Jump to content

xxx

Advanced Members
  • Content Count

    576
  • Joined

  • Last visited

  • Days Won

    69

Posts posted by xxx

  1. Hey Amholla,

    Good question.  For starters, we've found the 12-Day accelerated vitamin D3 loading schedule at 50,000 IU/day for 12 days, a total loading dose of 600,000 IU of vitamin D3, to be effective in elevating serum 25(OH)D3 concentration by 60 ng/mL above the starting/baseline concentration.  You're going to need at least another 10 days loading vitamin D3 at 50,000 IU/day to meet the minimum loading schedule.

    The following chart illustrates the time to respond to this treatment protocol in days from start of regimen with a significant reduction in CH frequency (from a mean of 3 CH/day down to a mean of 3 CH/week).  As you can see, the majority of CHers experiencing a favorable response do so within the first two weeks on this treatment protocol.

    v0LTmPQ.jpg

    This next chart illustrates the time in days to a complete cessation of CH from start of regimen.  This is a subset of the above time to favorable response.

    w7Mn47G.gif

    There are several factors that influence time to respond.  The first is the starting or baseline 25(OH)D3 serum concentration.  Seeing your PCP/GP for this lab test before starting this treatment protocol is important.  If the starting 25(OH)D3 serum concentration is low, it takes longer to elevate to a therapeutic concentration above the CH threshold. 

    The following normal distribution chart illustrates the results of baseline labs for 25(OH)D3 among 313 CHers experiencing active bouts of CH before starting this treatment protocol. 

    RAWsxuR.jpg

    If you didn't obtain this lab test before starting treatment, you're shooting in the dark when it comes to estimating a response time.  The odometer and speedometer on your body's dashboard are not working.  You don't know how far you've come or how fast you're going towards a favorable or CH pain free response.

    This next chart illustrates the normal distribution of 25(OH)D3 lab results after ≥ 30 days on this treatment protocol among CHers who experienced a favorable response with a reduction in CH frequency or a complete cessation of CH.  If you look at the blue sigmoid S-shaped cumulative probability curve in this chart, you'll see that 25% of CHers on this treatment protocol have responded by the time their 25(OH)D3 serum concentration reached 60 ng/mL.

    jb3Slkh.jpg

    There's another chart CHers taking this treatment protocol should understand.  It's the 25(OH)D3 time course response to various doses of vitamin D3.  As you can see at a vitamin D3 dose of 10,000 IU/day it can take a month for the 25(OH)D3 response to reach 60 ng/mL.

    cgjX3S5.jpg

    Clearly, waiting 30 days or more to experience the sought after pain free response while following this treatment protocol is too long for CHers.  This is why we start it with an accelerated vitamin D3 loading schedule taking 50,000 IU/day of vitamin D3 for a minimum of 12 days as illustrated in the following graphic. 

    YfAJvGn.jpg

    The latest revision to this treatment protocol now calls for loading at 50,000 IU/day with the Bio-Tech D3-50 and all the cofactors illustrated in the photo below until there's been a significant reduction in CH frequency or a CH pain free response or 30 days whichever occurs first, then see your PCP/GP for a second set of labs for serum 25(OH)D3, calcium and PTH.  We made this switch as the Bio-Tech D3-50 water soluble 50,000 IU vitamin D3 has a higher bioequivalence in elevating serum 25(OH)D3 at the same dose as the oil-based liquid softgel vitamin D3 formulations.  We switched to the Methyl Folate + B complex from the vitamin B 50/100 complex for the same reason.

    e0ybTAP.jpg

    If you're CH pain free and your serum calcium is within its normal reference range, you're good to go.  Drop the vitamin D3 intake to a maintenance dose of 50,000 IU/week.  If you haven't experienced a significant reduction in CH frequency and your serum calcium is within its normal reference range, continue loading for another 15 days then see your PCP/GP for another round of labs for 25(OH)D3, calcium and PTH.  We've had a number of CHers continue loading vitamin D3 under a physician's supervision with frequent labs for 25(OH)D3, calcium and PTH, achieve CH pain free responses between 160 ng/mL and 189 ng/mL 25(OH)D3 and still maintain their calcium serum concentration within its normal reference range.  The 3-year chart of my labs for 25(OH)D3, calcium and PTH are a good example.

    actUEr5.jpg

    The second pacing factor in time to respond is a combination of body mass and body mass index (BMI).  An adult male weighing 90 Kg (198 lbs) with a BMI ≥ 30 can easily take twice as long and need twice as much oral vitamin D3 as an adult male weighing 80 Kg (176 lbs) with a BMI of 24 to achieve a favorable CH response to this protocol.

    The third factor that causes the most problems for CHers starting this treatment protocol is an allergic reaction.  Allergens cause the immune system's Mast Cells to release large quantities of histamine.  This histamine in turn triggers neurons and glia in our trigeminal ganglia to express Calcitonin Gene-Related Peptide (CGRP). 

    CGRP is one of four neuropeptides responsible for the neurogenic inflammation and pain we know as CH.  As long as mast cells are releasing histamine, none of the CH preventatives (including vitamin D3) will be effective.  Bottom line, histamine to a CHer is like Kryptonite to Superman - Bad news.  If you do suspect an allergic reaction is interfering with vitamin D3 in preventing your CH, you need to treat the allergy with an antihistamine. 

