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Ilya K

Nausea with D3 Regimen & Cofactors

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Hey Everyone,

I'm pretty new to the community - started getting clusters last year, early September. And as all of you, thought they were sinus-related or something else so I had an MRI and CT scan, and everything came back normal. Last year my cycle started and ended earlier.

This year it came back around September 22nd. So I started off by seeing my PC doctor. I happened to get my 25 (OH) D tested and it was 23.6 ng/ml. After that I went to see a few neurologists, some thought it was a migraine but most thought it was cluster headaches due to the cyclical nature of the headaches, the location of the pain, and the fact that it was unilateral 95% of the time. 

I did further research and started reading about the side-effects of CGRPS, Verapamil and other preventative measures and realized those were not for me. I was also placed on a 5 day steroid course which reduced the severity of the attacks and the frequency, but nonetheless they are still happening.

My research further lead me to try the D3 loading regimen, with the approval of a few doctors of course. And this is what I have done so far:

10/8/19 - 10/14/19: I did 10k IUs of the D3 along with all the cofactors

10/15/19: I did 20k IUs of the D3 along with all the cofactors

10/16/19: 50k IUs along with all the cofactors

10/17/19: 20k IUs along with all the cofactors

I know that this isn't exactly how the loading schedule should be done, but I was scared of taking everything at once so fast. Lately I have been doing the 20k IUs/day and I have been feeling a bit nauseated and dehydrated, so my questions are:

  1. How can I reduce this nauseating and dehydrated feeling?
  2. Why are the cofactors all necessary even during maintenance periods? Has anyone tried going off of them to any success? Are they purely for absorption?
  3. If someone could get Batch involved, he has been a lifesaver thus far and his input would be invaluable.

 

Vitamins taken are: Kirkland Multimitamin, Pure D3 (5000 IU), Magnesium Calcium & Zinc from Walgreen, and a fish oil supplement from Trader Joes

 

Best,

Ilya

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Personally I found the fish oil to generate nausea.  The volume of pills may be contributing to the nausea as well rather than the specific substance.  Try dividing the doses instead of taking all at once to see what you might be sensitive to.  I would defer to Batch for final suggestions as this is his baby.

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31 minutes ago, Pebblesthecorgi said:

Personally I found the fish oil to generate nausea.  The volume of pills may be contributing to the nausea as well rather than the specific substance.  Try dividing the doses instead of taking all at once to see what you might be sensitive to.  I would defer to Batch for final suggestions as this is his baby.

Good to know, I may give that a shot. What did you do to mitigate the nausea with the fish oil?

Also I should mention I have allergies, but have been doing the immunotherapy shots for over a year so I don’t know if those are a factor. I’ve read Batch’s responses about taking Benadryl to prevent the histamine reaction. Does he need to be tagged or something to respond?

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I dont take the fish oil, Just D3 and Vik K part.  I do use benadryl 50 mg at night.  I imagine Batch gets pounded with questions and comments.  The summary of his protocol is available as a pinned post.  The fish oil can cause some reflux  so taking it with some food may help.

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8 hours ago, Ilya K said:

Does [Batch] need to be tagged or something to respond?

Send him a PM.  Click on the envelope icon at the top right of any page, and type Batch into the To line.  If he doesn't respond here, he will surely get back to you.  

The pinned post is outdated, and now even the link to more recent information is out of date.  This will get you to Batch's discussion of the protocol (scroll down the page), but I'm not sure how much it will help you with your specific question. https://vitamindwiki.com/Cluster+headaches+substantially+reduced+by+10%2C000+IU+of+Vitamin+D+in+80+percent+of+people

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28 minutes ago, CHfather said:

Send him a PM.  Click on the envelope icon at the top right of any page, and type Batch into the To line.  If he doesn't respond here, he will surely get back to you.  

The pinned post is outdated, and now even the link to more recent information is out of date.  This will get you to Batch's discussion of the protocol (scroll down the page), but I'm not sure how much it will help you with your specific question. https://vitamindwiki.com/Cluster+headaches+substantially+reduced+by+10%2C000+IU+of+Vitamin+D+in+80+percent+of+people

Just tried sending him a PM to the error message "Batch can not receive messages". 

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I split the vitamins up into 3 in the morning and 3 at night. Always take them with a meal. I was instantly vomiting after taking them all on an empty stomach which Wasn’t smart on my part. Good luck! 

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10 hours ago, kat_92 said:

I split the vitamins up into 3 in the morning and 3 at night. Always take them with a meal. I was instantly vomiting after taking them all on an empty stomach which Wasn’t smart on my part. Good luck! 

Awesome - thanks for the tip. I'll try it today.

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Ilya the vitamins will be a big help. As you know, your D is in the trash and really needs to come up!

And I share the Equinox date with you! Many start a cycle at that time of year. Sucks, but at least you have an idea of when it is coming and can prepare to battle if needed! :ph34r:

Let us know how breaking them up worked for you! Oh, are you using 'burpless' fish oil? I could not stand the other one. Going 'burpless' helped me a lot. 

I'll see if I can reach Batch too.

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20 minutes ago, spiny said:

Ilya the vitamins will be a big help. As you know, your D is in the trash and really needs to come up!

