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  1. Hey TTF, Sorry about the delay in responding. I'm on my annual fishing trip to Pelican, AK. Our house has no phone, TV or Internet access so I hike a quarter mile to the town library for WiFi access. Thi big Chinooks (King Salmon) are hitting as are the Halibut so I'm enjoying my vacation. There's nothing wrong with a vitamin D3 dose of 10,000 IU/day and the fastest way of building serum 25(OH)D3 is with a 50,000 IU/day loading dose for at least 12 days. That totals to 600,000 IU of vitamin D3 and that should elevate your serum 25(OH)D3 by 60 ng/mL on top of your baseline serum concentration. I'd shoot for a target 25(OH)D3 serum concentration range of 80 to 100 ng/mL We have also had a number of CHers respond to a collection of supplements with antihistamine properties I call the Antihistamine Full Monty. It includes 3 grams/day each of Turmeric (Curcumin), Quercetin, Resveratrol and Omega-3. It also includes 250 mcg/day Selenium, 5 mg/day Melatonin (taken at bedtime) and 8 grams/day vitamin C. You can also add 500 mg.day NAC. I buy the bulk powdered vitamin C in 1Kg bags and stir two level teaspoons in 8 oz of water then take sips all day until it's gone by bedtime. It tastes like unsweetened lemonade. You can taper the first four supplements to 2 grams/day after a week to 10 days fully CH pain free. I'd stay at 2 grams/day on the first four supplements for at least a month. Dealer's choice on tapering further. Tale care and please keep us posted. V/R, Batch
  2. Hey Justin, I just sent you a PM on loading. Check your PM InBox. Take care and please keep us posted. V/R, Batch
  3. https://vitamindwiki.com/High-Dose+and+Bolus+Dose+vitamin+D+safe+for+children+–+meta-analysis+April+2022 Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis. Summary "Thus, our findings suggest that vitamin D supplementation in the high-dose range of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to infants and preschool children to 6 years of age may be safe in both healthy children and in children with various diseases." Note: My daughter and Niece both followed the anti-inflammatory regimen treatment protocol taking 10,000 IU/day throughout their pregnancies. Their pregnancies and deliveries were flawless with three full term babies. These grand babies were bathed in maternal vitamin D3 from conception through breast feeding. They have T-Rex immune systems - They don't get sick. They're also budding Einsteins and Mensa candidates with exceptional neuromotor development. They've been taking vitamin D3 at 50 IU per pound of body weight per day since they stopped breastfeeding. Fred a.k.a., Winefred on the left was speaking fluent Hochdeutch (German) at age 3, attended pre-kindergarten at age 4 in Heidelberg, Germany where only German was spoken while my daughter was there on sabbatical. She came home from her first day of class and said the German kids don't speak German very well. Her bother Orrin in the middle is also bilingual. Emory Autumn on the right has become a charming and talented dancer. The 25(OH)D3 concentration in her cord blood at birth was 43 ng/mL. Take care, V/R, Batch
  4. For reference, the Coimbra Protocol (CP) was developed by Dr. Cicero Coimbra, MD, PhD, a neurologist in São Paulo, Brazil. He uses this protocol to treat his patients with MS and other autoimmune disorders and has a 95% MS remission rate. The following link will take you to a world map of CP trained doctors. There are five CP trained doctors here in the US. https://www.google.com/maps/d/viewer?mid=1fATZJUEhOsYYJdBY41h48FBkLaQ&ll=35.75118934523871%2C-97.08285860000004&z=4 The CP is very similar to the anti-inflammatory regimen treatment protocol for CH and Migraines with the following exceptions. The starting vitamin D3 maintenance dose in the CP is 1000 IU per Kg body weight per day. After that, the vitamin D3 dose is adjusted (up or down) to keep the parathyroid hormone (PTH) serum concentration in the low normal range. For a sleek rascal like me weighing in at 80 Kg, I would be starting the CP at a vitamin D3 maintenance dose of 80,000 