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lookey what I found ... Soooo ,, ( I feel like this is important).. the reason that the Shrooms and Seeds work ,, is because they bind with the excess acetaldehyde in your bodies converting it to LSH,,, I just ordered some for my son Defiance: It is my understanding the acetaldehyde naturally bound to the fresh seed active (the combination I call LSH for ease of communication) evaporates and thus leaves the compound I call LSA (for ease of communication) or something like that that I'll dig up if inquiring minds truly want to know. The evaporation leaves part of the original compound, which I call LSA, ready to react and form an adduct with another aldehyde when it is introduced to the LSA in solution. This is where we get our "Peppermint Tea" CWE for potentiated effects of older seeds... but it only works (well/consistently) with fresh or hermetically sealed peppermint leaves (or rum/sherry) due to the low evaporation temperature of acetaldehyde... the same reason the seeds lower in activity and change in effect from stimulation (LSH) to sedation (LSA) over time. The aldehyde of cinnamon is much more temperature stable... and so is the adduct formed when mixed in solution with the sacred-seed extract. This is mostly from the studies of a mixed group of enterprising entities as I'm sure some of you can relate... Back to top

lookey what I found ... Soooo ,, ( I feel like this is important).. the reason that the Shrooms and Seeds work ,, is because they bind with the excess acetaldehyde in your bodies converting it to LSH,,, I just ordered some for my son Defiance: It is my understanding the acetaldehyde naturally bound to the fresh seed active (the combination I call LSH for ease of communication) evaporates and thus leaves the compound I call LSA (for ease of communication) or something like that that I'll dig up if inquiring minds truly want to know. The evaporation leaves part of the original compound, which I call LSA, ready to react and form an adduct with another aldehyde when it is introduced to the LSA in solution. This is where we get our "Peppermint Tea" CWE for potentiated effects of older seeds... but it only works (well/consistently) with fresh or hermetically sealed peppermint leaves (or rum/sherry) due to the low evaporation temperature of acetaldehyde... the same reason the seeds lower in activity and change in effect from stimulation (LSH) to sedation (LSA) over time. The aldehyde of cinnamon is much more temperature stable... and so is the adduct formed when mixed in solution with the sacred-seed extract. This is mostly from the studies of a mixed group of enterprising entities as I'm sure some of you can relate...

Hey Bilal, Good move on switching to the Bio-Tech D3-50. Data for 2019 from the online survey of CHers reporting since 2011, indicated an up-tick in raw efficacy from 82% to 88% of CHers responding with a significant reduction in the frequency of their CH or a complete cessation of CH in the first 30 days after I started suggesting this change due to its higher bioequivalence compared to the oil-based vitamin D3 liquid softgel formulations. There's nothing wrong with zinc glycinate so no need to change. There appears to be a higher bioequivalence in the Methyl Folate + compared to the generic B complex. Regarding safe dosing with vitamin D3. A recent article in the Journal of Steroid Biochemistry and Molecular Biology at the following link, concluded in the results of a seven year study: There were no cases of vitamin D3 induced hypercalcemia a.k.a., vitamin D3 intoxication/toxicity at higher vitamin D3 doses and that long-term supplementation with vitamin D3 in doses ranging from 5,000 to 50,000 IU/day appears to be safe. https://www.sciencedirect.com/science/article/abs/pii/S0960076018306228 The following chart from this study illustrates it takes a long time for a stable dose of 10,000 IU/day vitamin D3 to reach a 25(OH)D3 equilibrium. The takeaway from this graphic points out the need to load vitamin D3 at higher doses (50,000 IU/day to 100,000 IU/day) to reach a therapeutic 25(OH)D3 response for CH in a matter of days where a maintenance dose of 10,000 IU/day can take 10 months. That's clearly too long if the CH beast is jumping ugly and a likely reason too many CHers claim this treatment protocol is ineffective for them. Watching the presentation by Dr. Ryan Cole on vitamin D3 at the following link is a must for everyone. https://www.bitchute.com/video/hfzL5gUeQvxr/ Take care and please keep us posted. V/R, Batch

