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If you are taking Indomethacin it might be a good idea to add in some Guarana or Guarana extract. It is a caffeine containing seed that is very popular in South America. There is a study on Pubmed showing evidence that Guarana extract protects against gastric lesions induced by Indomethacin. I agree that Indomethacin is "hard on the guts" but from info I have read I think that might be putting it pretty lightly. Indomethacin has the potential to be very hard on your body, especially if you are taking it everyday. http://www.ncbi.nlm.nih.gov/pubmed/14669256 -Ricardo