And I share the Equinox date with you! Many start a cycle at that time of year. Sucks, but at least you have an idea of when it is coming and can prepare to battle if needed! :ph34r:

Let us know how breaking them up worked for you! Oh, are you using 'burpless' fish oil? I could not stand the other one. Going 'burpless' helped me a lot. 

I'll see if I can reach Batch too.

Thank you Spiny, and no I am not using the ‘burpless’ one. I think I may actually be getting nauseous from the multivitamin, so it’s going to be a little bit of trial and error to figure that out. Today, I took 10000IUs of the D3, Magnesium and the multivitamin with breakfast and only had about 10 mins of nausea. Going to take the rest with dinner and see if the fish oil is the culprit.

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Sounds like a good plan you have. 

I have had and read of people having a reaction to the fillers in some meds. Like a name brand will have Y fillers and the generic will have X fillers. So, some people can take one and not the other. So, you might consider a different multi. Just a thought if changing the fish oil does not solve the issue.

Are you taking the Benadryl?

Batch is indeed not getting PM's at this point. Not sure why. But, he is very devoted to helping all and will show up when he is available. He never has let anyone down who PMed him to my knowledge. But at the moment that is not an available route to follow. We will wait to see if CHF's mail got to Batch.  

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6 minutes ago, spiny said:

Sounds like a good plan you have. 

I have had and read of people having a reaction to the fillers in some meds. Like a name brand will have Y fillers and the generic will have X fillers. So, some people can take one and not the other. So, you might consider a different multi. Just a thought if changing the fish oil does not solve the issue.

Are you taking the Benadryl?

Batch is indeed not getting PM's at this point. Not sure why. But, he is very devoted to helping all and will show up when he is available. He never has let anyone down who PMed him to my knowledge. But at the moment that is not an available route to follow. We will wait to see if CHF's mail got to Batch.  

Appreciate the quick feedback. Are all multivitamins created equal? Meaning if I buy a different brand or a gummy will it have everything necessary that the Kirkland one does?

Any regarding the Benadryl - do you think it's necessary if I'm not having any of my allergy symptoms? I've been on the allergy shots for over a year so I don't know if that's contributing or not.

Also is it normal to feel a sensation in my nostril sometimes throughout the day? Like it feels tingly or just abnormal. Is that still part of the trigeminal nerve maybe?

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In a fairly recent post someone was reacting to one (or more) components of the regimin. I'll try to find & link it... Just in case... I think it was discontinue the D3 for 2 days if no probs it was the D3, if probs discontinue the magenesium for 2 days etc to isolate the problem

Edited by Brain on fire

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Yes, it is. If you look it up, that nerve covers half your face and 1/4 of your head. That includes everything on your face and those teeth and sinuses. It even includes the hair on your head in my experience. 

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(1) Medication Interactions and Contraindications: 

     * Reactions to vitamin D3 are very rare as skin exposed to the UVB in direct sunlight produces vitamin D3 naturally.  However, if you are allergic to sunlight, do not start this regimen without contacting your PCP or neurologist first.  If you experience a reaction to this regimen including and not limited to, an upset stomach for more than a day, swelling in and around the mouth or face, or an obvious allergic reaction, discontinue the entire regimen and contact your family physician. 

   ** If you are presently taking verapamil as a cluster headache preventative or for a heart condition, studies have shown that after repetitive dosing with verapamil, the serum half-life can be in a range from 4.5 to 12 hours.  Other studies indicated calcium supplements interfere with calcium channel blockers like verapamil.  Calcium gluconate is also used to treat reactions to oral verapamil.  Accordingly, in order to minimize a possible interaction with calcium that may limit verapamil effectiveness, separate the verapamil and calcium doses by at least 8 hours.  Discus this regimen with your PCP, neurologist, or cardiologist in order to work out an optimum dosing schedule.

   *** If you are presently using blood-thinning drugs such as Warfarin or Coumadin for cluster headache or for a heart condition, vitamin K is generally contraindicated.  However, studies have found vitamin K2 to be an effective stabilizer in anticoagulant therapy, proving beneficial in situations of over-anticoagulation or when the response to therapy has been variable.  See your PCP, neurologist, and or cardiologist.

(4) Comorbidities:  Some comorbid conditions may interfere with the capacity of the anti-inflammatory regimen to prevent CH.  Some of these medical conditions include, but are not limited to: cardiac, thyroid, renal, hepatic, and pancreatic insufficiencies. Sub-clinical allergic reactions and sinusitis are also suspect.  If you have one or more of these conditions, work with your PCP to make sure they are being treated.  This may help make the anti-inflammatory regimen more effective as a CH preventative.

 

I just copied & pasted what was relevant.

**Edited to add: The link to the post is on page 2 of this thread***

Edited by Brain on fire
Addition to simplify

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Batch does suggest separating the Calcium from the Verap if you are taking it. Offset to prevent issues as stated. 

And that is the likely reason for using K2, not K!

You copied this from the site Batch has? Can you post the link to that?

Thanks Brain!!!

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5 minutes ago, spiny said:

Did he get an email or PM from here?

Yes, from here. And he responded by PM to me here.  I wasn't asking him about Ilya K's specific case, but about a good link to the D3 regimen, since the old one wasn't working. I have changed the links in the pinned posts.

(Can't type "Ilya K" without thinking about David McCallum in "The Man from UNCLE." Ilya Kuryakin.  A very old-time TV reference.)

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