Melissa, A CHer with active CH nursing a 7 month old baby... BINGO!!! You really need to be taking 10,000 IU.day vitamin D3 plus Omega-3 fish oil and all the vitamin D3 cofactors. If not, your baby needs a minimum of 400 IU/day supplemental vitamin D3. Yes... I can hear the wheels turning... Who is Batch and what are is qualifications for saying this? Good question... Although my answer may not be sufficient for you to follow the suggestion as I'm a 73 year old retired US Navy fighter pilot with a degree in Chemistry, 24 years as a CHer (chronic since 2005) and full time student of vitamin D3 since October of 2010. That's when I discovered that 10,000 IU/day vitamin D3 plus Omega-3 fish oil and all the vitamin D3 cofactors prevented my chronic CH... I've been CH pain free ever since. This regimen is so important for good health and among other benefits, it builds a T-Rex immune system, that I have my entire family taking it and none of them have CH. Of particular interest to you are my daughter and niece. Both have been taking this regimen for years. My daughter gave birth to her second child in July. This baby and his sister, now 3 years, were both bathed in maternal vitamin D3 at a dose of 10,000 IU/day since conception. Both pregnancies and deliveries were flawless. Moreover their neuromotor, physical and learning development while breastfeeding at this maternal vitamin D3 dose are nothing short of phenomenal. My niece took this same regimen through her pregnancy and is still taking it like my daughter while breastfeeding. Orrin, 5 months and Fred, a.k.a., Winefred, 3 years... Yes, I'm a doting old grandfather... but I've never seen more healthy babies... and Fred speaks English and Hochdeutch... I credit their excellent health and rapid development to their mother taking 10,000 IU/day through pregnancy and while breastfeeding... Fred also takes vitamin D3 at a dose of 50 IU per pound of body weight a day... She's a 40 pounder so that works out to a vitamin D3 dose of 2000 IU/day... and not the 600 IU/day recommended by bureaucrats at the National Academy of Medicine, formerly called the Institute of Medicine (IOM). Now to the experts with the sheepskins in the appropriate fields and years of professional experience with vitamin D3 studies who suggest 10,000 IU/day during pregnancy and while breastfeeding... Bruce W. Hollis, PhD, Professor of Pediatrics, Biochemistry and Molecular Biology, and Director of Pediatric Nutritional Science at The Medical University of South Carolina, Charleston, SC. The Institute of Medicine has set the “upper limit” of recommended intake at 4000 IU. Is it safe for an adult to take 6400 IU? "The IOM setting a limit of 4,000 IU per day was subjective and not based on any trials. The Endocrine Society guidelines state that 10,000 IU per day is safe. In my own experience with our trial and several other trials in which I have been involved (involving tens of thousands of patients), not a SINGLE adverse event has been observed due to vitamin D intake. I personally take 6,000 IU per day and have for years, and my daughter just had a child and is taking 10,000 IU per day while lactating (going on a year now). Totally safe." Hmmm... How about that... A highly qualified PhD, Professor of Pediatrics, Biochemistry and Molecular Biology and Director of Pediatric Nutritional Science at The Medical University of South Carolina, Charleston, SC recommends a maternal vitamin D3 dose of 10,000 IU/day... and that's what his daughter has been taking while breastfeeding... "Totally Safe." See the following link for more details: https://kellymom.com/nutrition/vitamins/vitamin-d-and-breastfeeding/ This was an interesting study where one group of 74 breastfeeding mothers took the "Old School" recommended prenatal vitamins and minerals with 400 IU/day vitamin D3 during pregnancy and while breast feeding... After 7 months of breastfeeding their mean serum 25(OH)D was only 79 nmol/L (36.6 ng/mL). 25(OH)D lab tests of their babies indicated 78% of them were vitamin D3 deficient until provided with 400 mg/day supplemental vitamin D3. The other group of 78 breastfeeding mothers took the same prenatal vitamins and minerals with 400 IU/day vitamin D3 PLUS another 6,000 IU/day vitamin D3. After 7 months of breastfeeding their mean serum 25(OH)D concentration was 151.2 nmol/L (60.5 ng/mL) and more importantly, their babies had a mean serum 25(OH)D concentration of 106.9 nmol/L (42.8 ng/mL) WITHOUT supplemental vitamin D3. Grassrootshealth recommends a maternal vitamin D3 intake during breastfeeding of 6400 IU/day... as a minimum... to ensure breast milk contains ≥ 400 IU/liter 25(OH)D. See the following link for more details. https://grassrootshealth.net/blog/vitamin-d-for-breastfeeding-mother/ Grassrootshealth.net also has a wonderful 25(OH)D home blood spot test kit for $70, no Rx needed and you'll get the results back in less than two weeks. I've used their DIY 25(OH)D test kits for years. See the following link for details. https://grassrootshealth.net/project/daction/ So there you have it... You can continue suffering from CH... or you can download the anti-inflammatory regimen, take a copy to your PCP, discuss it, then ask for the 25(OH)D lab test. When the results of that lab test come back indicating you're vitamin D3 deficient, start this regimen and follow it carefully. I'd go one step further and take your baby to the pediatrician and ask for the same 25(OH)D lab test. If you do this, your CH will become a thing of the past and your baby will be getting more than sufficient vitamin D3 while breastfeeding. Over the last seven years, at least 4 ladies with CH started this regimen and continued it through pregnancy and while breast feeding... Results... No standard CH medications with all the side effects, no CH and 4 very healthy babies. Take care and please keep us posted. V/R, Batch

