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Batch

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Everything posted by Batch

  1. Hey Alikhan, Oxygen therapy with hyperventilation can be effective aborting both cluster and migraine headaches. If you haven't tried it, the anti-inflammatory regimen with 10,000 IU/day vitamin D3 plus the cofactors has a proven track record preventing cluster and migraine headaches. You can download a copy of this treatment protocol at the following vitaminDwiki link: http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 Take care and please keep us posted. V/R, Batch
  2. Batch

    Demand Valve O2

    Trent, I haven't used my oxygen kit since I developed and started taking the anti-inflammatory regimen on 10 October of 2010 except for demonstrations. The aluminum M60, Flotec Inc InGage® 0-60 lpm regulator with DISS fitting and Carnét oxygen demand valve sit unused under a plastic bag in the laundry room. There's still over 1000 psi left in the M-Size welder's cylinder in the garage I picked up in August 2010. We live out in the woods with plenty of logging equipment so I actually do some oxy-acetylene cutting and welding. There's no question that an oxygen demand valve system makes for rapid, reliable and very simple CH aborts. That said, it is only an abortive. Since starting the anti-inflammatory regimen in October of 2010, I've found life a lot more enjoyable waking up in the morning after a night of CH pain free sleep. I can even take combat naps thanks to the vitamin D3... Take care and please keep us posted. V/R, Batch
  3. Batch

    Demand Valve O2

    Hey Trent, I'm impressed... A life time ban from E-bay... Wow! Welcome to the club... I received a life time band from Facebook for suggesting 10,000 IU/day vitamin D3 plus the vitamin D3 cofactors was an effective preventative for migraine headache. Given you've invested in more than sufficient numbers of M-Size and E-Size oxygen cylinders, I'd suggest a very cost effective alternative to an oxygen demand valve and regulator with DISS fittings. It's called the Redneck Oxygen Reservoir Bag. I made the first one from a new kitchen trash bag, a plastic soda bottle with the bottom cut off (keep the cap), oxygen tubing cut off of a disposable NRB oxygen mask at the mask end, some Duck Tape and electrician's tape. I cut the corners off the closed end of the trash bag as illustrated above, insert the oxygen tubing in one corner and the soda body through the other corner from inside the trash bag and seal both with electrician's tape for a gas tight seal then close the open end of the trash bag with a few strips of Duck tape you'll have a very effective oxygen delivery system that only needs a 7 to 9 liter/minute oxygen regulator if you fill ahead of time and turn off the oxygen at the supply valve. If you've taped the seams properly, the Redneck reservoir bag should stay inflated for at least 24 hours unused. The soda bottle becomes your handle and mouthpiece for inhaling 100% oxygen. I've found a fully inflated kitchen trash bag is good for three aborts using the following procedure and breathing technique. The procedure I suggest involves hyperventilating at forced vital capacity tidal volumes with room air for 30 seconds followed by inhaling a lungful of oxygen from the Redneck reservoir bag and holding it for 30 seconds. You continue repeating this sequence in rapid succession until the pain is gone. That usually takes an average of seven complete cycles or 7 minutes. You remove the bottle cap inhale the lungful of oxygen then replace the bottle cap. The purpose of intentionally hyperventilating at forced vital capacity tidal volumes is to pump CO2 from the blood stream faster than the body generates it from normal metabolism. This lowers the CO2 content of the arterial blood shifting the pH to the alkaline side of neutral (7.35 to 7.45) to a pH around 7.5 to 7.6 resulting in a temporary condition called respiratory alkalosis. This does two things that help abort CH much faster. A low arterial CO2 level and elevated arterial pH triggers a rapid vasoconstriction in and around the trigeminovascular complex. The elevated pH also increases blood hemoglobin's affinity for oxygen enabling it to carry 15% more oxygen sending hyperoxygenated arterial blood to the brain. Oxygen triggers vasoconstriction in the trigeminovascular complex. Hyperoxygenated arterial blood triggers vasoconstriction in an around the trigeminovascular complex even faster. The net result is very rapid and very effective CH aborts like 99% effective in an average of 7 minutes across pain levels 3 though 9 on the 10-Point headache pain scale. Hyperventilating at forced vital capacity tidal volumes involves exhaling forcibly and rapidly until if feels like your lungs are empty... they're not. At that point without delay, do an abdominal crunch like doing sit ups and hold the crunch for one second or until your exhaled breath makes a wheezing sound then inhale a lungful of room air and repeat the above sequence. You should be doing around 10 of these cycles in 30 seconds. On the 10th exhalation, hold the crunch/squeeze for 3 seconds. This will squeeze out an additional half to full liter of exhaled breath highest in CO2 As the guy who patented the oxygen demand valve method of rapid CH aborts in 2010, I've found the Redneck reservoir bag and the above procedures just as effective and fast as the far more expensive oxygen demand valve system and I bought the Cadillac of oxygen demand valves, the Carmét along with a Flowtec Inc, 0-60 lpm, InGage regulator with DISS fitting plus an M60 aluminum cylinder as my roadie along with a pigtail filler nfor a total cost of ~ $2100 USD in 2008. In 2008, I conducted a pilot study of the oxygen demand valve method of aborting CH using the same breathing technique above with seven CHers (1 ECHer and 7 CCHers). They each aborted their CH with this method of procedure for 8 weeks collecting pain level and abort times for each abort. All total, they collected this data on 366 aborts. Their average abort time was 7 minutes and over 99% of the aborts came in at ≤ 20 minutes. The following chart illustrates these results. As you can see, the oxygen demand valve method of procedure produced aborts 3 to 4 times faster than traditional oxygen therapy at a flow rate of 15 liters/minute. Now here's the payoff... The Redneck Reservoir bag method of aborting CH is just as effective in aborting CH as the oxygen demand valve method. If you'll look at the photo of my oxygen kit you'll see a sticker on the oxygen cylinder with check marks indicating 30 aborts, the average number of aborts I obtained with an M-Size Oxygen or Welder's cylinder with the oxygen demand valve. As the copay for each M-Size oxygen cylinder was $30 USD, that works out to $1/CH abort. I got nearly 300 aborts from an M-Size welder's cylinder using the Redneck Reservoir bag method so that makes the cost per abort roughly 10 cents USD. All that said, I developed the anti-inflammatory regimen CH preventative treatment protocol with 10,000 IU/day vitamin D3, Omega-3 Fish Oil and the vitamin D3 cofactors, magnesium, zinc, boron and vitamin A (retinol) in October of 2010. I was CH pain free following the second dose of this regimen. I've been CH pain free ever since. You can find the anti-inflammatory regimen CH preventative treatment protocol at the following link. http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 Take care and please keep us posted. V/R, Batch
  4. Batch

