[Question about D3 + other]

On 8/21/2020 at 4:16 PM, xxx said:

For what it's worth, here's the logic and science behind the 12-Day accelerated vitamin D3 loading schedule and why the initial target 25(OH)D3 serum concentration is 80 ng/mL.

1. From the online survey data of 313 CHers who have reported their results after starting this regimen since Dec 2011,  we have the normal distribution chart of baseline 25(OH)D3 lab results before starting this regimen and normal distribution chart of the objective (Favorable CH Response) 25(OH)D3 labs after ≥30 days on this regimen.

As you can see, CHers reporting in this survey with active CH, went from a mean 25(OH)D3 serum concentration of 24 ng/mL before starting the anti-inflammatory regimen to a mean of 80 ng/mL after ≥ 30 days on this regimen with a significant reduction in the frequency of thier CH.  The following chart illustrates the notional change in serum 25(OH)D3 made possible by starting this regimen with the 12-Day accelerated vitamin D3 loading schedule.

Data from the online survey confirms the above notional response.  As you can see, if the CHer took only 10,000 IU/day vitamin D3 and no loading, it could take well over 2 months to reach a mean 25(OH)D3 serum concentration of 80 ng/mL.

The following charts illustrate the favorable CH response to this regimen by day after starting it.  The first chart illustrates favorable responses by day after starting this regimen.  I  used a favorable response as at least a 50% reduction in CH frequency by at least 70% of participants.  Data from the survey indicate the mean reduction in CH frequency is 80% by 82% of participants.

This second cart illustrates days after start of regimen to a sustained complete cessation of CH symptoms.

Survey data collected during 2019 indicate the favorable response rate increased with over 90% of CHers reporting a favorable response.  I attribute most of this increase in the response rate to the switch to Bio-Tech D3-50.

2. Why is the initial 25(OH)D3 serum concentration target set at 80 ng/mL?  This is where a little statistics and what's called the confidence interval comes into play.  In statistics, a confidence interval is a type of interval estimate, computed from the statistics of the observed data, that might contain the true value of an unknown population parameter.  Data in the following chart comes from the D* Action database at Grassrootshealth.  It represents the results of 25(OH)D3 lab tests from over 10,000 people who take the 25(OH)D3 home blood spot test for their serum 25(OH)D3 every six months reporting their vitamin D3 dose over the six months prior to this lab test. As you can see, the mean 25(OH)D3 response to various vitamin D3 doses is represented by the blue lines and that at a dose of 10,000 IU/day, the mean 25(OH)D3 response is 76 ng/mL.  The red lines represent the 95% confidence interval.  In simple terms we can say that the results a given lab test for 25(OH)D3 at a dose of 10,000 IU/day will fall between these two red lines with 95% confidence.  The green dashed lines represent 25(OH)D3 serum concentrations at 40 ng/mL, 30 ng/mL and 20 ng/mL.  Accordingly we can say that at a dose of 10,000 IU/day the confidence interval for 25(OH)D3 response lies between 42 ng/mL and 118 ng/mL with 95% confidence. 

If you go back to the second chart illustrating the normal distribution of 25(OH)D3 results among CHers responding to this regimen with a significant reduction in the frequency of their CH, you can see this same confidence interval falls under the normal distribution curve.  For practical purposes, this is also the effective therapeutic range of serum 25(OH)D3 (40 ng/mL to 120 ng/mL) for favorable responses.   You can also see where a lower vitamin D3 dose of 5,000 IU/day results in a confidence interval between 25 ng/mL and 90 ng/mL.  In this case a significant number of CHers would not respond to this regimen.

As an "Oh by the way..."  the following charts from two different COVID-19 studies indicate taking 10,000 IU/day and keeping your 25(OH)D3 serum concentration over 40 ng/mL is a pretty good idea...  This isn't rocket science and you don't need to be a physician to understand the importance of this information.

Hope this helps explain a little more about the anti-inflammatory regimen treatment protocol.

Take care,

V/R, Batch

This is good stuff!

[Question about D3 + other]

On 8/16/2020 at 12:37 AM, xxx said:

Hey SECAuthentics,

All of us on the anti-inflammatory regimen experience burnthrough CH at one time or another.  The solution is simple.  If you haven't switched to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 now is a good time to do so.  You can order it from amazon or iherb.  In the mean time most CHers in your shoes, me included, have loaded vitamin D3 at 50,000 IU/day for a week then droped back to the usual maintenance dose.  When you switch to the Bio-Tech D3-50, one capsule a week is a good starting maintenance dose.