Hey Batch, I am still having 1 to 2 hits a day but thankfully they are at night and I'd take night headaches over one during the day while I am at work.... Admittedly I am on what I think is the old D3 regimen that consists of (x2 D3 @10,000 I/U, x1 magnesium citrate @250mg, x1 calcium @600mg and x1 fish oil @1200mg) and unfortunately I haven't had any labs drawn for a while but about 6 months ago I did and they were fine

Hey Drewbie, All, The basic regimen posted on vitaminDwiki is still valid for CH and MH. I was in the process of updating it with results from the online survey when the COVID-19 pandemic hit the US in early February. At that point I had two changes to supplements in the posted version. The first is we've found the Bio-Tech D3-50 50,000 IU water soluble form of vitamin D3 to be faster acting with a higher bioequivalence in elevating 25(OH)D3 serum concentrations than the same dose of the oil-based liquid softgel vitamin D3 formulations. I began suggesting this switch in 2019 here on this forum. The same goes for the switch from the vitamin B 50/100 complex to the Methyl Folate + B complex as it also has a higher bioequivalence. I began suggesting this switch from the vitamin B 50/100 complex to Methyl Folate + B Complex in December of 2019. Vitamin C (Ascorbic Acid) and Turmeric (Curcumin) are also covered in the 2017 posted version of this regimen on vitaminDwiki.com. I began posting about Quercetin some time in mid 2019 and if you attended the Clusterbusters Conference in Dallas in 2019, I briefed Quercetin as an addition to the basis regimen. I also posted about Quercetin as a supplement in an immune boosting strategy to help prevent viral infections in early June of 2020. The rational for the switch from Benadryl (Diphenhydramine HCL) to Quercetin was based on the capacity of Quercetin as an antihistamine. As Diphenhydramine is an anticholinergic that easily leads to drowsiness and Quercetin has an excellent safety profile, the switch to Quercetin for CHers suspecting an allergic reaction makes good sense. The emergence of the Wuhan virus and COVID-19 pandemic in early 2020 have posed additional considerations on the update to the posted version of this treatment protocol. For example, I've always known a healthy immune system played an important role in helping to prevent CH and MH. What I didn't fully grasp was the detrimental effects of a dysregulated immune system can be on CH. The results of several studies of COVID-19 and treatments practiced by emergency medicine physicians in the Front Line COVID-19 Critical Care Alliance (FLCCC) focused on a dysregulated immune system as the primary threat to survival from COVID-19. Their treatments include large doses of vitamin D3 (480,000 IU) on admission, Quercetin, zinc as well as IV vitamin C, and Thiamine (vitamin B1). See attached. I'm still working on the updated version of this treatment protocol. That said the updating process is not a simple task. Once I have a clean draft, it will go out to a select group of experts in nutritional science, nutritional medicine and headache specialists for chop and comments. That will take at least a month or longer depending on the comments and suggested changes. Until then, I'll keep you posted. Take care, V/R, Batch FLCCC_Alliance-MATHplus_Protocol_v6-2020-11-12-ENGLISH.pdf

I'm not sure the percentage. I take 1/2 mL 2x a day. Then I smoke CBD or take another dose if I feel an onset of a cluster. This is the CBD I use. https://cbdamericanshaman.com/water-soluble-full-spectrum-hemp-oil-30ml

Hi Patheticfern, May I ask you what doses you take ? I both a 10 ml bottle a while ago that has 15% CBD oil. The seller told me this is the lightest form of CBD for medical application. Can go up to 30 %. For me to have a little bit of an effect, I need around 20 drops while the guy in the store advised 3 drops per 3 hours... so much it makes me unwell. Maybe I need a higher concentration ? And how do you dose that ? Once a day or several times a day ? I have chronic paroxysmal hemicrania and chronic migraine. For the CPH, I need to take indomethacin to get it under control. Unfortunately, indomethacin makes my migraine attacks worse and resistant against triptans. I am currently experimenting again with topiramate. It has a clear effect on both headaches but I am too sensitive to it and too many side effects. siegfried

Hey TSmith, Sorry to be so slow in responding. My bird dog must have missed your post or I missed its email alert. My suggestion is to see your doctor for the lab tests of your serum 25(OH)D3, calcium and PTH. If your serum 25(OH)D3 is still over 150 ng/mL and your serum calcium still in the normal range, there's something else going on. Reviewing the bidding. From your earlier post, you indicated you were taking the supplements illustrated in the following photo. The Bio-Tech D3-50 is proving to be faster acting with a higher bioequivalence in elevating serum 25(OH)D3 than the same dose of the oil-based liquid softgel vitamin D3 formulations. The Methyl Folate+ is proving to be more effective as well for the same reasons. You're also indicated you're taking the following supplements in the next two photos. If you're taking all of the above, please let me know. There are a few more supplements and an additional lab test that may point us in the right direction to getting you CH pain free. The next supplement to add is N-Acetyl-Cysteine (NAC). It is a precursor to L-Cysteine. This is an amino acid that enables the enzymatic processes that among other things, up-regulates the expression of the vitamin D receptor (VDR) molecule. VDR attach to molecules of the vitamin D3 metabolite, 1,25(OH)2D3 at the cellular/nuclear level and that enables vitamin D3 to attach to a strand of DNA to initiate genetic expression. It's this genetic expression that helps prevent CH. In short, no VDR and there's no genetic expression no matter how high the 25(OH)D3 serum concentration. I order the NOW NAC at the following link. https://www.amazon.com/Now-Supplements-N-Acetyl-Cysteine-1000-Tablets/dp/B00KT3H13C/ref=sr_1_4?dchild=1&keywords=L-Cysteine&qid=1605713283&sr=8-4 Again, it's very important that we see you labs for 25(OH)D3, calcium and PTH. Take care and please keep us posted. V/R, Batch

