CHfather 832 Report post Posted August 14 Some more info about melatonin (more than I knew, anyway), and more thinking about understanding the brain processes involved in CH. Current understanding of pineal gland structure and function in headache; Peres M, Valença M, Amaral F, Cipolla-Neto J; Cephalalgia 333102419868187 (Aug 2019) PURPOSE The pineal gland plays an important role in biological rhythms, circadian and circannual variations, which are key aspects in several headache disorders. OVERVIEW Melatonin, the main pineal secreting hormone, has been extensively studied in primary and secondary headache disorders. Altered melatonin secretion occurs in many headache syndromes. Experimental data show pineal gland and melatonin both interfere in headache animal models, decreasing trigeminal activation. Melatonin has been shown to regulate CGRP and control its release. DISCUSSION Melatonin has been used successfully as a treatment for migraine, cluster headaches and other headaches. There is a rationale for including the pineal gland as a relevant brain structure in the mechanisms of headache pathophysiology, and melatonin as a treatment option in primary headache. https://clusterbusters.org/forums/forum/13-research-scientific-news/?do=add 1 1 Freud and Brain on fire reacted to this Share this post Link to post Share on other sites
Brain on fire 294 Report post Posted August 16 Thanks CHfather, for keeping us updated. I couldn't get anywhere with the link & would like more info. Share this post Link to post Share on other sites
CHfather 832 Report post Posted August 17 On 8/16/2019 at 7:10 AM, Brain on fire said: I couldn't get anywhere with the link & would like more info. Here's a proper link, but there's nothing else there about this article. Big bucks required to see the actual thing. Quite a few other melatonin studies also listed there. https://www.ncbi.nlm.nih.gov/pubmed/31370669 Share this post Link to post Share on other sites
Brain on fire 294 Report post Posted August 24 Thanks again, it would be nice if the people who could benefit from research could read about it without fees. Share this post Link to post Share on other sites
