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Be sure the open holes in the front of your mask are covered when you inhale. With your thumb or with tape. Be sure you have a firm fit to your face. Use your hand to hold it on, not the strap. You don't want any room air getting mixed with the pure O2. I'm going to venture that the first strategy you should try is inhale the O2 as deep as you can, hold it in for a couple of seconds, and exhale forcefully, almost to the extent that you are doing a crunch with your abdomen to get it all out. The purpose is to clear regular air out as much as possible and get as much pure O2 as possible into contact with you lungs. Also, remember that most people get quicker results when they get some caffeine down fast at the beginning of using the O2. You can start with strong coffee, or you can go straight to something like 5-Hour Energy, which has more caffeine and has other stuff in it that might help. As far as the breathing strategy you ultimately select, you can go either harder at the beginning (more forceful hyperventilation) or you can try starting out less dramatically. Once you can tell that the O2 is taking effect, you might dial it all down a bit. Remember to stay on the O2 for 5-10 minutes after your attack is aborted. Doing that seems to help hold off future attacks.