Clusters suck and are immutable part of our existence. I fully agree with advice given. There is no way in hell you can ever get anyone to appreciate the pain or come close to understanding unless its a fellow clusterhead. Even then our experience is our own. People think we exaggerate, embellish or plain seek attention. Of course thats not true at all. The bigger issue is anyone who has experienced the pain of childbirth, kidney stones, gout, a broken limb or othe painful event usually only has it once twice or a few times. We get way worse over and over and over. The way I deal is by trying to be my best self and carry on while in cycle as normally as possible. I do my best to not let the beast win. I do tell my staff when I'm in cycle so they understand my asshole self has a reason but I never expect anyone to understand; s\cause they can't. Yo must constantly work to be the best you and avoid self pity at all cost. Ignore the well intended suggestions of the essential oil, ibuprofen, gratuitous "i have that too", Forgive them for theres no way they can do anything but leave you alone

Thanks CH father, Currently I am just going with Vitamin D (oil) @ 10k IU ...I feel it has lowered the frequency. I am reluctant to do the drugs as I have yet to find a neurologist or DR to help guide me through them. Furthermore am terrified of the potential slap back affect. I have at hand 5mg Zomig Nasal Sprays, as well as pregabalin 25mgs / propranolol HCL 40mg/ Mylan-Verapamil SR 240mg. I've decided to use to the Zomig tonight if the pain becomes uncontrollable tonight. Edit: I am desperately trying to get Oxygen as well but my neuro said that he would not prescribe oxygen and told me to use the drugs first...

Maybe a $7-12 bottle of castor oil will make them bring down the price, Castor oil stopped my CH cycle it worked for me on the first night. And the only side affect a smelly shirt. Please read all you can on castor oil before you use it. You can see how I used it by looking at my post. Castor oil should not be taken internally. It should not be applied to broken skin. It should not be used during pregnancy, breastfeeding, or during menstruation It should not be injected

Hi all, Thanks to @xxx 's vitamin regime, I seem to be skating past my first cycle after taking an earlier version of the regime, and I thought I'd share my results so far. After my previous cycle about 6 months ago I started taking 10k/day D3 gel tabs plus the magnesium, Mature Multi, Super K, and fish oil supplements recommended (I see Batch has updated the regimen a bit recently, am currently looking into this) Due to Covid, I have yet to test my D levels, but I am planning to see my Dr for a followup soon. None the less, my usual cycles last 6-10 weeks of daily episodes. But so far I believe I may have clipped my current cycle to just one week of very mild headaches. Here's my log from when the cycle started: August 3rd: Woke with a shadow/Kip 1 at 8am. Oxygen for 5 minutes until PF August 5th- Woke at 2am. Kip 2. Oxygen for 5 min until PF August 7th Woke 8:30am . Kip 3. Oxygen 5 min until PF August 7th (2nd) 9pm. Kip 3/4. Oxygen 5 min then early sleep with shadows persisting August 11th 9:45pm Kip 2. Oxygen 8 min until PF August 12th 9:45pm Kip 3. Oxygen 5 min until PF So far no episodes since the 12th. Finger's crossed this cycle is over, which would be wonderful. Many thanks to @xxx and everyone else on here, I haven't been this hopeful in many years.

OK, reportin' back now because I think there have been some pertinent-ish results with the CBD oil and my relative's nerve pain/mood: 1) the thinner, clearer oil offered pain relief and mood uplift when administered sublingually or vaporized (vaporizing was the more economical route). 2) the thicker "waxy" oil has been the most potent of the 2 versions when vaporized. 3) A way was found to get a wholesale price. I think this has brought the cost for a few good vaped doses spread throughout the day to maybe under $10 total per day, as it is in the 1/4 to 1/3 gram per day range. That still add$ up aplenty but is much better than what was first feared. Any members here interested in how to get the wholesale thing going on for their individual needs can PM me and I'll tell ya what I know.

