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xxx

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Posts posted by xxx


  1. Bomachel,

    The answer to your question is Yuppers, that's exactly the test we need and your calcium serum concentration looks great at 9.8 mg/dL.  This is the assay to watch when loading vitamin D3.  As long as your serum calcium remains within the normal reference range 8.6 - 10.2 mg/dL there is no vitamin D3 intoxication/toxicity and your actual 25(OH)D3 serum concentration doesn't really matter, except as a reference point with respect to your CH activity.

    All CHers have a 25(OH)D3 tipping point CH threshold serum concentration, above witch we're CH pain free and at or below this tipping point, the CH beast is jumping ugly.  Moreover, the lower the 25(OH)D3 serum concentration goes below this tipping point threshold, the CH beast ugliness increases, i.e., we get hit harder and more frequently.

    There's something else CHers need to understand about staying CH pain free on this regimen and that deals with the relative relationship between our 25(OH)D3 serum concentration and the 25(OH)D3 CH tipping point or threshold serum concentration.  As you can see in the following conceptual graphic, both serum concentrations vary over time, inversely, and this is most frequently due to variations in our immune system activities.  For example, when our immune system activates due to a major source of inflammation caused by an infection, allergic response, trauma or surgery, the CH threshold increases.  At the same time, our 25(OH)D3 serum concentration drops as the white cells that make up most of our immune system increase their affinity for vitamin D3 and its first metabolite 25(OH)D3.  When these two 25(OH)D3 serum concentrations overlap, as illustrated by the purple hashed area in the chart below, the CH beast starts jumping ugly and we get hit.

    ZY9M8Tt.jpg

    What CHers taking this regimen also need to understand is keeping your 25(OH)D3 serum concentration high enough to remain CH pain free and avoid these overlaps with attendant CH burn through attacks, will require changes in the vitamin D3 maintenance dose at times.  The 3-year chart of my serum 25(OH)D3, calcium and PTH below illustrates I've done just that.  At times I've taken a vitamin D3 maintenance dose of 25,000 to 30,000 IU/day to avoid the effect of seasonal allergic reactions to pollen and mold spores.  This resulted in my 25(OH)D3 serum concentration elevating as high as 188 ng/mL.  You'll also notice the inverse, mirror relationship between serum calcium and PTH.  This is a classic indication of normal calcium homeostasis, the feedback system our bodies use to maintain serum calcium within a narrow range.

    What is significant about this chart is I switched to the Bio-Tech D3-50 50,000 IU water soluble form of vitamin D3 in January of 2019 taking one D3-50/week the day of my labs for 25(OH)D3, calcium and PTH and I've been CH ever since.  As you can also see, this dose has kept my 25(OH)D3 consistently up around 150 ng/mL and my calcium serum concentration has remained in the green zone within its normal reference range.  My PCP/GP has no problem with my 25(OH)D3 this high as he understands the dynamics of vitamin D3 therapy and that as long as the calcium serum concentration remains within its normal reference range and there are no other perturbations in my other labs linked to my 25(OH)D3, both of us are happy.

    O6UXXUu.jpg

    Hope this helps explain this topic.

    Take care and please keep us posted.

    V/R, Batch


  2. Hey Bomachel,

    If you've read my last post in this thread to Gilad of a few minutes ago, you would know there's no reason for your wife to stop taking vitamin D3 and that a serum concentration of 150 ng/mL is perfectly safe. I keep my 25(OH)D3 up around 150 ng/mL to remain CH pain free and my PCP has no problem with this.  He knows serum 25(OH)D3 is a poor indication of vitamin D3 intoxication/toxicity even if it's well above 100 ng/mL.

    It is a good idea to ask your wife's doctor for lab tests of your wife's serum calcium and PTH (Parathyroid Hormone).  As long as her serum calcium is within its normal reference range, her 25(OH)D3 serum concentration doesn't really matter.  My PCP/GP understands vitamin D3 therapy so has no problems with my serum 25(OH)D3 being well above 100 ng/mL as long as my serum calcium remains within its normal reference range.

