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  1. Cephalalgia

    Published on behalf of the International Headache Society, Cephalalgia provides an international forum for original research papers, review articles and short communications on topics such as: diagnosis and management of primary and secondary headaches and related syndromes, pathophysiology, pharmacology, epidemiology, imaging, genetics, medico-legal aspects, migraine and pharmacoeconomics.

    Source: http://cep.sagepub.com/

    Cephalalgia issues from 2011 until today, free full text on iTunes:


    There is one version for the iPad and another version for the iPod and iPhone on iTunes. With the search function you can find articles about e.g. "cluster headache". Enjoy reading! ;-)

  2. Perhaps these research results are one of the reasons for the new study:

    It is likely that clinical use of the R(+)-verapamil as an anti-inflammatory agent has potential therapeutic advantages. Given the effectiveness of these compounds at low concentrations and the broad spectrum of activity in inhibiting inflammatory responses, R(+)-verapamil appears to have significant potential in the treatment of chronic inflammatory neurological disorders.

    Source:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014428/

  3. A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of R-Verapamil in the Prophylaxis of Episodic Cluster Headache. - Study to Evaluate the Safety and Efficacy of R-Verapamil in the Prevention of Episodic Cluster Headache.

    For more please see: https://www.clinicaltrialsregister.eu/ctr-search/trial/2012-003729-62/GB

    Does anybody know more about this new study and about R-Verapamil?

  4. After a little break for server maintenance the Eurolight survey is back. If you live in Europe, suffer from cluster headache and if you havenÂ’t participated yet, please register here to take the survey:


    The explanations and the questionnaires are available in twelve languages. Please share this information with any European cluster headache patient you know.

  5. What is the purpose of the study?

    Your participation in this Cluster Headache survey is for the benefit of yourself and other cluster headache patients. The study aims to evaluate the physical, emotional, socio-economic impact of cluster headaches as well as the disease-management satisfaction. The results will help to have a better understanding of cluster headache as a serious health problem and to assess the burden of cluster headache. The obtained information will contribute to evaluating the needs for an optimal disease management and ultimately improving cluster headache services and quality of life. The data will be used for publications in lay and scientific literature as well as reports to the European Commission

    More: http://www.eurolight-online.eu/index.cfm/spKey/news.eurolight_news/spId/DE6F4535-9D37-08D4-293C5ED1751B9882.html

  6. Currently the questionnaire is available in the following languages:













    Does anybody have a contact to a Czech or Portuguese CH support group and/or medical centre for (cluster-) headaches, to let them know about this survey?

    All other European CH support groups have been informed, I think. If not: Please change that and let them know too!

    pf wishes


  7. Forty years ago, LSD was used in the treatment of alcoholics - with good results. Perhaps it's time to look at it again?

    In the 1950s, ‘60s and ‘70s, researchers in many places in the world experimented with LSD in the treatment of various disorders, including alcoholism. Not all experiments were scientifically tenable by today's standards, but some were. Now Teri Krebs and Pål-Ørjan Johansen, researchers at the Norwegian University of Science and Technology (NTNU), have taken a closer look at these experiments. Their results are being published in the Journal of Psychopharmacology.

    More: http://www.ntnu.edu/news/2012-news/lsd

  8. In 2002 the Swedish headache expert Karl Ekbom reportet about his experience with 554 CH patients during the years 1963 – 1997. Source: Ekbom K, Svensson DA, Träff H, Waldenlind E.: Age at onset and sex ratio in cluster headache: observations over three decades. Cephalalgia. 2002 Mar; 22(2): 94-100. http://www.ncbi.nlm.nih.gov/pubmed/11972575

    The same year he wrote in another paper: „… In our experience few patients continue to get cluster headache beyond the age of 65 to 70, and the remission periods tend to become longer during the last decade. Chronic cluster headache may become episodic before ending.” Source: Ekbom K, Hardebo JE.: Cluster headache: aetiology, diagnosis and management. Drugs. 2002; 62(1): 61-9. http://www.ncbi.nlm.nih.gov/pubmed/11790156 - (Quoted from the full text of this paper.)

    Best wishes for an earlier permanent remission!

  9. Quote: "In order to optimize the therapeutic effect without risking dangerous side effects (of warfarin), such as bleeding, close monitoring of the degree of anticoagulation is required by blood testing (INR). During the initial stage of treatment, checking may be required daily; intervals between tests can be lengthened if the patient manages stable therapeutic INR levels on an unchanged warfarin dose."

    From http://en.wikipedia.org/wiki/Warfarin

    For an explanation of "INR" = "International Normalized Ratio" please see


    In Sameh M. Hakim's pilot study the target INR was between 1.5 - 1.9 http://www.ncbi.nlm.nih.gov/pubmed/21395575

    Quote from a case report:

    "With the start of oral anticoagulant, there was a reduction in the frequency of cluster headache crises. They were no longer daily, but the complete remission was not achieved. On July 11, as the INR was still of 1.8, warfarin was increased to 10 mg/day, obtaining a INR > 2.5. From then on, the patient did not present headache. Prednisone and divalproate sodium were gradually reduced and, finally, discontinuated, and verapamil (480 mg/day) was maintained with no recurrence of the crises."

    Source: http://dx.doi.org/10.1590%2FS0004-282X2004000600029

    More case reports about warfarin + CH:


  10. 15th Congress of the International Headache Society 23-26 June 2011, Berlin, Germany, Program Abstracts, Free full text: 


    Search the key word index PDF file for "cluster", if you're looking for CH related research. The abstract about BOL is on PDF page 155: PS2-76 J. Halpern1,2, M. Karst3, T. Passie2,4: Cluster headache attack cessation and remission extension of months or longer in six treatment-refractory patients administered only 3 doses of bol-148

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