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xxx

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    pete_batcheller

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  1. To all, This is a dream come true. https://www.clinicaltrials.gov/ct2/show/NCT04570475?sfpd_s=09%2F16%2F2020&sfpd_d=14 This is the gold standard RCT protocol I've been working with Dr. Mark Burish, MD, PhD., Will Erwin Headache Research Center, UT Houston School of Medicine to develop for almost a year at this point. We cut a lot of corners getting the protocol down to two pills with two look alike placebos and no loading dose, but I'm confident this dose will result in at least 70% of CHers responding with a significant reduction in the frequency of their CH during the course of this protocol. Take care, V/R, Batch
  2. This is a dream come true. https://www.clinicaltrials.gov/ct2/show/NCT04570475?sfpd_s=09%2F16%2F2020&sfpd_d=14 This is the gold standard RCT protocol I've been working with Dr. Mark Burish, MD, PhD., Will Erwin Headache Research Foundation, UT Houston School of Medicine to develop for almost a year at this point. We cut a lot of corners getting the protocol down to two pills with two look alike placebos and no loading dose, but I'm confident this dose will result in at least 70% of CHers responding with a significant reduction in the frequency of their CH during the course of this protocol. Take care, V/R, Batch
  3. xxx

    Skipping indocin -> not a good idea !

    Hey Siegfried, CPH responds to vitamin D3 at higher 25(OH)D3 serum concentrations when accompanied with other anti-inflammatory agents. Please shoot me a PM with your contact data so I can send you a copy of the latest version of the anti-inflammatory regimen treatment protocol. Take care, V/R, Batch
  4. xxx

    I have migraines

    Hey Nicole, Check your message InBox. I've sent you a PM. Take care, V/R. Batch
  5. Dear GBeth, Check your PM InBox. I've sent you a message that should help. Take care, V/R, Batch
  6. xxx

    IMPORTANT CMS O2 SURVEY!!

    Name is required information.
  7. xxx

    Question about D3 + other

    There's an excellent video of Dr. Paul Marik, MD, Chief of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, explaining his MATH+ COVID-19 protocol at the following link. It's long, but well worth the time. https://www.youtube.com/watch?v=xZJixjgu3tk I've been exchanging email with Dr. Marik for the last 5 months. There's an excellent analysis of the MATH+ protocol at the following link. https://covid19criticalcare.com/math-hospital-treatment/scientific-review-of-covid-19-and-math-plus/#1596274217294-29a4f4e2-63ce Take care, V/R, Batch
  8. xxx