    In 2019 Quercetin became the antihistamine of choice over Benadryl (Diphenhydramine HCL) when CHers suspect or realize they're having an allergic reaction.  1 gram/day Quercetin is a good starting point and you can titrate the dose p to 3 grams/day.  1 to 3 grams/day Resveratrol and 6 to 8 grams/day vitamin C are also part of the intervention for allergic reactions.  If there's no joy after a week of the above interventions for an allergic reaction, start taking the Benadryl at 25 mg every four hours throughout the day. 

    If there's still no joy with vitamin D3 preventing your CH, see your PCP/GP for a  5-day burst dose of prednisone at 50 mg/day.  Burst doses of prednisone at 50 mg/day for a period this short should not require a taper.   If the burst dose of prednisone results in a reduction in CH frequency, see your PCP/GP for a consult with an allergist to find out what is causing the allergic reaction.

    This latest revision to the posted version of this treatment protocol is still in work.  I hope to have it completed and published on vitaminDwiki.com soon.

    Take care and please keep us posted.

    V/R, Batch

    • Like 1
  2. One of the best explanations for the cause of the euphoria many of us experience after a heavy CH hit follows.

    There's a cocktail of several known chemicals produced by the brain that can have a euphoric effect on a person. (Particularly after a painful CH).

    -Endorphins (The brain's natural opiates released in response to pain.) may be the most well known of these chemicals and they can be produced for a variety of reasons, one of which is, athletic activity or in our case as CHers, during a heavy hit.

    -Dopamine is another well known chemical that makes us feel good and can be produced when eating delicious food.

    Dopamine is also the primary chemical that is produced in overflow quantities when using methamphetamine a.k.a. speed or meth. The excess dopamine is what causes the user to feel "high". When the excess dopamine is destroyed the user "crashes".  (What's unclear here is the sequencing.  Is dopamine released in response to the endorphins or the CH pain?  In either case, it's nice.)

    -Serotonin is another important chemical in determining mood/well-being. It can be produced naturally by simple exposure to light.

    Serotonin is one the primary chemicals adjusted in most major antidepressants. These drugs are known as SSRI - Selective Serotonin Reuptake Inhibitors. The SSRI works by blocking the sending neuron from taking back serotonin, thereby increasing the available serotonin levels in the synapse.

    For what it's worth... Better living through bio-chemistry.

    Take care,

    V/R, Batch

  3. Hey Bob,

    Take up welding.  Welder's O2 comes from the same distillation process as medical O2 and is stored in the same LOX tanks.  After the initial cost of your first cylinder, the actual welder's oxygen cost is roughly the same as your medical insurance co-pay ~ $30 for an M-Size O2 cylinder refill.   I've had an M-Size O2 cylinder in my garage for 11 years, last filled 10 years ago and it still has ~ 1000 psi on the gauge.  Of course I also do oxy-acetylene welding and haven't needed oxygen as a CH abortive since developing and starting the anti-inflammatory regimen with 10,000 iU/day vitamin D3 plus cofactors in October of 2010 .

    Take care,

    V/R, Batch

  4. Hey Bilal,

    Good move on switching to the Bio-Tech D3-50.  Data for 2019 from the online survey of CHers reporting since 2011, indicated an up-tick in raw efficacy from 82% to 88% of CHers responding with a significant reduction in the frequency of their CH or a complete cessation of CH in the first 30 days after I started suggesting this change due to its higher bioequivalence compared to the oil-based vitamin D3 liquid softgel formulations.  There's nothing wrong with zinc glycinate so no need to change.  There appears to be a higher bioequivalence in the Methyl Folate + compared to the generic B complex.

    Regarding safe dosing with vitamin D3.  A recent article in the Journal of Steroid Biochemistry and Molecular Biology at the following link, concluded  in the results of a seven year study:  There were no cases of vitamin D3 induced hypercalcemia a.k.a., vitamin D3 intoxication/toxicity at higher vitamin D3 doses and that long-term supplementation with vitamin D3 in doses ranging from 5,000 to 50,000 IU/day appears to be safe.

    https://www.sciencedirect.com/science/article/abs/pii/S0960076018306228

    The following chart from this study illustrates it takes a long time for a stable dose of 10,000 IU/day vitamin D3 to reach a 25(OH)D3 equilibrium.

    xwGC7Ff.jpg

    The takeaway from this graphic points out the need to load vitamin D3 at higher doses (50,000 IU/day to 100,000 IU/day) to reach a therapeutic 25(OH)D3 response for CH in a matter of days where a maintenance dose of 10,000 IU/day can take 10 months.  That's clearly too long if the CH beast is jumping ugly and a likely reason too many CHers claim this treatment protocol is ineffective for them.

    Watching the presentation by Dr. Ryan Cole on vitamin D3 at the following link is a must for everyone.  https://www.bitchute.com/video/hfzL5gUeQvxr/

    Take care and please keep us posted.

    V/R, Batch

  5. Hey Bilal,

    I'm familiar with your problem.  Spring pollen lets the CH beast try to open a big ol can of whupass on me If I let it.  Fortunately with over 10 years experience with the anti-inflammatory regimen and lots of data from fellow CHers in the same boat, I've found loading vitamin D3 at 50,000 IU/day to 100,000 IU/day with the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 for three to five days and doubling my maintenance dose from 50,000 IU/week to 100,000 IU/week with the D3-50s for at least a month keeps the CH beast away.   Since the pandemic started, I've also titrated the Quercetin and Turmeric (Curcumin) doses from 1.5 grams/day up to 3 grams/day and it clearly helps.  I also make sure I take 50 mg/day zinc picolinate and at least 8 grams/day vitamin C.