Hi @Chloe Chriselle ! Yes, for about 6 months I've been taking daily: 10,000 IU D3 400mg Magnesium 1 pill Life Extension Super K 1 Kirkland Mature Multi 1200mg Fish Oil I started doubling my D3 around the time of my last post. Since my last post on August 17th I have had 3 more mild episodes, but none painful enough to need anything but Oxygen. What I've noticed so far is my cycle just hasn't set in to its usual routine. Usually after the first week of my cycle I settle into nightly attacks that wake me up at 4am-ish already at Kip 5 or higher. For this cycle, so far, the regular routine just hasn't set in , episodes are days apart, and pain levels are far milder than normal. My last headache was 5 days ago, so cycle not complete nut very sporatic. I still havn't had any blood tests done, but looking to make appointment this week to check my D levels, ect. Hope this helps!

Spiny, As I indicated in an earlier post in this thread, Pepcid (Famotidine) is a histamine H2 receptor blocker. There's evidence Quercetin is a little safer and more effective as an antiviral than Famotidine. That said, the COVID-19 Critical Care Working Group (FLCCC) treatment protocol for COVID-19 patients in the ER calls for intravenous methylprednisone, high-dose ascorbic acid (vitamin C), thiamine (Vitamin B1) and heparin. Optional additions include melatonin, zinc, vitamin D3, atorvastatin, famotidine and magnesium. Quercetin also acts as an ionophore transporting zinc ions across cell walls to help stop viral replication. Vitamin C and quercetin have synergistic effects that make them useful in the prevention and early at-home treatment of COVID-19. Both are part of the MATH+ protocol developed by the Front Line COVID-19 Critical Care Working Group (FLCCC). For COVID-19 prophylaxis, the FLCCC recommends vitamin C, quercetin, zinc, melatonin and vitamin D3 The at-home treatment for mildly symptomatic patients is very similar to the prophylactic regimen, but adds several optional drugs, including aspirin, famotidine (an antacid) and ivermectin (a heartworm medication that has been shown to inhibit SARS-CoV-2 replication in vitro) There are two distinct phases or stages of COVID-19 — the viral replication stage and the immune dysfunction stage — and the treatment must be appropriate for the stage you’re in. Equally crucial is starting aggressive treatment as early as possible. Vitamin D3 boosts immune system functions that help prevent viral infections. Vitamin D3 at a high enough dose and responding 25(OH)D3 serum concentration, also helps prevent immune system dysfunction Quercetin was initially found to provide broad-spectrum protection against SARS coronavirus in the aftermath of the SARS epidemic that broke out across 26 countries in 2003. Now, some doctors are advocating its use against SARS-CoV-2, in combination with vitamin C, noting that the two have synergistic effects. Incidentally, ascorbic acid (vitamin C) and the bioflavonoid quercetin (originally labeled vitamin P) were both discovered by the same scientist — Nobel prize winner Albert Szent-Györgyi. Quercetin’s antiviral capacity has been attributed to five main mechanisms of action: Inhibiting the virus’ ability to infect cells by transporting zinc across cellular membranes Inhibiting replication of already infected cells Reducing infected cells’ resistance to treatment with antiviral medication Inhibiting platelet aggregation — and many COVID-19 patients suffer abnormal blood clotting Promoting SIRT2, thereby inhibiting the NLRP3 inflammasome assembly involved with COVID-19 infection Similarly, vitamin C at extremely high doses also acts as an antiviral drug, effectively inactivating viruses. During the 2003 SARS pandemic, a Finnish researcher called for an investigation into the use of vitamin C after research showed it not only protected broiler chicks against avian coronavirus, but also cut the duration and severity of common cold in humans and significantly lowered susceptibility to pneumonia. I compiled a list of immune boosting COVID-19 prophylaxis people can take at home in the following table provided by experts in nutritional medicine. Column 4 is my summation. Supplement Riordan Orthomolecular EVMS/FLCC Batcheller Vitamin C 1-2g t.i.d. 3 g/d (1g t.i.d.) 500 mg BID 3 g/d (1g t.i.d.) Vitamin D3 5,000 IU/d 10K IU/d for 2 wk* 1000-4000 IU/d 50,000 IU/wk** Vitamin A 10,000 IU/d 3,000-6000 IU/d Vitamin B1 25 mg/d Zinc Picolinate 30 mg BID 30 mg/d 75-100 mg/d 50 mg/d Quercetin 500 mg/d 250-500 mg BID 400 mg BID Selenium 200 mcg/d 200 mcg/d 55 mcg/d Magnesium 500 mg/d 400-800 mg/d Melatonin 1-5mg/d 0.3-2.0 mg/d Omega-3 PUFAs 1500 mg/d Multi Vitamin 1 Tablet/d 1 Tablet/d *** * 10,000 IU/day vitamin D3 for 2 weeks then drop back to 5000 IU/day ** 50,000 IU/day vitamin D3 for 12 days then drop back to 50,000 IU/week. Water soluble vitamin D3 suggested such as Bio-Tech D3-50 as it has a higher bioequivalence than the oil-based liquid softgel vitamin D3 formulations. *** The Kirkland Adult 50+ Mature Multi is an excellent source of vitamin D3 cofactors. It just doesn't have enough magnesium or any vitamin K2 Of course you won't hear anything about this from HHS, the good Dr. Fauci at NIH, the FDA or CDC. They're heavily influenced by the Big Pharmas who don't want people to know how effective vitamins and minerals can be in treating viral infections. Members of these organizations are also heavily invested in vaccine development (at tax payer expense) so don't want the public to hear about any competitive treatments that are more effective, safer and less expensive. Take care, V/R, Batch