IU/day. That’s 8 times the vitamin D3 dose taken by the average CHer following the anti-inflammatory regimen treatment protocol to control and prevent CH. Patients following thie CP must avoid calcium rich foods like dairy products and drink 2.5 liters of water a day to keep the serum calcium level within its normal reference range. This article is long and detailed so here’s the bottom line. Taking high-dose vitamin D3 (10,000 IU/day and much higher) is very safe as long as the protocols are followed with lab assays for serum 25(OH)D3, calcium and PTH.. Conclusions In summary, to our knowledge, our work provides the first long-term documentation of selected critical laboratory parameters during the application of the CP using a high-dose oral vitamin D3 in a broad spectrum of different autoimmune diseases, demonstrating that this procedure is well tolerated with respect to renal function and calcium metabolism. In terms of individualized treatment, we suggest to further use serum levels of PTH as biomarker for an individual response to vitamin D3, the individual ability to convert vitamin D to the active metabolite, the 1,25(OH)2D’s interaction with its receptor and the response elements and finally the differential supplementation with vitamin D3. In further studies, possible differences of the clinical outcome of CP treatment should be investigated. Take care, V/R, Batch
  5. The following study found no problems with high dose vitamin D3 in patients following the Coimbra Protocol. (CP) Safety Data in Patients with Autoimmune Diseases during Treatment with High Doses of Vitamin D3 According to the “Coimbra Protocol” Ulrich Amon, Raul Yaguboglu, Madeleine Ennis, Michael F. Holick and Julian Amon Nutrients 2022-04-10 https://www.mdpi.com/2072-6643/14/8/1575
  6. Why are doctors reluctant to accept vitamin D
  7. An excellent State of the Art Review of the Cluster Headache syndrome. For members who didn't attend the Clusterbusters 14th Annual Cluster Headache Conference - Dallas, Texas in 2019, neurologists Emmanuelle Schindler and Mark Burish, the authors of this review, were among the featured speakers. Both are dedicated to finding effective treatments for CH. Emmanuelle is the PI for an RCT using psilocybin as the intervention for CH. Mark was impressed enough with the results from my study of CHers following the anti-inflammatory regimen and treatment protocol with 10,000 IU/day of vitamin D3 plus the cofactors, to initiate an RCT of his own using a similar treatment protocol. That RCT started recruiting earlier this year. Take care, V/R, Batch
  8. Hey Billyx, Thank you for the reply. The 14-day loading schedule should have elevated your 25(OH)D3 up by 170 nmol/L bringing your total 25(OH)D3 serum concentration up around 300 nmol/L (121 ng/mL). That's good and it should be more than sufficient to bring about a therapeutic response with a significant reduction in CH frequency or better yet, a complete cessation of CH. Accordingly, as you're still getting hit with CH, it's more than likely you're also experiencing an immune system response to allergens. These can be subclinical with no obvious or outward observable symptoms. Allergic reactions kick off a lot of histamine and histamine to a CHer is like Kryptonite to Superman, bad news. None of the prevents work during an allergic reaction and that includes vitamin D3. The best course of action I take when an allergic reaction is present, is to start what I call the "Full Monty" clutch of supplements with antihistamine properties on top of the basic anti-inflammatory regimen supplements. I take 3 grams/day each of Turmeric (Curcumin), Resveratrol, Quercetin and Omega-3 fish oil. I also take 8 grams/day vitamin C in divided doses. I buy the powdered bulk vitamin C in 1 Kg bags ( 3 cents/gram USD) and mix two level teaspoons (8 grams) in 8 oz of water and take sips throughout the day until it's all gone by bedtime. I also take 10 mg/day melatonin at bedtime. I stay on this concoction for at least a week after cessation of CH then taper the doses. It never hurts to keep taking at least 4 grams/day vitamin C all the