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Posted

this paragraph I found particularly interesting

gammaCore is a revolutionary non-invasive vagus nerve stimulation (nVNS) therapy developed by US based healthcare company electroCore. The patient delivers the therapy by holding the device on the neck over the vagus nerve for 90 seconds which painlessly delivers a proprietary electrical signal that activates specific fibers in the vagus nerve bundle. This stimulates the production of inhibitory transmitters in the central nervous system, and reduces the over expression of the excitatory neurotransmitter glutamate, which has been implicated in a number of headache disorders

Posted

Don't get too overly-excited about this thing. Their European trial results were meh, at best. The two people I know who were in on the initial US trial got no relief from it. It's a reach, at best. . .at very low-risk to the company, because it's non-invasive and non-pharmaceutical, so their development costs are nil.

Now, studying glutamatergic activity and various inhibitors, well, that's not a bad place to look if you know what you're looking at.

Posted

This is the company's press release about the latest gammaCore results: http://www.electrocoremedical.com/randomized-data-presented-at-international-headache-meeting-ehmtici-shows-gammacore-significantly-reduces-cluster-headache-attack-frequency-the-worst-pain-known-to-medical-scienc

More detail: Posters presented at European headache organization meeting (top three): http://ecorelibrary.com/?m=1  (There might be a simple sign-in to see these.)

Thread at this board from one US test subject: https://www.clusterheadaches.com/cb/cgi-bin/yabb2/YaBB.pl?num=1388946884/0

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