    As far as emgality is concerned, I'm firmly convinced it's the vitamin D3 that's preventing her CH not the emgality.  I'm not a fan of emgality (galcanezumab-gnlm) or any of the other monoclonal antibodies for the simple reason they weaken the immune system.  Just listen to the TV adds for Humira (adalimumab).  I also think putting foreign DNA in my bloodstream is a very bad idea.  If your wife has a constant craving for cheese and squeaks a lot, the following graphic might just explain why.  It's the murine (mouse) genes...  It's a safe bet your wife's neurologist didn't explain this when he prescribed her emgality.

    daf6HJM.jpg

    It's also important to understand that none of the anti-CGRP monoclonal antibodies can ever be fully effective in preventing CH or migraines because they cannot reach the neurons and glia in our trigeminal ganglia where CGRP that causes CH is expressed.  Here's why.  Monoclonal antibodies (mAbs) have a molecular mass of 150 kDa (150,000 Daltons).  The fenestration (windows) through the Blood Brain Barrier (BBB) that protect the brain and CNS from foreign matter has a maximum aperture of 400 Da.  That means these anti-CGRP mAbs are 375 times too big to pass through the BBB.  That emgality has any effect on reducing CH frequency deals with its capacity to lower serum concentration of CGRP expressed by cells outside the CNS.

    On the other hand, vitamin D3 and its first metabolite 25(OH)D3 have a molecular mass of 385 Da and 400 Da respectively so both pass readily through the BBB and into the neurons and glia in our trigeminal ganglia where they down-regulate (depress) the expression of CGRP, SP, VIP and PACAP to help prevent our CH.  All of these neuropeptides are elevated during the pain phase of CH and MH.  My degree was in Chemistry if you're wondering.

    Take care and please keep us posted.

    V/R, Batch


  3. Hey Gilad,

    It's best die episodic CHers to remain on this regimen year-round.  We chronic types don't have a choice.  By staying on this regimen year-round, when your regularly scheduled episodic cycle time comes around, it's likely to be a non-event and you'll skate through the cycle CH pain free.  On top of that, the health benefits of staying on this regimen year-round are hard to ignore like a super boosted immune system high on vitamin D3, helps prevent viral infections like COVID-19.  Even if you do get infected, an immune system boosted on vitamin D3 reduces the severity of viral infections and speeds up recovery time.  There's already a study concluding this benefit for COVID-19.  

    You also need to understand that the adult 25(OH)D3 burn rate is roughly 15 ng/mL/month.  That means if you stop taking vitamin D3 while CH pain free with your 25(OH)D3 serum concentration at 80 ng/mL, in as little as three months, your 25(OH)D3 serum concentration will drop down to 35 ng/mL and six to seven months later, it will be even lower so you'll be back as square one with the CH beast jumping real ugly at your next scheduled cycle time. 

    The supplements illustrated by brand and dose in the following photo are what I take and suggest to other CHers.  There are two changes to the supplements listed in the posted version of this regimen at the following vitaminDwiki link. 

    http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708

    I made the switch to the Bio-Tech D3-50 50,000 IU water soluble form of vitamin D3 from the liquid softgel vitamin D3 formulations in June of 2018 and the switch to the Methyl Folate + B vitamin complex from the generic vitamin B 50/100 complex in January of 2019 for the following reasons.  We've found the Bio-Tech D3-50 to be faster acting with a higher bioequivalence in elevating serum 25(OH)D3 than the same dose of the liquid softgel vitamin D3 formulations.  The rationale for the switch to the Methyl Folate + was made for the same reason, a higher bioequivalence.

    e0ybTAP.jpg
    I made another change to the accelerated vitamin D3 loading schedule basically to make it easier and take less time to elevate serum 25(OH)D3 to roughly 80 ng/mL, the initial target.  Instead of the 2-week or 4-week loading schedule, the latest version of the anti-inflammatory regimen calls for a 12-day accelerated vitamin D3 loading schedule taking 50,000 IU/day for 12 days for episodic CHers to reach an initial target of 80 ng/mL, 14 days for chronic CHers to reach an initial target of 90 ng/mL and 16 days for migraineurs to reach an initial target of 100 ng/mL. 

    The following graphic illustrates the advantage of these loading schedules over just taking the maintenance dose of 10,000 IU/day.  Data from the online survey of 313 CHers taking this regimen running since December of 2011 indicate the minimum CH threshold in 25(OH)D3 serum concentration above which the CHer is pain free is a range between 40 ng/mL (100 nmol/L) and 50 ng/mL (125 nmol/L).  This survey data also indicates this CH threshold for CHers can be as high as 70 to 90 ng/mL during periods of increased inflammation and immune system activation caused by allergic reactions and infections.