    If you've had a recent lab assay for your 25(OH)D3 serum concentration, whatever it is, it's below the CH pain free threshold.  I've kept my 25(OH)D3 up around 150 ng/mL for the last two years and it's kept me CH pain free.  I've been working with one CHer who found his CH pain free threshold was 161 ng/mL.  Anything less than that and his CH beast started jumping ugly.

    Take care and please keep us posted.

    V/R, Batch

    • Like 3
  6. Hey John,

    CH Father's, Spiny's and Pebles' comments all hit the mark debunking the article in question.  There are studies and then there are articles about studies. While well designed studies/clinical trials as well as their published results and conclusions must conform to accepted standards, good science and format, articles do not.  This article was a POS.

    While the cited study at PLoS provides what appears to be consistent results from their study of oxygen therapy breathing 95% O2 and 5% CO2 resulting in "normalized" cerebral blood flow and that hyperoxia breathing normobaric 100% oxygen results hypocapnia (too little blood CO2) with attendant vasoconstriction and reduced cerebral blood flow, it fails to tell the "rest of the story" as Paul Harvey used to say. 

    This study fails to point out that even with the reduced cerebral  blood flow the authors opined would result in hypoxia (too little oxygen delivered to the brain) and the release of potentially threatening enzymes, hormones and other peptides, the actual oxygen content of the cerebral blood flow through the brain was more than sufficiently high to prevent ischemia.

    So where does that leave CHers who have read this article and who need to use oxygen therapy as a CH abortive?  If you disregard the junk science in this article, and use the most effective oxygen therapy procedure available to abort your CH rapidly, you're in great shape.

    The topic of oxygen therapy as a CH abortive is near and dear to my heart.  From 2005 when Dx'd as a Chronic CHer, until 2010 when I developed the anti-inflammatory regimen to prevent my CH very effectively, oxygen therapy was my only CH intervention. 

    I developed a very effective method of rapidly aborting my CH in 2005 that uses oxygen flow rates of 25 yo 40 liters/minute.  This method of oxygen therapy essentially allows the CHer to hyperventilate with 100% oxygen to a safe and effective rapid abort.  As a patent holder of the Demand Valve Method of Oxygen Therapy issued by the USPTO in 2010,  I spent the better part of a year reading through hundreds of studies and RCTs involving the inhalation of 100% oxygen in developing the patent application.

    The following link provides the abstract for one of these studies titled, The Influence of Arterial Oxygenation on Cerebral Venous Oxygen Saturation During Hyperventilation, by Matta, et al.,  published in 1994.  It concluded oxygen therapy at flow rates that support hyperventilation were not only safe, but it resulted in venous blood flow measured at the Jugular vein, indicated blood flow from the brain had twice the oxygen content of normobaric oxygenation. 

    https://link.springer.com/article/10.1007/BF03015651

    By the way, this is the very same principle of respiratory physiology that makes aborting CH using a oxygen demand valve with oxygen flow rates that support hyperventilation so safe and effective with average abort times of 7 minutes. 

    You can achieve the same rapid abort times (7 minutes) by repeating the following sequence seven times. Each sequence involves hyperventilating with room air for 30 seconds at forced vital capacity tidal volumes followed by inhaling a lungful of 100% oxygen and holding it for 30 seconds.  The only difference between this method of oxygen therapy and the demand valve method is this method consumes one tenth the volume of oxygen or an average of 28 liters per CH abort where the demand valve method consumes an average of 280 liters of oxygen per abort.

    Regarding oxygen safety.  It's very safe.  I was flying Navy fighters on and off aircraft carriers before they started Top Gun.  I have over 3000 hours flying Navy fighters and all of that flight time was spent breathing 100% oxygen from engine start through cat shot, missions lasting 1.8 hours or more in duration to landing back aboard ship chocked and tied down.  Then I took off the oxygen mask and turned off the oxygen.  I would also note that during high G-force maneuvering in aerial combat, I routinely sucked down 100% oxygen at flow rates above 40 liters/minute.  I passed my annual flight physicals every year of my 24 years of Naval Service.   Moreover I'm still here at 76 and in very good health having used oxygen therapy daily for 5 years and I still pass my annual physicals.

    1OCrJHE.jpghuG7WP5.jpg

    Several hundred thousand Navy and Marine Corps pilots flying tactical fighter and attack aircraft have been breathing 100% oxygen on all missions since 1943 when US and UK engineers cockroached (copied) the oxygen regulator design from a German bF-109 Messerschmidt that crash landed in the UK.  It took only a few months to retrofit this new design into Naval aircraft.  Bottom line, all these Navy and Marine Corps pilots have passed their annual physicals yearly since then with PA and lateral chest X-Rays indicating no adverse effects.

    Finally, think about the following.  Navy and Marine Corps Pilots are required to breath 100% oxygen on all flights.  NASA requires Astronauts breath 100% oxygen during suited EVA operations as well as during launch and reentry.  Would they do this if breathing 100% oxygen was inherently unsafe?  Let that sink in for a while.

