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Lieutenant2

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Everything posted by Lieutenant2

  1. And there are two of the biggest barriers we have faced in the history of CH. First, we look to the "renowned researchers" and put them on a pedestal, waiting for them to hand down their wisdom and treating only their words as valid. We can all go ahead and name them, Goadsby and Sewell and so on and so forth. . .I'll even throw in hacks like Halpern. We canonize them based on what, exactly? I can appreciate their work, but they are not gods, nor should they be the only ones whose work is considered valid. Second, the old hypothalamus thing again. It's a little like quantum physics, really.
  2. Little update here. . .I've been asked to share this additional link to some basic FAQs about 5-MeO-DALT. There has been a lot of discussion and experimentation taking place in the Facebook CH group, it seems that most people are turning to social media for their CH discussions now. But in an effort to help overcome some of the overly-scientific jargon. . . https://www.dropbox.com/s/ug6orptw9vzujgc/5meo_FAQ.pdf?dl=0
  3. I like the Horizon Pro-20A scale because it comes with a little measuring tray that is perfect for handling powders. It's available for under $25 US. And I hope you meant a 15mg dose. . .always start low. As we learn more about 5-MeO-DALT, it is becoming apparent that higher doses don't necessarily mean better results. Most CHers, even some seriously refractory chronics, are getting very good results at 15mg every 5 days. No point going higher in dose if you don't have to!
  4. Lt2, to help me understand it better as I read it carefully in the next couple of days, can you say a few words about what you see the paradigm shift as being? Yessir. . .I think your follow-up to Fabac was a pretty good synopsis. The very short version is that, for 5+ years that I'm aware of, the bulk of clinical research has focused on hypothalamic malformations, serotonin, and a very narrow band of related possibilities. Following those lines, most of the research being done has worked toward these ends. Everybody has been looking for the magical "thing" that causes CH. With the resul
  5. Not saying it will have a major impact on your ability to use seeds or your addition GI issues, but I have always found famotidine to be the best sidekick to some of the meds we take that can cause reflux and other problems. It's a histamine receptor agonist, and helps the stomach limit acid production. Plus, it's dirt cheap!
  6. All due respect, anybody who is upset with this study clearly doesn't understand it. This is a critical paradigm shift in cluster headache research that opens an incredible number of new avenues for research and, ultimately, treatment. This is the best news we as a patient group have had in the 5+ years I've been involved. Just my $0.02, of course.
  7. One of the drawbacks to DMT (aside from the obvious) is that it's very non-selective in its receptor binding. Since it so closely mimics serotonin, it will basically get in wherever it can fit in (that's a massive oversimplification, of course). But for CH, it's really like having a mosquito on your leg and blasting it with a shotgun. You may or may not get the mosquito, but you're sure as hell gonna get something! If you want a better tryptamine, 5-MeO-DALT. Just sayin'.
  8. You seriously should consider reading Dr. Mate's book: "When the Body Says No". Your post is basically a summary of the book! Or at least suggest it to your brother. It's fascinating stuff, and I believe it holds a key to understanding where CH comes from.
  9. I think you have to smoke the banana peels. Just sayin'.
  10. Hey Par. . .unfortunately, the Sandomigran is a bit beyond my depth of knowledge. I understand it pushes some of the same "buttons" as the tryptamines and other common preventives, but seeing as that's only about 10% of the picture, I really have no idea how it might work. But I would assume that any doctor writing that prescription for CH would at least have some information or history of success with it. Pretty common for migraines, from what I've read.
  11. Very nice analogies, diamondmaker! In fact, I guess what we're really talking about here is both psychological/emotional AND physical, because there is of course a manifestation of it that is visible. Plus, it hurts like hell and we're not making that up, despite the attempts of some docs to call it psychosomatic pain! I also work off of this whole concept of a "feedback loop" that we first need to interrupt before we start treating root causes, and that interruption can be very much physical. But I digress. . .probably a different topic altogether. Synaptic pruning and all.
  12. Yeah Par, I think it might be a good time to stop all tryptamines and get some medical advice. Oxygen can be deadly, as silly as that sounds. Falling asleep with 12lpm running isn't a good idea. We're equipped to breathe ~20.8% oxygen at atmospheric pressures, not 100% oxygen.
  13. Hey Par. . .glad to hear you're being persistent! Something I have learned over the years, fixing CH isn't a pill or a potion, it's a PROCESS. It took us years to develop this disorder, it takes time to get rid of it. But that's a totally different topic. . . Basoon, CHfather has a great question there. (He and I are going to open a research lab if we can get along in the same room. ) But yes, each of us has a different response to any form of psychedelics. Someone I know was very comfortable at 15mg, only feeling a slight buzz. Able to read, carry on conversations, totally normal. And
  14. Hey Par. . .sorry to hear about your CH taking a turn for the worse! Please don't let yourself suffer in the name of some experiment, do whatever you have to do to get out of the pain cycle! Also, there are some good threads in here, probably from about a year ago, discussing the whole episodic vs chronic thing. Being chronic is not a death sentence, and from personal experience here, I feel being chronic might be better. Sounds crazy, I know. But try to find those threads, they might give you some perspective and help you get your mind in the right place! Stay strong and fight!