    AFvZz5p.jpg

    At the end of the applicable loading schedule, if CH pain free, you can drop to an initial vitamin D3 maintenance dose of 50,000 IU once a week and 30 days after starting this regimen, see your PCP/GP for labs of your serum 25(OH)D3, calcium and PTH (Parathyroid Hormone).  The following graphic is 3-year chart of my labs for 25(OH)D3, calcium and PTH.  As you can see, I've kept my 25(OH)D3 serum concentration well above 100 ng/mL and as high as 188 ng/mL the entire time yet my serum calcium has remained within its normal reference range.  My PCP/GP has no problem with my 25(OH)D3 this high as long as my serum calcium remains in the normal range.

    hVz4sJb.jpg

    If there's been no change in CH patterns after a week to 10 days loading, it's likely you've got something cooking away causing inflammation so it's time to add the supplements illustrated in the following two photos.  Migraineurs will need to add them as well.  You don't need to take them all at once, but I would start by adding the first three supplements illustrated in this first photo.  Our bodies cannot synthesize vitamin C so it's prudent for everyone to take it.  I take 4 to 6 grams/day vitamin C.  The Turmeric (Curcumin) is a potent anti-inflammatory so helps vitamin D3 reduce the neurogenic inflammation associated with CH.   If you suspect an allergic reaction is keeping you from a CH pain free response, I'd start taking 800 mg/day Quercetin.   Among other things, Quercetin is a potent antihistamine and it has no adverse effects like the drowsiness most people get taking Benadryl (Diphenhydramine).  Quercetin is also potent immune booster and broad-spectrum antiviral. 

    4XgnvQq.jpg

    rRoplHy.jpg

    These three loading schedules are only starting points that should work for most CHers.  There are provisions to continue loading past these schedules under a doctors supervision until you've experienced at least two days (48 hours) CH pain free or 30 days, whichever occurs first.  At that point it's very important to drop back to one D3-50/week and see your PCP/GP for lab tests of your serum 25(OH)D3, calcium and PTH.  

    If you've not experienced at least 48 hours CH pain free by the 30 day mark and your serum calcium is still in the normal reference range, work with your PCP/GP for more frequent labs like every ten days then continue loading.  When you ask for labs of your serum 25(OH)D3, calcium and PTH have your PCP/GP specify Quest Diagnostics as they use the Liquid Chromatography, Dual Mass Spectroscopy (LC-MS/MS) assay for 25(OH)D3 that's good to 512 ng/mL.   Some of the other 25(OH)D3 assay methods only go up to 117 ng/mL.

    It's important to note that staying on the loading for more than 12 days schedule will elevate serum 25(OH)D3 above 100 ng/mL.  This is not an indication of vitamin D3 intoxication/toxicity.  This is why we need to know the calcium serum concentration.  As long as it remains within its normal reference range, there's no vitamin D3 intoxication/toxicity even if the serum 25(OH)D3 concentration is above 200 ng/mL (500 nmol/L).  We've had some CHers who needed to elevate their 25(OH)D3 above 300 ng/mL under a physician's supervision with frequent labs and their serum calcium concentration remained within its normal reference range.

    So there you have it.  All of the information in this post is covered in the draft update to the posted version of this treatment protocol.  I'd hoped to have it ready for prime time last February, but the COVID-19 changed all that as I refocused my efforts on researching the relationship between vitamin D3 and other nutrients with COVID-19.  I'm adding a new section that address taking vitamin D3 and other vitamins and minerals as an immune boosting strategy to prevent and treat COVID-19.

    Finally, I'd like to point out that neither my wife or I has had the flu since starting the anti-inflammatory regimen in late 2010.  Neither of us take flu shots or any other Rx medications.  I've also had the RT-PCR assay and tested negative for the SARS-CoV-2 virus three times this summer as a negative on this assay is required within 3 to 5 days of flying to Alaska.

    Take care and please keep us posted.

    V/R, Batch


  4. Well done Double A. Great artwork!

    An art major working on is Masters at the Tyler School of Art and Architecture, Temple University, listened to my description of a cluster headache beast that chewed through my brain and eye socket, then sculpted the following as one of his art projects.  It won an award so I took a photo of it.

    CHXXgrJ.jpg

    Take care and keep up the great art work.

