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  1. Hey Sparklegirl, I remember getting hit 8 times/day. It was bad. See your PCP for assays of your serum 25(OH)D3, calcium and PTH (Parathyroid Hormone). It's a safe bet your serum 25(OH)D3 concentration is low < 30 ng/mL (75 nmol/L). If I'm correct, starting the anti-inflammatory regimen CH and MH preventative treatment protocol is prudent and the best way to get your CH under control. The following photo illustrates the supplements by brand and doses I take and suggest to other CHers. It helps to start this protocol by loading vitamin D3 to elevate serum 25(OH)D3 more rapidly. The loading dose I've used is two of the 50,000 IU Bio-Tech D3-50 capsules/day plus 0.5 mL/day of the Nutrasal Micro D3 nano emulsion taken sublingual (under the tongue for two minutes without swallowing). This brings the loading dose to 140,000 IU/day and It's taken for five (5) days for a total of 700,000 IU of vitamin 'D3 then drop back to an initial maintenance dose of 100,000 IU/week of the Bio-Tech D3-50. It's also helpful to double the magnesium dose by taking 400 mg with breakfast and 400 mg with the evening meal. This provides 12 hours and 12 feet GI tract separation between doses and that helps avoid osmotic diarrhea. See your PCP in 30 days for another round of assays for serum 25(OH)D3, calcium and PTH. Your 25(OH)D3 serum concentration should be up around 80 to 100 ng/mL (200 to 250 nmol/L). If the CH beast is still jumping ugly after completing the above loading schedule, I would start the antihistamine Full Monty. This is a clutch of supplements with antihistamine properties that includes 2 to 3 grams/day Turmeric (Curcumin), Quercetin, Resveratrol, Omega-3 (EPA and DHA) fish oil. It also includes 8 grams/day viramin C, 5 mg/day Melatonin (taken at bedtime), 250 mcg Selenium and 1000 mg/day NAC (N-Acetyl Cysteine). Stay at this dose for 5 days then drop the dose of the first four supplements to one gram/day. Take care and please keep us posted. V/R, Batch
  2. Snafu, I'm just a 78 year old retired Navy fighter pilot so I need to keep the concept of detoxing from the COVID-19 mRNA biologics simple enough to get my head around it. There's more than enough medical evidence from several studies linking the mRNA biologics to injuries of the innate and adaptive immune systems. Accordingly, it appears taking nutritional supplements that boost immune system (white blood cell) functions is a prudent course of action. If you look at the available COVID-19 mRNA vaccine detox protocols, you'll see most include vitamin C, vitamin D3 and its cofactors. To my way of thinking, that makes the anti-inflammatory regimen and treatment protocol a good choice as an mRNA biologic detox. The really exciting data from Dr. Michael Holick's study is the vitamin D3 dose dependency in gene expression among the immune system's white blood cells. Basically, more is better when it comes to the vitamin D3 dose as higher doses increase the number of genes activated. The only caveat is we need to keep the serum calcium concentration within its normal reference range and not depress the PTH concentration below its low normal level. This requires 2.5 liters of water a day, avoidance of high calcium foods like all dairy products and frequent assays for serum 25(OH)D3, calcium and PTH. The next question is how much vitamin D3 is enough? The answer, based on my experience over the last three years, is the dose that elevates serum 25(OH)D3 up to around 150 ng/mL. There's no single answer so the basic approach is load and test. After that, the best indication of efficacy is an absence of viral infections. That can take months or longer. Take care and please keep us posted. V/R, Batch
