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Has anyone ever tried antibiotics to treat cluster headaches? So, I thought I had sinus infections when I first started getting CH about 10 years ago. I wasn't diagnosed. I was in my 20's and I think my stepfather would get sinus infections so I came to the conclusion I had them too. I have none of the symptoms of sinus infections however, aside from the splitting headache. I also get migraines so I would confuse my CH for migraines, but the CH lasts for days, even about a week or longer. So I was going to a doctor about 1 every 2 months for these "weird headaches" other than my migraines. They would give me antibiotics and other meds. Unfortunately (and fortunately) they've stopped prescribing me the antibiotics because they didn't want my body to become immune or to form a dependency, BUT after 2 days on antibiotics, my CH is gone, dead, stopped in its tracks. Now, I DO NOT recommend this type of treatment because I believe I'm suffering some of the effects of this homemade "therapy", but has anyone ever heard of this? Tried this? Know why this would work so damn well? Thanks Jaymi