    V/R, Batch

    .

    • Like 2

  5. Hey MM,

    I know what you've been going through and the good news is it doesn't need to be that way.  You're very likely vitamin D3 deficient.  When you see your doctor on Monday ask for labs of your serum 25-Hydroxy Vitamin D3, a.k.a., 25(OH)D3, calcium and PTH.  The odds are very high your 25(OH)D3 will come back < 40 ng/mL.  As CHers we need to maintain our 25(OH)D3 between 80 ng/mL and 100 ng/mL.  We do this by taking at least 10,000 IU/day vitamin D3 plus the vitamin D3 cofactors.

    You can pull down a copy of the published treatment protocol at the following link.  Readers of my webpage at vitamin D3 wiki have downloaded over 60,000 copies of this CH and MH preventative treatment protocol since I posted it on 21 Jan 2017.  It works.:

    http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708

    The following photo illustrates the supplements by brand and dose that I take and suggest to other CHers and Migraineurs to prevent their headaches. 

    e0ybTAP.jpg

    Take care and please keep us posted.

    V/R, Batch

    • Like 1

  6. Hey Mike,

    Vitamin D3 is not a monotherapy.  To be effective in preventing CH it needs all the cofactors illustated in the following photo of what I take and suggest to other CHers.

    e0ybTAP.jpg

    You can find the published treatment protocol at VitaminDWiki at the following link.

    http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708

    Readers of my webpage at VitaminDWiki have downloaded 61,671 copies of the anti-inflammatory regimen CH and MH preventative treatment protocol since I posted it on 21 Jan 2017.  Dr. Mark Burish, MD, PhD,  Director, Will Erwin Headache Research Center, UT Houston, thought enough of this CH preventative treatment protocol and the medical evidence from the online survey of CHers taking the anti-inflammatory regimen to control their CH for the last 9 years, to publish an RCT on clinicaltrials.gov based on this treatment protocol.

    https://www.clinicaltrials.gov/ct2/show/NCT04570475?sfpd_s=09%2F30%2F2020&amp;sfpd_d=14

    If you have any further questions about this regimen, please shoot me a PM

    Take care and hang in there.

    V/R, Batch

    • Like 2

  7. To all,

    This is a dream come true.

    https://www.clinicaltrials.gov/ct2/show/NCT04570475?sfpd_s=09%2F16%2F2020&sfpd_d=14 

    This is the gold standard RCT protocol I've been working with Dr. Mark Burish, MD, PhD., Will Erwin Headache Research Center, UT Houston School of Medicine to develop for almost a year at this point.   We cut a lot of corners getting the protocol down to two pills with two look alike placebos and no loading dose, but I'm confident this dose will result in at least 70% of CHers responding with a significant reduction in the frequency of their CH during the course of this protocol.

    Take care,

    V/R, Batch

    • Like 3
    • Thanks 3

  8. This is a dream come true.

    https://www.clinicaltrials.gov/ct2/show/NCT04570475?sfpd_s=09%2F16%2F2020&sfpd_d=14 

    This is the gold standard RCT protocol I've been working with Dr. Mark Burish, MD, PhD., Will Erwin Headache Research Foundation, UT Houston School of Medicine to develop for almost a year at this point.   We cut a lot of corners getting the protocol down to two pills with two look alike placebos and no loading dose, but I'm confident this dose will result in at least 70% of CHers responding with a significant reduction in the frequency of their CH during the course of this protocol.

    Take care,

    V/R, Batch

    • Like 1
    • Thanks 2

  9. Hey Siegfried,

    CPH responds to vitamin D3 at higher 25(OH)D3 serum concentrations when accompanied with other anti-inflammatory agents.  Please shoot me a PM with your contact data so I can send you a copy of the latest version of the anti-inflammatory regimen treatment protocol.