  3. Hey Snafu, Great question. For starters, the Wuhan Corona virus is now endemic in the population like influenza. As coronavirus mutate rapidly, it's very likely healthy innate and adaptive immune systems will neutralize one mutant variant and develop the specific antibodies for that strain. However, the next mutant variant may be sufficiently different in its genetic makeup to avoid detection by the antibodies developed for the previous variant and this results in yet another infection. This is likely what you're experiencing. There's an excellent 2019 gene activation study by Dr Holick and colleagues. This a landmark study as it shows a significant dose response in gene activation in 3 groups of healthy volunteers who took varying amounts of vitamin D daily for 6 months. The doses used in the 3 groups were 600, 4000, and 10,000 units a day. https://www.nature.com/articles/s41598-019-53864-1. "There was a dose-dependent 25(OH)D alteration in broad gene expression with 162, 320 and 1289 genes up- or down-regulated in their white blood cells (our immune systems), respectively.” This is great science. It makes me wonder how many genes would have been activated with 20,000, 30,000 units or more a day of vitamin D3 for 6 months. I don't have the gene activation counts for vitamin D3 doses of 20,000 to 30,000 IU/day or higher, but I do have first hand end results. Over the last 30 months, I've averaged a vitamin D3 dose around 30,000 IU/day with a few weeks as high as 80,000 IU/day to remain CH pain free during periods of high pollen and mold spore counts. This much vitamin D3 elevated my serum 25(OH)D3 concentration up to around 150 ng/mL (375 nmol/L) and at a couple points, as high as 270 ng/mL (675 nmol/L). The net results were clear. I remained CH pain free and I also remained asymptomatic to Wuhan Coronavirus infections by the alpha through omicron 2 and 3 mutant variant exposures. This doesn't mean I wasn't infected. What was likely happening was my innate immune system's killer T-Cells were activated beating back the coronavirus infection and stopping viral replication before it reached the point of emerging symptoms (sore throat, temperature, malaise, etc.). There's a great chart by Dr. Paul Marik, MD, Chief of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, illustrating the time line from inoculation by the Wuhan Coronavirus. As you can see, viral incubation and replication can be in progress with an innate immune system, naive to a new viral strain and not boosted by vitamin D3, for up to five days before symptoms present/become evident. In my case, its likely my T-Cell activation has been occurring within a couple days of inoculation by a new Wuhan Coronavirus variant. Since the Wuhan Coronavirus landed in the US, I've also taken larger doses of vitamin C (8 grams/day in divided doses) as an antiviral supplement. Zinc has been part of the anti-inflammatory regimen and treatment protocol since I developed it in 2010. I added Quercetin in April of 2020. Quercetin is a zinc ionophore that enables water soluble zinc ions to pass through the fatty acids that make up cell membranes to stop viral replication. Had Ivermectin been available, I would have taken it as a prophylaxis. Accordingly, the message here should be clear. Higher vitamin D3 doses resulting in an elevated 25(OH)D3 serum concentration around 150 ng/mL, coupled with vitamin C, zinc and Quercetin have enabled my innate and adaptive immune systems to keep me asymptomatic to Wuhan Coronavirus infections. The bottom line, see your PCP for assays of my serum 25(OH)D3, calcium and PTH. As long as your calcium serum concentration is within its normal reference range, I would load vitamin D3 for 6 days at 100,000 IU/day (2.5 mg/day) then drop back to a maintenance dose at least 5000 IU/day higher than usual. Test again in two weeks with assays for serum 25(OH)D3, calcium and PTH. You're looking for an initial target 25(OH)D3 serum concentration around 150 ng/mL (375 nmol/L) without going bust on serum calcium concentration too high or PTH serum concentration too low. In my opinion, for what it's worth, this is a prudent course of action for CHers who have had one or more COVID-19 mRNA vaccinations. There is sufficient evidence from properly structured, peer reviewed RCTs that each mRNA vaccination results in progressively weaker immune systems as evidenced by significant increases in diseases and medical conditions normally kept in check by healthy immune systems. Take care and please keep us posted. V/R, Batch
  4. Fauci Resigns https://www.reuters.com/world/us/fauci-step-down-president-bidens-chief-medical-adviser-2022-08-22/ It's going to take some time to prove, but the COVID-19 Coronavirus and mRNA biologic jabs are contributors to CH. Take care and make it a good day. V/R, Batch
  5. Just to make sure. Ergocalciferol is vitamin D2 and Cholecalciferol is vitamin D3. If you can confirm you have Cholecalciferol, you're good to go. That said, Ergocalciferol is usually only available by prescription.
