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    pete_batcheller

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  1. Hey TTF, Sorry about the delay in responding. I'm on my annual fishing trip to Pelican, AK. Our house has no phone, TV or Internet access so I hike a quarter mile to the town library for WiFi access. Thi big Chinooks (King Salmon) are hitting as are the Halibut so I'm enjoying my vacation. There's nothing wrong with a vitamin D3 dose of 10,000 IU/day and the fastest way of building serum 25(OH)D3 is with a 50,000 IU/day loading dose for at least 12 days. That totals to 600,000 IU of vitamin D3 and that should elevate your serum 25(OH)D3 by 60 ng/mL on top of your baseline serum concentration. I'd shoot for a target 25(OH)D3 serum concentration range of 80 to 100 ng/mL We have also had a number of CHers respond to a collection of supplements with antihistamine properties I call the Antihistamine Full Monty. It includes 3 grams/day each of Turmeric (Curcumin), Quercetin, Resveratrol and Omega-3. It also includes 250 mcg/day Selenium, 5 mg/day Melatonin (taken at bedtime) and 8 grams/day vitamin C. You can also add 500 mg.day NAC. I buy the bulk powdered vitamin C in 1Kg bags and stir two level teaspoons in 8 oz of water then take sips all day until it's gone by bedtime. It tastes like unsweetened lemonade. You can taper the first four supplements to 2 grams/day after a week to 10 days fully CH pain free. I'd stay at 2 grams/day on the first four supplements for at least a month. Dealer's choice on tapering further. Tale care and please keep us posted. V/R, Batch
  2. Hey Justin, I just sent you a PM on loading. Check your PM InBox. Take care and please keep us posted. V/R, Batch
  3. https://vitamindwiki.com/High-Dose+and+Bolus+Dose+vitamin+D+safe+for+children+–+meta-analysis+April+2022 Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis. Summary "Thus, our findings suggest that vitamin D supplementation in the high-dose range of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to infants and preschool children to 6 years of age may be safe in both healthy children and in children with various diseases." Note: My daughter and Niece both followed the anti-inflammatory regimen treatment protocol taking 10,000 IU/day throughout their pregnancies. Their pregnancies and deliveries were flawless with three full term babies. These grand babies were bathed in maternal vitamin D3 from conception through breast feeding. They have T-Rex immune systems - They don't get sick. They're also budding Einsteins and Mensa candidates with exceptional neuromotor development. They've been taking vitamin D3 at 50 IU per pound of body weight per day since they stopped breastfeeding. Fred a.k.a., Winefred on the left was speaking fluent Hochdeutch (German) at age 3, attended pre-kindergarten at age 4 in Heidelberg, Germany where only German was spoken while my daughter was there on sabbatical. She came home from her first day of class and said the German kids don't speak German very well. Her bother Orrin in the middle is also bilingual. Emory Autumn on the right has become a charming and talented dancer. The 25(OH)D3 concentration in her cord blood at birth was 43 ng/mL. Take care, V/R, Batch
  4. For reference, the Coimbra Protocol (CP) was developed by Dr. Cicero Coimbra, MD, PhD, a neurologist in São Paulo, Brazil. He uses this protocol to treat his patients with MS and other autoimmune disorders and has a 95% MS remission rate. The following link will take you to a world map of CP trained doctors. There are five CP trained doctors here in the US. https://www.google.com/maps/d/viewer?mid=1fATZJUEhOsYYJdBY41h48FBkLaQ&ll=35.75118934523871%2C-97.08285860000004&z=4 The CP is very similar to the anti-inflammatory regimen treatment protocol for CH and Migraines with the following exceptions. The starting vitamin D3 maintenance dose in the CP is 1000 IU per Kg body weight per day. After that, the vitamin D3 dose is adjusted (up or down) to keep the parathyroid hormone (PTH) serum concentration in the low normal range. For a sleek rascal like me weighing in at 80 Kg, I would be starting the CP at a vitamin D3 maintenance dose of 80,000 IU/day. That’s 8 times the vitamin D3 dose taken by the average CHer following the anti-inflammatory regimen treatment protocol to control and prevent CH. Patients following thie CP must avoid calcium rich foods like dairy products and drink 2.5 liters of water a day to keep the serum calcium level within its normal reference range. This article is long and detailed so here’s the bottom line. Taking high-dose vitamin D3 (10,000 IU/day and much higher) is very safe as long as the protocols are followed with lab assays for serum 25(OH)D3, calcium and PTH.. Conclusions In summary, to our knowledge, our work provides the first long-term documentation of selected critical laboratory parameters during the application of the CP using a high-dose oral vitamin D3 in a broad spectrum of different autoimmune diseases, demonstrating that this procedure is well tolerated with respect to renal function and calcium metabolism. In terms of individualized treatment, we suggest to further use serum levels of PTH as biomarker for an individual response to vitamin D3, the individual ability to convert vitamin D to the active metabolite, the 1,25(OH)2D’s interaction with its receptor and the response elements and finally the differential supplementation with vitamin D3. In further studies, possible differences of the clinical outcome of CP treatment should be investigated. Take care, V/R, Batch
  5. The following study found no problems with high dose vitamin D3 in patients following the Coimbra Protocol. (CP) Safety Data in Patients with Autoimmune Diseases during Treatment with High Doses of Vitamin D3 According to the “Coimbra Protocol” Ulrich Amon, Raul Yaguboglu, Madeleine Ennis, Michael F. Holick and Julian Amon Nutrients 2022-04-10 https://www.mdpi.com/2072-6643/14/8/1575
  6. jlb54

    I am unable to get Kirkland Mature Multivit in Canada. It appears to be restricted - who knew? Can you recommend another multivit? Which ingredients in the multivit are essential to the Vit D protocol?