    New to the group - some observations

    Hey Signals, Welcome to Clusterbusters. We know what you've been going through so you've come to the right place. Regarding travel and taking the vitamin D3 regimen, I pack a ziplock bag with enough vitamin D3 and cofactors to last the duration of my travels plus enough for a few more days in case of delays and keep it in my carry on bag. In the 8 + years since I developed this regimen, I've never had any problems with TSA or customs during international travel. I switched to the Bio-Tech D3-50 water soluble 50,000 IU vitamin D3 capsules. They make the loading schedule a snap at one capsule a day. I've been taking one D3-50 a week as my maintenance dose and this has been adequate to kept me CH pain free. At one D3-50 a week the daily cost is ~3 cents/day where the oil-based liquid softgels cost 6 cents per 5000 IU or 12 cents/day. Check your PM InBox, I've sent some additional info. Take care and please keep us posted. V/R, Batch
  5. Into Light, Gotcha... PM on the way to Spikeinthehead. V/R, Batch
  6. Batch

    Question For Batch

    Hey Chris, Excellent question. Data from the online survey of 313 CHers taking this regimen suggest the following initial target serum concentration ranges measured ≥ 30 days after start of regimen: ECHers - 80 to 90 ng/mL CCHers - 90 to 100 ng/mL To be clear, these are the initial target ranges. If you don't experience a significant reduction in the frequency of your CH or a complete cessation of CH at the 30 day mark, start/continue loading vitamin D3 at 50,000 IU/day. How long should you stay on the loading schedule becomes the next question. The average 25(OH)D3 response to loading dose of vitamin D3 is an increase of 10 ng/mL for every 100,000 IU of vitamin D3. Accordingly, as your 25(OH)D3 serum concentration is in the upper 60s ng/mL and you want it in the upper 80s or 90s, you need a total loading dose of 200,000 IU of vitamin D3 to elevate your serum 25(OH)D3 into the upper 80s in ng/mL and 300,000 IU of vitamin D3 to elevate your 25(OH)D3 into the 90s ng/mL. At a loading dose of 50,000 IU/day that works out to four days on this loading schedule if you're an ECHer and six days if you're a CCHer. Again, these are still initial target ranges. If you're not CH pain free or have experienced a significant reduction in the frequency of your CH... continue loading for a few more days. Some CCHers have loaded for 30 days at 50,000 IU/day vitamin D3 in order to experience a CH pain free response. This has driven their 25(OH)D3 up to 150 ng/mL, which is where I've maintain my 25(OH)D3 for nearly a year. It was 180 ng/mL prior to that. My PCP has no problems with my 25(OH)D3 this high as long as my serum calcium remains within its normal reference range... and it has. In any event, see your PCP/GP or neurologist for lab tests of your serum 25(OH)D, calcium and PTH after a loading schedule to determine its effect. As long as your serum calcium remains within its normal reference range, your 25(OH)D3 serum concentration doesn't really matter except as a point of reference to a pain free response. Take care and please keep us posted. V/R, Batch
  7. Batch

    Migraine...I hope you can help

    Hey Wesconsin, Welcome aboard. You've come to the right place. Check your PM inbox. I've sent you some information on preventing migraine headache. Take care, V/R, Batch
  8. Siegfried, Check your In Box. I've sent you some information about the anti-inflammatory regimen with vitamin D3. It's surprisingly effective in preventing migraine headaches with a few additions. Take care and please keep us posted. V/R, Batch
  9. Batch

    D3 Regimen restocking - Advice from batch

    Hey Dana, As far as a restock of your anti-inflammatory regimen supplements go, the following photo illustrates the "Go To" supplements I take and suggest to other CHers. The doses illustrated are daily with the exception of the Bio-Tech D3-50 50,000 IU (1,250 mcg) water soluble vitamin D3. Here I take one D3-50 capsule a week as the maintenance dose. That works out to an average dose of 7,000 IU/day. If that maintenance dose is insufficient to keep you CH pain free, reduce the daily interval from 7 days down to 6 days (8333 IU/day), 5 days (10,000 IU/day), 4 days (12,500 IU/day), 3 days (16,667 IU/day) or 2 days (48 hrs at 25,000 IU/day) as appropriate. Obtaining these supplements down under can be problematic on a couple counts. First of all, laws in Australia prohibit sales of vitamin D3 over 2000 IU (50 mcg). That makes the only good solution for high potency vitamin D3, ordering the Bio-Tech D3-50 from iherb.com. The next problem comes ordering the Kirkland Adult 50+ Mature Multi. It appears this brand has a different formulation when ordered from Australia, New Zealand and the UK and iherb.com doesn't carry it. Fortunately, iherb carries 21st Century, Sentry Senior, Multivitamin & Multimineral Supplement, Adults 50+, 125 Tablets have a nearly identical formulation as the Kirkland Adult 50+ Mature Multi so should be a good substitute. https://www.iherb.com/pr/21st-Century-Sentry-Senior-Multivitamin-Multimineral-Supplement-Adults-50-125-Tablets/37357 In any case, when looking locally for a good alternative for the Kirkland Adult 50+ Mature Multi, try to find a product that comes closest to the following supplement facts on the Kirkland Adult 50+ Mature Multi. It has nearly all the vitamin D3 cofactors. It just doesn't have enough magnesium or any K2 complex, hence the Nature Made Extra Strength 400 mg magnesium and Life Extension Super K with Advanced K2 Complex. Hope this helps. Take care, V/R, Batch
  10. Batch