  6. Hey Snowflake, Thanks for the reply and photos. Yes, I remember our WhatsApp call. Please see your PM InBox for more details. Getting off the antidepressants is important. They do more harm than good. The calciferol you're taking is actually vitamin D2 not D3. Calciferol is the generic name for vitamin D2. The Rx for calciferol was the hint this was the case and the photo you sent of the pill bottle confirmed my suspicion. We've found that vitamin D2 is less effective in preventing CH, but don't let this stop you from loading with calciferol as it is far better than no vitamin D at all. As vitamin D3 is chemically very similar to vitamin D3, it also occupies the VDR (Vitamin D Receptor) preventing cutaneous vitamin D3 your skin produces from being helpful. You should be able to buy the Bio-Tech D3-50 through iherb.com. If not, you can go directly to Bio-Tech Pharmacal at the following link. https://www.pureformulas.com/brand/bio-tech-pharmacal.html?cawelaid=530005240004320953&catrk=spfid-70&caagid=2399212863&catci=kwd-20815491185%3Aloc-190&capcid=79783491151498&cadevice=c&accountid=53000524 The sooner you switch to the Bio-Tech D3-50 the better as the 25(OH)D2 will stay in blood serum for several months before it's finally replaced by 25(OH)D3. I would also switch to magnesium oxide or magnesium glycinate as many people find the magnesium citrate you're taking acts as a potent laxative. The rest of your supplements look good. Take care and please keep us posted. V/R, Batch
  7. Hey Abyss. Howz the head? Are you CH pain free? We don't know your actual 25(OH)D3 serum concentration as the assay method used by your present lab tops out at a maximum measurement of 140 ng/mL. Even it it's 150 to 160 ng/mL it is just fine and no worry. Have your PCP write the next set of lab orders for Quest Diagnostics nearest your home and the QuestAssurD (D2, D3) assay method that measures combined D2, D3 up to 512 ng/mL. That said, your PTH looks about right, but we still need your serum calcium assay to make sure it is still within its normal reference range. One more day loading at 140, 000 should be okay then drop back to 100,000 IU/week with the Bio-Tech D3-50 (Save the Micro D3 for loading) and wait 10 days for another round of assays for your serum 25(OH)D3, calcium and PTH. We need all three of these assays to get a better understanding of your situation. Take care and please keep us posted. V/R, Batch
  8. Hey Snowflake, The Micro D3 is available from amazon as is the Bio-Tech D3-50. Some countries will not allow amazon to sell these items as their dose exceeds a stupid limit made by Big Pharma. There's 2000 IU per drop and 20 drops in 0.5 mL. Were do you live? Take care and please keep us posted. V/R, Batch
  9. Hey Snowflake, Thanks for the update. Off hand your 25(OH)D3 response is still low. This can be due to poor absorption in the GI tract. One way of finding out if this is the problem is to order some Micro D3. This is a nano emulsion of vitamin D3 that's taken sublingual (under the tongue) without swallowing for at least two minutes. The dose I use is 0.5 mL (40,000 IU/day). When taken sublingual, the vitamin D3 bypasses the GI tract and passes directly into the bloodstream under your tongue. Doing this sublingual dose for a week should jack your serum 25(OH)D3 up by at least 20 ng/mL (50 nmol/L). Can you shoot me a photo of the label on your Rx vitamin D3? Take care and please keep us updated. V/R, Batch
  10. Hey Abyss, My bird dog alerts me when posts or PMs are made to me or about vitamin D3 here at Clusterbusters so I've read your post and assays for 25(OH)D3. Off hand I'd say you're headed in the right direction given you were clearly vitamin D3 deficient. The following chart from the study of CHers taking vitamin D3 and cofactors to control and prevent their CH tells the story. I've been running this study continuously since December of 2011. As you can see, you were clearly under the black baseline normal distribution curve on the left. Just be careful with the loading dose of 100,000 IU/day of Bio-Tech D3-50 and 0.5 mL (40,000 IU/day) of the micro D3 taken sublingual (under the tongue) for 5 days. My dear friend Henry Lahore who runs the VitaminDWiki.com web site calls this a "Cluster Balm" as it totals 700,000 IU of vitamin D3. In military parlance, this is a MOAB (Mother Of All Bombs) when taken as total loading dose. Accordingly, you need to use the Shoot - Look - Shoot -Look doctrine when loading with the Cluster Balm as it is very important to assess the effects of a loading dose like this before loading