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I don't know if this can help Mike but I hope so. I was desperately trying to find a preventative that would work for me. I tried Emgality for 7 months and it just was not effective at all for me. I don't have anything bad to say but sadly it didn't help me. I had thought verapamil didn't work when I had stopped it at 360 earlier in my journey. I later read a medical paper that the therapeutic dose for chronic started at 480-600. I than started verapamil again and found 480 did help a small amount and was over overjoyed. I am on 720 (240 every 8 hours) currently and have nights now that I sleep. I still have attacks mostly at night but not every night. Perhaps a higher dose of verapamil may help you. Your doctor may find this is appropriate to try ? Good luck Mike

You’re so right that the results have to come from the forums, as the results of the med trails are always statistical and most of the times not first hand by trail participants. I’ve been in the Aimovig trail in 2019 and Emgality trail in 2020. On both occasions trying to break my cycles as the meds (verapamil, naratriptan, sandomigran, prednisone, D3) I took were not sufficient anymore while the beast was jumping very ugly 8-14 times a day with kip 8-10 very often. I had 5 rounds of Aimovig and it did not break my cycle. It was only when I upped my verapamil from 600 to 720 that I noticed in hindsight brought the relief of ending my cycle. Aimovig had no side effects besides a minor obstipation. The Emgality I took last year also did not break my cycle, in fact this cycle started last year June and is still ongoing now for 11 months. I do not contribute that to Emgality, I believe the beast wants to ‘play’ with me a little longer than normal. I have to say that in my current cycle before I used the Emgality I had the GON injection which also has zero effect, but also no side effects. From the participants in both trail groups I understood that 4 of of 10 had positive results, their cycles did not start. Saying this, my observation is that those CGRP medicines are not meant to break cycles, it is to prevent them. Once in cycle there is little one can do apart from having your rescue meds on stand by and try to ride it out the best you can.