    Take care,

    V/R, Batch

    • Like 3
  7. Pebbles,

    I think we can agree, a gold standard, randomized, double blind, placebo controlled RCT of vitamin D3 and cofactors as an intervention for cluster headache is needed.  Dr. Mark Burish, MD, PhD., Director, Will Erwin Headache Research Center, UT Houston Health Science Center and featured speaker at Clusterbusters conferences registered just such an RCT on ClinicalTrials.gov 30 Sept 2020.   As Dr. Burish’s study is based on the anti-inflammatory regimen, I’m confident the results will be compelling.

    His study also uses a Crossover design feature where following the double blind phase, participants will be unmasked and those who received the placebo will be given the same vitamin D3 and cofactor intervention/treatment.  This will serve as a force multiplier adding strength to the study conclusions as the crossover design reduces the influence of confounding factors by allowing crossover participants to serve as their own control group.  As this RCT won’t start recruiting until later this year, it’s going to be a couple years before it concludes any results. 

    On the other hand, with respect to the use of vitamin D3 as an intervention for a Wuhan coronavirus infection, a.k.a., COVID-19, there are 34 studies registered in ClinicalTrials.gov.  Most are RCTs and five have already reported out concluding favorable results.  See the following link for details.  http://vitamindwiki.com/tiki-index.php?page=COVID-19+treated+by+Vitamin+D+-+studies%2C+reports%2C+videos#TR

    As Meta-Analyses and Systematic Reviews rate highest in the hierarchy of medical evidence pecking order above RCTs, the meta-analyses at the following link provide clear proof of efficacy.

    https://vitamindwiki.com/Vitamin+D+supplementation+fights+COVID-19+%E2%80%93+11th+meta-analysis+Jan+24%2C+2021

    Interesting comment (the Cluster data is problematic because it largely represents "numerators in search of denominators.").

    As a rule, I try to avoid circumlocution.  What are you trying to tell readers of this thread… or me?  Are you questioning the role of the virgule, or are you suggesting an intervention in search of a pathology?  Please elucidate.

    Take care,

    V/R, Batch

  8. Hey Squizzlet,

    I'm working with a cluster headache group in Finland.  They conducted a survey of their members regarding migraine headache.  Of the 300 responders, 150 of these CHers also suffered from migraine headache.  This is an eye popping statistic with less than 1% of CHers here in the US with migraines until you look at the map of Finland and realize half of the country lies North of the Arctic Circle, i.e., not much sunshine and when it does shine, the angle to the horizon is so  low, the synthesis of cutaneous vitamin D3 is nil.

    There's another interesting statistic.  The study I've been running since December of 2011 of cluster headache sufferers (CHers) taking the anti-inflammatory regimen with 10,000 IU/day vitamin D3 plus cofactors to control their CH has 313 participants as of December of 2019.  The second highest country by participants is Finland, second only to the US and ahead of the UK, Canada, Australia and New Zealand in total number of participants.

    The 30 day efficacy of participants from Finland has 20 of 23 participants (83%) reporting a significant reduction in the frequency of their CH from a mean of 3 CH/day down to 3 CH/week.  The 30 day efficacy for CHers here in the US is 82%. As there are so many CHers in Finland with migraine, I hope to gather more data on how their migraine headaches respond to this regimen.  I'm presently tracking 12 migraineurs taking the anti-inflammatory regimen, 10 of them reported a significant reduction in the frequency of their migraines and five reported a complete cessation of their migraines.

    If you're interested in this CH preventative regimen that's also proving effective in preventing migraine headache, you can download a copy of the treatment protocol at the following vitaminDwiki.com link.

    http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708

    Take care and please keep us posted.

    V/R, Batch

  9. Hey Amardeep,

    This may be a long shot, but here you go anyway.  The following doctor may be the one you are looking for in India who treats CHers and headache patients.

    Dr Renu Mahtani MD
    407, Millennium Star,
    Dhole Patil Road,
    Pune - 411001
    Maharashtra, India
    Contact : +91-7887887665 (WhatsApp then call )
    Email : mahtani.renu@gmail.com
    Website: www.renumahtani.com  

    Dr. Mahtani is a neurologist trained in the use of the Coimbra Protocol. 

    https://www.coimbraprotocol.com/the-protocol-1

    This is a treatment protocol for remitting recurring multiple sclerosis developed by Dr. Cicero Coimbra, MD, PhD, a neurologist in São Paulo, Brazil.  His protocol is similar to the anti-inflammatory regimen I developed in 2010, with the exception, it calls for significantly higher vitamin D3 maintenance doses and there's a prohibition on calcium intake.  His protocol is exceptionally effective and has a 95% complete remission rate among his patients suffering from recurring multiple sclerosis.

    Dr. Coimbra has had a few more years experience treating his MS patients with this protocol than I have with the anti-inflammatory regimen preventing CH.  You can download the posted version of the anti-inflammatory regimen migraine headache (MH) and cluster headache (CH) preventative treatment protocol at the following vitamindwiki.com link. 

    http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708

    Dr. Coimbra has since expanded the use of his protocol to treating patients with autoimmune disorders.  I've exchanged study results with him on the use of vitamin D3 and cofactors in preventing CH and MH.  I've also spoken with a Coimbra trained physician here in the US who has had success in treating chronic headache patients with the Coimbra protocol.

    So there you have it.  A long shot, but one with little down-side should you decide to give Dr. Mahtani a call or email.

    Take care and please keep us posted.

    V/R, Batch

    .

