Psilocybin works

[Lizzie Hall]

I have been in remission for at least 9 years by using the mushroom cure. People said back that when someone finds help; they don't go on these forums anymore.

It took me 3 times; so don't give up. You don't take enough to trip,just a little bit relaxed.

[bwunk]

I am guilty of using this site for tips on the psilocybin prevention. And it has worked so far for me, I am headache free for TWO YEARS!!.   But when it started working i stopped coming here dailey, i am gonna change that.  

[Dave Horton]

Is there a certain strain that works better than others?

[eileenbunny]

For most people, mushrooms are not a cure. They are a treatment. We don't know as much about them for migraine as we do for cluster. There has not been a strain that has been identified to be better than others. Find one where you understand dosing and try following the busting protocol to see if it works. You can always adjust.

[Serenity]

Hi @Lizzie Hall I'm currently microdosing MM, and it's working like a charm on many levels, except the migraines. That's why I'm thinking about going all in, but it's hard to find others that tried this, too (a lot of stories about CH, but not migraines). So, I was very glad to read your post, and I would like to ask you about how you did it:

How much? How often? Did you have slapbacks? Did you take triptans before/after?

Every information I can get is highly appreciated <3

[Kevin Kelly]

I too am looking for more information on the "mushroom cure" as you call it or treatment as someone else mentioned. I have tried posting and asking for general information, but so far only one person has responded to me. I have had migraines since 2001 due initially to a spinal fluid leak. I don't have cluster headaches, and my leaks have been sealed at Duke University Hospital in NC, but I'm still suffering, possibly due to a pain cycle that I've been in for so long. My brain just thinks I'm not safe, so it continues to send pain signals to my nervous system. Have seen many of the best neurologists on the east coast and tried many medications but never mushrooms. Would really appreciate any basic information from someone with migraines who has tried mushrooms and received a benefit. I'm reading some of the other posts trying to glean information and create a plan of action, but as a newbie, it's difficult to figure out where to start. How did you all get started? Do I just have to read more and teach myself? Would really appreciate some input or guidance. This forum was suggested to me by my neurologist who felt that mushrooms might help me, so I'm determined to try them. Just not sure how to go about it yet. Thanks in advance

[Craigo]

On 11/23/2025 at 5:25 AM, Kevin Kelly said:

I too am looking for more information on the "mushroom cure" as you call it or treatment as someone else mentioned. I have tried posting and asking for general information, but so far only one person has responded to me. I have had migraines since 2001 due initially to a spinal fluid leak. I don't have cluster headaches, and my leaks have been sealed at Duke University Hospital in NC, but I'm still suffering, possibly due to a pain cycle that I've been in for so long. My brain just thinks I'm not safe, so it continues to send pain signals to my nervous system. Have seen many of the best neurologists on the east coast and tried many medications but never mushrooms. Would really appreciate any basic information from someone with migraines who has tried mushrooms and received a benefit. I'm reading some of the other posts trying to glean information and create a plan of action, but as a newbie, it's difficult to figure out where to start. How did you all get started? Do I just have to read more and teach myself? Would really appreciate some input or guidance. This forum was suggested to me by my neurologist who felt that mushrooms might help me, so I'm determined to try them. Just not sure how to go about it yet. Thanks in advance

Hey Kevin. To my knowledge there is no specific migraine busting protocol. FunTimes offered a solid reply to your earlier post on the general board and the key information regarding the process is on the following page.

https://clusterbusters.org/resource/alternative-treatments/#busting

You might find the Yale psilocybin migraine study useful to look at as the dose they used somewhat correlates to the Cluster Busters range, if I am correct They gave 0.143 mg/kg of pure psilocybin and when you apply a conversion factor for Psilocybe cubensis potency (roughly 0.8 percent psilocybin by dry weight with variance as to strain, when it was picked and even which part of the fruit) that works out to the same content found in about 1.5 g of dried cubensis - give or take, maybe a little less. The key difference is that the study used one single dose followed by a two-week observation period whereas cluster warriors traditionally repeat doses every five to seven days.

https://www.sciencedirect.com/science/article/pii/S187874792301214X

My personal thoughts - start a bit lower than the typical 1.5g dried cubensis mushroom to get accustomed to the feeling, I quite enjoy the euphoria and introspection and find it doesn’t last too long before I’m hungry and tired. 

For what it’s worth a quick scour of the literature found the most recent paper with title including "migraine" "psilocybin" - a case report of a single male migraineur in his 30s whom used psilocybin alongside otc pain relief at 1.2g dried as an acute treatment with greater reported efficacy than pain relief alone.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10561985/

You may find another popular treatment option used by members of the CH community worth a look-in whilst you are here, the Vitamin D3 Anti-Inflammatory Regimen. You’ll find the information here or collated by myself and Pete Batcheller over at www.vitamindregimen.com

I would say that given a sensible approach and applying the protocols as per the guides, IMHO both of these patient led avenues are generally safe and worth investigating - in any event a walk down the unknown path can cause a bit of anxiety so good luck as you navigate - I remember being nervous as heck in 2015 when I started the D3 regimen against my Doctors best recommendations and yet 8 days later things took a turn for me, I cried like baby, hugged wifey and got my life back - 10 years later I think there is still a part of me that is in disbelief that it actually worked and I only wish that could be the same for everyone.

Whilst I have had success with D3, I found a penchant in the hobby of mycology, I have a wonderful big laminar flow hood that takes up our spare room and all the mycological tools to grow wild and wonderful varieties from "cubes" to turkey tails and beyond - and have done so over the years with great success, it is a fascinating and wildly fulfilling hobby with lots of highs (no pun intended) and lows of the process. It isn't a fast thing either and after weeks, sometimes months of cultivation to have a fruiting body appear overnight is awesome or to awake one morning after the same period to find dreaded trichoderma has destroyed all your hard work is devastating! Still, well worth it for the journey and knowledge learned!

Were there any specific questions you wanted answers to, I’m sure we will do our best to help. Best wishes to you.

Cheers, Craig.