shocked Posted March 12, 2015 Share Posted March 12, 2015 Molecular Analysis of Cluster Headache Clinical Journal of Pain: January 2015 http://journals.lww.com/clinicalpain/Abstract/2015/01000/Molecular_Analysis_of_Cluster_Headache.8.aspx novel rearrangement involving NRXN3 gene might be related to CH in a subset of cases. shocked Quote Link to comment Share on other sites More sharing options...
CHfather Posted March 12, 2015 Share Posted March 12, 2015 shocked, Thanks so much for this and all the other interesting and valuable information you post here. Very much appreciated. Quote Link to comment Share on other sites More sharing options...
tangerinearmy Posted March 13, 2015 Share Posted March 13, 2015 for the uneducated ie me what does these report mean Quote Link to comment Share on other sites More sharing options...
CHfather Posted March 14, 2015 Share Posted March 14, 2015 t'a', all that they basically mean to me is that people might be getting closer to understanding the genetic basis of CH, which I figure could be a good thing. I thought it was at least mildly interesting, for example, that they looked at the Clock gene, which is related to circadian rhythms, and apparently didn't find anything abnormal there. And the two places they did find issues -- "mutations in the ADH4 gene and a novel rearrangement involving NRXN3 gene might be related to CH in a subset of cases" -- are both related to processing that common CH trigger, alcohol. NRXN3: "Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence" (http://www.ncbi.nlm.nih.gov/gene/9369). ADH4: "Scientists knew that the human ability to metabolize ethanol—allowing people to consume moderate amounts of alcohol without getting sick—relies on a set of proteins including the alcohol dehydrogenase enzyme ADH4." (http://news.sciencemag.org/biology/2014/12/ability-consume-alcohol-may-have-shaped-primate-evolution (This ADH4 connection was previously recognized: http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2009.01569.x/full) For an interesting story about ADH4 and your countryman (??) Ozzy Osbourne ("He had a change on the regulatory region of the ADH4 gene, a gene associated with alcoholism, that we've never seen before"), see http://abcnews.go.com/Health/Wellness/genetic-mutations-ozzy-osbourne-party-hard/story?id=12032552 All this is just chatter from me in terms of actual meaning of the study -- I just think that its existence is a good thing. Quote Link to comment Share on other sites More sharing options...
Psiloscribe Posted March 14, 2015 Share Posted March 14, 2015 Thanks Shocked, you're the man!! And thanks to CH Father for the synopsis. Yes all of this genetic work will lead to our best chance at a cure and it all seems to be picking up speed and more work around clusters. Good stuff Bob Quote Link to comment Share on other sites More sharing options...
shocked Posted March 26, 2015 Author Share Posted March 26, 2015 mildly interesting Thanks for your informative and entertaining links Chfather. Poor old Ozzy. Even though he seems to have parked his caravan on a different planet he still gets my vote for inclusion onto our honours list/hall of fame just for being the original “headbanger” http://en.wikipedia.org/wiki/Headbanging Unfortunately his son Jack has been diagnosed with MS, and suffers“agonising migraines” Dailymail - http://www.dailymail.co.uk/tvshowbiz/article-2510982/Jack-Osbourne-suffers-vision-problems-continues-DWTS-rehearsals.html shocked Quote Link to comment Share on other sites More sharing options...
shocked Posted March 26, 2015 Author Share Posted March 26, 2015 for the uneducated ie me what does these report mean Hey Tangerinearmy, I'm thrilled that you are interested. Reading this paper “literally” - It suggests - “mutations in the ADH4 gene” Does this mean we're “Mutants”! It also states - “a novel rearrangement involving NRXN3 gene” Does that make us noveltee's or novelties?? Published research in this field follows two lines, this ADH4 line and the HCRTR line. Here is a good read on HCRTR Frontiers in Neuroscience orexin/hypocretin receptor pharmacogenetics http://journal.frontiersin.org/article/10.3389/fnins.2014.00057/full Here is an overall view - The journal of Headache and Pain Genes and primary headaches: discovering new potential therapeutic targets http://www.thejournalofheadacheandpain.com/content/14/1/61 Here Professor Peter Goadsby explains the importance of finding a “Biomarker” What’s on the horizon for headaches Ob.Gyn. News Digital Network http://www.obgynnews.com/home/article/video-whats-on-the-horizon-for-headaches/6161043b663f24f639bec4d8b2070b49.html What this field of research might also suggest is that “we” (royal we) could be “related” shocked Quote Link to comment Share on other sites More sharing options...
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