescribe, I tell them what I would do and what other CHers have done under similar circumstances.  In the case of accutane (Isotretinoin), I would not take it even with a face broken out like zit city.   I would also advise members of my family not to take it.  The risks of adverse side effects are too great.  see following link.

https://en.wikipedia.org/wiki/Isotretinoin#Teratogenicity

Natural forms of vitamin C (ascorbic acid) are a more effective and natural method of controlling acne.  Liposomal essentially means wrapped in fat (lipids) to make this form of vitamin C fat soluble.  This allows liposomal vitamn C  to remain in our systems longer than the water soluble forms of vitamin C.  Vitamin C helps form collagen, the connective tissue in cell walls, muscles, joints, our skin, hair and fingernails.  Vitamin C also helps build a strong immune system and anti-inflammatory.  It helps build strong arteries, capillaries and microvascular systems in our skin that become inflamed during an acne infection.

I take 2400 to 4800 mg/day liposomal vitamin D3.

https://www.amazon.com/Liposomal-Bioavailable-Antioxidant-Supports-Collagen/dp/B07CQBT5R5?SubscriptionId=AKIAILSHYYTFIVPWUY6Q&amp;tag=duckduckgo-ffnt-20&amp;linkCode=xm2&amp;camp=2025&amp;creative=165953&amp;creativeASIN=B07CQBT5R5

Hope this helps.

Take care and please keep me posted,

V/R, Batch

Hey JH,

Thanks for the headzup you're starting the anti-inflammatory regimen. You've made a wise decision...

Regarding the folate, the Tolerable Upper Intake Level (UL) for Folic Acid is 1000 μg/day (1 mg/day).  That said, taking even higher doses of folate should not pose a problem.

We're almost in the same boat... I lost my left kidney to cancer last year...  This form of cancer was likely due to a 18 month long course of an experimental monoclonal antibody called daclizumab.  I was taking it back in 2000 as a participant in a clinical trial at the National Eye Institute, NIH Bethesda, MD to control an autoimmune eye disorder called uveitis.  My retina were trying to reject me...  The daclizumab was destroying my immune system resulting in all kinds of infections including colds, flu, pneumonia, pancreatitis, eosinophilic meningitis and squamous cell skin cancer... all in the course of this study.

Regarding my left-hand assisted nephrectomy, my urologist was amazed how fast I recovered from the laparoscopy and that my labs looked so good with the exception of my 25(OH)D which I keep up around 150 ng/mL.  When I explained why I kept it that high to prevent my CH, he got a smile on his face and said... "OK... as long as your serum calcium remains in the normal reference rage with your 25(OH)D this high... I've no problem with you doing this..."  My serum calcium has always remained within its normal reference range.

The only problem I've noticed with one kidney... I can only get half as pissed off as I used to...

Take care and please keep me posted.

Peter

Good moves...

Hey J,

Thanks for the update and sorry... Crap happens...  I'm guessing your taking enough vitamin D3.  That said, it may be worth switching to Bio-Tech D3-50 water soluble 50,000 IU vitamin D3 capsules.  Many of us have found this form of vitamin D3 to be faster acting and more potent in terms of elevating serum 25(OH)D concentrations higher than the same dose of the oil-based liquid soft gel vitamin D3 formulations. One of these Bio-Tech D3-50 50,000 IU capsules every 4th day will give you an equivalent dose of the liquid soft gel formulation at 25,000 IU/day.  I take one a week.  You'll need to order it from amazon.com or iherb.com.  In the mean time while you're waiting for delivery, 3 to 4 days of 50,000 IU/day vitamin D3 loading doses won't hurt.

https://www.amazon.com/Biotech-Pharmacal-D3-50-000iu-Capsules/dp/B000A0F2B2

Have you doubled up on the magnesium 400 mg with breakfast and 400 mg with the evening meal? I'd double the Omega-3 dose as well.  After that I'd start taking 1000 mg/day Turmeric (Curcumin), 500 mg/day Resveratol and 500 mg/day Quercetin. Bot help activate VDR to increase genetic expression.

The complete list of additional helper supplements for CHers and Migraineurs follows:

6.  CHers with Migraine and Migraineurs will need to add:

• 300 to 900 mg/day CoQ10 (300 mg 3 times a day). CoQ10 is a must for CHers and migraineurs if taking statins

• 1000 to 2000 mg/day Turmeric (Curcumin). 

• Probiotic with a high colony forming count containing a variety of Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium bifidum, and Streptococcus thermophilus.

• 300 to 600 mg/day Alpha-Lipoic Acid (ALA)

• 500 mg/day Resveritol

• 500 mg/day Quercetin

• 4 to 6 grams/day (1000 mg every two hours) liposomal vitamin C

• 4 to 6 grams/day L-Lysine taken with the liposomal vitamin C

• Additional Vitamin B2 (riboflavin) a total of 100 to 400 mg/day

• Some Migraineurs find Feverfew and Butterbur helpful in preventing migraines.

These will appear in the next upgrade version of this protocol.

Take care and please keep me posted.

V/R, Batch

Hey Eli,

Shoot me an email or pm me your email address so I can send you the latest version of the anti-inflammatory regimen.  My email address is pete.batcheller@verizon.net.

Take care,

V/R, Batch

Did you get the latest from VitaminDWiki.com ?  If not, please shoot me an email or pm me your email address and I'll send you an updated draft I'll be releasing in January along with the latest survey results.  My email address is pete.batcheller@verizonl.net.  Take care and please keep me posted. 

V/R, Batch