  7. Why are doctors reluctant to accept vitamin D
  8. An excellent State of the Art Review of the Cluster Headache syndrome. For members who didn't attend the Clusterbusters 14th Annual Cluster Headache Conference - Dallas, Texas in 2019, neurologists Emmanuelle Schindler and Mark Burish, the authors of this review, were among the featured speakers. Both are dedicated to finding effective treatments for CH. Emmanuelle is the PI for an RCT using psilocybin as the intervention for CH. Mark was impressed enough with the results from my study of CHers following the anti-inflammatory regimen and treatment protocol with 10,000 IU/day of vitamin D3 plus the cofactors, to initiate an RCT of his own using a similar treatment protocol. That RCT started recruiting earlier this year. Take care, V/R, Batch
  9. Hey Billyx, Thank you for the reply. The 14-day loading schedule should have elevated your 25(OH)D3 up by 170 nmol/L bringing your total 25(OH)D3 serum concentration up around 300 nmol/L (121 ng/mL). That's good and it should be more than sufficient to bring about a therapeutic response with a significant reduction in CH frequency or better yet, a complete cessation of CH. Accordingly, as you're still getting hit with CH, it's more than likely you're also experiencing an immune system response to allergens. These can be subclinical with no obvious or outward observable symptoms. Allergic reactions kick off a lot of histamine and histamine to a CHer is like Kryptonite to Superman, bad news. None of the prevents work during an allergic reaction and that includes vitamin D3. The best course of action I take when an allergic reaction is present, is to start what I call the "Full Monty" clutch of supplements with antihistamine properties on top of the basic anti-inflammatory regimen supplements. I take 3 grams/day each of Turmeric (Curcumin), Resveratrol, Quercetin and Omega-3 fish oil. I also take 8 grams/day vitamin C in divided doses. I buy the powdered bulk vitamin C in 1 Kg bags ( 3 cents/gram USD) and mix two level teaspoons (8 grams) in 8 oz of water and take sips throughout the day until it's all gone by bedtime. I also take 10 mg/day melatonin at bedtime. I stay on this concoction for at least a week after cessation of CH then taper the doses. It never hurts to keep taking at least 4 grams/day vitamin C all the time. Our bodies need vitamin C to synthesize collagen. We need collagen to help prevent brittle bones, maintain healthy cartilage and elastic skin. Besides being an antihistamine, vitamin C is also an excellent antioxidant, antiviral and antibacterial agent. Watch the following video of Linus Pauling giving a presentation on the use of vitamin C to prevent illness and disease. Pauling was 92 when he filmed this video. He had many critics of his suggested use of vitamin C in large quantities to prevent illnesses. Most of these critics came from the Big Pharmas. When he died at 93, he still had two more individual Nobel Prizes than any of his critics and he had outlived most of them. His first individual Nobel Prize was for Chemistry involving quantum mechanics, electron orbits and molecular shapes. (My degree was in Chemistry so quantum mechanics was a central theme throughout my studies.) Pauling's second individual Nobel Prize was for Peace. He stopped above ground nuclear warhead testing. He took 18 grams/day vitamin C. He also took 10,000 IU/day vitamin D3. Take care and please keep us posted. V/R, Batch
  10. Hey Billyx, Roughly 2% of CHers experience an up-tic in CH frequency after starting this treatment protocol. It appears this phenomenon is due to an enzyme imbalance. It usually clears all by itself in a few weeks if you continue the maintenance dose of 10,000 IU/day and all the cofactors. The Solgar supplements look great, but I don't see the Kirkland Adult 50+ Mature Multi. As you can see, it picks up all the micronutrient cofactors we need. Did you start this treatment protocol with the vitamin D3 loading schedule of 600,000 IU/day spread over 12 days at 50,000 IU/day? If not, I suspect your 25(OH)D3 serum concentration is still a bit low. At 10,000 IU/day for 20 days, your 25(OH)D3 serum concentration is likely around 135 nmol/L and it needs to be up to a minimum of 200 nmol/L