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Vitamin d


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Hey Scott,

Yes, 19 ng/mL is low when it come to serum 25(OH)D3 serum concentrations.  The normal reference range for this lab test is 30 to 100 ng/mL.  Vitamin D experts will tell you any serum concentration below 40 ng/mL is low.  Data collected from the online survey of CHers taking the anti-inflammatory regimen with at least 10,000 IU/day vitamin D3 plus the cofactors are illustrated in the baseline normal distribution curve for 25(OH)D3 lab results before starting this regimen.


As you can see, your 25(OH)D3 serum concentration falls under this curve.  As a CHer, you need to elevate and maintain your 25(OH)D3 serum concentration between 80 and 100 ng/mL in order to enjoy a CH pain free state.  You can find the anti-inflammatory regimen CH preventative treatment protocol at the following link.  Discuss it with your PCP/GP or neurologist then follow this treatment protocol and you'll elevate your 25(OH)D3 to a therapeutic level that will keep you CH pain free:


I've updated this treatment protocol by suggesting the supplements illustrated in the following photo.


You can order all of the above from amazon.com if you live in the US.  If not, you may need to order most of these same brands from iherb.com.  I've listed links at amazon and iherb.com below for each item.

A.    Bio-Tech D3-50, 100 water soluble 50,000 IU capsules



B.    Kirkland Adult 50+ Mature Multi



C.    Nature Made Extra Strength 400 mg Magnesium


https://www.iherb.com/pr/Nature-Made-Magnesium-Extra-Strength-400-mg-60-Softgels/76915. Order three (3)

D.    Nature Made Omega-3 Fish Oil Liquid Softgels



E.    LifeExtension Super K with Advanced K2 Complex

https://www.amazon.com/Life-Extension-Advanced-Complex-two-pack/dp/B00ATD4JKA/ref=sr_1_6?keywords=LifeExtension+Super+K+with+Advanced+K2+Complex&qid=1578005023&s=hpc&sr=1-6 Order two for a year's supply

https://www.iherb.com/pr/Life-Extension-Super-K-90-Softgels/90368 Order four bottles for a year's supply




We've made some adjustments to the treatment protocol available at the link above.  I say "We" as none of this would have been possible without the participation of thousands of CHers here at Clusterbusters and CH.com over the last 10 years.  In a very real sense, this is your regimen and treatment protocol.  Direct feedback from CHers taking this regimen is so valuable.  For example, this feedback indicates the efficacy of this regimen increases with time and higher serum concentrations of 25(OH)D3 due to higher daily maintenance doses of vitamin D3.

These protocol adjustments have been simple, yet effective.  When I first started posting about the efficacy of this regimen in December of 2010, it was one size fits all with 10,000 IU/day vitamin D3 plus the cofactors.  The first adjustment involved starting this regimen with a 2-Week or 4-Week accelerated vitamin D3 loading schedule to elevate serum 25(OH)D3 more rapidly and achieve a favorable response more rapidly.  Over the next two years that loading schedule evolved to a 12-Day loading schedule taking 50,000 IU/day vitamin D3 for 12 days.  It was just as effective and took less time to reach a therapeutic effect.

I attribute the increase in the raw efficacy of this regimen and CH preventative treatment protocol to the switch to the Bio-Tech D3-50 and the 12-Day accelerated vitamin D3 loading schedule.

My analysis of survey data through the end of 2018 indicated the mean 25(OH)D3 serum concentration for Episodic CHers experiencing a favorable response to the anti-inflammatory regimen was 80 ng/mL while the mean 25(OH)D3 serum concentration for Chronic CHers experiencing a favorable response to the anti-inflammatory regimen was 90 ng/mL.  Clearly, one size does not fit all... Accordingly, I've made the following changes to the vitamin D3 dosing strategy regarding the target 25(OH)D3 serum concentration ranges and accelerated vitamin D3 loading dose duration ranges.

Episodic CHer Target:  80 to 100 ng/mL - Load at 50,000 IU/day for 12 - 14 days

Chronic CHer Target:  90 to 120 ng/mL - Load at 50,000 IU/day for 14 - 16 days

Migraineur Target:  100 to 140 ng/mL - Load at 50,000 IU/day for 16 - 18 days

It's important to understand these suggested 25(OH)D3 serum concentration target ranges and loading schedules are starting points for the average CHer.  Many of us (like me) will require a higher 25(OH)D3 serum concentration, a longer period of loading at 50,000 IU/day and a higher maintenance dose to experience and maintain a CH pain free response.  

At the completion of these loading schedules reduce the vitamin D3 intake to an initial maintenance dose of 10,000 IU/day with the oil-based liquid softgel vitamin D3 formulations or if you're taking the suggested Bio-Tech D3-50, you'll need to take one (1) of these 50,000 IU water soluble vitamin D3 capsules a week.  Doing the math, that works out to an average dose of 7,140 IU/day.  Given the higher bioequivalence of the D3-50, this should be sufficient for most CHers.  Changing the dose is a simple matter of adding or subtracting a day or more between doses.

Take care and please keep us posted.

V/R, Batch

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XXX, Noticed you didn't mention large doses of Vitamin C. And I also take a Cal Mag product since the calcium helps

with D3 absorption. I take 2800 iu of liposomal (fat soluble) Vit C daily. BTW, these products are the best way to protect

your self from covid. After reading what you wrote about the D3 i'm going to increase from 5,000 to 10,000 it's daily.

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