    • Like 1
  10. Tmac,

    Seeing your doctor to obtain lab assays for your serum 25(OH)D3 calcium and PTH is prudent.   As long as your serum calcium remains within its normal reference range and your PTH is in the mid to low normal range, there's no problem no matter how high your serum 25(OH)D3 assay.  I get the same blurb from Quest on my 25(OH)D3 assays.  I think it's computer generated.

    It's obvious something is interfering with the vitamin D3 enabled genetic expression that helps prevent your CH.  If it's allergy driven as I suspect, it could be there's so much histamine in your system, Quercetin is ineffective and even Benadryl (Diphenhydramine HCL) isn't all that effective either.   Other sources of interference include anything that causes an immune system response like infections, (bacterial, viral or fungal), some Rx medications, trauma and surgery.

    When are your CH occurring?   If they're all at night while sleeping, try sleeping in a leather recliner in your family room.  The rationale...

    Q9wtTZc.jpg

    it could be dust mite poo.  These little beasties have inhabited human bedding for thousands of years.  They don't bite but their poo can be a potent allergen.  Even if your wife wins the Good Housekeeping Seal of Approval, keeping sheets and bedding washed every other day may not be good enough, dust mite poo still gets into pillow and mattress stuffing. 

    Accordingly, to reduce exposure, try sleeping in a leather recliner for a couple nights.  A recliner also has the advantage of keeping your head 8 inches above your heart.  Even while sleeping, this will cause your heart to beat slightly faster to pump blood up to your brain. The extra work requires a little extra oxygen so your respiration rate will elevate slightly.  This increases the arterial oxygen partial pressure and reduces your arterial CO2 partial pressure.  Both these conditions help prevent CH.  If your recliner has fabric upholstery, cover it with a plastic sheet.  Dust mites colonize anywhere there are dried skin flakes.

    If there's a reduction in CH frequency while sleeping in the recliner, it's time to invest in a Hypoallergenic and dust mite proof mattress cover and new pillows.  Changing filters in the air handler of your heating and cooling system frequently can help cut down on airborne allergens in your home's interior.  

    If there's no joy with the recliner, your PCP/GP has several lab tests that should indicate weather or not you have an allergy. If the tests are positive, he should be able to get you a consult with an allergist.

    Another way to find out if you're dealing with an allergic reaction is to ask your PCP for a short prednisone taper.  If the pred taper is sufficient to drop your CH frequency, start looking for the cause.  Hope this helps.

    Take care and please keep us posted.

    V/R, Batch

  11. They TMac,

    Good questions.  3 CH/night is not good and a 25(OH)D3 serum concentration greater than 150 ng/mL is not a worry by itself.  The goal of the anti-inflammatory regimen is a CH pain free response.  The fallback is a significant reduction in CH frequency from an average of 3 CH/day down to 3 to 4 CH/week as long as oxygen is available.  Given the amount of vitamin D3 you've been taking and your 25(OH)D3 serum concentration is >150 ng/mL, I'll make a SWAG (sophisticated wild-ass guess) you're battling an immune system reaction caused by an allergy. 

    An allergic reaction is characterized by the immune system's Mast Cells releasing large amounts of histamine.  Histamine to a CHer is like Kryptonite to Superman, bad news.  In the past, I and many other CHers found a first-generation antihistamine like Benadryl (Diphenhydramine HCL) taken at 25 mg four times a day brought the allergic reaction under control so vitamin D3 could again do its thing to prevent CH.  First-generation (drowsy type) antihistamines like Benadryl (Diphenhydramine HCL) pass through the blood brain barrier to block histamine H1 receptors on neurons and glia throughout the brain.  This is important for CHers as histamine insults neurons and glia in the trigeminal ganglia causing them to express and release CGRP, SP and likely other neuroactive proteins that are responsible for CH pathogenesis.

    Benadryl (Diphenhydramine HCL) works well in this role as an antihistamine but with the drawback that it induces drowsiness in many and it's also an anticholinergic (blocks the neurotransmitter acetylcholinesterase).  As  acetylcholinesterase is needed to allow nerve signals to pass from neuron to neuron through nerve synapse, Benadryl (Diphenhydramine HCL) slows down nerve functions.  I suggested the use of Benadryl (Diphenhydramine HCL) be limited to a week to 10 days as it has also been associated with neurodegenerative disorders when taken for long periods of time. 

    Fortunately, in early 2019 I began suggesting Quercetin, a naturally occurring plant flavonoid, as an effective antihistamine as it has no time limit on dosing and no anticholinergic properties like Benadryl (Diphenhydramine HCL).  As a side note, Quercetin acts as an ionophore when taken with zinc that allows zinc ions to enter cellular cytoplasm to inhibit virus replication.  Something you should think about with the Wuhan Coronavirus floating around.

    Loading? Yes, if I was getting hit like you have, I would start loading vitamin D3 at 50,000 IU/day for at least a week or until I made it through two full days CH pain free then drop back to the previous vitamin D3 maintenance dose at least 10,000 to 20,000 IU/week higher. 

    Over the years, we've had a number of CHers with your problem, a high 25(OH)D3 serum concentration and the CH beast is still jumping ugly.  In the past, loading vitamin D3 with a week to 10-day course of Benadryl (Diphenhydramine HCL) worked wonders in getting them back to a CH pain free state. 