any further. In short you load for five days using the Cluster Balm then drop back to a maintenance dose of 50,000 IU to 100,000 IU per week, while waiting for a week to 10 days for your 25(OH)D3 to equalize, then see your PCP for lab assays of your serum 25(OH)D3, calcium and PTH to assess the situation and its effects on your calcium homeostasis. If your 25(OH)D3 is still low < 80 ng/mL and serum calcium is still within its normal reference range, load again then test. See your PCP for these assays and have her specify the following from Quest Diagnostics in her lab orders: 25(OH)D3 - She should order the Quest Diagnostic assay method called the QuestAssureD™ 25-Hydroxyvitamin D (D2, D3). Test Code 92888, CPT Code: 82306. This LC-MS/MS assay method can measure serum 25(OH)D2 and 25(OH)D3 up to 512 ng/mL https://testdirectory.questdiagnostics.com/test/test-detail/92888/questassured-25-hydroxyvitamin-d-d2-d3?cc=MASTER The lab order must specify this assay by Name and Test Code as Quest has other assays for 25(OH)D3. She should also specify the Quest Diagnostics serum calcium and PTH (Parathyroid Hormone) assays as: Parathyroid Hormone (PTH) Intact and Total Calcium, Test Code: 8837, CPT Codes: 83970, 82310. https://testdirectory.questdiagnostics.com/test/test-detail/8837/pth-intact-and-calcium?cc=MASTER These three assays taken in concert, provide a very good assessment of your calcium homeostasis in action. Regarding the warning on your lab results that reads: "Values > 80 ng/mL may be associated with toxicity" Don't believe it. This is BS and a clear case of Big Pharma propaganda to discourage people from taking higher doses of vitamin D3. I'm a 1944 model and I've run my 25(OH)D3 more than three times this high up to 273 ng/mL yet I'm still here in good working order and good health with no hypercalcemia, a.k.a., Vitamin D Intoxication/Toxicity as indicated in the following 5-year chart of my assays for serum 25(OH)D3, calcium and PTH. Regarding your doctors scoffing at vitamin D3 therapy. This is understandable and not her fault. She was short sheeted in medical school with a curiculum devoid of nutritional medicine. As Big Pharma and their paid political hacks in Big Government fund most medical schools with lavish grants (using our tax dollars), they're taught there's a pill for every ill. In general, 9 out of 10 pharmaceutical treatments address only the symptoms, not the cause of a disorder. And when these treatments have side effects, Big Pharma has another pharmaceutical to treat the side effects. It's no wonder that most people over 50 are actually suffering from polypharmacy - Simultaneous use of too many pharmaceuticals. That said, I'm not a doctor. I don't diagnose, prescribe or treat people. I'm just are retired old Navy fighter pilot. What I do is provide information outreach with the best available information on the benefits of good health and a strong immune system made possible by taking optimum doses of vitamin D3 and its cofactors. What CHers and Migraineurs do with this information is up to them and their PCP. Take care and please keep us posted. V/R, Batch
  11. Hey Snowflake, You should be drinking 2.5 liters of water a day. You should also double the magnesium dose while loading from 400 mg/day to 800 mg/day split 400 mg with breakfast and 400 mg with the evening meal. This provides 12 hours and 12 feet of GI tract separation between doses and this helps prevent osmotic diarrhea. Are you taking all the other cofactors daily? Do you have all the supplements for the Antihistamine Full Monty on hand: (Turmeric (Curcumin), Quercetin, Resveratrol, Omega-3, Vitamin C and Melatonin)? Still need some answers. Take care, V/R, Batch
  12. Hey Snowflake, You're having a wild ride so I suspect you're also battling inflammation likely from your immune system's response to allergens. That said, I have more questions than answers at this point. A drop in serum 25(OH)D3 from 71 ng/mL to 61 ng/mL in a month is about right if no vitamin D3 was taken. How many days between these two lab tests for 25(OH)D3? How much vitamin D3 did you take in loading doses during that period? Have you been taking the Bio-Tech D3-50 and if so, what was the dose? Was it 50,000 IU/week or higher? I need some answers before we can work out a plan of action. A little help please. Take care, V/R, Batch
  13. Shaun, Max vibes and prayers heading your way. Hugs, Pete