    Question about D3 + other

    Spiny, As I indicated in an earlier post in this thread, Pepcid (Famotidine) is a histamine H2 receptor blocker. There's evidence Quercetin is a little safer and more effective as an antiviral than Famotidine. That said, the COVID-19 Critical Care Working Group (FLCCC) treatment protocol for COVID-19 patients in the ER calls for intravenous methylprednisone, high-dose ascorbic acid (vitamin C), thiamine (Vitamin B1) and heparin. Optional additions include melatonin, zinc, vitamin D3, atorvastatin, famotidine and magnesium. Quercetin also acts as an ionophore transporting zinc ions across cell walls to help stop viral replication. Vitamin C and quercetin have synergistic effects that make them useful in the prevention and early at-home treatment of COVID-19. Both are part of the MATH+ protocol developed by the Front Line COVID-19 Critical Care Working Group (FLCCC). For COVID-19 prophylaxis, the FLCCC recommends vitamin C, quercetin, zinc, melatonin and vitamin D3 The at-home treatment for mildly symptomatic patients is very similar to the prophylactic regimen, but adds several optional drugs, including aspirin, famotidine (an antacid) and ivermectin (a heartworm medication that has been shown to inhibit SARS-CoV-2 replication in vitro) There are two distinct phases or stages of COVID-19 — the viral replication stage and the immune dysfunction stage — and the treatment must be appropriate for the stage you’re in. Equally crucial is starting aggressive treatment as early as possible. Vitamin D3 boosts immune system functions that help prevent viral infections. Vitamin D3 at a high enough dose and responding 25(OH)D3 serum concentration, also helps prevent immune system dysfunction Quercetin was initially found to provide broad-spectrum protection against SARS coronavirus in the aftermath of the SARS epidemic that broke out across 26 countries in 2003. Now, some doctors are advocating its use against SARS-CoV-2, in combination with vitamin C, noting that the two have synergistic effects. Incidentally, ascorbic acid (vitamin C) and the bioflavonoid quercetin (originally labeled vitamin P) were both discovered by the same scientist — Nobel prize winner Albert Szent-Györgyi. Quercetin’s antiviral capacity has been attributed to five main mechanisms of action: Inhibiting the virus’ ability to infect cells by transporting zinc across cellular membranes Inhibiting replication of already infected cells Reducing infected cells’ resistance to treatment with antiviral medication Inhibiting platelet aggregation — and many COVID-19 patients suffer abnormal blood clotting Promoting SIRT2, thereby inhibiting the NLRP3 inflammasome assembly involved with COVID-19 infection Similarly, vitamin C at extremely high doses also acts as an antiviral drug, effectively inactivating viruses. During the 2003 SARS pandemic, a Finnish researcher called for an investigation into the use of vitamin C after research showed it not only protected broiler chicks against avian coronavirus, but also cut the duration and severity of common cold in humans and significantly lowered susceptibility to pneumonia. I compiled a list of immune boosting COVID-19 prophylaxis people can take at home in the following table provided by experts in nutritional medicine. Column 4 is my summation. Supplement Riordan Orthomolecular EVMS/FLCC Batcheller Vitamin C 1-2g t.i.d. 3 g/d (1g t.i.d.) 500 mg BID 3 g/d (1g t.i.d.) Vitamin D3 5,000 IU/d 10K IU/d for 2 wk* 1000-4000 IU/d 50,000 IU/wk** Vitamin A 10,000 IU/d 3,000-6000 IU/d Vitamin B1 25 mg/d Zinc Picolinate 30 mg BID 30 mg/d 75-100 mg/d 50 mg/d Quercetin 500 mg/d 250-500 mg BID 400 mg BID Selenium 200 mcg/d 200 mcg/d 55 mcg/d Magnesium 500 mg/d 400-800 mg/d Melatonin 1-5mg/d 0.3-2.0 mg/d Omega-3 PUFAs 1500 mg/d Multi Vitamin 1 Tablet/d 1 Tablet/d *** * 10,000 IU/day vitamin D3 for 2 weeks then drop back to 5000 IU/day ** 50,000 IU/day vitamin D3 for 12 days then drop back to 50,000 IU/week. Water soluble vitamin D3 suggested such as Bio-Tech D3-50 as it has a higher bioequivalence than the oil-based liquid softgel vitamin D3 formulations. *** The Kirkland Adult 50+ Mature Multi is an excellent source of vitamin D3 cofactors. It just doesn't have enough magnesium or any vitamin K2 Of course you won't hear anything about this from HHS, the good Dr. Fauci at NIH, the FDA or CDC. They're heavily influenced by the Big Pharmas who don't want people to know how effective vitamins and minerals can be in treating viral infections. Members of these organizations are also heavily invested in vaccine development (at tax payer expense) so don't want the public to hear about any competitive treatments that are more effective, safer and less expensive. Take care, V/R, Batch
  9. xxx

    Question about D3 + other

    Jon, Er... Make that Spiny, (Forgot my cheaters) Regarding Pepcid (famotidine), it's a histamine H1 blocker and there have been two completed studies taking it during a COVID-19 infection listed in clinicaltrials.gov. The first was based on a questionnaire sent to COVID-19 outpatients who took it during a COVID-19 infection. The second study involved a Therapeutic Plasma Eexchange as a treatment for COVID-19. The protocol called for supportive treatment that included Vitamin C, Zinc, Vitamin D, Famotidine, Enoxaparin and Methylprednisolone so Prpcid wasn't the only intervention. Neither have been through peer review. There was a reduction in mortality among COVID-19 patients who had taken Pepcid (famotidine). Take care, V/R, Batch
  10. xxx

    IMPORTANT CMS O2 SURVEY!!