Hey SECAuthentics, All of us on the anti-inflammatory regimen experience burnthrough CH at one time or another. The solution is simple. If you haven't switched to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 now is a good time to do so. You can order it from amazon or iherb. In the mean time most CHers in your shoes, me included, have loaded vitamin D3 at 50,000 IU/day for a week then droped back to the usual maintenance dose. When you switch to the Bio-Tech D3-50, one capsule a week is a good starting maintenance dose. I updated the basic regimen in July of 2018 adding the Bio-Tech D3-50 in place of the oil-based liquid softgel vitamin D3 formulation. In Jan of 2019, I added Methyl Folate + in place of the generic vitamin B 50/100 complex. The following photo illustrates the latest version of this regimen by brand and dose. CHers who stick with the above brands tend to experience a faster rate of response to this regimen. Take care and please keep us posted. V/R, Batch

I've had cluster headache for about 4 years now. I've tested a range of different treatments, both from the doctors and some more experimental, but nothing's helped much. I was travelling to India for work about six months ago, when I was recommended an ayurvedic doctor who had been successful in treating an acquaintance' migraines. Although I was a bit skeptical, I thought 'why the hell not' and went. The doctor had mixed a range of different medicines for me, and I went there for three days for a treatment that consisted of warm oil being dropped in my forehead and rubbed in to the skin around the neck. Already after the first night did I feel better, and after only 3 days of treatment I felt better than in months. Since then I only had slight 'shadow' attacks, so went to an ayurvedic practitioner in my hometown in Europe, and I still have most of the medicine left, and so far I've been able to avoid the clusters. I have no idea what all the medicines contain but one of the bottles have a list of ingredients, so in case someone finds this interesting I post them here: - Terminalia chebula 0.79% - Terminalia belerica 0.79% - Emblica officinalis 0.79% - Swertia chirata 0.79% - Curcuma longa 0.79% - Azardirachta indica 0.79% - Tinospora cordifolia 0.79% - Woodfordia fruticosa 2.534% - Madhuca indica 2.328% - Acacia nilotica 1.1672% - "Guda" 29.14%

Rimantas, I'd suggest sticking to the method most of us have found works and works consistently. 1- 5 days between doses. (if it's taken sooner, there's a high likelihood it won't work). 2- Don't take it with food. (Mixing mm with chocolate has a lot of oil in it and oil / fat reduces the absorption in the intestines) Eat a light fat fee meal about 2 to 3 hours before taking your dose. Drink plenty of water or gatorade (but not too much) during your dose. Some people have a natural tolerance to mm, but hitting a mild trip most of us have found is very important to how well it works on our CH. If you're only feeling mild effects of the mm and it's not working, then wait 5 days and move your dose up. (in my opinion). PFW, J

