Triptamine Posted December 22, 2016 Share Posted December 22, 2016 I take benzodiazepines daily. I am physically dependant on them. I can't stop suddenly or I experience serious withdrawal. My question is will this medication interfere with treating my cluster headaches with psilocybin. Thank you. Edited spelling. Quote Link to comment Share on other sites More sharing options...
Pebblesthecorgi Posted December 22, 2016 Share Posted December 22, 2016 Benzos as a class are metabolized in the liver but use a different enzyme system than psilocybin. But with all meds if they are used used regularly and in increasing doses one can not predict the effect on overall liver metabolism so caution is warranted. In the central nervous system benzos act on GABA receptors while psilocybin is thought to be largely serotonin. Benzos are often used to treat agitation from a bad trip. Mixing meds regardless of theoretically safety is a concern so caution and low doing is prudent. It might be wise to find a program to safely decrease dependence. Quote Link to comment Share on other sites More sharing options...
Caddgirl2003 Posted December 27, 2016 Share Posted December 27, 2016 Everything is different for everyone. My husband is 48 and have been getting these for 20 years. When he isn't getting them, once in awhile he will take a 0.5 MG klonopin of mine to help sleep. Now he has another "seasonal wave of headaches," if you will, he said it was a trigger for the headaches. He can't take a year vicodin either. I wonder if him having his wisdom teeth out and using the vicodin may have started this session. Best wishes to you! This is almost the worst curse. Quote Link to comment Share on other sites More sharing options...
CHfather Posted December 27, 2016 Share Posted December 27, 2016 The anesthetics used in most dental work, such as Xylocaine, contain epinephrine, which is a CH trigger for many -- if not most, or even all -- people. So my guess would be that that's what it was, probably not the Vicodin. I know of a couple of people in whom epi triggered not just attacks, but whole cycles. For future reference, Prilocaine seems not to cause bad effects. I so wish there was a way to get this information out to everyone with CH, since dental work so often creates so much misery. Quote Link to comment Share on other sites More sharing options...
Pebblesthecorgi Posted December 28, 2016 Share Posted December 28, 2016 Prilocaine is in the same chemical class as lidocaine which is a chemical group called amides. Prilocaine is a bit lipophilic and similar to lidicaine. Lipids are fat and the brain is mostly fatty molecules so any med that is attracted to fat (lipophilic) will hang out in the brain longer. The epinephrine in local anesthetics is there for two reasons. It constricts the blood vessels which decreased bleeding at the operative site and lets the anesthetic hang around longer for pain control. I suspect its the concetration of epinephrine that is troublesome buy since it is a strong vasoconstrictor the effect must be secondary. There are alternatives to amides in local anesthetics which are esters and every dentist knows this. Just tell them you are sensitive to esters and they will use the alternative. Quote Link to comment Share on other sites More sharing options...
CHfather Posted December 28, 2016 Share Posted December 28, 2016 Additionally . . . . Several people have said that they had dental work with "laughing gas" (nitrous oxide) without any cluster incidents. One person reported that he thought the "laughing gas" had triggered an attack. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.