    Life Update

    Awesome Dana. Hang tough Kat.
  11. Batch

    Females and O2

    Kat, Gender has little to do with the efficacy of oxygen therapy in aborting CH. If used properly with hyperventilation at forced vital capacity tidle volumes either with 100% oxygen at 30 to 40 liters/minute with a non-rebreathing oxygen mask, hyperventilating with an oxygen demand valve, or by hyperventilating with room air for 30 seconds at forced vital capacity tidle volumes then inhale a lungful of 100% oxygen and hold it for 30 seconds then repeat this sequence until the pain is gone. In all three methods, the average abort time should be around 7 minutes with > 95% efficacy and it has nothing to do with gender. What most doctors and neurologists don't understand about effective oxygen therapy as a CH abortive, is oxygen is only half of the abortive. The other half involves blowing off CO2 faster than the body generates it through normal metabolism by intentionally hyperventilating for 6 to 7 minutes pushes the body into respiratory alkalosis. In simple terms blowing off CO2 by hyperventilating shifts blood pH to the alkaline side of neutral making it more alkaline, hence the term respiratory alkalosis. I need to point out that respiratory alkalosis from intentionally hyperventilating is temporary and harmless. It clears normally within a few minutes once returning to normal breathing rates. Respiratory alkalosis does several things that help abort CH. The first effect of respiratory alkalosis with an elevated arterial pH, is to slow the expression of Calcitonin Gene-Related Peptide (CGRP) and Substance (SP) by neurons in the trigeminal ganglia. CGRP and SP are responsible or the neurogenic inflammation and pain we know as CH. What also happens during respiratory alkalosis is elevating arterial blood pH in the lungs to the alkaline side of neutral, increases blood hemoglobin's affinity for oxygen. This enables blood hemoglobin to carry up to 117% of oxygen where breathing a little faster than normal elevates blood oxygen to only 99%. This super-oxygenated blood flow and low arterial pH does two things. It speeds up the breakdown of CGRP and SP and It also triggers triggers pH homeostasis when chemo receptors in the brain stem and aortic arch sense the low arterial CO2 concentration. These chemoreceptors signal the breathing control neurons in the brain stem to slow the respiratory rate. They also signal the heart to beat more slowly and arteries and capillaries throughout the body including the brain and trigeminovascular complex to constrict. All this happens to slow the flow of blood to the lungs to prevent the loss of CO2 and allow its arterial concentration to rise back to normal levels. While we're intentionally hyperventilating, this triggers the vasoconstriction throughout the trigeminovascular complex and this serves as a significant CH abortive effect. I can hear the wheels turning... WTF are Forced Vital Capacity Tidal Volumes? The answer is simple once you understand the terms. Tidal Volume = The volume of air (or oxygen) inhaled and exhaled. The air comes into the lungs during inhalation and goes out when exhaling, just like the tide comes in and goes out. Vital Capacity = The maximum amount of air a person can expel from the lungs after a maximum inhalation without thinking about it. Forced Vital Capacity = By doing an abdominal crunch, tightening the abdominal and chest muscles as in doing sit-ups at the end of a forceful exhalation, squeezes out an additional half to full liter of exhaled breath highest in CO2 content. If you hold the abdominal crunch and chest squeeze for at least a second, your exhaled breath will make a wheezing sound. Try it now and hold the squeeze until your breath makes a wheezing sound. Accordingly, hyperventilating at forced vital capacity tidal volumes pumps CO2 from the blood stream much faster than "normal respiration." Now for the proof this method of oxygen therapy and breathing techniques makes oxygen therapy very effective with an average abort time of 7 minutes. We conducted a pilot study of this method of oxygen therapy (hyperventilating with 100% oxygen) with seven CHers (6 CCHers and 1 ECHer, six men and one woman) in 2008. Four of the CHers used an oxygen demand valve and the other three used a Flotec 0-60 liter/minute oxygen regulator set a a flow rate of 40 liters/minute with a Cluster O2 Kit mask from CH.com equipped with a 3-liter reservoir bag. Abort times with either method were the same. Each of the seven CHers collected abort time and CH pain level at start of therapy for every CH aborted for a period of 8 weeks. This came to a total of 366 aborts with this method of oxygen therapy. 364 of these aborts were rated as successful with a complete CH abort in 20 minutes or less for a success rate of 99.4%. The results are plotted out in the following graphic. The average abort time for these 364 aborts was 7 minutes. One of the pilot study participants collected abort time and pain level data for a week while waiting for his oxygen demand valve, using a disposable non-rebreathing (NRB) oxygen mask at an oxygen flow rate of 15 liters/minute. As you can see, the demand valve method (hyperventilating with 100% oxygen) results in CH aborts 3 to 4 times faster than using a disposable NRB oxygen mask at a flow rate of 15 liters/minute. We also discovered an interesting phenomenon that the higher the CH pain level, the longer it took to abort to abort the CH. This has never been reported in any of the previous RCTs or studies of oxygen therapy as an abortive for CH or Migraine. For reference, I hold a patent on the oxygen demand valve method of aborting CH. I've also over 15 years training in Aviation Physiology primarily involving oxygen breathing systems and their use in flight. Bottom line, hyperventilating at forced vital capacity tidal volumes with 100% oxygen or hyperventilating with room air at forced vital capacity tidal volumes then inhaling a lungful of 100% oxygen and holding it for 30 second then repeating this sequence 6 more times for an average total of 7 minutes are equally effective in aborting CH. Hope this helps. Take care, V/R, Batch
  12. Batch