time. Our bodies need vitamin C to synthesize collagen. We need collagen to help prevent brittle bones, maintain healthy cartilage and elastic skin. Besides being an antihistamine, vitamin C is also an excellent antioxidant, antiviral and antibacterial agent. Watch the following video of Linus Pauling giving a presentation on the use of vitamin C to prevent illness and disease. Pauling was 92 when he filmed this video. He had many critics of his suggested use of vitamin C in large quantities to prevent illnesses. Most of these critics came from the Big Pharmas. When he died at 93, he still had two more individual Nobel Prizes than any of his critics and he had outlived most of them. His first individual Nobel Prize was for Chemistry involving quantum mechanics, electron orbits and molecular shapes. (My degree was in Chemistry so quantum mechanics was a central theme throughout my studies.) Pauling's second individual Nobel Prize was for Peace. He stopped above ground nuclear warhead testing. He took 18 grams/day vitamin C. He also took 10,000 IU/day vitamin D3. Take care and please keep us posted. V/R, Batch
  9. Hey Billyx, Roughly 2% of CHers experience an up-tic in CH frequency after starting this treatment protocol. It appears this phenomenon is due to an enzyme imbalance. It usually clears all by itself in a few weeks if you continue the maintenance dose of 10,000 IU/day and all the cofactors. The Solgar supplements look great, but I don't see the Kirkland Adult 50+ Mature Multi. As you can see, it picks up all the micronutrient cofactors we need. Did you start this treatment protocol with the vitamin D3 loading schedule of 600,000 IU/day spread over 12 days at 50,000 IU/day? If not, I suspect your 25(OH)D3 serum concentration is still a bit low. At 10,000 IU/day for 20 days, your 25(OH)D3 serum concentration is likely around 135 nmol/L and it needs to be up to a minimum of 200 nmol/L for a therapeutic response with a reduction in CH frequency or a complete cessation of CH. I suggest you order the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 and the Nutrasal Micro D3 nano emulsion from Amazon if possible or iHerb.com. We've found taking two of the D3-50 capsules/day and 0.5 mL/day of the Micro D3 taken sublingual works great as a loading dose. It totals 140,000 IU/day. You'll need 3 to 4 days at this loading dose to elevate your 25(OH)D3 above 200 nmol/L before dropping back to a maintenance dose of 10,000 IU/day. Be sure to double the magnesium dose taking half of with with breakfast and the other half with the evening meal. This provides 12 hours and 12 feet of GI tract separation so both doses don't arrive in the colon at the same time. That causes osmotic diarrhea. If you order from iHerb.com the best alternatives to the Micro D3 are illustrated in the following photo. Take care and please keep us posted. V/R, Batch
  10. Emgality (Galcanezumab) Study - Trigeminal sensory modulatory effects of galcanezumab and clinical response prediction Arne May et al. Feb 2022 ResearchGate https://www.researchgate.net/publication/358667291_Trigeminal_sensory_modulatory_effects_of_galcanezumab_and_clinical_response_prediction Abstract. Galcanezumab, a monoclonal antibody against calcitonin gene-related peptide, is an emerging migraine preventative. We hypothesized that the preventive effects are conveyed via modulation of somatosensory processing and that certain sensory profiles may hence be associated with different clinical responses. We recruited migraine patients (n=26), who underwent quantitative sensory tests (QST) over the right V1 dermatome and forearm at baseline (T0), 2-3 weeks (T1), and one year (T12) after monthly galcanezumab treatment. The clinical response was defined as a reduction of ≥30% in headache frequency based on the headache diary. Predictors for clinical response were calculated using binary logistical regression models. After galcanezumab (T1 vs. T0), the heat pain threshold (HPT) (°C, 44.9 ± 3.4 vs. 43.0 ± 3.3, p=0.013) and mechanical pain threshold (MPT) (log mN, 1.60 ± 0.31 vs. 1.45 ± 0.26, p=0.042) were increased exclusively in the V1 