I updated the basic regimen in July of 2018 adding the Bio-Tech D3-50 in place of the oil-based liquid softgel vitamin D3 formulation.  In Jan of 2019, I added Methyl Folate + in place of the generic vitamin B 50/100 complex.  The following photo illustrates the latest version of this regimen by brand and dose.

CHers who stick with the above brands tend to experience a faster rate of response to this regimen.

Take care and please keep us posted.

V/R, Batch

Thanks Batch. I have been on those new D3-50 for about 3 weeks now. Yesterday was my 3rd day in a row without a headache....which has not happened since this new cycle began so hopefully I am turning the corner.

[Question about D3 + other]

13 hours ago, CHfather said:

Batch has written: "CH'ers who have used this regimen and experienced a significant reduction in the frequency and severity of their CH or gone pain free and then had this test have had an average 25(OH)D serum concentration of 81.4 ng/mL. (203.5 nmol/L), min = 34.0 ng/mL, max = 149.0 ng/mL."

OK, so I really need to get it over 81.4 ng/mL! As I said, my labs were 79 ng/mL back in March but dropped to 55.18 ng/mL in June.....probably not a coincidence that the Beast returned within a month. I've been taking the 50,000 iu D3 vitamins for about 2 weeks.....we will see what happens and I'll update next month when I get my labs rechecked.

[Question about D3 + other]

I first discovered Batch's D3 regimen on this site 4 years ago, back in July 2016. Eager to try anything I began the protocol and after 3-4 weeks with no relief in sight I was beginning to doubt if this treatment would work for me. I remember sometime after the 3rd or 4th week, the headaches stopped and I was in remission for 4 years (still taking the recommended daily doses every single day) I remember I had just (finally) gotten my oxygen prescription filled/delivered like a week before my last headache...only used these new oxygen tanks that I had to move mountains for 2 maybe 3 times. They've sat in the corner of my bedroom for the last 4 years, collecting dust. I contemplated getting the Oxygen Company to come pick them up, since I was still having to pay for them!

Well, I'm glad that I did not because the Beast returned Friday June 26, 2020. After almost 4 years of remission, here he was again. Disappointment would be a huge understatement because I had never really gone more that 1-1.5 years in remission since I was first diagnosed back in 2007. I thought this D3 regimen would keep me pain free forever, but nothing lasts forever, right??

I get labs done every frequently by my PCP for other reasons, so 2 weeks ago I decided to look back over this years labs and see what my D3 levels have been each time they were drawn. This is what I found: On 3/12/2020 my Vitamin D was 79 ng/mL, on 5/20/20 it was 55.18 ng/mL and on 7/22/20 it was 61.58 ng/mL. Since I have been taking the same amount of D3 (same brand too) every day for years I started wondering, WFT happened between March 12 and May 20th to make my Vitamin D levels drop so much and then I remembered.....COVID happened! I was furloughed from work on Monday Mar 23rd (and still am to this day) and did not go outside my house but maybe 2 times a week for at least the first couple of months during quarantine! No sun....no natural D3! That's got to be the reason, right?!?! I think I read somewhere that the desired levels of Vitamin D3  is in the 60's but can't remember. I've restarted the regimen loading doses again (50,000iu per day for 12 days) to spike my D3 levels back up but I was wondering if anyone else had any experiences like this or input?

On a side note, I use to be able to abort the cycles completely my micro-dosing small amounts of those other things, when/if I could ever find any. I was able to find some of those a few weeks back but this time they have not helped one bit. Nothing.

Does anyone else find that with each new cycle, whenever they come, that some things that worked in the past no longer work? Does elements of the cycle change? I used to NEVER get them in the middle of the night.....now I get them almost every night this time. I used to never get more than one a day....now I've gotten more than 10X per day multiple times this go round.....fortunately, the oxygen worked every single time I used it....until yesterday.....when for the first time it did not. I got to the oxygen in plenty of enough time, but after 20 minutes if had not done anything to abort the attack. I feel like this thing has a mind of it's own and every time I discover a road block, it figures out a way to circumvent it!

 

What the heck......