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Everything posted by ub

  1. Hey guys I'm a chemistry PhD student. I watched a documentary on CH and inspired by this I am in the process of designing a medicinal chemistry project with the eventual aim of discovering a compound to treat Cluster headaches. I understand LSD and particularly the non- hallucinogenic Bromo-LSD (BOL-148) is an excellent candidate for treating CH (and is being developed by entheogencorp.com). What I can't find so far in my reading is how exactly this compound works- ie. which receptor interactions are critical in the treatment of CH and in particular, responsible for the incredible remission time from pain that we see with bromo-LSD (or LSD for that matter. I am starting to wonder if we know which receptor interactions are indeed important? This is bit of a worry as any compounds that would result from this research should be assayed against something before going into animals to determine very promising lead compounds...but what assays(???)). I've got a good idea in terms of chemistry what I want to do but I am still not sure what exactly I am looking for in the pharmacology side of things. I do understand 5-HT receptors are involved (and for LSD, the rather unselective nature in hitting these receptors is the reason why we get the rather nasty hallucinogenic "side effects") To put the question in another way, if you had a chemist who is willing to design and synthesize a compound to hit receptors of your choosing in selective (or unselective) ways as an agonist, antagonist etc. which receptors would you get the chemist to target and in what way for treating CH? Is there any publications you guys are aware of that deal with these questions? Would anyone know of a study with the Bromo-LSD compound where they discuss which specific receptors are being hit and in what way? These questions might be bit elementary- forgive me, my training so far was entirely in and nothing but organic synthesis. (and I’m still am doing reading to learn more about CH). Any publications/studies you guys would like to point out to me would also be very helpful. Thanks guys. ps- this was cross posted to the other CH forum (can't post the link to that thread here because I need minimum of two posts to post links :-[)
  2. denny: ty, but ...(Potter does have a point) very interested in talking to the danish scientist!
  3. yeah, very nice review. registration was painless
  4. thanks very much man. i think this will be very useful let me digest all this now- I'll have specific questions afterwards I am sure and thank you so much everyone- entire CH community (including everyone who corresponded privately). the amount and quality of information you guys supplied me is absolutly breathtaking
  5. CH-father. ah i see. the only negative angle I am coming from is that if that is the case bio assay's will have to be developed from scratch (ie. more work involved). Potter- I am sure that is the case but what can I say- progress of science is slow and painful (and there is a serious lack of funding in fundamental science and I am feeling the brunt of it currently. In saying that, I am certian it is incomparable to the CH pain so accept my apologies). I'll be clear right now I can't promise anything- reason for me being here is to gain as much information about CH as possible. -is there any posts by these scientists that dropped by you guys have handy by chance? I'm quite serious about this though- I have a meeting with an academic today. I don't know what I want to do will have support academically and financially but in these things way to move foward is to try. in this vain, any more publications/studies/information you guys want to throw at me?
  6. shabooty: http://www.thedailybeast.com/newsweek/2009/10/14/the-psychedelic-solution.html after all's been said and done, I think we understand these molecules more than 2-bromo. I am sure you guys know this much better than me- but everything I've been reading says effect of these treatments are incredible. Ofcourse, law is the law. :-/
  7. (I'd very much caution against ordering research chemicals for personal non research, human use- 1. nobody knows what quality control there is. molecules like this gets made with very toxic, lethal reagents 2. depending where you are use of research chemicals in humans are against the law, 3. 2-bromo LSD hasn't really been through FDA yet- strictly speaking, we do not know yet how dangerous the stuff is to humans) I'd trust the stuff I order from chem suppliers to put into a petrish dish and run assays against cell cultures (for instance. and only after running some tests to make sure it is what it says it is, eg NMR) but never ever, ever to ingest them. I mean, there are safer options avaliable now I hesitate to reccomend them because of the laws but ordering 2-bromo from a research chemical supplier should be a non-option for non-researchers and extremly extremly dangerous. Can't stress that enough. :-/
  8. hey there Ricardo bekeeber: http://www.lookchem.com/2-Bromo-D-Lysergic-Acid-Diethylamide/ research chemical suppliers do supply these things for research purposes I think...not sure how reliable these suppliers are though. worst comes to worst a total synthesis of the thing would be a solution...(but id rather not- tot syn of bromo lsd looks like it will take atleast a month). this is one of the reasons why i think there is merit in more research even if 2-bromo lsd makes it through clinical trials and gets fda approval etc. in chemistry point of view the molecule is rather complex and it looks like it will be expensive to manufacture
  9. CHfather - incredible help with those links, thanks a ton. I'll let you (and anyone else in the forum) know if I need to find something more specific after I go through the reading. (in this context could i ask you and others to give a small thought to what I wrote below?) also- is Ricardo still around? sounds like a very knowledgeable person my best plan of action right now is to order some LSD, 2-bromo LSD and have a pharmocologist do some reference assay's so I have something to compare to when novel compounds I have in mind are made...but that is re-inventing the wheel so to speak. if pharmacological data in the context of treating CH is known that would be very helpful... (these may not exist, I have been looking when I can for these) re Lisuride: from wikipedia it says "It has a high affinity for the dopamine D2, D3 and D4 receptors, as well as serotonin 5-HT1A[1] and 5-HT2A/C receptors" If i can find a sentence like this for 2-bromo LSD it would be incredible. We know which receptors LSD hits and what way already- and that it's (LSD is) effective for treating CH- we just need to get rid of the halluciginicity. If we have the same data for 2-bromo LSD simple process of elimination will tell us what binding figures and in what way receptors do indeed need to be hit for treating CH (and not inducing hallucination). This will help me because I already have a very good idea of what sort of chemical structure I want to make (not LSD) but only by running some sort of assay agaisnt something will i be able to justify saying "this compound especially seems like something we should find funding for animal and eventually human trials". ie. in research like this compounds need to first pass the petrish-dish test, and I am trying to learn what petrish-dish test (so to speak) would be most appropiate for CH. Hope that make sense.. everyone else; hold your horses, I hadn't done anything yet (!!!) (but very happy to be involved- CH sounds horrific and I am not sure why more research has not been done on this- especially with such excellent lead compounds like LSD being known. In this respect 2-bromo must be a very good step foward) if anyone has more links stored up for CH mechanism/biology/how bromo-LSD/LSD works in treating CH side of things please share them with me here. Jorunal articles are no problems (just a citation would be fine)- my university has access to most journals What keeps puzzling me is that the landmark 2-bromo paper in Cephalalgia (http://cep.sagepub.com/content/30/9/1140) is such a jump from a compound to human trials...surely this compound must of been assayed against something to determine the worthwhileness in treating CH before going into humans. The process can't have been "oh 2-bromo is not hallucinogenic and was given to headache people already...let's also give it to CH patients and see what happens". (although that is what is implied) And yet I can't locate any other publications that must exist before 2-bromo making it into humans in context of CH... Invitation for anyone else to ponder with me ... (sorry I think I've said the same thing in 4 different ways now. meanwhile I'll go through the reading above, thanks CHfather once again)