    Take care,

    V/R, Batch

    • Like 1

  10. There's an excellent video of Dr. Paul Marik, MD,  Chief of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, explaining his MATH+ COVID-19 protocol at the following link.  It's long, but well worth the time.

    https://www.youtube.com/watch?v=xZJixjgu3tk

    I've been exchanging email with Dr. Marik for the last 5 months.  There's an excellent analysis of the MATH+ protocol at the following link.

    https://covid19criticalcare.com/math-hospital-treatment/scientific-review-of-covid-19-and-math-plus/#1596274217294-29a4f4e2-63ce

    Take care,

    V/R, Batch

    • Like 1

  11. Spiny,

    As I indicated in an earlier post in this thread, Pepcid (Famotidine) is a histamine H2 receptor blocker.  There's evidence Quercetin is a little safer and more effective as an antiviral than Famotidine.  That said, the COVID-19 Critical Care Working Group (FLCCC) treatment protocol for COVID-19 patients in the ER calls for intravenous methylprednisone, high-dose ascorbic acid (vitamin C), thiamine (Vitamin B1) and heparin. Optional additions include melatonin, zinc, vitamin D3, atorvastatin, famotidine and magnesium. 

    Quercetin also acts as an ionophore transporting zinc ions across cell walls to help stop viral replication. 

    Vitamin C and quercetin have synergistic effects that make them useful in the prevention and early at-home treatment of COVID-19. Both are part of the MATH+ protocol developed by the Front Line COVID-19 Critical Care Working Group (FLCCC).

    For COVID-19 prophylaxis, the FLCCC recommends vitamin C, quercetin, zinc, melatonin and vitamin D3

    The at-home treatment for mildly symptomatic patients is very similar to the prophylactic regimen, but adds several optional drugs, including aspirin, famotidine (an antacid) and ivermectin (a heartworm medication that has been shown to inhibit SARS-CoV-2 replication in vitro)

     

    • There are two distinct phases or stages of COVID-19 — the viral replication stage and the immune dysfunction stage — and the treatment must be appropriate for the stage you’re in. Equally crucial is starting aggressive treatment as early as possible.
     
     

    Vitamin D3 boosts immune system functions that help prevent viral infections.  Vitamin D3 at a high enough dose and responding 25(OH)D3 serum concentration, also helps prevent immune system dysfunction

    Quercetin was initially found to provide broad-spectrum protection against SARS coronavirus in the aftermath of the SARS epidemic that broke out across 26 countries in 2003.   Now, some doctors are advocating its use against SARS-CoV-2, in combination with vitamin C, noting that the two have synergistic effects. 

    Incidentally, ascorbic acid (vitamin C) and the bioflavonoid quercetin (originally labeled vitamin P) were both discovered by the same scientist — Nobel prize winner Albert Szent-Györgyi.  Quercetin’s antiviral capacity has been attributed to five main mechanisms of action:

    1. Inhibiting the virus’ ability to infect cells by transporting zinc across cellular membranes
    2. Inhibiting replication of already infected cells 
    3. Reducing infected cells’ resistance to treatment with antiviral medication 
    4. Inhibiting platelet aggregation — and many COVID-19 patients suffer abnormal blood clotting 
    5. Promoting SIRT2, thereby inhibiting the NLRP3 inflammasome assembly involved with COVID-19 infection  

    Similarly, vitamin C at extremely high doses also acts as an antiviral drug, effectively inactivating viruses. During the 2003 SARS pandemic, a Finnish researcher called for an investigation into the use of vitamin C after research showed it not only protected broiler chicks against avian coronavirus, but also cut the duration and severity of common cold in humans and significantly lowered susceptibility to pneumonia.

    I compiled a list of immune boosting COVID-19 prophylaxis people can take at home in the following table provided by experts in nutritional medicine.  Column 4 is my summation.

    Supplement

    Riordan

    Orthomolecular

    EVMS/FLCC

    Batcheller

    Vitamin C

    1-2g t.i.d.

    3 g/d (1g t.i.d.)

    500 mg BID

    3 g/d (1g t.i.d.)

    Vitamin D3

    5,000 IU/d

    10K IU/d for 2 wk*

    1000-4000 IU/d

    50,000 IU/wk**

    Vitamin A

    10,000 IU/d

       

    3,000-6000 IU/d

    Vitamin B1

         

    25 mg/d

    Zinc Picolinate

    30 mg BID

    30 mg/d

    75-100 mg/d

    50 mg/d

    Quercetin

     

    500 mg/d

    250-500 mg BID

    400 mg  BID

    Selenium

    200 mcg/d

    200 mcg/d

     

    55 mcg/d

    Magnesium

     

    500 mg/d

     

    400-800 mg/d

    Melatonin

     

    1-5mg/d

    0.3-2.0 mg/d

     

    Omega-3 PUFAs

     

     

     

    1500 mg/d

    Multi Vitamin

     

    1 Tablet/d

     

    1 Tablet/d ***

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

                    *       10,000 IU/day vitamin D3 for 2 weeks then drop back to 5000 IU/day

    **     50,000 IU/day vitamin D3 for 12 days then drop back to 50,000 IU/week.  Water soluble vitamin D3 suggested such as Bio-Tech D3-50 as it has a higher bioequivalence than the oil-based liquid softgel vitamin D3 formulations.

