Matt19

Thank you. As I mentioned rebound congestion is an issue, and I cannot rule out the possibility of rebound headaches. I have been prescribed a weak steroid nasal spray to combat rebound congestion. My theory has long been that its success was due to opening up airways, increasing the body efficiency to intake oxygen, maybe it is just that simple. Its action on serotonin receptors is a new discovery to me and though it was an interesting link. Obviously, prevention is key to minimize the need for oxymetazoline. My main focus now is to find a reliable preventative that works for me. My strategy will be reducing mucus production and inflammation of nasal mucosa. Thinking vit D and magnesium to start. I am also a chronic sufferer and will be exploring the small possibility that I have a fungal sinus infection that exacerbates my condition. This can be ruled out by taking fulconazole.

Been having a look into some of the prevention methods being used on here. The use of Vit D, magnesium and keto diets all seem to have reasonably high success. I mentioned in an earlier post that after I use oxymetazoline I can always pull a ridiculous amount of mucus from my sinus cavity and nasal passages and this eases the pain of my attack. After some reading online I have discovered that Vit D deficiency is linked with chronic sinusitis, magnesium is used to reduce mucus in CF patients, and the body requires carbohydrates to produce mucus so a keto diet will inevitably reduce mucus production. Could be a coincidence. Just thought this was interesting.

In that case F#$K YOU big pharma, No I dont want your shitty sumatriptan for £20 a pop.

God imagine if you have to pay for sumatriptan injections how much money you could save. I'll probably be murdered by big pharm lol

Hi all I searched through previous content and found this, it was originally posted in dec 2018. I just added a comment to it to get it back on the feed. Please dont be sceptical people. If you really think about it no one could possibly have anything to gain by informing you that a £2 bottle of over the counter decongestant will abort 20+ of their headaches

I have been researching oxymetazoline for some time now and have been using as a substitute for sumatriptan for nearly 3 years. I am 100% certain that this aborts my cluster headaches. Oxymetazoline as an α-adrenoceptor agonist, however it works as a full and potent agonist of serotonin receptor types 5-HT1A, 5-HT1B AND 5-HT1D, and is a partial agonist of 5-HT1C. Sumatriptan works as an agonist of serotonin receptor types 5-HT1B and 5-HT1D. It is believed that sumatriptan aborts cluster headaches because of cerebral vasoconstriction caused by its action as an agonist on serotonin receptor type 5-HT1D So I firmly believe oxymetazoline aborts cluster headaches. So far you are my first confirmation. Spread the word

BEFORE YOU READ I AM NOT A MEDICAL PROFESSIONAL PLEASE SPEAK WITH YOUR GP BEFORE TRYING ANY TREATMENT OR MEDICATION!!! Hi everyone I have had cluster headaches for more than a decade. And for all of this time I have been searching for new drugs to abort my cluster headaches. The drug has to meet certain criteria, it needs to be fast acting, discrete, cheap, easily available and constrict blood vessels ideally by acting as an agonist to the same serotonin receptor types as sumatriptan (5-HT1B and 5-HT1D). So, after years of searching I have come up with Oxymetazoline, an over the counter decongestant nasal spray. This drug meets all of the above criteria. Importantly it works as a full and potent agonist of type 5-HT1B and 5-HT1D receptors. www.sciencedirect.com/science/article/pii/001429999190432P I have been testing on myself for the last 3 years with good results. I abort at least 7/10 attacks with oxymetazoline alone. When oxymetazoline fails I use oxygen and it quickly finishes the attack off. For me, the combination of oxymetazoline and oxygen has proven itself to be a near unstoppable way of dealing with the beast (far more effective than oxygen alone). I would like to mention that rebound congestion is an issue that I have raised with my GP and have been prescribed a weak steroid nasal spray to combat this. I have not used sumatriptan except when abroad for more than a year. Since I have substituted sumatriptan for oxymetazoline I have had no drop in frequency of attacks and nasal congestion will almost always progresses to a cluster headache if not treated so I can't rule out rebound headaches as a possibility. However, I have had phenomenal success with my current strategy of viewing congestion (rebound or otherwise) as an early warning sign of an attack and treating with oxymetazoline. This will sound disgusting but this is how I use oxymetazoline. At the first sign of an attack (congestion) I administer two metered spray doses to each nostril. As soon as my airways open up I can always pull an extreme amount of mucus from my nose and sinuses into my throat I spit this out if I can but have to swallow if not. Every time I pull some mucus back it's like the pressure and pain decreases slightly. I keep breathing and pulling mucus away from my sinuses until the attack stops. Because of the current success I have been having with oxymetazoline and pulling mucus, my personal leading theory is as follows: Often humans over complicate things and more often than not the answer is simple. So, I believe Cerebral blood vessels dilate causing a pressure pocket inside the sinus cavity, this then fills up with air and mucus inflating inside the head like a balloon, this gets so big that it starts to put pressure on nerve bundles thus causing the severe pain associated with the condition. (Just a laugh, dont destroy me lol) Just to clarify to everyone this post is not a recommendation to try any drug before speaking to a medical professional. I have not read about this anywhere else and I am interested to see if anyone else has been down this rabbit hole. If not, I hope this helps someone.