    D3 injection

    Hey Ali, Great question and I understand your concerns. For starters, the anti-inflammatory regimen is very safe. With well over 2000 CHers taking it there have been no reports of adverse events requiring medical attention and no reports of vitamin D3 intoxication/toxicity since I started posting about the efficacy of the anti-inflammatory regimen in December of 2011. Moreover, this regimen is so safe and so important for good health, I've had my entire family taking it for nearly 7 years and none of them have CH. My daughter and niece took this regimen at 10,000 IU/day vitamin D3 through their pregnancies. The net results are I have three grand babies who were bathed in maternal vitamin D3 since conception through breastfeeding. Once done with breastfeeding, they get a vitamin D3 dose of 50 IU per pound of body weight per day. These three kids have had a remarkable physical and neuromotor rate development. All three are budding Einsteins with incredible intellectual development. More importantly, they all have T-Rex immune systems and don't get sick. The oldest, Fred, a.k.a., Winefred was speaking fluent German (Hochdeutsch) at age 2 and she just completed kindergarten at a public school in Heidelburg, Germany. You can download a copy of the anti-inflammatory regimen CH and MH preventative treatment protocol at the following VitaminDWiki link: http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 Regarding vitamin D3 injections, I don't have any first-hand data on the efficacy of this method of vitamin D3 application, but there was a study assessing the effectiveness of 300,000 IU vitamin D3 as an IM injection compared to 300,000 IU vitamin D3 taken orally. The researchers found that both treatment regimens significantly increased vitamin D blood levels. Vitamin D status at 3 months was significantly higher in oral than in the injection group, with levels at 36 and 23.5 ng/ml respectively (p=0.03). At 6 months, levels were similar (20.8 and 24.8 ng/ml respectively). Hope this helps. Take care and please keep us posted as you start this regimen. We gain important information in feedback reports from CHers like you. V/R, Batch
  13. Batch

    Periodic Cluster changing to continuous?

    Hey Dan, I've a published version of the anti-inflammatory regimen CH and MH preventative treatment protocol posted for download on the following VitaminDWiki link: http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 Take care and please keep us posted. V/R, Batch
  14. Batch

    Life Update

    Hey Dana, G'day mate. Bonzer feedback! I can't think of a better way of convincing wallflower CHers, waiting for the next 2-step tango with the devil, to start this vitamin D3 regimen than with a success story like yours. Your words are far more convincing than anything I could say. Perth has some very fine local brews so please sip a frosty brew for me or my other favorite down under, Bundy & Coke. Good on ya, V/R, Batch
  15. Batch

    Vitamine D3

    Hey Cocobongo, Howz the head? Good work checking out the supplement facts and great question. It's clear the Kirkland Adult 50+ Mature Multi is formulated differently for different countries outside the US. Go with the second supplement. The goal of this regimen is a CH pain free response. If the CH beast continues jumping ugly, don't be afraid to increase the vitamin D3 daily maintenance dose until you're CH pain free. Be sure to see your PCP/GP for labs of your serum 25(OH)D, calcium and PTH 30 days after you reach a stable vitamin D3 dose. As long as your serum calcium is within its normal reference range, the actual 25(OH)D serum concentration doesn't really matter even if it's over 100 ng/mL. My 25(OH)D averages 150 ng/mL with normal calcium and low PTH as expected. My PCP/GP has no problems with this. Take care and please keep us posted.
  16. Batch

    Antibiotics and a decrease in clusters.

    Hey Bridge, Interesting observation and great question. Over the last 9 years providing outreach on the benefits of vitamin D3 at a minimum of 10,000 IU/day plus Omega-3 fish oil and the vitamin D3 cofactors as an effective CH preventative, we've discovered situations similar to yours. We've found that infections (viral, bacterial and fungal), allergic reactions, trauma and surgery all contribute to an increase in the frequency, severity and duration of CH even when taking vitamin D3 at a dose of 10,000 IU/day. Digging into the causality, it appears that any medical condition that triggers inflammation and activates the immune system, consumes serum 25-Hydroxy Vitamin D3 [25(OH)D3] rapidly frequently leaving too little serum 25(OH)D to prevent CH. The best course of action for bacterial infections is to take an antibiotic. The big problem in doing this is nearly all antibiotics are indiscriminate, so kill off the friendly colonies of bacteria living in our GI tract called the microbiome. As the microbiome plays a key roll in our immune system, keeping it healthy is important. Accordingly, we've found that it's best to start a course of probiotic ASAP after treatment with the antibiotic is complete. We've also found that increasing the vitamin D3 dose in a range from 15,000 IU/day up to 25,000 IU/day elevates serum 25(OH)D sufficiently to counter most viral infections. 6 to 8 grams a day of vitamin C is also helpful in combating viral, bacterial and fungal infections. Hope this helps explain your observation. Take care and please keep us posted V/R, Batch
  17. Batch

    Looking for advice

    Hey Ryan, Understand the cluster headache beast has been jumping ugly on the back of your eye and side of your face on one side of your head. If you want to stop this beast from doing a scrum inside your head and get back on the playing field, I've sent you a PM with the "How To." Take care and please keep us posted. V/R, Batch
  18. Hey Jeler, Thanks for the feedback on your CH and lab data. What brand/type of vitamin D3 are you taking? Having worked with over 100 CHers a year taking this regimen since December of 2010, your best bet is to continue your present dosing with this regimen and test again in 3 months. It's important to ask your PCP/GP to order labs for your 25(OH)D, calcium and PTH to get a good sensing of your calcium homeostasis. Take care, V/R, Batch
  19. Batch

