Central Sensitization

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Central sensitization is loosely defined as an increased response to stimulation that is mediated by amplification of signaling in the central nervous system (CNS).

What is Central Sensitization?

http://juniorprof.wordpress.com/2008/07/07/what-is-central-sensitization/

JUNIORPROF

Pain hypersensitivity

Pain systems need to be sensitive enough to detect potentially harmful stimuli. But often they become too sensitive, causing us pain that provides no benefit. This hypersensitivity arises because our pain pathways actually increase in sensitivity when they relay pain messages, and the mechanisms of this sensitization are beginning to be revealed.

http://www.wellcome.ac.uk/en/pain/microsite/science4.html

Clifford J Woolf

Bilateral Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Patients With Cluster Headache

http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2010.01791.x/abstract

Headache, The Journal of Head and Face Pain

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