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Thanks for the reply. I appreciate the advice. Actually any advice is appreciated ! Anyone else out there have any suggestions? I'm trying to get more information on dosing. How much to start?? I'm thinking .2 grams. Have purchased a good scale and am looking at BMK and Ghost/Blue Meanies to start. Any comments ?

Yes, they work. The anti-inflammatory impact is significant. I also do not have a cluster headache. I have had a constant headache, 24/7/3365, always, even while sleeping, since 7:34 am March 16th 2009. Botox takes 2-3 points off of the pain. Qulipta takes 2-3 points off of the pain. Shrooms, get rid of 75% of the pain for me. It is not fun. S&S is critical. Knowing the strain and dose is critical. Knowing what you are doing before you do it is critical. Where to get the information, not sure, the government does not allow proper research. Not in grams, but on potency. Some have 1,000 units, some have 19,000 units, per gram. Watch every video you can.

Notebook LLM Audio Summary Podcast Generation (AI generated). Leaky_Gut_Causes_Chronic_Migraines_and_Pain.m4a

In lieu of a recent article I wrote exploring the literature that may support dysbiosis in cluster headache (check general board), a number of parallels were cautiously drawn from emerging migraine literature, which I thought worth sharing in one place here on the migraine board. These recent studies explore the emerging role of dysbiosis as a causative factor in migraine pathogenesis, exploring potential links via the gut-brain axis, microbial imbalance and therapeutic interventions like probiotics or faecal microbiota transplantation (FMT). Whilst I don’t suffer from migraine myself, having read this body of work, if I did I think it would be a fair and reasonable question to be asking: “Do I have dysbiosis, and if so, what can I do about it?” None of the papers below explore the role of optimised nutrition in detail, nor do they touch on two of my favourite patient-led protocols that are known to reshape the gastrointestinal environment and microbiome - high-dose vitamin D and psilocybin - but the door remains open for those avenues to be investigated (and hopefully discussed here). Happy reading – welcome your comment and you’ll find a NotebookLM audio summary generation below if you’d rather listen to a podcast rather than read studies. I have offered the links to the articles and a short generated summary snippet - any of the articles are behind a paywall and you’d like me to shoot you off a copy please reach out via DM. Gut microbiota dysbiosis enhances migraine-like pain via TNFα upregulation Published January 2020 https://doi.org/10.1007/s12035-019-01721-7 Yuanyuan Tang, Sufang Liu, Hui Shu, Lora Yanagisawa, Feng Tao Key finding: Antibiotic-induced dysbiosis and germ-free status markedly worsen nitroglycerin-triggered migraine-like pain in mice through TNFα-mediated trigeminal sensitisation; probiotics reverse the effect. The association between migraine and gut microbiota: a systematic review Published April 2023 https://doi.org/10.1007/s13760-025-02779-y Alon Gorenshtein, Kamel Shihada, Liron Leibovitch, Tom Liba, Avner Goren Key finding: Consistent reduction in anti-inflammatory genera (especially Faecalibacterium) and increased Veillonella in migraineurs; overall picture of dysbiosis and reduced diversity. A causal effect of gut microbiota in the development of migraine Published July 2023 https://doi.org/10.1186/s10194-023-01609-x Qiang He, Wenjing Wang, Yang Xiong, Chuanyuan Tao, Lu Ma, Junpeng Ma, Chao You, and The International Headache Genetics Consortium Key finding: Mendelian randomisation evidence of causal links from multiple bacterial taxa (including Bifidobacteriaceae) to migraine, migraine with aura, and migraine without aura. Making migraine easier to stomach: the role of the gut–brain–immune axis in headache disorders Published 2023 https://doi.org/10.1111/ene.15934 Marissa Sgro, Jason Ray, Emma Foster, Richelle Mychasiuk Key finding: Narrative review emphasising that a diverse, healthy microbiome is required for optimal brain health and that dietary manipulation is a logical therapeutic lever. Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation Published 14 August 2023 https://doi.org/10.3390/microorganisms11082083 Ágnes Kappéter, Dávid Sipos, Adorján Varga, Szabolcs Vigvári, Bernadett Halda-Kiss, Zoltán Péterfi Key finding: Explicitly proposes fecal microbiota transplantation as a future therapeutic option for migraine on the basis of restored serotonin signalling and reduced neuroinflammation. Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases Published 11 October 2023 https://doi.org/10.3390/nu15204327 Manuela Di Lauro, Cristina Guerriero, Kevin Cornali, Maria Albanese, Micaela Costacurta, Nicola Biagio Mercuri, Nicola Di Daniele, Annalisa Noce Key finding: Places gut dysbiosis at the centre of a bidirectional relationship between migraine and cardiometabolic disorders; advocates nutritional and lifestyle approaches to restore eubiosis. Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1α levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation Published 2024 https://doi.org/10.1186/s10194-024-01730-5 Doga Vuralli, Merve Ceren Akgor, Hale Gok Dagidir, Ozlem Gulbahar, Meltem Yalinay, Hayrunnisa Bolay Key finding: First human evidence of raised circulating LPS and leaky-gut markers in chronic migraine + medication-overuse headache, directly implicating intestinal hyperpermeability. The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis Published 11 July 2024 https://doi.org/10.3390/nu16142222 Parisa Gazerani, Laura Papetti, Turgay Dalkara, Calli Leighann Cook, Caitlin Webster, Jinbing Bai Key finding: Strong call for personalised dietary and pre/probiotic interventions; highlights bidirectional influence between diet, microbiome, and migraine susceptibility. Oral and Gut Dysbiosis in Migraine: Oral Microbial Signatures as Biomarkers of Migraine Published 2025 https://doi.org/10.1212/NXI.0000000000200437 Soomi Cho, Yeonjae Jung, Hyun-Seok Oh, Jungyon Yum, Seungwon Song, JaeWook Jeong, Woo-Seok Ha, Kyung Min Kim, Won-Joo Kim, Min Kyung Chu Key finding: Oral dysbiosis is even more pronounced than gut dysbiosis in migraine; specific oral microbial clusters predict migraine status with high accuracy and correlate with headache frequency. Unravelling the gut–brain connection: a systematic review of migraine and the gut microbiome Published 3 April 2025 https://doi.org/10.1186/s10194-025-02039-7 Caroline W Mugo, Ella Church, Richard D Horniblow, Susan P Mollan, Hannah Botfield, Lisa J Hill, Alexandra J Sinclair, Olivia Grech Key finding: Synbiotic and combined probiotic–synbiotic regimens consistently reduce attack frequency, severity, duration, and analgesic consumption in randomised trials. Gut microbiota, probiotics, and migraine: a clinical review and meta-analysis Published 12 September 2025 https://doi.org/10.22514/jofph.2025.043 Olga Grodzka, Izabela Domitrz Key finding: Meta-analysis of RCTs confirms probiotics significantly lower migraine frequency; effect on severity approaches significance despite limited trials.

Two useful tools I wanted to share for anyone here who keenly follows research on cluster headaches, migraine or anything for that matter. The first is Harzing’s Publish or Perish. It is a free citation analysis program that lets you easily search scientific literature across a range of journal sources. Link: https://harzing.com/resources/publish-or-perish The second that I am really loving at the moment is Google’s NotebookLM. It allows you to upload papers, PDFs, and links, then ask structured questions and generate summaries, comparisons and notes directly from your sources. For anyone trying to understand mechanisms, track themes across papers or just stay organised while reading, it is extremely handy. Link: https://notebooklm.google Both tools make it easier for patients who like to follow the science closely to evaluate studies and stay on top of emerging research. If anyone wants a quick explanation of how to use either tool for cluster headache-related topics, I am happy to share examples. The last tool - bonus lol, I went looking for something to match CHFathers cat picture in a recent AI post - found another Google tool. An experimental tool for visual exploration: you input images for subject, scene, style and the system remixes them into new visuals - here's what I got for my new CH Forums profile pic - I am here to stay now! https://labs.google/fx/tools/whisk