dermatome, but not the forearm. These changes were immediate, did not differ between responders and non-responders, and did not last in one year of follow-up (T12 vs. T0). However, baseline HPT (OR: 2.13, 95% CI: 1.08-4.19, p = 0.029) on the forearm was a robust predictor for a clinical response three months later. In summary, our data demonstrated that galcanezumab modulates pain thresholds specifically in the V1 dermatome, but this modulation is short-lasting and irrelevant to clinical response. Instead, the clinical response may be determined by individual sensibility even before the administration of medication. Dr. Arne May, MD, PhD. has been a member of the ICHD-3 Working Group on Trigeminal Autonomic Cephalalgias for many years. Take Care, V/R, Batch
  11. Hey Juss, The anti-inflammatory regimen treatment protocol includes the Kirkland Adult 50 + Mature Multi. As you can see from the Mature Multi Supplement Facts label above, it contains only 220 mg calcium. Regarding inflammation and oxidative stress, Vitamin D3 and Omega-3 PUFAs reduce both. Take care and please keep us posted. V/R, Batch
  12. Hey Sue, You really need to thank Craig Stewart. He did all the work to make this video possible. Regarding Vitamin A, the Kirkland Adult 50 Plus Mature Multi contains Vitamin A as Beta Carotene. Our bodies convert Beta Carotene to the active form of Vitamin A. Accordingly, if you're taking the Kirkland Mature Multi, you are getting sufficient amounts of Vitamin A. Take care and please keep us posted. V/R, Batch
  13. All, Making this Youtube video with Craig was a hoot! Without his dedication, determination and professionalism, it would not have been possible. We both hope it attracts more CHers and Migraineurs to start this treatment protocol. As you can see as a 77 year old retired Navy fighter pilot, I'm also mastering the art of full time geezer. Take care, V/R, Batch
  14. Hey ibh, Good plan and don't be afraid to try other salts of magnesium. Take care, V/R, Batch
  15. Hey LBH, The magnesium and all the other cofactors in this treatment protocol are essential for proper and effective vitamin D3 pharmacokinetics and pharmacodynamis. Without supplemental magnesium at 400 mg/day, what little magnesium in your body will be consumed by the enzymatic processes that hydroxylate vitamin D3 to 25(OH)D3 and on to 1,25(OH)2D3, the genetically active vitamin D3 metabolite that helps control and prevent your CH. This could take a few days to a few weeks and when the magnesium deficiency does occur, you'll have a poor magnesium - calcium ratio and this will lead to muscle cramps and other problems. Take care and take all the cofactors, including magnesium. V/R, Batch
  16. Hey Sue, Red wine has resveratrol, but you'll get hammered drinking enough red wine to equal 3 grams of resveratrol. A couple handfuls of dark grapes will help a little. As far as Quercetin goes, see the following link. Most are super foods.. https://www.healwithfood.org/foods-that-contain/best-quercetin-sources.phphttps://www.healwithfood.org/foods-that-contain/best-quercetin-sources.php Take care and please keep us posted. V/R, Batch
  17. Hey Sue, Roughly 3% of CHers experience a spike in CH frequency and intensity shortly after starting vitamin D3 therapy. What appears to be happening is a shortage of vitamin D3 cofactors at the cellular level is causing this problem. These cofactors are needed to support the enzymatic processes that metabolize or more correctly Hydroxylate vitamin D3 to its genetically active metablolite 1,25(OH)2D3. There are a lot of moving parts to the hydroxylation process and other supporting enzymatic processes along the vitamin D3 metabolic pathway that are needed to support vitamin D3 enabled genetic expression. The following chart illustrates all the enzymes involved. A lack of vitamin D3 cofactors at any part of this process can cause problems. The best course of action should a spike in CH frequency and intensity occur after starting this treatment protocol is to stop taking vitamin D3 for a few days, but continue taking ALL the cofactors. This problem usually cures itself anyway, but following the above suggested process makes it happen much faster. Take care and please keep us posted. V/R, Batch