    Vitamin d3 regimen

    Hey Kat, The liquid softgel vitamin D3 will work just fine. There's no need for additional calcium as long as you're taking the Kirkland brand Adult 50+ Mature Multi. It is formulated with 230 mg of calcium and coupled with normal dietary calcium, you should be OK. Remember to double the magnesium dose to 800 mg/day during the 12-Day accelerated vitamin D3 loading schedule. Split the dose to 400 mg magnesium in the morning with breakfast and the other 400 mg with the evening meal. Doing this should reduce the probability of osmotic diarrhea. Take care and please keep us posted. V/R, Batch
  20. Batch

    Vitamin d3 regimen

    Hey Kat, I'll echo CHfather's comment to start the anti-inflammatory regimen now. You'll need a round of labs for your serum 25(OH)D, calcium and PTH after 30 days on this regimen anyway. We can reverse engineer your 25(OH)D3 results to come up with an estimate of your starting concentration. I'm in the process of updating the posted version of this treatment protocol on my webpage at VitaminDWiki at the following link with a change in the suggested type/brand of vitamin D3 from the oil-based liquid softgel 5,000 IU vitamin D3 formulations to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 capsules. http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 I and many other CHers have found the Bio-Tech D3-50 to be faster acting with a higher bioequivalence than the liquid softgel formulations at the same dose. What this means is more CHers respond faster to this treatment protocol. The following photo illustrates the supplements I take. You can order these supplements from amazon.com and iherb.com whichever has the best price. I'd like to point out that at 22 cents per capsule taken once a week, the cost of this form of vitamin D3 is ~ 3 cents/day. Two of the 5,000 IU liquid softgels cost 12 cents a day. Dosing with the Bio-Tech D3-50 is different when it comes to the maintenance dose. I've been taking one (1) of the Bio-Tech D3-50 capsules a week. I think this is a good starting maintenance dose after the 12-Day accelerated vitamin D3 loading schedule illustrated in the following notional graphic. As you can see, the 12-Day vitamin D3 loading schedule at 50,000 IU/day for 12 days elevates serum 25(OH)D far more rapidly than just taking a maintenance dose of 10,000 IU/day which can take a month or more to elevate your 25(OH)D to a therapeutic level capable of preventing your CH. Taking the 12-Day accelerated loading schedule means you elevate your serum 25(OH)D to a therapeutic level faster for the expected reduction in CH frequency or complete cessation of CH symptoms. You may need to lower the vitamin D3 maintenance dose following the 30 day labs by adding an additional day or more between doses from one 50,000 IU capsule a week to one capsule every 8, 9 or 10 days. The key is frequent lab tests until you reach a stable dose and 25(OH)D response as you'll see in the following charts of my labs for 25(OH)D, calcium and PTH over the last 3 years. My PCP has no problems with my 25(OH)D3 concentrations this high as long as my serum calcium remains within its normal reference range. As you can see, it has. It's normal for PTH to be at the low end of its normal reference range when serum 25(OH)D is above 100 ng/mL. What you need to avoid is taking the PTH to zero by pushing your 25(OH)D too high like > 190 ng/mL. Like anything else, if the parathyroid glands sense there's no need to produce the PTH, they will eventually stop expressing this hormone and that would not be good. Regarding the efficacy of this regimen in preventing the other TACs, I don't have any concrete data. That said, as these TACs share much of the same pathogenesis with Calcitonin Gene-Related Peptide (CGRP) and Substance P (SP) playing major roles in neurogenic inflammation and nociception (pain) common to All TACs including CH, it's not unreasonable to expect vitamin D3 and its cofactors will help lower the frequency, severity and duration of the other TACs like it does for CH by down-regulating the expression of these two neuroactive peptides. There's really no harm in trying. Regarding the anti-inflammatory regimen acting as a CH abortive, it's really a matter of response times. We expect abortives like subcutaneous sumatriptan succinate to abort a CH in a matter of 5 to 10 minutes and nasal spray of same in 10 to 20 minutes. A single oral dose of 50,000 IU of vitamin D3 can produce a marked reduction in CH frequency in as little as 12 hours so it's more a preventative than abortive. That said, several of us are working on an inhaled formulation of micellized (water soluble) vitamin D3 nano mist or nasal spray as a potential abortive. It's too soon to tell, but I suspect this method of administration will be faster acting in terms of reducing CH frequency and possibly aborting CH. I hope this covers your questions. Please keep us posted as you start this regimen. Take care, V/R, Batch
  21. Hey Darren, Zookah gave you the best advice. Your healthcare system in Canada does not cover routine 25(OH)D lab test unless there's a potential medical emergency. You can try telling your PCP/GP or neurologist you're taking 50,000 IU/day vitamin D3 and want to make sure it's not causing hypercalcemia, a.k.a., vitamin D3 intoxication/toxicity. If your PCP/GP is on the ball, he'll order a lab test of your serum calcium as well. If that doesn't work, you can order a DIY 25(OH)D home blood spot test kit from GrassrootsHealth at the following link. They will ask you to join their D*Action program and register (it's free). The D*Action program tracks people taking vitamin D3 with a questionnaire and 25(OH)D lab tests. The charge for the home 25(OH)D lab test is $65 USD. I've used it many times and keep a D*Action test kit on my desk at all times. https://grassrootshealth.net/project/order-home-test-kit/ The assay method used for this DIY home test for 25(OH)D is called LC-MS/MS (liquid chromatography dual mass spectroscopy). This is the only assay method I suggest as it's capable of measuring total 25(OH)D serum concentrations up to 512 ng/mL, where the DiaSorin assay method, chemiluminescent immunoassay (CLIA) is only good up to 117.4 ng/mL. This is important as many CHers need to elevate their serum 25(OH)D above 120 ng/mL to experience a CH pain free response to this regimen. Regarding the safety of the anti-inflammatory regimen including the 12-Day accelerated vitamin D3 loading schedule... It's very safe. I've been providing information outreach on the this regimen since December of 2010. I estimate over 2000 CHers have started this regimen since then and I've yet to see a CHer report hypercalcemia as a result of following this CH preventative treatment protocol. The anti-inflammatory regimen is so safe I also have the rest of my family including three grand kids on this regimen and none of them have CH. The kids get a vitamin D3 dose of 50 IU per pound of body weight per day. For reference, I've had to take average doses of vitamin D3 up to 40,000 IU/day due to allergic reactions to pollen and mold spores in order to remain CH pain free. This has driven my 25(OH)D well above the 100 ng/mL upper limit of the normal reference range for this lab test as you'll see in the following chart of my lab results for 25(OH)D, calcium and PTH over the last 3 years. My PCP is OK with my 25(OH)D serum concentration this high as long as my serum calcium remains within its normal reference range... and as you can see, it has. I'm 75, in good health, and I don't take any Rx medications. It appears you've read enough about this treatment protocol to know that you'll need a second set of labs for your serum 25(OH)D, calcium and PTH when you've been on this regimen for at least 30 days. This is one of the reasons it's very helpful to have your PCP/GP or neurologist working with you in a team effort as you start this regimen. Accordingly, it may be helpful if you download a copy of the treatment protocol at the following link and take it to your PCP/GP or neurologist when you ask for the 25(OH)D lab test. http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 It's interesting to note that readers of my web page at VitaminDWiki.com have downloaded over 34,000 copies of the above treatment protocol since I put it up online in January of 2017. When you have the results from this second set of labs in hand, please try to take the online survey of CHers taking this regimen. I'm using the results as part of a study to help neurologists and headache specialists become aware of the benefits of this treatment protocol so more CHers can experience the wonderful sensation of CH pain free life. To start this survey, click on the following link: http://www.esurveyspro.com/Survey.aspx?id=fb8a2415-629f-4ebc-907c-c5ce971022f6 Thanks, take care and please keep us posted. V/R, Batch
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    Intro / Vitamin D

