Adenosine

[CHsince99]

1. Alcohol consumption increases adenosine.  https://pmc.ncbi.nlm.nih.gov/articles/PMC6826818/

2. High-flow oxygen reduces adenosine.  https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.00097/full

3. Caffeine blocks adenosine.  https://pubmed.ncbi.nlm.nih.gov/20164566/

4. Adenosine has been associated with cluster headaches.  https://pubmed.ncbi.nlm.nih.gov/38127692/

Therefore, I think I'll try reducing adenosine.  Coffee is not the only thing that is supposed to work for that.  https://selfhacked.com/blog/adenosine-risks/

[Jamesmsv]

Very interesting line of thought, are you planning a trial of one of the supplements listed in the selfhacked article? Please keep us posted.

[CHfather]

Seems like adding zinc is the most practical of the things listed there, although there's no indication there of how much zinc to take, so I suppose that could become another whole area of study.  The vitamin D3 regimen already includes zinc, I think at 10 mg/day in the recommended multivitamin.  I think he also recommended supplementing at some times with 50 mg zinc, and as I recall, there was mention of studies showing that taking zinc can reduce migraine attacks.  Whether that's considered to be related to adenosine, I don't know.

[CHsince99]

Thank you for the above posts.  Will let you know if I have any luck.  I also asked my doctor at the headache clinic about it.

[CHsince99]

CHfather:  Thanks for your note on zinc.  At a minimum, I'm going to start by taking a daily multivitamin that was recommended by a previous doctor, called "Physician's Daily + D3", which contains 25 mg of Zinc Citrate and then a second supplement of 30 mg Zinc Picolinate.  I'm kind of skeptical that the body would absorb any more zinc.