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.....fixed it for you..........................

For 2019, the 30-day efficacy jumped to over 90% of CHers starting this regimen experiencing a significant reduction in CH frequency from a mean of 21 CH/week down to a mean of 4 CH/week. Better yet, over 65% of CHers starting this regimen experienced a lasting cessation of CH in the first 30 days. I attribute this increase in efficacy to the switch to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3. That's the only thing that's changed since July of 2018. I know the medical evidence purists will say an open label observational study rates a low level of medical evidence. To that I say, this is not your every-day average observational study. It's been running for over 8 years with over 320 participants and the year-over-year 30-day efficacy has remained constant at ≥80% for a favorable response and ≥50% for a lasting complete cessation of CH in the first 30 days. Moreover the generalizability of these results is very good as participants have come from 35 different countries around the world. That's not to mention all the health benefits made possible by the anti-inflammatory regimen at a cost of ~ 50 cents/day or $15/month USD. The Emgality cost is $550/month and it carries some onerous adverse side effects. Bottom line... The Anti-CGRP mAbs are never going to work as they cannot pass through the blood brain barrier to reach the site of action in neuronal nuclei within the trigeminal ganglia where CGRP is expressed. At best all the Anti-CGRP mAbs can do in lower the CGRP serum concentration. Here's the math and molecular biology behind this statement. These mAbs have a molecular mass of 150 kDa (150,000 Daltons) but the fenestration (windows) through the BBB have a maximum aperture of 400 Da. That makes the monoclonal antibodies 375 time too big to pass through the BBB windows. A molecule of vitamin D3 has a molecular mass of 385 Da so it passes readily through the BBB and into neuronal nuclei to do its thing through genetic expression to down-regulate (decrease) the expression of CGRP, SP, VIP and PACAP. The Anti-CGRP mAbs only react to CGRP.

For those of you who also have chronic migraine, do you find that your migraines get worse and/or more frequent during a CH cycle? I seem to be tapering down from my CH cycle, and it occurred to me that I've had fewer migraines (more like my normal number) in the last month. I asked my doctor and she said that her patients with both often see an increase in the migraines during a CH cycle. While miserable for us the oh-so-lucky ones, that's kinda interesting. Curious if others here have experienced the same, and if you've seen anything that explains that. Thanks.

@igdc hey! This is interesting. I had the same situation. There were days where I didn’t have any ch type pain behind my eye (usual) but I had a migraine so bad I couldn’t even move my head. I’m not sure if it was an actual migraine or just an all over headache from all the meds I was trying. kat