  18. We've known all along virus mutate so here's more on Omicron-2 https://vitamindwiki.com/Omicron-2%3A+in+40+countries%2C+some+with+Omicron-1+can+get+it+-+Jan+25%2C+2022 So far Omicron-2 looks to be more transmissible than Omicron-1 and people who have had Omicron 1 are catching Omicron-2 The question now is the mortality rate. A 25(OH)D3 serum concentration between 80 and 100 ng/mL appears to lessen the infection rate and symptoms. More to follow. So much for God's greatest gift to people afraid of COVID-19 alpha variant, which is almost gone from circulation. Take care, V/R, Batch
  19. Here's some interesting info on Omicron and its infections. It gets a bit technical, but if you wade through the following link, the basic message is Omicron has the most mild infection symptoms that usually last 2 to 3 days, and as yet no mortality substantiated. Of course, lots of vitamin D3 helps recovery (at least 10,000 IU/day maintenance dose) after a few days at a loading dose of at least 50,000 IU/day plus all the cofactors. https://nutritionmatters.substack.com/p/omicrons-generally-less-harmful-mechanisms My cut at a home treatment for Omicron is illustrated in the following photo of supplements I take as a prevent. Not shown is Ivermectin at 12 mg/day for at least 5 days then 12 mg/week. This is essentially the basic anti-inflammatory regimen for CH with the addition of 50 mg zinc picolinate, 800 mg Quercetin as the zinc inonophor, and lots of liposomal tamin C (at least 3 grams/day) in divided doses throughout the day. Take care, V/R, Batch
  20. Sue, A glass of Orange juice is a good way to start the day except for all the Fructose. That said you would need to eat 36 naval oranges a day to get 3 grams of vitamin C (Ascorbic Acid). 1000 mg vitamin C capsules are much less expensive and the powdered bulk vitamin C even less expensive. Watch the video of Linus Pauling explain why we need 6 to 7 grams/day vitamin C to prevent disease and illness. He took 18 grams/day vitamin C. Linus Pauling was 92 when this presentation was recorded. He was awarded 2 individual Nobel Prizes, the first in Chemistry for his papers on Quantum Mechanics and the shape of molecules and the second for Peace for stopping above ground nuclear warhead testing. He had many critics of his recommendation to take 7 grams of vitamin C per day and even more if suffering from a disease. When he died at age 93, he still had two more Nobel Prizes than any of his critics... and, he had outlived most of them. Take care and please keep us posted. V/R, Batch
  21. Hey Cast Iron, We've seen CH frequency go up when CHers cut back or discontinued verapamil. Good head work sides with the obvious conclusion, If you're following the anti-inflammatory protocol and you're still taking verapamil, it's best to stick with the verapamil dose that keeps CH frequency low. I've spent the last 10 years analyzing data from the online survey of CHers following this protocol to gain control of their CH and hopefully stop them and direct feed back from CHers. What I've concluded is allergic reactions are the single biggest problem that keeps vitamin D3 from doing its thing to control and prevent CH. As allergic reactions kick off large quantities of histamine and histamine to a CHer is like Kryptonite to Superman, bad news. We need to get the allergic reaction under control first to give vitamin D3 and the cofactors a chance to do their thing. The best course of action involves taking 3 grams/day each of Turmeric (Curcumin), Resveratrol, Quercetin and Omega-3 fatty acids. These are the best and most effective natural antihistamines we can take short of a first-generation antihistamine like Benadryl (Diphenhydramine HCL) taken at 25 mg every 4 hours throughout the day. I've also tried a nasal rinse by cupping my hands under warm running water then lowering my nose into the water and inhaling enough water to reach the back of the nasal cavity then blow it out. Keep your head down while doing this to prevent water from running down the back of your throat. 