Long Night in General Board Posted January 24, 2010 I have a few different medical issues, the major one was endometriosis. My specialist recommended a Lupron injection that would last for 6 months. once I took it there was no way to get it out of my body for now the next 4 months. The past few days have been horrible. I can generally tell a cluster cycle by how it starts. one a night abut 2 am every other day for a few days then one a night and it gets worse from there. In 3 days I have gone from one nightly to 6 last night. I have my O2 tank but after last night it is almost empty. I am thinking that the Lupron treatment has made this cycle worse. I normally only get a cycle every 1 and a half either in March or Sept. I haven't had one in over a year now and was totally unprepared for this to begin. I am not able to find anything on Lupron and clusters and not sure I can take it if this cycle gets any worse. I am just trying to find any information or help right now.