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Melatonin & pineal gland

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Some more info about melatonin (more than I knew, anyway), and more thinking about understanding the brain processes involved in CH.

Current understanding of pineal gland structure and function in headache; Peres M, Valença M, Amaral F, Cipolla-Neto J; Cephalalgia 333102419868187 (Aug 2019)

PURPOSE The pineal gland plays an important role in biological rhythms, circadian and circannual variations, which are key aspects in several headache disorders.

OVERVIEW Melatonin, the main pineal secreting hormone, has been extensively studied in primary and secondary headache disorders. Altered melatonin secretion occurs in many headache syndromes. Experimental data show pineal gland and melatonin both interfere in headache animal models, decreasing trigeminal activation. Melatonin has been shown to regulate CGRP and control its release.

DISCUSSION Melatonin has been used successfully as a treatment for migraine, cluster headaches and other headaches. There is a rationale for including the pineal gland as a relevant brain structure in the mechanisms of headache pathophysiology, and melatonin as a treatment option in primary headache.


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On 8/16/2019 at 7:10 AM, Brain on fire said:

I couldn't get anywhere with the link & would like more info.

Here's a proper link, but there's nothing else there about this article. Big bucks required to see the actual thing. Quite a few other melatonin studies also listed there. https://www.ncbi.nlm.nih.gov/pubmed/31370669

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On 8/24/2019 at 2:26 AM, Brain on fire said:

Thanks again, it would be nice if the people who could benefit from research could read about it without fees.

Isn’t it a pip that doctors pay next to nothing for the journals which would cost patients and arm and a leg!

then again, having worked for Big Poison as a Mechanism of Action illustrator in Pharma ads, i know that the journals carry very costly ads.


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