Episodic sufferer here in the middle of a cycle. Has anyone experienced a period of time where prednisone was no longer working for them? Prednisone has always worked 100% of the time i've been on it, for every cycle i've ever had. I took a two week taper at the beginning of my current cycle and it worked gangbusters as usual. Now i'm on another two week taper which does not seem to be working. Additionally, I'm getting multiple attacks a day, which is also unusual for me as i've always experienced just one per day. Thanks