Hey Kevin. To my knowledge there is no specific migraine busting protocol. FunTimes offered a solid reply to your earlier post on the general board and the key information regarding the process is on the following page. https://clusterbusters.org/resource/alternative-treatments/#busting You might find the Yale psilocybin migraine study useful to look at as the dose they used somewhat correlates to the Cluster Busters range, if I am correct They gave 0.143 mg/kg of pure psilocybin and when you apply a conversion factor for Psilocybe cubensis potency (roughly 0.8 percent psilocybin by dry weight with variance as to strain, when it was picked and even which part of the fruit) that works out to the same content found in about 1.5 g of dried cubensis - give or take, maybe a little less. The key difference is that the study used one single dose followed by a two-week observation period whereas cluster warriors traditionally repeat doses every five to seven days. https://www.sciencedirect.com/science/article/pii/S187874792301214X My personal thoughts - start a bit lower than the typical 1.5g dried cubensis mushroom to get accustomed to the feeling, I quite enjoy the euphoria and introspection and find it doesn’t last too long before I’m hungry and tired. For what it’s worth a quick scour of the literature found the most recent paper with title including "migraine" "psilocybin" - a case report of a single male migraineur in his 30s whom used psilocybin alongside otc pain relief at 1.2g dried as an acute treatment with greater reported efficacy than pain relief alone. https://pmc.ncbi.nlm.nih.gov/articles/PMC10561985/ You may find another popular treatment option used by members of the CH community worth a look-in whilst you are here, the Vitamin D3 Anti-Inflammatory Regimen. You’ll find the information here or collated by myself and Pete Batcheller over at www.vitamindregimen.com I would say that given a sensible approach and applying the protocols as per the guides, IMHO both of these patient led avenues are generally safe and worth investigating - in any event a walk down the unknown path can cause a bit of anxiety so good luck as you navigate - I remember being nervous as heck in 2015 when I started the D3 regimen against my Doctors best recommendations and yet 8 days later things took a turn for me, I cried like baby, hugged wifey and got my life back - 10 years later I think there is still a part of me that is in disbelief that it actually worked and I only wish that could be the same for everyone. Whilst I have had success with D3, I found a penchant in the hobby of mycology, I have a wonderful big laminar flow hood that takes up our spare room and all the mycological tools to grow wild and wonderful varieties from "cubes" to turkey tails and beyond - and have done so over the years with great success, it is a fascinating and wildly fulfilling hobby with lots of highs (no pun intended) and lows of the process. It isn't a fast thing either and after weeks, sometimes months of cultivation to have a fruiting body appear overnight is awesome or to awake one morning after the same period to find dreaded trichoderma has destroyed all your hard work is devastating! Still, well worth it for the journey and knowledge learned! Were there any specific questions you wanted answers to, I’m sure we will do our best to help. Best wishes to you. Cheers, Craig.

I see the kitty in your profile pic now @Craigo

Hi Nut cluster. I’m clearly not female (I missed the social cues upon joining the forum regarding using a cat as my profile picture), I don’t have much to add regarding estrogen but I have always been intrigued with vitamin D biology during pregnancy and your post captured my interest so please excuse me if this is a little off topic but wanted to share. Cholecalciferol / vitamin D3 is converted via hydroxylation into the blood storage form calcifediol which is then further converted into its hormonal form, calcitriol, mostly (but not exclusively) by the kidneys. The blood level of calcitriol is maintained in a strict range to maintain calcium homeostasis and is regulated by parathyroid hormone. During pregnancy the levels of calcitriol, the hormonal form, increases by double or triple to levels you’d see in granulomatous disease or intoxication but without hypercalcemia. The body deliberately raises both calcitriol and binding proteins in order to support placental development, immuno-regulation and fetal skeletal growth. The levels then fall back into normal range 2-6 weeks postpartum. There is still much we don’t understand about this intriguing process. It’s interesting that many female warriors report skipping cycles during pregnancy and to also consider why they return postpartum (and perhaps also why MS relapse may occur postpartum), and although tempting to speculate it may have something to do with the increase in calcitriol and its immuno-modulatory properties, probably an oversimplification - the body is just so complex. Dr. Hollis & Dr. Wagner have a combined century or so of research looking at vitamin D and reproductive outcomes, this was a great talk from last year although can’t recall if they cover the specifics of the points above.