    ***      The Kirkland Adult 50+ Mature Multi is an excellent source of vitamin D3 cofactors.  It just doesn't have enough magnesium or any vitamin K2

    Of course you won't hear anything about this from HHS, the good Dr. Fauci at NIH, the FDA or CDC.  They're heavily influenced by the Big Pharmas who don't want people to know how effective vitamins and minerals can be in treating viral infections.  Members of these organizations are also heavily invested in vaccine development (at tax payer expense) so don't want the public to hear about any competitive treatments that are more effective, safer and less expensive.

    Take care,

    V/R, Batch

     

     

     

    • Like 1

  12. Jon, Er... Make that Spiny, (Forgot my cheaters)

    Regarding Pepcid (famotidine), it's a histamine H1 blocker and there have been two completed studies taking it during a COVID-19 infection listed in clinicaltrials.gov.  The first was based on a questionnaire sent to COVID-19 outpatients who took it during a COVID-19 infection.  The second study involved a Therapeutic Plasma Eexchange as a treatment for COVID-19.  The protocol called for supportive treatment that included Vitamin C, Zinc, Vitamin D, Famotidine, Enoxaparin and Methylprednisolone so Prpcid wasn't the only intervention. Neither have been through peer review.   There was a reduction in mortality among COVID-19 patients who had taken Pepcid (famotidine).

    Take care,

    V/R, Batch

    • Like 1

  13. Here's a lesson learned from the last time CMS requested public comments on their Non-Coverage Determination for home oxygen therapy for Medicare Beneficiaries suffering from CH in 2010. 

    Do not write about your personal experience with home oxygen therapy as a CH abortive.  It will be redacted and a waste of time.  Do write about what you have observed in other CHers using oxygen as a CH abortive.  Do write about the cost differential between home oxygen therapy as a CH abortive and the $100 dollar a pop street price for a subcutaneous imitrex injection limited to nine per month. 

    For example, the average CHer experiences three (3) CH in a 24 hour period.  When used with proper procedures, an M-Sized O2 cylinder contains sufficient gaseous oxygen for 30 CH aborts at a flow rate of 25 liters/minute (more than 100 aborts using my latest procedure hyperventilating with room air for 30 seconds then inhaling a lungful of 100% oxygen and holding it for 30 seconds).  Doing the math, the average CHer will consume 3 M-Size oxygen cylinders in a month.  At an average co-pay cost of $30 dollars per M-Size oxygen cylinder after insurance, that comes to $90 dollars a month out of pocket to cover aborts for all CH.  The out of pocket co-pay for a single 6 mg/.05ml subcutaneous injection of imitrex comes to $28 dollars.  Doing the math, with the limit of 9 injections/month, the total cost comes to $252/month for nine (9) aborts.  This doesn't cover the cost of the horrific pain CHers experience without home oxygen as an abortive when they've used up their monthly allowance of nine imitrex injections.

    Take care and take action.

    V/R, Batch

     

    • Like 1

  14. Siegfried,

    What was your 25(OH)D3 serum concentration?  Here are my labs for serum 25(OH)D3, Calcium and PTH over the last three years.

    hVz4sJb.jpg

    My PCP understands calcium homeostasis and that I keep my 25(OH)D3 serum concentration this high to prevent my CH during periods of high pollen and mold spore counts.   Accordingly, he has no problems with it being this high as long as my serum calcium remains within its normal reference range and as you can see, it has.  Did your PCP run labs for your serum calcium and PTH?

    Take care and please keep us posted.

    V/R, Batch

    • Like 2

  15. For what it's worth, here's the logic and science behind the 12-Day accelerated vitamin D3 loading schedule and why the initial target 25(OH)D3 serum concentration is 80 ng/mL.

    1. From the online survey data of 313 CHers who have reported their results after starting this regimen since Dec 2011,  we have the normal distribution chart of baseline 25(OH)D3 lab results before starting this regimen and normal distribution chart of the objective (Favorable CH Response) 25(OH)D3 labs after ≥30 days on this regimen.