4 to 5 snuffels like this should be sufficient to rinse the area around the Sphenopalatine ganglion or "pterygopalatine ganglion". This is the only ganglion located outside the skull. We have two of them each located on opposite sises of the nasal cavity and they are both connected directly to the trigeminal ganglia on both sides of our brain. Doing this nasal rinse has helped me during the heavy leaf mold spore season. An alternative to this over the sink nose rinse is to buy one of the Navage Nasal Rinse Systems. They're less expensive on ebay. https://www.ebay.com/itm/284619933346?_trkparms=amclksrc%3DITM%26aid%3D1110006%26algo%3DHOMESPLICE.SIM%26ao%3D1%26asc%3D20200818143230%26meid%3D0397482d3fdc444aa0e26ad6e537594f%26pid%3D101224%26rk%3D3%26rkt%3D5%26sd%3D334041507637%26itm%3D284619933346%26pmt%3D0%26noa%3D1%26pg%3D2047675%26algv%3DDefaultOrganicWeb%26brand%3DNavage&_trksid=p2047675.c101224.m-1 The thinking behind the nasal rinse is by doing this a few times a week, we wash away any allergens that have accumulated in the nasal mucus membranes around the Sphenopalatine gangiia on you hit side and this lowers the allergic load. These units come with salt pills the make the rinse isotonic in salinity for less irritation. It also helps to take at least 3 grams/day vitamin C. I take 8 grams/day by adding two level teaspoon measures of powdered vitamin C to an 8 oz glass of water. I take gulps throughout the day until it is all gone by bedtime. You may need to increase your vitamin D3 dose and serum 25(OH)D3 concentration. Do this in steps and see your PCP to test regularly for serum 25(OH)D3, calcium and PTH. Take care and please keep us posted, V/R Batch
  22. Hey Cast Iron, I suspect the lab assay method being used to measure your 25(OH)D3 has an upper measurement limit around 400 nmol/L (160 ng/mL). You need to ask your PCP to specify the LC-MS/MS: liquid chromatography-dual mass spectrometry assay for your 25(OH)D3. This assay method has a maximum measurement of 512 ng/mL for the combined D2 - D3. As your 25(OH)D2 measurement is likely less than 4 ng/mL, this assay method should measure your 25(OH)D3 as high as 508 ng/mL. If you followed the treatment protocol I had published on the VitaminDWiki web site at the following link, you would have seen the recommended assay be done at Quest Diagnostics with the QuestAssureD™ 25-Hydroxyvitamin D (D2, D3). http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 The following chart of my assays for 25(OH)D3 were measured with the Quest Diagnostics QuestAssureD™ 25-Hydroxyvitamin D (D2, D3) assay method. As you can see, when I stopped taking vitamin D3 for three months in a 25(OH)D3 burn down test, my 25(OH)D3 assay dropped by 45 ng/mL (112.5 nmol/L) or 15 ng/mL per month. I might add that I remained CH pain free the entire time. How is your head? Are you still CH pain free? Take care and please keep us posted, V/R Batch
  23. ER CARD, While I was on the Board of Directors at O.U.C.H., we developed a Medical Alert Card for Oxygen Therapy for CHers who had to go to the ER with bad CH. The document is signed by the CHer's neurologist or PCP explaining the bearer suffers from Cluster Headache and needs oxygen therapy as a CH abortive at 15 to 25 liters/minute STAT! The thinking behind this card was that it would help eliminate most of the Stump the Dummy questions frequently asked by ER receptionists and get the CHer oxygen as an abortive as fast as possible. Take care, V/R, Batch The quality of this image is not that good. Unfortunately, this web portal limits attachments fo 23 KB and that's not enough for the original pdf document. Take care, V/R, Batch
