Cluster Headache Clinical Trials and Open Studies
On This Page
Explore the research on cluster headache, from causes to current treatments.
For over 20 years, Clusterbusters has partnered with academic and medical researchers to understand cluster headache and improve treatment. We help act as a bridge to help advance research by posting ongoing studies below. Some studies are testing preventives, some are looking at treatments we already use in new ways, and some are simply gathering information about what living with this condition actually looks like day to day.
The clinical trials and studies listed below are open and enrolling now. Each listing explains who is eligible and how to reach the study team. When a study wraps up, watch our news and updates for what the researchers found.
Sign Up for the Patient Registry
Take a few minutes to your name and help make the next study possible. Be matched with research and clinical trials relevant to your cluster headache experience. Open to anyone with cluster headache, worldwide.
Current Studies
The following studies are actively enrolling participants. If you have cluster headache you may be eligible for one or more of these trials.
We will update this section in the fall of 2026.
Closed Studies
These studies have completed enrollment. They are included here as a record of the research Clusterbusters has supported and facilitated over the years.
UT Houston Batch’s Vitamin D Regimen
This study is closed.
This study was closed due to a lack of sufficient participants over 3 years. This study is therefore not considered a positive or a negative trial for Vitamin D, but rather an incomplete trial. UT Houston is running a clinical trial of a modified version of Batch’s Vitamin D regimen. For more info, contact nctt.wec@uth.tmc.edu or phone 713.486.7771
NDPH Patient Experience Survey
This study is closed.
Share your New Daily Persistent Headache experience anonymously with the #NDPH Patient Experience Survey. It’s a collaboration between NDPHaware.org and UTHealth Houston. Your voice will improve research and access to appropriate treatments.
Chronicle Clinical Study
This study is closed.
The purpose of this clinical research study is to evaluate the long-term effects of a study medicine as a potential new treatment for those who suffer from chronic Cluster Headache (cCH).
Oxygen Interview Study
This study is closed.
Volunteers needed for a study seeking to better understand the use of oxygen in cluster headache. Adults ages 18 and over with cluster headache needed for an approximately 1-hour long telephone interview.
New study for SUNCT/SUNA
This study is closed.
Clusterbusters has partnered with the Beckley Foundation to gather data on the rare TAC conditions SUNCT and SUNA. This data will help design a new study into effective treatments for these debilitating conditions. If you have been diagnosed with SUNCT or SUNA please take some time to complete this survey. If you know of anyone else with one of these diagnosis, please share the information on the survey with them.
Personal and Environmental Factors in Cluster Headache Attacks
This study is closed.
There are many reasons why cluster headache attacks may occur. The aim of this study is to determine what personal and environmental factors may play a role in the timing and severity of cluster attacks. Gathering data on this topic is critical to help formulate guidelines which doctors can follow in order to best manage patients with cluster headache. This study is being conducted at Yale University’s Department of Neurology under the leadership of Drs. Brian Koo and Emmanuelle Schindler, and has been approved by Yale’s Institutional Review Board for Research.
Cluster Headache Diagnosis Study (CHAT)
This study is closed.
CHAT-III (Computerized Headache Assessment Tool-III) is an online headache diagnosis program, previously validated in people with migraine headaches. The current study focuses on the diagnosis of cluster headache and related headaches.
Eli Lilly: Enrolling Episodic and Chronic Cluster Headache Studies
This study is closed.
Eli Lilly has recently informed Clusterbusters that they are continuing to enroll patients with Episodic Cluster Headache and Chronic Cluster Headache into their clinical studies. Additional sites in North America and Europe are now ready to enroll patients.
Genetic Study
This study is closed.
We are looking for individuals who have received a diagnosis of CH from a doctor, who have at least one immediate family member who also has received a diagnosis of CH from a doctor to participate in the study together.
Pathway CH-2 Study
This study is closed.
PATHWAY CH-2 cluster headache study. Below are images of the most recent posters on ATI’s European clinical results for your review. These posters were presented at the International Headache Conference earlier and contain the same clinical data that was presented at the ClusterBusters conference by Dr. Tepper and Dr. Robbins.