TRPV1 - Whatever that is

[CHfather]

I have NO idea what this means or why it's important, but it's a new study so I figure it's important to some researchers someplace (or maybe to Ricardo or some other very dedicated thinkers here).  http://www.ncbi.nlm.nih.gov/pubmed/22289052?dopt=Abstract

Last sentence:  "Our findings that TRPV1 is inhibited by the specific antimigraine drug sumatriptan, and that TRPV1 channels are functional in neurons projecting to cerebral dura suggests a specific role for these channels in migraine or cluster headache."

[spiny]

So, NO pepper??? :-?

[CHfather]

well, i think i read in a different medical journal that based on careful study, most scientists were now recommending against poking pepper into one's own eye , but beyond that, i have no idea what the pepper is doing in this abstract. testing some circuitry or something, it seems.

[Ricardo]

This is really interesting....I had never heard of this before...Came across a couple of other related articles--

http://www.sciencedebate.com/science-blog/how-headache-tree-causes-cluster-headache-and-migraine

This one I found really interesting as it hits on the "Tumor Necrosis Factor" thing I was talking about.  "Our results suggest that increased levels of TNF[ch945] and its receptors under pathological conditions may have considerable impact on the function of spinal cord TRPV1 receptors"

http://www.jneuroinflammation.com/content/7/1/49

Seeing as how the hallucinogens lower TNF levels, you would expect the TRPV1 levels to lower too...(maybe )

Good find!  I'm betting this is the tip of the iceberg...

-Ricardo