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t'a', all that they basically mean to me is that people might be getting closer to understanding the genetic basis of CH, which I figure could be a good thing.  I thought it was at least mildly interesting, for example, that they looked at the Clock gene, which is related to circadian rhythms, and apparently didn't find anything abnormal there. 

And the two places they did find issues -- "mutations in the ADH4 gene and a novel rearrangement involving NRXN3 gene might be related to CH in a subset of cases" -- are both related to processing that common CH trigger, alcohol.  NRXN3: "Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence" (http://www.ncbi.nlm.nih.gov/gene/9369).  ADH4: "Scientists knew that the human ability to metabolize ethanol—allowing people to consume moderate amounts of alcohol without getting sick—relies on a set of proteins including the alcohol dehydrogenase enzyme ADH4." (http://news.sciencemag.org/biology/2014/12/ability-consume-alcohol-may-have-shaped-primate-evolution  (This ADH4 connection was previously recognized: http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2009.01569.x/full)

For an interesting story about ADH4 and your countryman (??) Ozzy Osbourne ("He had a change on the regulatory region of the ADH4 gene, a gene associated with alcoholism, that we've never seen before"), see http://abcnews.go.com/Health/Wellness/genetic-mutations-ozzy-osbourne-party-hard/story?id=12032552

All this is just chatter from me in terms of actual meaning of the study -- I just think that its existence is a good thing.

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  • 2 weeks later...
mildly interesting

  Thanks for your informative and entertaining links Chfather.

Poor old Ozzy. Even though he seems to have parked his caravan on a different planet he still gets my vote for inclusion onto our honours list/hall of fame just for being the original “headbanger”


Unfortunately his son Jack has been diagnosed with MS, and suffers“agonising migraines”

Dailymail -



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for the uneducated ie me what does these report mean

Hey Tangerinearmy, I'm thrilled that you are interested.

Reading this paper “literally” -

It suggests - “mutations in the ADH4 gene”

Does this mean we're “Mutants”!

It also states - “a novel rearrangement involving NRXN3 gene”

Does that make us noveltee's or novelties??

Published research in this field follows two lines, this ADH4 line and the HCRTR line.

Here is a good read on HCRTR

Frontiers in Neuroscience orexin/hypocretin receptor pharmacogenetics


Here is an overall view -

The journal of Headache and Pain

Genes and primary headaches: discovering new potential therapeutic targets


Here Professor Peter Goadsby explains the importance of finding a “Biomarker”

WhatÂ’s on the horizon for headaches

Ob.Gyn. News Digital Network


What this field of research might also suggest is that “we” (royal we) could be “related”


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