    Here's a lesson learned from the last time CMS requested public comments on their Non-Coverage Determination for home oxygen therapy for Medicare Beneficiaries suffering from CH in 2010. Do not write about your personal experience with home oxygen therapy as a CH abortive. It will be redacted and a waste of time. Do write about what you have observed in other CHers using oxygen as a CH abortive. Do write about the cost differential between home oxygen therapy as a CH abortive and the $100 dollar a pop street price for a subcutaneous imitrex injection limited to nine per month. For example, the average CHer experiences three (3) CH in a 24 hour period. When used with proper procedures, an M-Sized O2 cylinder contains sufficient gaseous oxygen for 30 CH aborts at a flow rate of 25 liters/minute (more than 100 aborts using my latest procedure hyperventilating with room air for 30 seconds then inhaling a lungful of 100% oxygen and holding it for 30 seconds). Doing the math, the average CHer will consume 3 M-Size oxygen cylinders in a month. At an average co-pay cost of $30 dollars per M-Size oxygen cylinder after insurance, that comes to $90 dollars a month out of pocket to cover aborts for all CH. The out of pocket co-pay for a single 6 mg/.05ml subcutaneous injection of imitrex comes to $28 dollars. Doing the math, with the limit of 9 injections/month, the total cost comes to $252/month for nine (9) aborts. This doesn't cover the cost of the horrific pain CHers experience without home oxygen as an abortive when they've used up their monthly allowance of nine imitrex injections. Take care and take action. V/R, Batch
  11. xxx

    Paroxysmal Hemicrania -> Day 4

    Siegfried, What was your 25(OH)D3 serum concentration? Here are my labs for serum 25(OH)D3, Calcium and PTH over the last three years. My PCP understands calcium homeostasis and that I keep my 25(OH)D3 serum concentration this high to prevent my CH during periods of high pollen and mold spore counts. Accordingly, he has no problems with it being this high as long as my serum calcium remains within its normal reference range and as you can see, it has. Did your PCP run labs for your serum calcium and PTH? Take care and please keep us posted. V/R, Batch
  12. xxx

    Question about D3 + other

    For what it's worth, here's the logic and science behind the 12-Day accelerated vitamin D3 loading schedule and why the initial target 25(OH)D3 serum concentration is 80 ng/mL. 1. From the online survey data of 313 CHers who have reported their results after starting this regimen since Dec 2011, we have the normal distribution chart of baseline 25(OH)D3 lab results before starting this regimen and normal distribution chart of the objective (Favorable CH Response) 25(OH)D3 labs after ≥30 days on this regimen. As you can see, CHers reporting in this survey with active CH, went from a mean 25(OH)D3 serum concentration of 24 ng/mL before starting the anti-inflammatory regimen to a mean of 80 ng/mL after ≥ 30 days on this regimen with a significant reduction in the frequency of thier CH. The following chart illustrates the notional change in serum 25(OH)D3 made possible by starting this regimen with the 12-Day accelerated vitamin D3 loading schedule. Data from the online survey confirms the above notional response. As you can see, if the CHer took only 10,000 IU/day vitamin D3 and no loading, it could take well over 2 months to reach a mean 25(OH)D3 serum concentration of 80 ng/mL. The following charts illustrate the favorable CH response to this regimen by day after starting it. The first chart illustrates favorable responses by day after starting this regimen. I used a favorable response as at least a 50% reduction in CH frequency by at least 70% of participants. Data from the survey indicate the mean reduction in CH frequency is 80% by 82% of participants. This second cart illustrates days after start of regimen to a sustained complete cessation of CH symptoms. Survey data collected during 2019 indicate the favorable response rate increased with over 90% of CHers reporting a favorable response. I attribute most of this increase in the response rate to the switch to Bio-Tech D3-50. 2. Why is the initial 25(OH)D3 serum concentration target set at 80 ng/mL? This is where a little statistics and what's called the confidence interval comes into play. In statistics, a confidence interval is a type of interval estimate, computed from the statistics of the observed data, that might contain the true value of an unknown population parameter. Data in the following chart comes from the D* Action database at Grassrootshealth. It represents the results of 25(OH)D3 lab tests from over 10,000 people who take the 25(OH)D3 home blood spot test for their serum 25(OH)D3 every six months reporting their vitamin D3 dose over the six months prior to this lab test. As you can see, the mean 25(OH)D3 response to various vitamin D3 doses is represented by the blue lines and that at a dose of 10,000 IU/day, the mean 25(OH)D3 response is 76 ng/mL. The red lines represent the 95% confidence interval. In simple terms we can say that the results a given lab test for 25(OH)D3 at a dose of 10,000 IU/day will fall between these two red lines with 95% confidence. The green dashed lines represent 25(OH)D3 serum concentrations at 40 ng/mL, 30 ng/mL and 20 ng/mL. Accordingly we can say that at a dose of 10,000 IU/day the confidence interval for 25(OH)D3 response lies between 42 ng/mL and 118 ng/mL with 95% confidence. If you go back to the second chart illustrating the normal distribution of 25(OH)D3 results among CHers responding to this regimen with a significant reduction in the frequency of their CH, you can see this same confidence interval falls under the normal distribution curve. For practical purposes, this is also the effective therapeutic range of serum 25(OH)D3 (40 ng/mL to 120 ng/mL) for favorable responses. You can also see where a lower vitamin D3 dose of 5,000 IU/day results in a confidence interval between 25 ng/mL and 90 ng/mL. In this case a significant number of CHers would not respond to this regimen. As an "Oh by the way..." the following charts from two different COVID-19 studies indicate taking 10,000 IU/day and keeping your 25(OH)D3 serum concentration over 40 ng/mL is a pretty good idea... This isn't rocket science and you don't need to be a physician to understand the importance of this information. Hope this helps explain a little more about the anti-inflammatory regimen treatment protocol. Take care, V/R, Batch
  13. xxx