    Hey Jost, Thanks for the feedback and sorry you're having a rough time. I'll be updating my web page at VitaminDWiki as soon as I get some feedback on the protocol update from a few vitamin D3 experts and neurologists who treat CHers and migraineurs with vitamin D3. I've been to Phoenix in the August time frame, so don't envy your situation with the temperature. Infections and allergies consume serum 25(OH)D rapidly, frequently leaving too little remaining to prevent CH or migraines. The best course of action reported by many CHers when they encounter infections is to load vitamin D3 for 3 to 4 days and increase their vitamin C intake to at least 6 grams/day. Allergies require a week to 10-day course of a first-generation antihistamine like Benadryl (Diphenhydramine HCL) taken at 25 mg every four hours throughout the day. (Loading vitamin D3 = taking a loading dose of 50,000 IU/day vitamin D3 for a few days to elevate serum 25(OH)D3 rapidly to a therapeutic serum concentration). The following notional graphic illustrates the advantage of a 12-Day accelerated vitamin D3 loading schedule over just taking a maintenance dose of vitamin D3. By "loading" you get to a therapeutic 25(OH)D3 serum concentration in 12 days where taking only a maintenance dose of 10,000 IU/day vitamin D3 could take upwards of one to two months to start experiencing a favorable response to this regimen with respect to CH or a viral infection. Unlike bacterial infections that require an appropriate antibiotic, there are no silver bullets for viral infections. Accordingly, in the case of a viral infection (colds and flu) bumping the vitamin D3 and vitamin C doses is the best and safest course of action. Taking these vitamins helps your body's immune system resolve a viral infection faster and more effectively. Taking an antibiotic for a viral infection is not only ineffective, antibiotics by their very nature are indiscriminate, so also kill off the friendly colonies of bacteria living in the GI tract called the microbiome. As most of our immune systems reside in the GI tract, keeping the microbiome "happy" is prudent. If your doctor has prescribed an antibiotic, be sure to start a course of probiotic as soon as you've completed the antibiotic. Regarding migraine headache... The basic anti-inflammatory regimen supplements as illustrated in the following photo by brand and maintenance dose help many migraineurs starting this regimen prevent their migraine headaches. Most of us taking the Bio-Tech D3-50 water soluble (micellized) 50,000 IU vitamin D3 capsules have found one (1) D3-50 capsule a week is an effective maintenance dose. It's always a good idea to see your PCP/GP or neurologist for lab tests of your serum 25(OH)D, calcium and PTH. Without knowing your 25(OH)D serum concentration, you're shooting in the dark at an appropriate vitamin D3 loading dose or where you are with respect to target 25(OH)D serum concentrations. For example, data from the online survey for CHers and other sources for migraineurs indicate the following mean 25(OH)D serum concentrations resulting in a significant reduction in headache frequency or complete cessation of headache symptoms. For practical purposes, the following 25(OH)D3 concentrations become the initial targets when starting this treatment protocol. Mean 25(OH)D Serum Concentration among Episodic CHers - 80 ng/mL Mean 25(OH)D Serum Concentration among Chronic CHers - 90 ng/mL Mean 25(OH)D Serum Concentration among Migraineurs - 120 ng/mL The following normal distribution of 25(OH)D3 lab test results from the online survey harvest in July of 2018 tells an important story CHers and Migraineurs need to understand. The green normal distribution curve illustrates the mean 25(OH)D3 serum concentration response of 80 ng/mL to an average vitamin D3 dose of 10,000 IU/day. What this also indicates is half of the CHers (Episodic and Chronic) responding to this regimen needed a higher 25(OH)D3 concentration for a favorable response. The blue S-shaped sigmoid curve illustrates the cumulative probability. As it's clear from the 25(OH)D responses, up to half of CHers starting this regimen, took a higher maintenance dose of vitamin D3 than 10,000 IU/day to experience a favorable response. That makes the blue sigmoid curve a reasonable dose response curve. In simple terms, a higher vitamin D3 dose results in a higher 25(OH)D3 serum concentration needed for a favorable CH response. For reference and regarding safety of vitamin D3 doses > 10,000 IU/day and high 25(OH)D serum concentrations > 100 ng/mL (250 nmol/L), I've maintained my serum 25(OH)D between 130 ng/mL and 188 ng/mL over the last three years due to allergic reactions to pollen and mold spores with no problems. My PCP is ok with my 25(OH)D serum concnetrations this high as long as my serum calcium remains within its normal reference range. As you'll see in the following chart of my lab results... it has. Besides a higher 25(OH)D serum concentration between 120 ng/mL and 150 ng/mL, most migraineurs will need some or all of the following supplements for a pain free response. o 300 to 900 mg/day CoQ10 (300 mg 3 times a day). CoQ10 is a must for CHers and migraineurs if taking statins o 3 to 6 grams/day liposomal vitamin C (1000 to 2000 mg with breakfast, lunch and dinner) o 1000 to 2000 mg/day Turmeric (Curcumin). o Probiotic with a high colony forming count containing a variety of Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium bifidum, and Streptococcus thermophilus. o 300 to 600 mg/day Alpha-Lipoic Acid (ALA) o 500 mg/day Resveratrol o 500 mg/day Quercetin o 3 to 6 grams/day L-Lysine I take the first three of these supplements daily for good health and to keep my 75 year-old heart ticking. Regarding oxygen therapy. Too many neurologists and most PCP/GPs have never treated a patient with CH so are unfamiliar with the Standards of Care recommended interventions (abortives and preventatives) for CH that list oxygen therapy as the first abortive of choice at 15 liters/minute. The rest have been brainwashed by the Big Pharmas that oxygen therapy is ineffective for cluster and migraine headache and that the very expensive patented pharmaceuticals (read sumatriptan succinate [Imitrex] and its derivatives) are very effective. What you need to do is print out the EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias by the God Squad of neurologists, expert in treating patients with CH and who are also members of the ICHD 3 working groups for CH and other TACs. They include: A. May, M. Linde, P. Sandor, S. Evers and P. Goadsby. You can download a copy at the following link and take it to your neurologist when you ask for an Rx for oxygen therapy as an abortive for your CH. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1468-1331.2006.01566.x You can also download and print out the following link for: Treatment of Cluster Headache: The American Headache Society Evidence-Based Guidelines. https://www.ncbi.nlm.nih.gov/pubmed/27432623 Results and Recommendations: For acute treatment, sumatriptan subcutaneous, zolmitriptan nasal spray and high flow oxygen remain the treatments with a Level A recommendations. I hope this slayed all the dragons making it difficult for you to control your CH and MH... Take care and please keep us posted. V/R, Batch