Hey Dehabel. You're not annoying. You've received some great answers about Benadryl (Diphenhydramine HCL). Diphenhydramine is classified as an anticholinergic - a chemical that blocks the action of the neurotransmitter acetylcholine (ACh) at synapses in the central and the peripheral nervous systems. Accordingly, it should only be taken for a week to 10 days dosing at 25 mg every 3 to 4 hours during the day and at bedtime. As Diphenhydramine a also classified as a first-generation antihistamine, it's antcholinergic properties will make you drowsy so you should avoid driving while taking this much. If you do need to drive during the day, wait until you're home for the day then take 50 mg as you walk through the door and another 50 mg at bedtime. If an allergic reaction is contributing to the frequency, severity and duration of your CH, Benadryl (Diphenhydramine HCL) should start providing relief in a few days. If there's been no change in your CH patterns, after a week, discontinue.' The Diphenhydramine mechanism of action is relatively simple. As a first-generation antihistamine, it crosses the blood brain barrier (BBB) into the brain and blocks histamine H1 receptors at the genetic layer in neurons throughout the brain and in particular, the trigeminal ganglia where histamine released as a result of an allergic reaction, triggers the expression of Calcitonin Gene-Related Peptide (CGRP) and Substance P (SP) another neuroactive peptide. These are two of the four neuropeptides responsible for the neurogenic inflammation and pain we know as cluster and migraine headache. It is also important to note that second- and third-generation (non-drowsy) type antihistamines cannot cross the BBB to block histamine H1 receptors in neurons throughout the brain and CNS so will be less effective. I look at Benadryl (Diphenhydramine HCL) as a diagnostic tool. If it works to reduce the frequency, severity and duration of your CH, histamine is the likely culprit. If it doesn't work, the odds are higher histamine is not your problem. Many of us have found adjusting the vitamin D3 intake to be a more effective and much safer method of controlling and preventing CH than taking Benadryl (Diphenhydramine HCL). The following photo illustrates the supplements by brand in the basic anti-inflammatory regimen CH and MH preventative treatment protocol. All are taken daily with the largest meal of the day at the doses shown for the first 12 days. After that, you reduce the vitamin D3 dose (Bio-Tech D3-50) to one capsule a week and continue taking everything else daily. There's a lot more to this regimen and you'll need to discuss it with your PCP/GP before starting it, when asking for labs of your serum 25(OH)D3, calcium and PTH (Parathyroid Hormone). CHers who stick with the brands illustrated below tend to have higher favorable response rates. With the exception of the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 that I added in place of the 5,000 IU oil-based liquid softgel vitamin D3 formulations in July of 2018 and the Methyl Folate + I added in place of the vitamin B 50/100 complex in January of 2019, the rest of these supplements have remained unchanged since 16 December, 2011. The rationale for these changes is due to the higher bioequivalence and improved efficacy in controlling and preventing CH and MH these two supplements offer. Readers of my webpage at vitaminDwiki.com at the following link have downloaded 51,216 copies of the anti-inflammatory regimen CH and MH preventative treatment protocol since I posted it in January of 2017. https://vitamindwiki.com/Cluster+headaches+substantially+reduced+by+10%2C000+IU+of+Vitamin+D+in+80+percent+of+people You will also find a copy of this protocol at the above link. If you're interested in starting this CH and MH preventative treatment protocol please take a copy to your PCP/GP to discuss and ask for lab tests of your serum 25(OH)D3, calcium and PTH before starting this treatment protocol. You can also download a copy of this treatment protocol by clicking on the following link. http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 I've sent you a PM with more information about this CH and MH preventative treatment protocol. That you experienced an 8-year haitus, free of CH tells me you're a good candidate for the anti-inflammatory regimen. It's likely something changed in your diet or there was a decrease amount of summer sun you were getting that caused your CH to return. This bring us to the burning questions you may have... Will this treatment protocol be effective for me and is it safe? The best answer I can provide comes from data compiled from the online survey of 313 CHers who have started this treatment protocol since 16 December, 2011 when I placed this survey on the Internet. The year over year efficacy of this treatment protocol between December of 2011 and December 2018, finds 80% of CHers experiencing a significant reduction in the frequency of their CH from 21 CH/week down to 4 CH/week in the first 30 days after starting it. 53% of CHers starting this regimen experience a lasting cessation of CH in the first 30 days. It's important to understand that this regimen needs to be taken daily in order to experience results like this. Most of us who take this regimen daily, consider it a way of life that keeps us CH pain free. Moreover, the health benefits that come from taking this regimen are hard to ignore. The exciting news comes from CHers who started this survey during 2019 after I changed the suggested form of vitamin D3 to the Bio-Tech D3-50. The efficacy of this protocol during 2019 finds over 90% of CHers experiencing a favorable response with a significant reduction in the frequency of their CH in the first 30 days from 21 CH/week down to 4 CH/week and 67% of CHers experiencing a complete and lasting cessation of their CH in the first 30 days. I've tracked results from all open source RCTs of CH prophylaxis and none of them come even close to this level of efficacy. Moreover, since this treatment protocol went online, there have been no reports of hypercalcemia, a.k.a., vitamin D3 intoxication/toxicity nor have there been any adverse events reported that required medical attention. The following charts illustrate data from 313 CHers who started this treatment protocol since December of 2011, then took this survey ≥ 30 days later. The following chart illustrates the normal distribution (green curve) and cumulative probability (blue curve) of lab results for serum 25(OH)D concentrations after ≥ 30 days on this regimen. The following two charts illustrate the time to respond after starting this regimen. Taken in concert with the efficacy data, the above charts make a clear case that an inverse relationship exists between the frequency of CH and 25(OH)D3 serum concentration. In simple terms, when the frequency of CH is high, the 25(OH)D3 serum concentration is low around a mean of 24 ng/mL and when the CH frequency is low or the CHer is CH pain free, mean 25(OH)D3 serum concentration is higher around 80 ng/mL. This is why it's important to obtain lab tests of your serum 25(OH)D3, calcium and PTH before starting this regimen and again 30 days after starting it. You can thank the 313 CHers who took the time to take this survey. They came from 35 countries around the world. Take care and please keep us posted should you decide to start this treatment protocol. V/R, Batch