for a therapeutic response with a reduction in CH frequency or a complete cessation of CH. I suggest you order the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 and the Nutrasal Micro D3 nano emulsion from Amazon if possible or iHerb.com. We've found taking two of the D3-50 capsules/day and 0.5 mL/day of the Micro D3 taken sublingual works great as a loading dose. It totals 140,000 IU/day. You'll need 3 to 4 days at this loading dose to elevate your 25(OH)D3 above 200 nmol/L before dropping back to a maintenance dose of 10,000 IU/day. Be sure to double the magnesium dose taking half of with with breakfast and the other half with the evening meal. This provides 12 hours and 12 feet of GI tract separation so both doses don't arrive in the colon at the same time. That causes osmotic diarrhea. If you order from iHerb.com the best alternatives to the Micro D3 are illustrated in the following photo. Take care and please keep us posted. V/R, Batch
  11. Emgality (Galcanezumab) Study - Trigeminal sensory modulatory effects of galcanezumab and clinical response prediction Arne May et al. Feb 2022 ResearchGate https://www.researchgate.net/publication/358667291_Trigeminal_sensory_modulatory_effects_of_galcanezumab_and_clinical_response_prediction Abstract. Galcanezumab, a monoclonal antibody against calcitonin gene-related peptide, is an emerging migraine preventative. We hypothesized that the preventive effects are conveyed via modulation of somatosensory processing and that certain sensory profiles may hence be associated with different clinical responses. We recruited migraine patients (n=26), who underwent quantitative sensory tests (QST) over the right V1 dermatome and forearm at baseline (T0), 2-3 weeks (T1), and one year (T12) after monthly galcanezumab treatment. The clinical response was defined as a reduction of ≥30% in headache frequency based on the headache diary. Predictors for clinical response were calculated using binary logistical regression models. After galcanezumab (T1 vs. T0), the heat pain threshold (HPT) (°C, 44.9 ± 3.4 vs. 43.0 ± 3.3, p=0.013) and mechanical pain threshold (MPT) (log mN, 1.60 ± 0.31 vs. 1.45 ± 0.26, p=0.042) were increased exclusively in the V1 dermatome, but not the forearm. These changes were immediate, did not differ between responders and non-responders, and did not last in one year of follow-up (T12 vs. T0). However, baseline HPT (OR: 2.13, 95% CI: 1.08-4.19, p = 0.029) on the forearm was a robust predictor for a clinical response three months later. In summary, our data demonstrated that galcanezumab modulates pain thresholds specifically in the V1 dermatome, but this modulation is short-lasting and irrelevant to clinical response. Instead, the clinical response may be determined by individual sensibility even before the administration of medication. Dr. Arne May, MD, PhD. has been a member of the ICHD-3 Working Group on Trigeminal Autonomic Cephalalgias for many years. Take Care, V/R, Batch
  12. Hey Juss, The anti-inflammatory regimen treatment protocol includes the Kirkland Adult 50 + Mature Multi. As you can see from the Mature Multi Supplement Facts label above, it contains only 220 mg calcium. Regarding inflammation and oxidative stress, Vitamin D3 and Omega-3 PUFAs reduce both. Take care and please keep us posted. V/R, Batch
  13. Hey Sue, You really need to thank Craig Stewart. He did all the work to make this video possible. Regarding Vitamin A, the Kirkland Adult 50 Plus Mature Multi contains Vitamin A as Beta Carotene. Our bodies convert Beta Carotene to the active form of Vitamin A. Accordingly, if you're taking the Kirkland Mature Multi, you are getting sufficient amounts of Vitamin A. Take care and please keep us posted. V/R, Batch
  14. All, Making this Youtube video with Craig was a hoot! Without his dedication, determination and professionalism, it would not have been possible. We both hope it attracts more CHers and Migraineurs to start this treatment protocol. As you can see as a 77 year old retired Navy fighter pilot, I'm also mastering the art of full time geezer. Take care, V/R, Batch
  15. Hey ibh, Good plan and don't be afraid to try other salts of magnesium. Take care, V/R, Batch
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