Dopamine receptor polymorphism and risk for migrai

[alleyoop]

Dopamine receptor 3(DRD3) polymorphism and risk for migraine

Background/objectives:[ch8194] Dopamine has been implicated in the pathogenesis of migraine. We investigated the possible association between the polymorphism 312G>A (rs6280) in the DRD3 gene(essential tremor 1-ETM1- locus, chromosome 3q13) and the risk for migraine and for triggering migraine attacks by alcohol.

Methods:[ch8194] We studied the frequency of the DRD3 genotypes and allelic variants in 197 patients with migraine and 282 healthy controls using a polymerase chain reaction and MlsI-restriction fragment length polymorphisms method.

Results:[ch8194] The frequencies of the DRD3 genotypes and DRD3Gly9 were similar in patients with migraine and controls and were unrelated to the age of onset of migraine, gender, family history of migraine and triggering of migraine attacks by alcohol. The frequency of the genotype DRD3Gly9Gly9 was significantly higher in patients with migraine with aura when compared with patients with migraine without aura, but not with controls.

Conclusion:[ch8194]DRD3 genotype and allelic variants were not related to the risk for migraine in Caucasian Spanish people.

http://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2010.02988.x/abstract

[MattyAA]

So they probably found gene that could cause migraine or I misread something here?

[alleyoop]

Hey Matt, I just report this stuff, I don't interpret it, leave that to smarter folks than me! 

Maybe someone will come along and interpret this, but simply put, I think that they are saying that they couldn't find any genetic link, nor any external link to migraine in this study.

[MattyAA]

Oh, thanks for clarification, I guess then I misread that

Though pity they haven't found cause of it, would surely in some way help us step closer to CH causation.