Might as well add this here since I think it would complete well other info in this thread: after busting successfully, no more pain at all, 2 weeks after my insurance 4th bust, I was starting to feel very subtle tickles... but mostly I wanted to experiment recreational use of my new RC seeds batch. So I did 175 RC seeds, soaked for 90 minutes in vodka and peppermint tea, to see if I would get a buzz. Even with a few joints to boost it up, it didn't feel much like a buzz... then yes, maybe it was a buzz... Definitely no visual effects. I wasn't satisfied on the tripping side and was thinking to try more the week after. That's when CH slapped back. I went to bed with a big shadow, and woke up twice with with kip 5-6, then the second time, the coffee kept me up, then another attack hit me at 11 a.m., then big shadow all day, then... Then it has been 6 days now , and it seems like I'm slipping into a new cycle. Was 175 too much? (With vodka and peppermint) Was my cycle actually never ended really? I'm I turning chronic? :o I'm waiting to see how it grows... it's been keeping me pretty much awake past 2 nights with kips 4... well it's an opportunity to test my meditation like technique to control them. It works (well lower kips anyways)... it's part of my own research on CH and hypothalamus... will report about it when the thoughts are ripe. Meanwhile I know I need more than 175 RC seeds to get to the tripping point, and maybe it wasn't such a great idea to try them recreationaly, so soon after busting anyways... can't play with that CH... no sense of humor.

Thoughts I had: Most stores sell seeds with a fungicide on them that you really don't want to ingest...Always look for it specified that they are untreated seeds. As far as both Morning Glory and Hawaiian Baby Woodrose--only certain varieties are active. With Morning Glory, I know the Heavenly Blue, Pearly Gates, and Flying Saucers strains are active. I don't know much about the HBWR strains.   Purple--what you say about the LSA LSH conversion is right on. Nobody really knows what is going for sure, I have never seen any lab work showing an actual conversion of LSA to LSH. All I can really say is that I have had very different experiences depending on if I have taken my seeds with water compared to with peppermint tea or alcohol. The straight seeds and water were VERY sedating, I was kinda amazed by how hard it has knocked me down, actually. When I've added peppermint or alcohol, it has kept me awake and felt much trippier. The reason I included the quote about the fresh seeds, is that there is a theory (that I believe) that fresh seeds contain more LSH than LSA, and over time the seeds convert into almost all LSA. If you are looking for a sedating trip (LSA), it would seem you might NOT want fresh seeds. We have no idea if the LSH is more effective than LSA, (or even effective at all for that matter) for busting at this point. It has seemed so for me, but I do not know many that have tried it. -Ricardo

Spiny, There are two changes to the supplements listed in the posted version of this treatment protocol that will appear in the updated version I hope to have available later this month. They include switching to the Bio-Tech D3-50 50,000 IU water soluble form of vitamin D3 that's suggested at a dose of one (1) D3-50/week as the initial maintenance dose. Rationale: The Bio-Tech D3-50 is proving to be faster acting with a higher bioequivalence in elevating serum 25(OH)D3 than the same dose of the oil-based liquid softgel vitamin D3 formulations. The D3-50 is also less expensive at one 23 cent capsule a week or ~3 cents/day. Bio-Tech D3-50 https://www.amazon.com/Bio-Tech-Pharmacal-D3-50-100-Count/dp/B000A0F2B2?ref_=ast_bbp_dp&th=1&psc=1 https://www.iherb.com/pr/Bio-Tech-Pharmacal-Inc-D3-50-Cholecalciferol-100-Capsules/55186 The other change is a switch to Methyl Folate + (vitamin B complex) in place of the vitamin B 50/100 complex. Rationale: This form of Folate and B complex appears to have a higher bioequivalence in preventing CH and MH. These are also the same B vitamins called for in the Coimbra protocol used to prevent MS and other autoimmune disorders. Methy Folate + Vitamin B Complex https://www.amazon.com/Bioactive-Formulated-Pharmaceutical-Methylcobalamin-Synergistically/dp/B01MQJVHHC?ref_=ast_bbp_dp https://www.iherb.com/pr/Doctor-s-Best-Fully-Active-B-Complex-with-Quatrefolic-30-Veggie-Caps/50940?refid=1c105ef4-ca2e-4f09-bcc7-bddc10c426b9&reftype=rec Take care and please keep us posted. V/R, Batch

CBD oil works for migraine, but it works better before you have an episode rather than during you have an episode. I used to have migraines usually once or twice a month and then they would last for about 3 to 4 days, but now, I take CBD Harlequin Feminized, 2 drops daily under my tongue empty stomach in the morning, and I am free of these migraine pains.

Mystina, did the alcohol-soaked seeds actually help you? Somehow I'm remembering that RC seeds don't seem to work for you, despite taking large amounts. Ricardo also says that soaking seeds in peppermint tea or wine makes LSH instead of LSA. (For full disclosure, others have said they doubt this. I have no idea.) Cold peppermint tea, he says. Discussion of that in this thread: http://www.clusterheadaches.com/cb/cgi-bin/yabb2/YaBB.pl?num=1323888444/17