  14. Hey TTF, Sorry about the delay in responding. I'm on my annual fishing trip to Pelican, AK. Our house has no phone, TV or Internet access so I hike a quarter mile to the town library for WiFi access. Thi big Chinooks (King Salmon) are hitting as are the Halibut so I'm enjoying my vacation. There's nothing wrong with a vitamin D3 dose of 10,000 IU/day and the fastest way of building serum 25(OH)D3 is with a 50,000 IU/day loading dose for at least 12 days. That totals to 600,000 IU of vitamin D3 and that should elevate your serum 25(OH)D3 by 60 ng/mL on top of your baseline serum concentration. I'd shoot for a target 25(OH)D3 serum concentration range of 80 to 100 ng/mL We have also had a number of CHers respond to a collection of supplements with antihistamine properties I call the Antihistamine Full Monty. It includes 3 grams/day each of Turmeric (Curcumin), Quercetin, Resveratrol and Omega-3. It also includes 250 mcg/day Selenium, 5 mg/day Melatonin (taken at bedtime) and 8 grams/day vitamin C. You can also add 500 mg.day NAC. I buy the bulk powdered vitamin C in 1Kg bags and stir two level teaspoons in 8 oz of water then take sips all day until it's gone by bedtime. It tastes like unsweetened lemonade. You can taper the first four supplements to 2 grams/day after a week to 10 days fully CH pain free. I'd stay at 2 grams/day on the first four supplements for at least a month. Dealer's choice on tapering further. Tale care and please keep us posted. V/R, Batch
  15. Hey Justin, I just sent you a PM on loading. Check your PM InBox. Take care and please keep us posted. V/R, Batch
  16. https://vitamindwiki.com/High-Dose+and+Bolus+Dose+vitamin+D+safe+for+children+–+meta-analysis+April+2022 Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis. Summary "Thus, our findings suggest that vitamin D supplementation in the high-dose range of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to infants and preschool children to 6 years of age may be safe in both healthy children and in children with various diseases." Note: My daughter and Niece both followed the anti-inflammatory regimen treatment protocol taking 10,000 IU/day throughout their pregnancies. Their pregnancies and deliveries were flawless with three full term babies. These grand babies were bathed in maternal vitamin D3 from conception through breast feeding. They have T-Rex immune systems - They don't get sick. They're also budding Einsteins and Mensa candidates with exceptional neuromotor development. They've been taking vitamin D3 at 50 IU per pound of body weight per day since they stopped breastfeeding. Fred a.k.a., Winefred on the left was speaking fluent Hochdeutch (German) at age 3, attended pre-kindergarten at age 4 in Heidelberg, Germany where only German was spoken while my daughter was there on sabbatical. She came home from her first day of class and said the German kids don't speak German very well. Her bother Orrin in the middle is also bilingual. Emory Autumn on the right has become a charming and talented dancer. The 25(OH)D3 concentration in her cord blood at birth was 43 ng/mL. Take care, V/R, Batch
  17. For reference, the Coimbra Protocol (CP) was developed by Dr. Cicero Coimbra, MD, PhD, a neurologist in São Paulo, Brazil. He uses this protocol to treat his patients with MS and other autoimmune disorders and has a 95% MS remission rate. The following link will take you to a world map of CP trained doctors. There are five CP trained doctors here in the US. https://www.google.com/maps/d/viewer?mid=1fATZJUEhOsYYJdBY41h48FBkLaQ&ll=35.75118934523871%2C-97.08285860000004&z=4 The CP is very similar to the anti-inflammatory regimen treatment protocol for CH and Migraines with the following exceptions. The starting vitamin D3 maintenance dose in the CP is 1000 IU per Kg body weight per day. After that, the vitamin D3 dose is adjusted (up or down) to keep the parathyroid hormone (PTH) serum concentration in the low normal range. For a sleek rascal like me weighing in at 80 Kg, I would be starting the CP at a vitamin D3 maintenance dose of 80,000 IU/day. That’s 8 times the vitamin D3 dose taken by the average CHer following the anti-inflammatory regimen treatment protocol to control and prevent CH. Patients following thie CP must avoid calcium rich foods like dairy products and drink 2.5 liters of water a day to keep the serum calcium level within its normal reference range. This article is long and detailed so here’s the bottom line. Taking high-dose vitamin D3 (10,000 IU/day and much higher) is very safe as long as the protocols are followed with lab assays for serum 25(OH)D3, calcium and PTH.. Conclusions In summary, to our knowledge, our work provides the first long-term documentation of selected critical