  23. Brain on Fire, Great idea, wrong audience. I teamed up with two Top Gun heavy hitter neurologists from American Headache Society, Dr. Deborah Friedman, MD, MPH, FAAN and Dr. David Dodick, MD in 2009 to overturn the CMS non-coverage determination that prevents Medicare beneficiaries from obtaining oxygen therapy as an abortive for cluster headache. We assembled what we thought was significant body of medical evidence attesting to the efficacy and safety of oxygen therapy as a CH abortive. It included all the known studies, papers by Dr. Lee Kudrow, MD and other noted neurologists with hundreds of years accumulated experience with oxygen therapy as an effective abortive for patients with CH. Unfortunately, the unelected, monkey-ass bureaucrats at CMS/OCSQ (Center for Clinical Standards and Quality) rule the roost when it comes to non-coverage determinations. They wouldn't listen to real medical evidence and logic if it was coming from the burning bush or bit them on the ass. They methodically disqualified every study provided for not adhering to all the latest rules of medical evidence then pronounced there was insufficient medical evidence to reverse the existing non-coverage determination for home oxygen therapy for Medicare and Medicaid beneficiaries with CH. Congress and your local representatives? NFW! The probability of finding meaningful support for our cause in Congress in the form of favorable legislation for oxygen therapy, ranks right up there with finding a snowflake in hell. As soon as most politicians are elected they get a lobotomy followed by a chemical memory eraser. They have only one goal after being elected... Getting re-elected. Re-election requires money and you'll never guess who fills re-election campaign war chests with the most money. The Pharmaceuticals/Health Products industries lead by the Big Pharmas to the tune of $4.2 Trillion dollars spent on Congress over the last 20 years. https://www.opensecrets.org/lobby/top.php?indexType=i&showYear=a And, of course, the Big Pharmas don't like anything used in healthcare if its not patented for profit. Oxygen is a USP so cannot be patented. Big Pharma's solution to this problem is to have their K street lobbyists write legislation for Congress that makes it difficult to obtain home medical oxygen. This legislation is written vaguely so as to allow government agencies like HHS and their minions at CMS to write regulations making it more difficult for a physician to prescribe oxygen therapy than an Rx for opiates. Their final hammer is to make coverage determinations on what medical treatments CMS will cover. Our only solution it to go to the top and the Twitter-in-Chief, President Trump. The best way to do this is to contact the White House at the following link. https://www.whitehouse.gov/contact/ It will give you the option of "Contact the President" or "Help with a Federal Agency." Select the second option, fill in the blanks then in the final blank "What would you like to say" start out with the regulations governing home oxygen therapy for cluster headache sufferers are too restrictive to the point Medicare and Medicaid beneficiaries with cluster headache are not covered. Point out that President Trump made a promise to the American people he would help cut the red tape and restrictive regulations that make things like home oxygen therapy so costly and difficult to obtain. Give your own story in your own words like how you're forced to use Triptans like Imitrex costing $900/month for the nine shots per month covered under Medicare as an abortive but the estimated $100/month for home oxygen therapy is not covered. The average cluster headache sufferer has three of these terribly painful headaches a day, 90 a month, yet Medicare will only cover relief for 9 of these terrible headaches a month with Imitrex. Home oxygen therapy would cost much less at $90 to $100 per month and could be used for all cluster headaches not just 9 a month with Imitrex, then be forced to suffer agonizing pain during 80 more of these cluster headaches without any relief. Ask why an expensive pharmaceutical like Imitrex is covered as a cluster headache abortive for Medicare and Medicaid beneficiaries, yet USP oxygen is not. Ask if existing legislation and regulations governing coverage for home oxygen therapy has been influenced by Big Pharma to their advantage in the market place? The simple solution is to make home oxygen therapy an OTC item. This would eliminate burdensome regulations, increase competition and ultimately lower the cost of home oxygen therapy. The savings at HHS/CMS would also be huge as a large part of the CMS budget is spent administering prescriptions for oxygen and the durable medical equipment associated with home oxygen therapy for Americans with COPD. The American Lung Association (ALA) thinks there may be as many as 24 million American adults living with COPD and that doesn't count Americans with Bronchitis or Emphysema who also need supplemental oxygen. Again, use your own words. If one or two up to maybe five CHers go to this White House website and complain about home oxygen therapy, it's likely nothing will happen. If the number of hits goes above 50, they have tracking systems that will flag this topic. Then the odds of meaningful action go up big time. Take care... and Take Action. V/R, Batch
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    Intro / Vitamin D