Hey everyone I’ve had a look through old posts and nothing really recent is coming up and not all experiences are in the same place so thought I would start a new thread to help us all figure out how hormones may impact CH. Whether you’re male/female/trans (saw that trans people have particular insights on this topic in old threads) what are your experience in this regard? So, here’s what’s going on for me atm. I’m female, early 40s and the last couple of years my CH have been less frequent. Usually I get them every year at around this time (I’m in the UK and it tends to link to daylight saving). Over the years (about 20) they have switched between the other clock change in about April but usually not more than one cycle per year. During pregnancy I didn’t have them, but both pregnancies were Jan-Sept so not during Oct clock change. However, about 2 weeks after both pregnancies I got hit (as you can imagine, my sleep was bad during that cycle). This last few years I’ve skipped a clock change and the headaches have shifted to the next one. So instead of going a year I’m going 18 months remission. It has now been 19 months since my last attack and I have only had a couple of possible shadows (those that usually indicate the start of a cycle but it hadn’t followed the pattern which is to be like that every day until the start of the bad ones). Hoping that they’re gone for good but thinking it may be linked to a drop in estrogen. I have also noticed other symptoms which could indicate a drop in Estrogen (oestrogen in case anyone is searching). My worst headache cycle was a year I got a contraceptive implant (which I had taken out because the correlation with intensity was so strong) so I’ve always thought hormones may influence the severity of the cycle. I am obviously very happy that the CH might be stopping but I may also need to address other symptoms that are starting to bother me. Naturally I am trying to avoid doing anything that will bring back CH. Can anyone else share any experiences at all which may be linked to hormones so we can have them all in one place for anyone looking? Whether you come across this thread today, or in 10 years from now add your thoughts so we can learn as much as possible about this condition!

Hi all! I'm considering starting a new local/regional support group for Illinois since we have a conference every other year in Chicago. Any ideas on days/times that would be good for attendance? Would a 6pm CT or 7pm CT on a weekday work well or a weekend day/time? I'd like to be able to advertise something like the 2nd Thursday of the month at 7pm type of time so it's consistent. Open to ideas and I'll lead it until someone else feels comfortable and I will always be available for support. Just thought this might be helpful and if there are people who have an idea of another location that could use a virtual/zoom support group, let me know. We have California and Texas and both have been really amazing groups.

I too am looking for more information on the "mushroom cure" as you call it or treatment as someone else mentioned. I have tried posting and asking for general information, but so far only one person has responded to me. I have had migraines since 2001 due initially to a spinal fluid leak. I don't have cluster headaches, and my leaks have been sealed at Duke University Hospital in NC, but I'm still suffering, possibly due to a pain cycle that I've been in for so long. My brain just thinks I'm not safe, so it continues to send pain signals to my nervous system. Have seen many of the best neurologists on the east coast and tried many medications but never mushrooms. Would really appreciate any basic information from someone with migraines who has tried mushrooms and received a benefit. I'm reading some of the other posts trying to glean information and create a plan of action, but as a newbie, it's difficult to figure out where to start. How did you all get started? Do I just have to read more and teach myself? Would really appreciate some input or guidance. This forum was suggested to me by my neurologist who felt that mushrooms might help me, so I'm determined to try them. Just not sure how to go about it yet. Thanks in advance

Was hoping I would get some responses from the group. Is there anyone out there that can steer me in the right direction? There seems to be so much information to digest as a newbie. My goal is to find out the quickest way to get started experimenting with mushrooms and what the ground rules are. I read the info within the blue banner and read the newbie page. Just hoping for some input from members of this group who might be able to share some advice or experiences. Thanks