laboratory parameters during the application of the CP using a high-dose oral vitamin D3 in a broad spectrum of different autoimmune diseases, demonstrating that this procedure is well tolerated with respect to renal function and calcium metabolism. In terms of individualized treatment, we suggest to further use serum levels of PTH as biomarker for an individual response to vitamin D3, the individual ability to convert vitamin D to the active metabolite, the 1,25(OH)2D’s interaction with its receptor and the response elements and finally the differential supplementation with vitamin D3. In further studies, possible differences of the clinical outcome of CP treatment should be investigated. Take care, V/R, Batch
  18. The following study found no problems with high dose vitamin D3 in patients following the Coimbra Protocol. (CP) Safety Data in Patients with Autoimmune Diseases during Treatment with High Doses of Vitamin D3 According to the “Coimbra Protocol” Ulrich Amon, Raul Yaguboglu, Madeleine Ennis, Michael F. Holick and Julian Amon Nutrients 2022-04-10 https://www.mdpi.com/2072-6643/14/8/1575
  19. Why are doctors reluctant to accept vitamin D
  20. An excellent State of the Art Review of the Cluster Headache syndrome. For members who didn't attend the Clusterbusters 14th Annual Cluster Headache Conference - Dallas, Texas in 2019, neurologists Emmanuelle Schindler and Mark Burish, the authors of this review, were among the featured speakers. Both are dedicated to finding effective treatments for CH. Emmanuelle is the PI for an RCT using psilocybin as the intervention for CH. Mark was impressed enough with the results from my study of CHers following the anti-inflammatory regimen and treatment protocol with 10,000 IU/day of vitamin D3 plus the cofactors, to initiate an RCT of his own using a similar treatment protocol. That RCT started recruiting earlier this year. Take care, V/R, Batch
  21. Hey Billyx, Thank you for the reply. The 14-day loading schedule should have elevated your 25(OH)D3 up by 170 nmol/L bringing your total 25(OH)D3 serum concentration up around 300 nmol/L (121 ng/mL). That's good and it should be more than sufficient to bring about a therapeutic response with a significant reduction in CH frequency or better yet, a complete cessation of CH. Accordingly, as you're still getting hit with CH, it's more than likely you're also experiencing an immune system response to allergens. These can be subclinical with no obvious or outward observable symptoms. Allergic reactions kick off a lot of histamine and histamine to a CHer is like Kryptonite to Superman, bad news. None of the prevents work during an allergic reaction and that includes vitamin D3. The best course of action I take when an allergic reaction is present, is to start what I call the "Full Monty" clutch of supplements with antihistamine properties on top of the basic anti-inflammatory regimen supplements. I take 3 grams/day each of Turmeric (Curcumin), Resveratrol, Quercetin and Omega-3 fish oil. I also take 8 grams/day vitamin C in divided doses. I buy the powdered bulk vitamin C in 1 Kg bags ( 3 cents/gram USD) and mix two level teaspoons (8 grams) in 8 oz of water and take sips throughout the day until it's all gone by bedtime. I also take 10 mg/day melatonin at bedtime. I stay on this concoction for at least a week after cessation of CH then taper the doses. It never hurts to keep taking at least 4 grams/day vitamin C all the time. Our bodies need vitamin C to synthesize collagen. We need collagen to help prevent brittle bones, maintain healthy cartilage and elastic skin. Besides being an antihistamine, vitamin C is also an excellent antioxidant, antiviral and antibacterial agent. Watch the following video of Linus Pauling giving a presentation on the use of vitamin C to prevent illness and disease. Pauling was 92 when he filmed this video. He had many critics of his suggested use of vitamin C in large quantities to prevent illnesses. Most of these critics came from the Big Pharmas. When he died at 93, he still had two more individual Nobel Prizes than any of his critics and he had outlived most of them. His first individual Nobel Prize was for Chemistry involving quantum mechanics, electron orbits and molecular shapes. (My degree was in Chemistry so quantum mechanics was a central theme throughout my studies.) Pauling's second individual Nobel Prize was for Peace. He stopped above ground nuclear warhead testing. He took 18 grams/day vitamin C. He also took 10,000 IU/day vitamin D3. Take care and please keep us posted. V/R, Batch