    Today, many CHers have found loading vitamin D3 and taking Quercetin has similar CH pain free outcomes.  Over the last four months, I've worked with CHers who tried 4-Day "pulsed" loading schedules taking 200,000 IU of vitamin D3 on Day-1 then coasting without any vitamin D3 on Days-2, 3 and 4, taking all the cofactors daily.  They repeat the 4-Day pulsed loading schedules until they experience a CH pain free response or four cycles.  At that point it's prudent to drop back to a vitamin D3 maintenance dose and see your PCP/GP for a set of labs of your serum 25(OH)D3, calcium and PTH.  If your serum calcium remains within its normal reference range, try three more pulsed loading cycles.

    If you do the math the 4-Day pulsed loading schedule still works out to an average dose of 50,000 IU/day for 4 days.  They've also upped the Quercetin dose and added Turmeric (Curcumin) and vitamin C.  The dosage here is 3 grams/day each of Quercetin, Turmeric (Curcumin) and Vitamin C with the 3 grams of vitamin C broken up into 3 equal doses taken throughout the day to maintain a relatively constant serum concentration.  There are a couple studies that found vitamin C increased the effectiveness of both Quercetin and Turmeric (Curcumin) when taken together.

    Pulsed loading causes a spike in serum vitamin D3 concentration illustrated in the following graphic that increases the osmotic diffusion differential between vitamin D3 in the blood stream and vitamin D3 at the cellular level. 

    xvPcaL1.jpg

    This increased osmotic diffusion differential results in more vitamin D3 entering cells throughout the body much faster.  Obviously, as CHers we're looking for this increase to occur in neurons and glia within the trigeminal ganglia to bring our CH under control.  If you think this is an extreme vitamin D3 loading dose.  It's not.  There are studies using a single oral dose of 300,000 IU to 600,000 IU vitamin D3 with no adverse effects.

    Regarding your lab result for 25(OH)D3.  Quest Diagnostics has two different 25(OH)D3 assay methods.  They've a fast inexpensive automated assay for 25(OH)D3 that tops out at a serum concentration of 150 ng/mL and the QuestAssured Liquid Chromatography Dual Mass Spectroscopy (LC-MS/MS) assay method that reads total 25(OH)D (D2 and D3) up to 512 ng/mL.  If your doctor didn't specify the Quest Diagnostics Test Name: 92888- "QuestAssureD 25-OH Vitamin D (Total), LC/MS/MS assay for 25(OH)D3" in your lab order, you likely got the low cost rapid automated assay.

    That said, a 25(OH)D assay >150 ng/mL although not a worry by itself, is meaningless if you're CH pain free.  The important lab assays for you at this point are for your serum calcium and Parathyroid Hormone (PTH).  Did your doctor order these two assays and do you have the results?  As long as your serum 25(OH)D3 is within its normal reference range, there's no hypercalcemia (too much calcium in the bloodstream), a.k.a., vitamin D3 intoxication/toxicity.  This means your 25(OH)D3 is not a worry no matter how high it goes as long as your serum calcium is normal. 

    The following 3-year chart of my lab assays for serum 25(OH)D3, calcium and PTH are a good example.  It illustrates my 25(OH)D3 serum concentration has been well above 100 ng/mL, as high as 188 ng/mL and has averaged 150 ng/mL since January of 2019 while my calcium serum concentration has remained within its normal reference range the entire time.  My PCP understands vitamin D3 and calcium homeostasis so has no problem with my 25(OH)D3 serum concentration this high to prevent my CH as long as my serum calcium remains within its normal reference range.  As you can see, it has.

    hVz4sJb.jpg

    Hope this helps.  Take care and please keep us posted.

    V/R, Batch

    • Like 2
  12. Hey Krios,

    We've seen a higher response rate among CHers new to this regimen when they take the Bio-Tech D3-50 50,000 IU water soluble vitamin D3.  As you're still experiencing CH, this is usually an indication your 25(OH)D3 is too low.  Accordingly, you need a higher maintenance dose of vitamin D3.  The most effective method of elevating serum 25(OH)D3 and faster way of returning to a CH pain free state is by starting a 4-Day vitamin D3 loading schedule taking  50,000 IU/day for 4 days.  There's also "Pulsed" loading where you take 200,000 IU of vitamin D3 on Day-1 then coast taking no vitamin D3 on Days 2, 3, and 4.  You take all the cofactors daily.  On day 5 if you're CH pain free restart your maintenance dose at least 5,000 IU/day higher.  If you're not CH pain free by Day-5 continue loading or pulsed loading until you experience a CH pain free response for at least 48 hours then return to a maintenance dose 5,000 IU/day higher than previous.

    Either way the goal of the anti-inflammatory regimen is a CH pain free response.  The latest update to this treatment protocol will included loading or pulsed loading until you experience a CH pain free response for 48 hours then drop back to a maintenance dose.  Of course it's always wise to see your PCP/GP for labs of your 25(OH)D3, calcium and PTH any time you've changed your vitamin D3 dosing and at least once a year after you've reached a stable vitamin D3 dose that keeps you CH pain Free.'

    Take care and please keep us posted.

    V/R, Batch

    V

    • Thanks 1
  13. Hey Snowflake,

    I'm very happy to see you've responded to the anti-inflammatory regimen with a complete cessation of CH.  I know how wonderful that feels. I've sent you a PM so we're in direct contact.

    There are a few things you'll need to remember at this point.  The first is you'll need to stay on this regimen until you end up on the other side of the air-grass interface in order to experience its many benefits.

    Second, there will be times when the CH beast overrides vitamin D3 and jumps ugly.  When that happens, and it will, don't worry.  Start loading vitamin D3 until you're back CH pain free then up the maintenance dose by 5,000 IU/day for a few months.