This is my first post to the group. I actually posted it over on the Clusterbusters side, but they referred me here. So maybe someone on the migraine side of the forum can help me out. After meeting with my neurologist at Yale New Haven hospital today, he suggested that I try asking some questions about taking mushrooms for headaches in this forum. He seemed to think that there was some validity to the use of mushrooms for chronic migraine. I do not have cluster headaches, so will clarify that right away. I have, however, suffered from migraines since 2001 when II was diagnosed with a spontaneous spinal fluid leak. Worst pain I could imagine for about 6 weeks. Bedridden. Eventually things improved, but have never resolved, so I have been searching out specialists from Hartford Hospital in CT to The Philadelphia Headache Center in PA to Yale New Haven in CT. I recently made 4 trips in 6 months to Duke University Hospital in NC earlier this year where the fabulous doctors there found a particularly troublesome leak called a venous fistula, actually several of them. They were repaired and I felt better for about 10 days, then the headaches returned. So, my working theory is that my brain has become accustomed to sending pain signals to my nervous system, even without a physical malady. I am now doing EMDR therapy and trying various anti-anxiety medication to try to break the pain cycle. Some progress has been made, but I am far from where I want to be, thus my post. I'm wondering if there is someone out there who might be able to guide me in this new world of potential treatment using mushrooms. I know next to nothing about them, though have tried them in college many years ago (I am 65 now). Thanks for your attention and I look forward to having a conversation about how to move forward.

Hey thanks for the help. I actually am able to have vials RX and dose myself. Also have a demand valve setup. Appreciate the links. Mike

I think something went wackadoodle with the above link - let's see if this one will work (the site itself seems like a nice one): https://clusterfree.org/

Notebook LLM Audio Summary Podcast Generation (AI generated). Vitamin_D_deficiency_linked_to_migraine_treatment.m4a

Vitamin D Deficiency and Supplementation in Migraine: A Scoping Review of Clinical Efficacy, Evidence Gaps, and Research Priorities Amey Marathe, Shailly Vaghasiya, Arth Shah, Soaham Desai Published in Annals of Indian Academy of Neurology on November 12, 2025 Link: https://doi.org/10.4103/aian.aian_417_25 Abstract: Background and Objectives: Migraine is a debilitating neurological disorder affecting 10%–20% of the global population, with significant socioeconomic burdens. Vitamin D deficiency, prevalent in over 1 billion individuals, has been proposed as a modifiable risk factor in migraine management due to its potential role in pain modulation and neuroinflammation. This scoping review aimed to map global vitamin D deficiency prevalence across migraine subtypes and geographic regions, synthesize clinical correlations between vitamin D status and migraine characteristics, and explore heterogeneity in therapeutic evidence across paediatric, chronic, and refractory migraine subgroups. Methods: A systematic search of PubMed, Scopus, and Embase was conducted, identifying 3,447 records initially. After screening and eligibility assessment, 30 studies were included. These encompassed observational studies (n = 14), randomized controlled trials (n = 9), and systematic reviews (n = 7). Data were synthesized narratively due to clinical heterogeneity and the predominance of cross sectional evidence. Results: Vitamin D deficiency (serum 25 hydroxyvitamin D [25(OH) D] <20 ng/mL) was highly prevalent among migraine patients (65%–88%), particularly in chronic migraine (80%–92%) and high latitude populations (>40°N: 75%–90%). Inverse correlations were observed between vitamin D levels and headache frequency and disability scores. High dose vitamin D supplementation (≥50,000 IU/week) reduced migraine attacks by 50%–72% in deficient adults, while minimal benefit was seen in replete individuals. Single trials revealed enhanced efficacy when combined with probiotics or topiramate in refractory and paediatric cases, respectively, but this requires further validation. Conclusion: Vitamin D deficiency is consistently associated with increased migraine burden. Supplementation shows context dependent efficacy, particularly in deficient individuals and specific subgroups. Future research should focus on mechanistic trials, global standardization of assays, and comprehensive outcome assessments. Clinically, baseline 25(OH)D testing is recommended to guide targeted supplementation strategies.

