Libertas

I think it could potentially be legal in the US, depending on ones reading of the Federal Analogue Act. If it's not intended for human consumption then it's not controlled?

Research chemical market, aka 'legal highs'. Yes the LSM-775 could be very promising, I just wouldn't know how one would go about orchestrating a study to find it's true potential. :-?

I have research papers to upload but cannot workout how to do it. If someone could let me know that would be great.

I have had the opportunity to try three novel lysergamides over the past few months and although I do not suffer from CH I hope that what I have written below will be of use to those that do suffer. All the compounds listed below are legal in the UK and many other countries, two of which are currently available on the RC market. AL-LAD (6-allyl-6-nor-lysergic acid diethylamide) This compound was originally synthesised by David Nichols in the mid 80s and made popular by Shulgin in his book TiHKAL. Up until now I don't think it has been available on the psychedelic scene, at least not widely. Nichols' orginial research paper suggests that this compound is 2-3 times more potent than LSD, in humans at least, this is not the case. Most reports indicate that it is slightly less potent than LSD, I find 150mcg is about equal to 100mcg of LSD. AL-LAD is generally much 'lighter' than LSD on the mind, it is more euphoric and much more forgiving. It doesn't have as deep an intospective quilty as LSD, which can sometime lead to difficult experiences, this could be beneficial for CH suffers looking to use psychedelics with no prior experience with them. The duration of AL-LAD is also noteably shorter than LSD, for me it lasts only 4-5 hours, however most people find it last around 6-7 hours. The body load is very mild, even more so than with LSD. High doses have been taken with no notable effect on the body. LSZ (d-lysergic acid 2,4-dimethylazetidide) This compound is a rigid analogue of LSD, the diethylmine moiety has been constrained into an azetidine ring. Again this compound was discovered by Nichols and up until now there have been very few human assays. There are three possible stereoisomers of the dimethylazetdidie group, the (S,S)-(+) isomer is the more potent halluginogen and this is the one that is currently on the RC market. Nichols' paper suggests this compound is more potent than LSD, I have found it not to be the case. Perhaps it is as potent but I think it's a little less potent if anything. The effects of LSZ are very similar to LSD, it could still be considered a little more forgiving than LSD but it certainly has an introspective quality. The duration is around 8-10 hours, a little less than LSD. Some people report mild GI issues with it and there have been a couple of caes of hyperthermia with large doses (>1mg). The receptor affinities are very similar to LSD so this compound could work well as an alternative. LSM-775 (d-lysergic acid morpholide) I believe this was first synthesied by Hofmann, there are only a few research papers discussing it, all of which are very contradictory. One states it is a tenth the potency of LSD while another suggests a third greater dose is required. Personally I found it to be almost inactive as a psychedelic, I tried doses from 100mcg to 1mg, as did other people and there was only a mild ergoloid feeling at doses greater than 300mcg. I beleive this compound could be the most beneficial to CH suffers due to the lack of psychedelic activity, unfortunately I haven't been able to find any data relating to 5-HT receptor affinities but of course one would expect them to follow the same lysergamide pattern.

Yes Psilocybin is of great interest to me too, as are some of the other 4-HO substituted tryptamines. Although I do not have much experience with them yet. I know David Nutt here in the UK is trying hard in this area to start a legitimate trial for PTSD using Psilocybin. Well this is what I really want to discover... Is LSD (and it's derivatives) an effective treatment for CH - the literature certainly suggests so (with BOL-148 at least), as do the various reports here. As for legally acquiring LSD derivatives, well that of course depends on your jurisdiction. Here in the UK only N-alkyl derivatives of lysergamide are controlled under the Misuse of Drugs Act 1971 - this opens a massive window of potential compounds to be synthesised and tested. There is of course the Medicines Act 1968 and a whole load of other legislative crap to tackle if one was to try and bring these compounds to the NHS as an official medication. However for the sake of self treatment purchasing said lysergamides (AL-LAD, LSZ etc) as research chemicals would be completely legal. As for the reliability of acquiring such materials, this of course depends on your source. Currently there is only one organisation producing these lysergamides (due to the complexity of the synthesis) for the RC market. Nearly all distributors provide NMR and LC/MS data for the compounds so structure confirmation/purity can be ascertained. Of course you could always have the compound analysed yourself should you manage to source it.

I will make a thread on the topic in the coming days when I have some free time, I have research papers to dig out too. Althoguh I did post a very brief description of the effects of AL-LAD and LSZ in someone elses post in the Science/Reseach section. Such compounds are available on the UK research chemical market, a quick Google will list a couple of suppliers. Also on Silk Road (hopefully I'm aloud to mention that, if not please delete)

Thanks for the warm welcome. Libster sounds a bit like Lobster so maybe I'll go with Libsky

Well it's the same everywhere really, using any mind altering substance for whatever reason is still very much taboo in most cultures. People always discriminate against things they don't understand and choose not to understand. This is why I feel these online communities are so vital.

Thanks for fixing it FunGuy

I have used both of these compounds for their psychedelic properties, I do not suffer from CH so I can't comment on that. However they are both very similar in action to LSD. Both are 'lighter' than LSD on the mind, AL-LAD more so than LSZ. AL-LAD is generally very easy on the body, even at high doses. LSZ on the other hand can cause mild GI issues for some people and hyperthermia when taken in excess (>1mg). Neither are as potent as LSD, 150mcg of AL-LAD is roughly equal to 100mcg of LSD. LSZ is only slightly more potent than AL-LAD. It should also be noted that there are 3 possible stereoisomers of the azetidine ring in LSZ, the isomer on the RC market at the moment is the more potent hallucinogen, the (S,S)-(+) isomer.

Hey guys, Although I don't suffer from cluster headaches I thought I'd sign up here to give support and to learn more about this debilitating condition. I use psychedelic compounds as tools to explore my mind. I have much experience with lysergamides, including novel research chemicals such as AL-LAD (6-allyl-6-nor-lysergic acid diethylamide) and LSZ (lysergic acid 2,4-dimethylazetidide). I'm very interested in the use of these compounds in areas outside psychedelic exploration such as with cluster headaches, I hope that the new availabilty of legal lysergamide RCs will help people with cluster headaches. Anyway that's all for now, I'll see you around. LibertasMentis