    Hey RSG, CH Father gave you the right link for the anti-inflammatory regimen treatment protocol at http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 I've made a couple changes since I posted that 2017 version. In July of 2018, I switched brands and type of vitamin D3 from the Nature's Bounty oil-based 5000 IU liquid softgels to the Bio-Tech D3-50 50,000 IU water soluble (micellized) vitamin D3. I've found the Bio-Tech D3-50 to be faster acting and more potent in elevating serum 25(OH)D than the oil-based formulations. Data from the online survey of CHers taking this regimen now supports a longer accelerated vitamin D3 loading schedule from 12-Days at 50,000 IU/day vitamin D3 to 14-Days at 50,000 IU/day. This change increases the total loading dose of vitamin D3 from 600,000 IU to 700,000 IU spread over 14 days at 50,000 IU/day for episodic CHers and 16 days for chronic CHers. This also results in a new initial target serum concentration from 80 ng/mL to 90 ng/mL for episodic CHers and from 80 ng/mL to 100 ng/mL for chronic CHers. The initial vitamin D3 maintenance dose of vitamin D3 is now 15,000 IU/day. These loading schedules and maintenance doses apply to the oil-based liquid softgel vitamin D3 formulations, If you follow my lead and that of several other CHers who switched to the Bio-Tech D3-50 50,000 IU vitamin D3 capsules as I have, the loading and maintenance doses will be different as follows. If you're an episodic CHer start this regimen with the 12-Day loading schedule at 50,000 IU/day (one of the Bio-Tech D3-50 capsules a day for 12 days) then fall back to a new initial maintenance dose with the Bio-Tech D3-50 of one (1) capsule a week. If you're a chronic CHer, start this regimen with a 14-Day accelerated vitamin D3 loading schedule (one of the Bio-Tech D3-50 capsules a day for 14 days) then fall back to a new initial maintenance dose with the Bio-Tech D3-50 of one (1) capsule a week. If you do the math, 50,000 IU divided by 7 days comes to roughly 7,000 IU/day as the maintenance dose with the Bio-Tech D3-50. Due to the increased potency of the Bio-Tech D3-50 compared to the oil-based liquid softgel vitamin D3 formulations at the same dose, this equates to an equivalent of 15,000 IU/day of the liquid softgel vitamin D3 formulations. With either type of vitamin D3, if you haven't experienced a favorable response or complete cessation of CH symptoms by the end of the loading cycle, increase the loading period by two days at 50,000 IU/day for two days then drop back to the maintenance dose. If there's still no response, within three days of the additional loading doses, you may be experiencing an allergic reaction to airborne of food borne allergens. These allergic reactions can be subclinical with no outward or obvious symptoms. In this case, start a week to 10-day course of a first-generation antihistamine like Benadryl (Diphenhydramine HCL) at 25 mg every four hours throughout the day. Just be careful and not drive as this much Diphenhydramine will make you drowsy. If you need to drive during the day, wait until you're home for the day then take 50 mg of Benadryl as you walk through the door, and another 50 mg at bedtime. If there's no response to the Benadryl after five days, discontinue as an allergy is not the likely culprit preventing a favorable response to this regimen. It's important to take all of the vitamin D3 cofactors and conutrients illustrated in the following photo. In particular, it's best to double the magnesium dose from 400 mg/day to 800 mg/day while loading vitamin D3. Take 400 mg of magnesium in the morning with breakfast and the other 400 mg in the evening with dinner. Doing this will help avoid osmotic diarrhea. The Kirkland brand Adult 50+ Mature Multi is also very important as it's formulated with most of the vitamin D3 cofactors. It just doesn't have enough magnesium or any vitamin K2 complex (MK4 and MK7). At 22 cents per capsule taken at a maintenance dose of one (1) capsule a week, the Bio-Tech D3-50 is also the least expensive form of vitamin D3 at 3 cents/day. The Nature's Bounty has a price of 6 cents per 5000 IU vitamin D3 liquid softgel or 12 cents/day for the 10,000 IU maintenance dose. It is very important to see your PCP/GP or neurologist for lab tests of your serum 25(OH)D, calcium and PTH 30 days after start of regimen. As long as you're CH pain free or have experienced a significant reduction in the frequency of your CH and your serum calcium concentration is within its normal reference range, your actual 25(OH)D serum concentration doesn't really matter. Hope all this makes sense. I'll be publishing a revised version of this treatment protocol on VitaminDWiki as soon as a few key vitamin D3 experts and physicians have had an opportunity to comment on the new protocol. Take care and please keep us posted. V/R, Batch
  25. Batch

    2019 Patient Conference

    I'm booked... See you there. This should be a hoot! V/R, Batch
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