Just an FYI that the link is bad. 404 not found error.

Hi Mike, Sorry to hear that the headbangers are back... It's always a serious bummer to read about this sort of situation. Attached is a PDF of the D3 Quick Start guide. There has been some good discussions on splitting your trex injections as most find that they get the same relief with a half dose and this method helps to reduce overuse. There are other resources on here if you are open to less conventional methods to manage your bangers (Blue ribbon at the top-New users please read here first). I hope this passes soon!! Quick Start Guide - Sept 2023.pdf

Hello, It has been a decade since I have visited y’all. I regret forgetting how support this group had giving me on the past. I’m sorry I have not been there to support others when I was pain free. There is a vitamin D cocktail that helped me very much, could you direct me to it? Recently I have been diagnosed with an autoimmune disease called CIDP and coincidentally or not my headaches have returned after being five years pain free. Up to an imitrex injection nightly for a month and high flow O2 throughout the day. Not going completely away at all. Im am going to hit the forum archives hard. So as you all know I am in panic mode and am reaching out for help and support. Thank you, Mike D

This is a new and highly relevant study for anyone with CH considering or already following the Vitamin D3 Anti-Inflammatory Regimen. In participants with baseline 25(OH)D3 levels below 20ng/mL, researchers used the same loading dose of 600,000 IU that the regimen recommends. What makes this particularly interesting is that their maintenance doses were substantially higher than the standard 10,000 IU per day typically required to sustain serum levels in the 80–100 ng/mL range. Across roughly ninety patients these higher doses were well tolerated, with no evidence of renal impairment or disturbances in calcium homeostasis. This offers compelling reassurance for CH'ers who may feel uneasy about achieving or maintaining the regimen’s target vitamin D levels. Regular monitoring remains essential, but this study reinforces that the dosing strategy is safe when managed appropriately. It also suggests that if some CH'ers fail to achieve a therapeutic response with the base regimen they may entertain elevating their 25(OH)D3 level higher in order to reach a therapeutic threshold (again with close monitoring of labs).

Notebook LLM Audio Summary Podcast Generation (AI generated). Unlocking_Remission__How_High-Dose,_Monitored_Vitamin_D3_Safely.m4a

Prolonged high dose daily oral vitamin D3 in the management of psoriasis: A retrospective chart analysis Renu Mahtani, Sudhir Singh, Pradeep MK Nair, Satya Prakash Singh & Mankul Goyal Published in IP Indian Journal of Clinical and Experimental Dermatology on 26 September 2025 Link: https://doi.org/10.18231/j.ijced.89447.1758864688 Abstract: Background: Autoimmune disorders, particularly psoriasis, are often associated with vitamin D deficiency and vitamin D resistance. Higher daily doses of vitamin D3 are considered effective in overcoming vitamin D resistance and reversing psoriasis symptoms. This study was conducted to evaluate the safety and efficacy of individualized, prolonged high‑dose daily oral vitamin D3 therapy in patients with moderate‑to‑severe psoriasis. Materials and Methods: In this study, we present data from 95 patients with moderate‑to‑severe psoriasis who underwent individualized high‑dose daily oral vitamin D3 (cholecalciferol) therapy. From this cohort, six representative cases are described in detail to illustrate the approach to personalized dosing and the monitoring process using biochemical markers such as parathyroid hormone (PTH) and ionized calcium. The efficacy of the intervention was assessed using Psoriasis Area and Severity Index (PASI) scores, while safety was evaluated through regular monitoring of serum creatinine and ionized calcium levels. Statistical analyses were conducted to examine the relationship between vitamin D3 dosage, serum 25(OH)D levels, PTH suppression, and clinical improvement. Results: Significant clinical improvement or remission was noted, without hypercalcemia or toxicity. PTH levels consistently declined in parallel with clinical response, suggesting vitamin D action. Conclusion: Monitored oral vitamin D3 therapy in higher than supplemental dose, can be a safe and effective treatment for psoriasis.