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Denny is generally correct, but there are some studies that show that CH is sometimes responsive to indomethacin. Here's one abstract (below). So, it could be that since you seem to be someone who has been "refractory to the usual therapy for CH," your doc is giving you the indomethacin to see what happens. If it works, no matter what condition you have (CH or one of the lookalikes), you've learned something valuable. Note what's in the conclusion about time and dosage for CH patients. Indomethacin is hard on the gut for most people. It's often prescribed along with something protective. As I say, there are some other publications that also mention indomethacin sometimes working for CH. From: http://journals.sagepub.com/doi/abs/10.1177/0333102409357642?journalCode=cepa Introduction: Response to indomethacin is an essential feature for the diagnosis of both paroxysmal hemicrania (PH) and hemicrania continua (HC). Cluster headache (CH) is widely considered to be a disease unresponsive to indomethacin. Case reports: We report four patients with CH who responded to indomethacin. Two patients, who were refractory to the usual therapy for CH, fulfilled the criteria for chronic CH. Conversely, two patients had a history of episodic CH and showed response to both indomethacin and the usual therapy for CH. Literature review: We also reviewed the literature for the presence of indomethacin response in patients with CH. We noted a large number of cases labeled as CH by the authors which showed a response to indomethacin. Discussion: Many cases of definite or possible CH were wrongly labeled as PH because of patients' responding to indomethacin. Conclusion: The response to indomethacin in patients with CH may not be as immediate as in other indomethacin-responsive headaches, and many patients may need larger doses.