  15. Yes, well. . .as much as I respect your opinion and your education, I will just disagree and leave it at that. I assure you, I speak from direct experience as a chronic CH patient who has not had a CH attack in 11 months, and I am not the only one, and there are a couple people with "PhD" after their names who are helping with this. . .so, would I be willing to bet a paycheck that I'm right here? Absolutely. Unfortunately, there is still much work to do, and arguing about it in a public forum is less than productive. Sometimes it's hard to see the forest for the trees. And even if I'm 100
  16. Thanks, CHfather! Couple interesting points. . .you mention 2-bromo-LSD (BOL-148) a something that treats a "physical" problem, but I don't see it that way. Psychedelics get their results because they are treating a mental/emotional issue. Psilocybin is probably the single best treatment for PTSD, and that disease is 100% emotional. Meds that treat the physical are those that alter a structure, so for example verapamil altering calcium channel ions. Psilocybin, LSD, LSA, and even BOL (it's just LSD with a bromine molecule stuck to it, high school chemistry) treat the mental state/emotions of t
  17. Interesting dynamic here, in that the doctors who practice medicine are not the doctors who research, and vice-versa. I don't blame them individually, it's kinda like the guy who designed your car isn't the same guy who works on your car when it breaks. Want to move the science forward? Do it yourself. You'd be surprised at how easy it is to learn about the brain, its mechanisms, cluster headaches, etc.
  18. Interesting stuff, for sure. And I am inclined to agree to the extent that it pertains to SIGNALING. It would be very hard to convince me that there is a physical malformation in the axons/dendrites of the cells in the hypothalamus. This is probably splitting hairs, since we tend to think of the signals in our brain as electric signals, but they're actually chemical signals. So is "bad chemical channels" the same as "malformation"? Yeah, that could be argued. What I do know is that attempts to treat CH as a physical disorder (surgery, electrical stimulation, medication) have failed or are te
  19. Don't get too overly-excited about this thing. Their European trial results were meh, at best. The two people I know who were in on the initial US trial got no relief from it. It's a reach, at best. . .at very low-risk to the company, because it's non-invasive and non-pharmaceutical, so their development costs are nil. Now, studying glutamatergic activity and various inhibitors, well, that's not a bad place to look if you know what you're looking at.
  20. Thanks Tim! Some of us were talking about that in the back of the room, basically trying to do the math. We weren't sure to what extent you were getting a reduction in frequency, that was probably our biggest question. Thanks for clearing that up!
  21. Hmmm. . .well, in basic terms, when we use tryptamines to treat CH, they don't really "stick/unstick", what they really do is plug into our serotonin receptors, send a signal downstream (in our case, the signal is basically "stop draining serotonin randomly") and then they're gone. So as long as the signal is sent, there's not much else we can do for about five days. Effectiveness is really all about how many receptors we can hit and the strength of the signal. As for the MRI, if you haven't already had one, you definitely should. If you only have CH, your MRI is going to show absolutely not
  22. Par. . .I couldn't find any data on affinity or downstream signaling for any of the other substituted tryptamines, so I'm not really sure where they may lie on the spectrum. Technically, I guess any tryptamines is fair game for self-treatment of CH as long as we know what we're getting into.
  23. Hey Par, good update. The nocturnal thing has me really baffled, it seems like you're getting some relief during the day, yet still have the nocturnal hits. Strange. As for the correlation between diabetes and CH, on the surface, blood sugar shouldn't have anything to do with your attacks. At least not in the classical definition of what CH is. Personally, I work off of a totally different theory of what causes CH, it's not a popular theory, but in my world, your diabetes would have an impact on your CH (could be positive or negative, really. . .depending on whether it's a stressor for you o
  24. Also good points. All three of those studies, and especially the 2nd and 3rd, identify activation/abnormalities in the hypothalamus DURING AN ATTACK, even in the third where they induced a "mild NTG headache" in episodics who were out of cycle. An attack is an attack. So in my opinion, saying there is unusual hypothalmic activity during an attack is like saying we experience lacrimation during an attack. Of course we do. Show me a measurable difference in the hypothalmi of CHers vs. non-CHers, and I'll start to believe that there is a physical cause. And then we can laser that sucker out and b
  25. I love this thread, honestly. These are the types of discussions we should have as a patient community. We all have it, now what IS it? Alleyoop, thanks for the book suggestions. I have put them on my list. ANother one I'll add, it's entertaining as hell and it's a must for anybody interested in brain science: "The Tale of the Dueling Neurosurgeons" by Sam Kean. It's like a PhD-level education in neurology, but told through stories of people throughout history who have suffered strange and specific brain injuries. Really an awesome read. Anyway, I think the main point any of us adventurou
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