    D3 Experience

    Bryan, I would try loading vitamin D3 at 50,000 IU/day for a week just to build your 25(OH)D3 reserves higher and in the process, help get the CH beast back under control. Taking vitamin D3 is particularly important to help prevent viral infections like COVID-19. It's also best to start taking at least 50 mg/day zinc picolinate, 400 mg/day Quercetin and 1 gram of vitamin C three times a day. These are the immune boosting supplements that work the best. The nutritional supplements illustrated in the photo below provide a safe (No Harms) and proven prophylaxis for most viral infections. If you're already taking the anti-inflammatory regimen, all you need to do is add the 50 mg/day zinc picolinate, 400-800 mg/day Quercetin and 3 grams/day liposomal vitamin C (1 gram every 3 hours). Zinc: The need for supplementation increases with age Take care, V/R, Batch.
  14. xxx

    Question about D3 + other

    Hey SECAuthentics, All of us on the anti-inflammatory regimen experience burnthrough CH at one time or another. The solution is simple. If you haven't switched to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 now is a good time to do so. You can order it from amazon or iherb. In the mean time most CHers in your shoes, me included, have loaded vitamin D3 at 50,000 IU/day for a week then droped back to the usual maintenance dose. When you switch to the Bio-Tech D3-50, one capsule a week is a good starting maintenance dose. I updated the basic regimen in July of 2018 adding the Bio-Tech D3-50 in place of the oil-based liquid softgel vitamin D3 formulation. In Jan of 2019, I added Methyl Folate + in place of the generic vitamin B 50/100 complex. The following photo illustrates the latest version of this regimen by brand and dose. CHers who stick with the above brands tend to experience a faster rate of response to this regimen. Take care and please keep us posted. V/R, Batch
  15. xxx

    Paroxysmal Hemicrania -> Day 4

    Hey Siegfried, A vitamin D3 level of 85 ng/mL only helps a little over 50% of CHers prevent their CH. The rest need higher 25(OH)D3 serum concentrations up to 180 ng/mL as illustrated in the normal distribution chart of 25(OH)D3 labs reported by 257 CHers who reported a favorable response to vitamin D3 in the online survey. Granted, this data is from cluster headache sufferers not people diagnosed with hemicrania continua (HC). That said, there is ample evidence that HC shares most of the same pathophysiology as CH which means it should respond to the anti-inflammatory regimen with therapeutic doses of vitamin D3. I've worked with two HC sufferers who responded to the anti-inflammatory regimen. Both took the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 at one 50,000 IU capsule/day for at least two weeks before experiencing a significant and lasting reduction in the severity of their HC. They also took the Methyl Folate + vitamin B complex, which like the Bio-Tech D3-50 has a higher bioequivalence. As you've already noticed, indomethacin is hard on the stomach and GI tract due to bleeds. If you do continue taking it, experienced headache specialists familiar with indomethacin side effects suggest acid-suppression medicine due to this gastrointestinal side effect. Take care and please keep us posted. V/R, Batch
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