    RAWsxuR.jpg

    6pCJkDY.jpg

    As you can see, CHers reporting in this survey with active CH, went from a mean 25(OH)D3 serum concentration of 24 ng/mL before starting the anti-inflammatory regimen to a mean of 80 ng/mL after ≥ 30 days on this regimen with a significant reduction in the frequency of thier CH.  The following chart illustrates the notional change in serum 25(OH)D3 made possible by starting this regimen with the 12-Day accelerated vitamin D3 loading schedule.

    AFvZz5p.jpg

    Data from the online survey confirms the above notional response.  As you can see, if the CHer took only 10,000 IU/day vitamin D3 and no loading, it could take well over 2 months to reach a mean 25(OH)D3 serum concentration of 80 ng/mL.

    The following charts illustrate the favorable CH response to this regimen by day after starting it.  The first chart illustrates favorable responses by day after starting this regimen.  I  used a favorable response as at least a 50% reduction in CH frequency by at least 70% of participants.  Data from the survey indicate the mean reduction in CH frequency is 80% by 82% of participants.

    YwrQOyw.jpg?1

    This second cart illustrates days after start of regimen to a sustained complete cessation of CH symptoms.

    zVgzGeT.jpg

    Survey data collected during 2019 indicate the favorable response rate increased with over 90% of CHers reporting a favorable response.  I attribute most of this increase in the response rate to the switch to Bio-Tech D3-50.

    2. Why is the initial 25(OH)D3 serum concentration target set at 80 ng/mL?  This is where a little statistics and what's called the confidence interval comes into play.  In statistics, a confidence interval is a type of interval estimate, computed from the statistics of the observed data, that might contain the true value of an unknown population parameter.  Data in the following chart comes from the D* Action database at Grassrootshealth.  It represents the results of 25(OH)D3 lab tests from over 10,000 people who take the 25(OH)D3 home blood spot test for their serum 25(OH)D3 every six months reporting their vitamin D3 dose over the six months prior to this lab test. As you can see, the mean 25(OH)D3 response to various vitamin D3 doses is represented by the blue lines and that at a dose of 10,000 IU/day, the mean 25(OH)D3 response is 76 ng/mL.  The red lines represent the 95% confidence interval.  In simple terms we can say that the results a given lab test for 25(OH)D3 at a dose of 10,000 IU/day will fall between these two red lines with 95% confidence.  The green dashed lines represent 25(OH)D3 serum concentrations at 40 ng/mL, 30 ng/mL and 20 ng/mL.  Accordingly we can say that at a dose of 10,000 IU/day the confidence interval for 25(OH)D3 response lies between 42 ng/mL and 118 ng/mL with 95% confidence. 

    qVS7rzk.jpg

    If you go back to the second chart illustrating the normal distribution of 25(OH)D3 results among CHers responding to this regimen with a significant reduction in the frequency of their CH, you can see this same confidence interval falls under the normal distribution curve.  For practical purposes, this is also the effective therapeutic range of serum 25(OH)D3 (40 ng/mL to 120 ng/mL) for favorable responses.   You can also see where a lower vitamin D3 dose of 5,000 IU/day results in a confidence interval between 25 ng/mL and 90 ng/mL.  In this case a significant number of CHers would not respond to this regimen.

    As an "Oh by the way..."  the following charts from two different COVID-19 studies indicate taking 10,000 IU/day and keeping your 25(OH)D3 serum concentration over 40 ng/mL is a pretty good idea...  This isn't rocket science and you don't need to be a physician to understand the importance of this information.

    czNU7ua.jpg

    HLy1kOm.jpg

    Hope this helps explain a little more about the anti-inflammatory regimen treatment protocol.

    Take care,

    V/R, Batch

    • Like 1

  16. Bryan,

    I would try loading vitamin D3 at 50,000 IU/day for a week just to build your 25(OH)D3 reserves higher and in the process, help get the CH beast back under control.  Taking vitamin D3 is particularly important to help prevent viral infections like COVID-19.  It's also best to start taking at least 50 mg/day zinc picolinate, 400 mg/day Quercetin and 1 gram of vitamin C three times a day.  These are the immune boosting supplements that work the best.

