I see a few people just discovering MAPS. Here is a video from one of the researchers associated with MAPS.
This video with David Nichols explains how LSD works in the brain, and touches on the idea of why people get annoyed by the trip after six hours or so.
When you take LSD, it first targets your serotonin receptors, after about 4-6 hours, the compound is broken down by the liver, and then re-enters the blood stream as a modified compound which targets dopamine receptors. Most users get annoyed and want the experience to end around the 4-6 hour mark. But of course everyone's brain chemistry is different and different people experience different things
This is just a snippet, of what the video contains. It is very "sciency" and difficult to follow at times
But I am sure those who watch will at least have a laugh, and take something from it, and hold a slightly better understanding of what LSD does in the brain.
It also touches on psilocybin, and what receptors are targeted, the difference in LSD and psilocybin is remarkable.