  24. Hey Cast Iron, Sorry to be so slow coming to the party. As long as your serum calcium assay remains within its normal reference range there's no hypercalcemia, a.k.a., vitamin D3 intoxication/toxicity. I've kept my 25(OH)D3 up around 450 nmol/L (180 ng/mL) for quite a while as you can see in the 5-year chart of my lab assays for 25(OH)D3, calcium and PTH.. It's presently up around 680 nmol/L (270 ng/mL) due to Fall/Winter leaf mold spores that trigger allergic rhinitis. After many years watching my assays for serum 25(HO)D3, calcium and PTH, my PCP looks at my 25(OH)D3 assay, smiles and then says, "I have no problem with your 25(OH)D3 this high as long as it helps prevent your CH and your serum calcium remains within its normal reference range." Mast cells, part of our immune system's family of white blood cells, release large quantities of histamine and other proinflammatory mediators when insulted by allergens. The histamine in turn, triggers neurons and glia within our trigeminal ganglia to express Calcitonin Gene-Related Peptides (CGRP) and other neuropeptides. Neurologists tell us the CGRP expressed within neurons and glia is responsible for the neurogenic inflammation and the pain we know as cluster headache. The bottom line is histamine to a CHer is like Kryptonite to Superman - Bad News. None of the prevents including vitamin D3 work very well during an allergic reaction. Many CHers, me included, have found a combination of 3,000 mg/day Tumeric (Curcumin), 3,000 mg/day Resveratrol, 6 to 8 grams/day vitamin C (taken in divided doses throughout the day), double the Omega-3 dose and Benadryl (Diphenhydramine HCL) at 25 mg 4 times a day all help block histamine effects and this lets the genetically active vitamin D3 metabolite 1,25(OH)2D3 down-regulate the expression of CGRP, other neuropeptides and proinflammatory mediators. This cocktail of extra supplements can take as little as a day and up to a week to take effect for some CHers. Others will find it makes their CH less severe and more controllable, like easily aborted with oxygen therapy. I also use a combination of 100,000 IU/day of Bio-Tech D3-50 and 0.5 mL/day (40,000 IU/day) of the Nutrasal Micro D3 taken sublingual as a loading dose. The Atkins-Ketogenic Diet can help. Avoid all sugars and fruit juices high in fructose. Avoiding all wheat and grain products can also help. If you do eat grain products, make sure they are Non-GMO. Most wheat and grain products are contaminated with glyphosate, the herbicide in RoundUp.. Ir causes all kinds of problems. As a herbicide it kills off the friendly colonies of bacteria living in our GI tract called the microbiome. A unique aspect of glyphosate’s insidious cumulative toxicity is its ability to get inserted into proteins by mistake in place of the coding amino acid glycine. Glycine is the smallest amino acid – one of the twenty or so building blocks of proteins according to the DNA code. Glyphosate is a complete glycine molecule, except that it has an extra methylphosphonate unit attached to its nitrogen atom. Hope this helps. Take care and please keep us posted. V/R, Batch
  25. xxx

    Flying

    Hey BoscoPiko, Cluster headaches are very sensitive to serum oxygen concentrations. If the partial pressure of arterial oxygen (PaO2) drops below a given threshold as it will when flying at a cabin pressure equal to 7,000 feet altitude (2100 meters) in most commercial airliners, PaO2 will drop by 30%. This opens the door to the CH beast jumping real ugly. The same thing happens when we sleep as our respiration rate is as low as it can get while we're alive. The low respiration rate also causes an increase in the partial pressure of arterial CO2 (PaCO2). The combination of low arterial oxygen and high arterial CO2 makes for a perfect storm occurring as most of you know, one to two hours after falling asleep. If you're an episodic CHer in cycle or chronic and need to fly, take a couple Imitrex (Sumatriptan Succinate) 50 mg tabs an hour prior to takeoff and carry an Imitrex inhaler or Imitrex SC injection pen during flight. If you're a CHer maintaining a CH pain free status taking a vitamin D3 maintenance dose of 10,000 IU/day and cofactors, take a 100,000 IU loading dose of vitamin D3 24 to 36 hours prior to the flight. The following chart illustrates the changes in vitamin D3 and 25(OH)D3 serum concentrations following a single oral dose of 100,000 IU vitamin D3. Take care and keep your immune system boosted with vitamin D3. V/R, Batch
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