  22. Hey Billyx, Roughly 2% of CHers experience an up-tic in CH frequency after starting this treatment protocol. It appears this phenomenon is due to an enzyme imbalance. It usually clears all by itself in a few weeks if you continue the maintenance dose of 10,000 IU/day and all the cofactors. The Solgar supplements look great, but I don't see the Kirkland Adult 50+ Mature Multi. As you can see, it picks up all the micronutrient cofactors we need. Did you start this treatment protocol with the vitamin D3 loading schedule of 600,000 IU/day spread over 12 days at 50,000 IU/day? If not, I suspect your 25(OH)D3 serum concentration is still a bit low. At 10,000 IU/day for 20 days, your 25(OH)D3 serum concentration is likely around 135 nmol/L and it needs to be up to a minimum of 200 nmol/L for a therapeutic response with a reduction in CH frequency or a complete cessation of CH. I suggest you order the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 and the Nutrasal Micro D3 nano emulsion from Amazon if possible or iHerb.com. We've found taking two of the D3-50 capsules/day and 0.5 mL/day of the Micro D3 taken sublingual works great as a loading dose. It totals 140,000 IU/day. You'll need 3 to 4 days at this loading dose to elevate your 25(OH)D3 above 200 nmol/L before dropping back to a maintenance dose of 10,000 IU/day. Be sure to double the magnesium dose taking half of with with breakfast and the other half with the evening meal. This provides 12 hours and 12 feet of GI tract separation so both doses don't arrive in the colon at the same time. That causes osmotic diarrhea. If you order from iHerb.com the best alternatives to the Micro D3 are illustrated in the following photo. Take care and please keep us posted. V/R, Batch
  23. Emgality (Galcanezumab) Study - Trigeminal sensory modulatory effects of galcanezumab and clinical response prediction Arne May et al. Feb 2022 ResearchGate https://www.researchgate.net/publication/358667291_Trigeminal_sensory_modulatory_effects_of_galcanezumab_and_clinical_response_prediction Abstract. Galcanezumab, a monoclonal antibody against calcitonin gene-related peptide, is an emerging migraine preventative. We hypothesized that the preventive effects are conveyed via modulation of somatosensory processing and that certain sensory profiles may hence be associated with different clinical responses. We recruited migraine patients (n=26), who underwent quantitative sensory tests (QST) over the right V1 dermatome and forearm at baseline (T0), 2-3 weeks (T1), and one year (T12) after monthly galcanezumab treatment. The clinical response was defined as a reduction of ≥30% in headache frequency based on the headache diary. Predictors for clinical response were calculated using binary logistical regression models. After galcanezumab (T1 vs. T0), the heat pain threshold (HPT) (°C, 44.9 ± 3.4 vs. 43.0 ± 3.3, p=0.013) and mechanical pain threshold (MPT) (log mN, 1.60 ± 0.31 vs. 1.45 ± 0.26, p=0.042) were increased exclusively in the V1 dermatome, but not the forearm. These changes were immediate, did not differ between responders and non-responders, and did not last in one year of follow-up (T12 vs. T0). However, baseline HPT (OR: 2.13, 95% CI: 1.08-4.19, p = 0.029) on the forearm was a robust predictor for a clinical response three months later. In summary, our data demonstrated that galcanezumab modulates pain thresholds specifically in the V1 dermatome, but this modulation is short-lasting and irrelevant to clinical response. Instead, the clinical response may be determined by individual sensibility even before the administration of medication. Dr. Arne May, MD, PhD. has been a member of the ICHD-3 Working Group on Trigeminal Autonomic Cephalalgias for many years. Take Care, V/R, Batch
  24. Hey Juss, The anti-inflammatory regimen treatment protocol includes the Kirkland Adult 50 + Mature Multi. As you can see from the Mature Multi Supplement Facts label above, it contains only 220 mg calcium. Regarding inflammation and oxidative stress, Vitamin D3 and Omega-3 PUFAs reduce both. Take care and please keep us posted. V/R, Batch
  25. Hey Sue, You really need to thank Craig Stewart. He did all the work to make this video possible. Regarding Vitamin A, the Kirkland Adult 50 Plus Mature Multi contains Vitamin A as Beta Carotene. Our bodies convert Beta Carotene to the active form of Vitamin A. Accordingly, if you're taking the Kirkland Mature Multi, you are getting sufficient amounts of Vitamin A. Take care and please keep us posted. V/R, Batch
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