    Third and most important, start the rest of your family on this regimen.  The health benefits are too great to ignore.  It is so safe, I've had my entire family including cousins and second cousins, kids and grand kids taking this regimen since 2012.  I've four grand kids who were bathed in maternal vitamin D3 from conception through breast feeding as their mothers have been taking this regimen with 10,000 IU/day vitamin D3.  These kids have T-Rex immune systems.  They don't get sick.  They're also budding Einsteins and Mensa candidates with exceptional neuromotor development.   Kids under 100 lbs get 50 IU of vitamin D3 per pound of body weight per day.

    This regimen is also proving to be effective in preventing serious infection by the Wuhan (SARS-CoV-2) Corona virus.  My son and niece have both had a brush with the Wuhan virus.  My niece found the infection was less bothersome than a cold and lasted only 5 days until asymptomatic.  My son didn't even know he'd been infected until he went in for elective surgery and the Wuhan virus antibodies turned up in his PreOp labs.

    The following vitamindwiki.com link will take you to a webpage on the use of vitamin D3 as an intervention for COVID-19.

    COVID-19 treated by Vitamin D - studies, reports, videos

    As of Jan 29 had:  34 trials4 trial results,  13 meta-analyses and reviews,   46 observations,   29 recommendations,   42 associations,  84 speculations,  38 videos   see also COVID-19 and Vitamin D:   Governments.   Health problems.   Hospitals

    Take care and please keep us posted.

    V/R, Batch

  14. Hey Drewbie,

    Good question.  I can't answer it directly with a "yes: or "no".  What I can say is we are seeing CHers who were low- and non-responders to the anti-inflammatory regimen, achieve favorable results by adding 3 grams/day Quercetin, Turmeric (Curcumin) and 3 to 6 grams/day Vitamin C divided into 3 or more doses taken during the day.   The thinking here is that among its many physiological functions as a plant-based flavonoid  found  in abundance in apples, honey, raspberries, onions, red grapes, cherries, citrus fruits, and green leafy vegetables, Quercetin acts as a natural antihistamine.  There is also sufficient open source medical evidence that Quercetin limits the effectiveness of candesartan, an an angiotensin receptor blocker.

    On a related note, there is sufficient medical evidence that Quercetin acts as an ionophore to transport zinc ions into cells infected with the Wuhan (SARS-CoV-2 Coronavirus) where it inhibits the enzyme that enables replication of the Wuhan virus, thus stopping the infection.

    Bottom line, it's dealer's choice.  You'll need to decide what to do.

    Take care and please keep us posted.

    V/R, Batch

  15. Hey Drewbie,

    Your analysis is spot on!  The year-over-year efficacy of the anti-inflammatory regimen CH and MH preventative treatment protocol as captured with the online survey that's been running since December of 2011 found an average of 80% of the 313 CHers starting this regimen experienced a significant reduction in the frequency of their CH from a mean of 3 CH/day down to a mean of 3 CH/week in the first 30 days. 52% of these 313 CHers experienced a lasting cessation of CH in the first 30 days.

    I might add that this raw efficacy for a favorable response edged up to 88.9% for 2019-2020.  During this same 2-year time frame, the complete cessation rate increased from 53% to 66.7%.  I suspect this increase in efficacy is due to the switch to the Bio-Tech D3-50 I began posting about in June of 2018 and the switch to Methyl Folate + I began posting about in early 2019. 

    I've researched available open source, published results of cluster headache prophylaxis RCTs.  None of them has risen to a level efficacy where 2/3 of participants experienced a complete and lasting cessation of CH.  And, I might add, with no adverse events noted/reported.

    The majority of my research has focused on why 12% to 18% of CHers do not respond to this regimen.  Roughly half of these non-responding CHers managed to experience a CH pain free response by working with their PCP/GP with frequent labs for serum 25(OH)D3, calcium and PTH to safely increase their 25(OH)D3 serum concentration up between 100 and 180 ng/mL (250 to 450 nmol/L). 

    I've been tracking two of these non-responder CHers who have worked with their PCP/GP taking 50,000 IU/day vitamin D3 for months to elevate their 25(OH)D3 serum concentration higher than 200 ng/mL (500 nmol/L).  Both CHers have normal calcium serum concentrations and one of them finally experienced a lasting cessation of CH.  They were both taking 3 grams/day Quercetin and Turmeric (Curcumin) and up to 6 grams/day vitamin C in divided doses.

    I am far from having definitive answers why some CHers do not respond to this treatment protocol, but there are a couple reasons that are common among them.  The first is allergic reactions.  It appears no matter how high their 25(OH)D3 serum concentration, an allergic reaction can knock CHers out of CH remission unless first-generation antihistamines like Benadryl (Diphenhydramine HCL) or Quercetin are taken at high enough doses.  The second is CHers who have gone on a Ketogenic diet avoiding all sugars and wheat products, appear to respond at higher rates.

    Regarding your question on triggers still being a problem after successfully controlling CH with vitamin D3 and its cofators?  It all depends on the trigger.  The only way to know for sure if a previous trigger is still a problem after a CH pain free response due to vitamin D3 is by using the "By Guess and By Golly" test method.  I would keep the oxygen, vitamin D3 loading doses along with plenty of Quercetin and vitamin C handy.

    Take care and please keep us posted.

