Botox Sensitive Teeth/difficulty chewing in General Board Posted September 20, 2017 If chewing is a CH trigger, or you have trigeminal neuralgia, it may actually help somewhat. I know that when my botox starts to wear off, about 2 weeks before it's time for my appointment, my teeth get really sensitive... They're sensitive anyways as I have TMJ disorder, and trigeminal neuralgia, but, they get a lot moreso without the botox. So it might be worth a shot? If nothing else, at all has helped, it might be useful. But as it was said, it would take at LEAST 2 rounds for you to find out for sure. From some of the research, Botox over the long term lowers CGRP antibodies and makes it so the nerve doesn't release it. Which helps with inflammation... But you'd need around a year of injections for that to happen I think?