    The nutritional supplements illustrated in the photo below provide a safe (No Harms) and proven prophylaxis for most viral infections.  If you're already taking the anti-inflammatory regimen, all you need to do is add the 50 mg/day zinc picolinate, 400-800 mg/day Quercetin and 3 grams/day liposomal vitamin C (1 gram every 3 hours).

     

     

    Zinc: The need for supplementation increases with age

    Take care,

    V/R, Batch.

    image.png

    • Like 1

  17. Hey SECAuthentics,

    All of us on the anti-inflammatory regimen experience burnthrough CH at one time or another.  The solution is simple.  If you haven't switched to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 now is a good time to do so.  You can order it from amazon or iherb.  In the mean time most CHers in your shoes, me included, have loaded vitamin D3 at 50,000 IU/day for a week then droped back to the usual maintenance dose.  When you switch to the Bio-Tech D3-50, one capsule a week is a good starting maintenance dose.

    I updated the basic regimen in July of 2018 adding the Bio-Tech D3-50 in place of the oil-based liquid softgel vitamin D3 formulation.  In Jan of 2019, I added Methyl Folate + in place of the generic vitamin B 50/100 complex.  The following photo illustrates the latest version of this regimen by brand and dose.

    e0ybTAP.jpg

    CHers who stick with the above brands tend to experience a faster rate of response to this regimen.

    Take care and please keep us posted.

    V/R, Batch

    • Like 3

  18. Hey Siegfried,

    A vitamin D3 level of 85 ng/mL only helps a little over 50% of CHers prevent their CH. The rest need higher 25(OH)D3 serum concentrations up to 180 ng/mL as illustrated in the normal distribution chart of 25(OH)D3 labs reported by 257 CHers who reported a favorable response to vitamin D3 in the online survey.

    6pCJkDY.jpg

    Granted, this data is from cluster headache sufferers not people diagnosed with hemicrania continua (HC).  That said, there is ample evidence that HC shares most of the same pathophysiology as CH which means it should respond to the anti-inflammatory regimen with therapeutic doses of vitamin D3.  I've worked with two HC sufferers who responded to the anti-inflammatory regimen.  Both took the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 at one 50,000 IU capsule/day for at least two weeks before experiencing a significant and lasting reduction in the severity of their HC.  They also took the Methyl Folate + vitamin B complex, which like the Bio-Tech D3-50 has a higher bioequivalence.

    As you've already noticed, indomethacin is hard on the stomach and GI tract due to bleeds.  If you do continue taking it, experienced headache specialists familiar with indomethacin side effects suggest acid-suppression medicine due to this gastrointestinal side effect.

    Take care and please keep us posted.

    V/R, Batch

    • Like 1

  19. Hey Tess,

    Sounds like you're on the right track with all the supplements and your plan to switch back to the liquid softgel vitamin D3 formulation.  If you add 50 mg/day zinc picolinate and 400 to 800 mg/day Quercetin, you'll have an immune boosting combination that should lower the incidence of viral infections as illustrated in the following photo of what I've been taking since January of this year.   There's ample medical evidence of efficacy in reducing viral infections for vitamin D3, vitamin C, zinc, and Quercetin in the form of RCTs.  There's an extensive list of vitamin D3 studies at vitaminDwik.com at the following link that provide additional proof of efficacy in treating or preventing 88 health problems.  https://vitamindwiki.com/tiki-index.php?page_id=1336

    DmvdWAs.jpg

    I was on travel in February and went through Seattle when the COVID-19 Pandemic epicenter was there and I've also flown to Juneau, Alaska from Seattle in June so have I've been through two rounds of the COVID-19 Reverse Transcription - Polymerase Chain Reaction (RT-PCR) assay labs with negative results both times over the last two months.

    As a side note, I've not had the flu since I developed and started this vitamin D3 regimen in October of 2010.  Same for my wife.  Between us we've had less than a handful of colds since then as well.

    Carol Baggerly at the GrassrootsHealh Nutrient Research Institute has been all over the relationship between vitamin D3, vitamin C and zinc status as they relate to COVID-19 severity like a hawk on a June bug as illustrated in the following graphics.

    p5Sox3Z.jpgkbJRuwP.jpg

    yH1tvow.jpghxkdMyx.jpgw7Epgij.jpg

    Please keep us posted.

    Take care,

    V/R, Batch

    • Like 1
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