    V/R, Batch

     

  16. Hey Krios,

    Thanks for the updates.  Howz the head now?  Has the frequency of your CH dropped further?

    Did you start this regimen with the lab test of your baseline 25(OH)D3 serum concentration before starting vitamin D3?.  If so, what was it?  The normal distribution chart of baseline 25(OH)D3 serum concentrations at baseline from 313 CHers with active bouts of CH responding to the online survey as of Dec, 20, 2019 are illustrated in the following graphic.

    RAWsxuR.jpg

    The normal distribution chart of 25(OH)D3 serum concentrations after 30 days on this treatment protocol are illustrated in the following graphic.

    6pCJkDY.jpg

    The following chart illustrates favorable responses by day after start of regimen.  As you can see, most CHers respond within the first two weeks after starting this regimen.

    v0LTmPQ.jpg

    When you've been on this regimen for at least 30 days, see your PCP/GP for lab tests of your serum 25(OH)D3, calcium and PTH.  When you have the results in hand, please take the online survey of CHers taking the anti-inflammatory regimen.  To start this survey, click on the following link:
    http://www.esurveyspro.com/Survey.aspx?id=fb8a2415-629f-4ebc-907c-c5ce971022f6

    Data from this survey is helping neurologists and pain specialists consider this treatment protocol for their patients with CH.  The more data, the better.  This data has already convinced one neurologist to fund a gold standard RCT on this treatment protocol as a CH intervention.  That RCT should start recruiting later this year.

    Thanks agaain for the feedback.  Take care and please keep us posted.

    V/R, Batch

  17. Pebbles,

    Interesting comments.  What are you telling readers of this thread?  Is it the age old aphorism dating back to biblical times – “All that glitters is not gold” or is it in your opinion, there’s insufficient medical evidence that vitamin D3 and its cofactors help prevent cluster headache or help prevent serious infection by the Wuhan virus resulting in COVID-19?

    If that’s your opinion, wonderful.  This is exactly what this forum is all about, open discussions and the free exchange of information, ideas and experiences.

    Take care,

     

    V/R, Batch

  18. Hey Drewbie,

    Good move starting the anti-inflammatory regimen.  I've had my entire family and close friends taking it since 2011 and none of them have CH.  The first step is to see your doctor/PCP to discuss this regimen and to ask for lab tests of your serum 25(OH)D3, calcium and PTH.  Without these lab tests, CHers are shooting in the dark.  When you do get the results back, see where you stack up with respect to the studies in the following link.

    https://vitamindwiki.com/COVID-19+treated+by+Vitamin+D+-+studies%2C+reports%2C+videos

    Take care and please keep us posted.

    V/R, batch

     

  19. Hey Drewbie, All,

    The basic regimen posted on vitaminDwiki is still valid for CH and MH.  I was in the process of updating it with results from the online survey when the COVID-19 pandemic hit the US in early February.  At that point I had two changes to supplements in the posted version.  The first is we've found the Bio-Tech D3-50 50,000 IU water soluble form of vitamin D3 to be faster acting with a higher bioequivalence in elevating 25(OH)D3 serum concentrations than the same dose of the oil-based liquid softgel vitamin D3 formulations.  I began suggesting this switch in 2019 here on this forum.  The same goes for the switch from the vitamin B 50/100 complex to the Methyl Folate + B complex as it also has a higher bioequivalence.   I began suggesting this switch from the vitamin B 50/100 complex to Methyl Folate + B Complex in December of 2019.

    Vitamin C (Ascorbic Acid) and Turmeric (Curcumin) are also covered in the 2017 posted version of this regimen on vitaminDwiki.com.  I began posting about Quercetin some time in mid 2019 and if you attended the Clusterbusters Conference in Dallas in 2019, I briefed Quercetin as an addition to the basis regimen.  I also posted about Quercetin as a supplement in an immune boosting strategy to help prevent viral infections in early June of 2020.

    The rational for the switch from Benadryl (Diphenhydramine HCL) to Quercetin was based on the capacity of Quercetin as an antihistamine.  As Diphenhydramine is an anticholinergic that easily leads to drowsiness and Quercetin has an excellent safety profile, the switch to Quercetin for CHers suspecting an allergic reaction makes good sense.

    The emergence of the Wuhan virus and COVID-19 pandemic in early 2020 have posed additional considerations on the update to the posted version of this treatment protocol.  For example, I've always known a healthy immune system played an important role in helping to prevent CH and MH.  What I didn't fully grasp was the detrimental effects of a dysregulated immune system can be on CH.  The results of several studies of COVID-19 and treatments practiced by emergency medicine physicians in the Front Line COVID-19 Critical Care Alliance (FLCCC) focused on a dysregulated immune system as the primary threat to survival from COVID-19.  Their treatments include large doses of vitamin D3 (480,000 IU) on admission, Quercetin, zinc as well as IV vitamin C, and Thiamine (vitamin B1).   See attached.

    I'm still working on the updated version of this treatment protocol.  That said the updating process is not a simple task.  Once I have a clean draft, it will go out to a select group of experts in nutritional science, nutritional medicine and headache specialists for chop and comments.  That will take at least a month or longer depending on the comments and suggested changes.   Until then, I'll keep you posted.

    Take care,

    V/R, Batch

     

    FLCCC_Alliance-MATHplus_Protocol_v6-2020-11-12-ENGLISH.pdf

    • Like 1
×
×
  • Create New...