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Everything posted by cluster

  1. cluster

    The Economist: Acid tests

    LSD - Acid tests Research into hallucinogenic drugs begins to shake off decades of taboo http://www.economist.com/node/18864332?story_id=18864332&fsrc=rss
  2. And here is the original version, free full text for a limited time, no registration needed: HTML: http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2011.01856.x/full PDF: http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2011.01856.x/pdf
  3. The full story about Dr. Hakim's Warfarin study, free full text at MedScape, free registration required: http://www.medscape.com/viewarticle/742009
  4. cluster


    http://www.youtube.com/watch?v=adBC2wIEB7g Happy Birthday Bob!
  5. Just in case this hasn't been posted before: Podcasts for Patients: Cluster Headache - Acute and Prophylactic Therapy http://www.headachejournal.org/view/0/podcastsForPatients.html#cluster Avi Ashkenazi's paper is here, free full text + free PDF download until the end of May 2011: http://dx.doi.org/10.1111/j.1526-4610.2010.01830.x Ashkenazi A, Schwedt T (February 2011). "Cluster headache-acute and prophylactic therapy". Headache 51 (2): 272–86.
  6. Summary in plain English: 67 chronic CH sufferers (attacks n = 3-6/day, duration 35-67 min) previously unsuccessfully treated with lithium, verapamil, corticosteroids, topiramate and gabapentin became completely pain free after 2 – 3 injections with Leuprorelin 11,75 mg. 49 of these 67 chronic CH sufferers have been completely pain free for more than 4 years. 18 of these 67 sufferers had a relapse 10-15 months after the treatment with 2-4 attacks/day which disappeared in a week following 1 injection of leuprorelin. Please see http://en.wikipedia.org/wiki/Leuprorelin for more information about the substance. There was a successful RCT with a single injection of 3.75 mg leuprorelin = leuprolide acetate published in 1993: Nicolodi M, Sicuteri F, Poggioni M (August 1993). "Hypothalamic modulation of nociception and reproduction in cluster headache. I. Therapeutic trials of leuprolide". Cephalalgia 13 (4): 253–7. Abstract here: http://dx.doi.org/10.1046%2Fj.1468-2982.1993.1304253.x Some of the results of this RCT from the full text: Does anybody here have some personal (good or bad) experience with the Leuprorelin treatment?
  7. cluster


    Have a look at this abstract: http://www.abstracts2view.com/aan2009seattle/view.php?nu=AAN09L_P02.168 John Claude Krusz "lives" here: http://www.anodyneheadachepain.com
  8. cluster

    BOL study - published

  9. cluster

    EHMTIC 2010

    EHMTIC (October 2010). "Abstracts of the 2nd European Headache and Migraine Trust International Congress (EHMTIC). October 28-31, 2010. Nice, France". J Headache Pain. 11 (Suppl 1): S2–150. The free full text here: http://dx.doi.org/10.1007%2Fs10194-010-0259-3 … includes the following abstracts: 88 Sustained efficacy of occipital nerve stimulation in drug-resistant chronic cluster headache after up to 5 years treatment. 115 Treatment of cluster headache using peripheral nerve stimulation; a case report 142 Age at onset and gender ratio in cluster headache: clinical observations over 15 years 166 Involvement of latent Herpes Zoster Virus in the development of forehead allodynia and aggravation of cluster headache (2nd report) 178 Chronic headache in paediatric age (incl. CH) n.b.: "( chronic cluster headache is more frequent in young females than in males …" 180 Leuprorelin as therapy of chronic cluster headache refractory to conventional prophylactic therapies and deep brain stimulation: open label observation 182 Propofol narcosis in refractory chronic cluster headache 183 Features of cluster headache refractory to conventional therapies and deep brain stimulation 216 Two cases of cluster headache relieved by pregabalin 219 Low prevalence of chronic cluster headache and aura, and uncoupling of sense and behavior of restlessness in Japanese 223 Markers of endothelial activation in primary headache disorders (incl. CH) 226 Levels of nitric oxide metabolites in cerebrospinal fluid in active cluster headache 237 Orbital myositis posing as cluster headache 262 Is subcutaneous stimulation of the greater occipital nerve the invasive treatment of choice in patients with chronic headache syndromes? 274 Memantine for prevention of cluster headache: a possible new treatment? 292 Two cases of cluster-like headache secondary to surgical intervention 293 Prophylaxis therapy of the episodic and chronic cluster headache with zonisamide: an open study 312 Illicit drug use in males with cluster headache compared with that in the general population: a cross sectional survey 332 Central facilitation of trigeminal nociceptive processing in episodic and chronic cluster headache 334 Greater occipital nerve infiltration with cortivazol for cluster headache (CHCI): a double blind randomized controlled trial 371 Unilateral and bilateral trigeminal autonomic symptoms in cluster headache 389 Headache and BOTOX®: a case report of hemicrania continua responsive to botulinum toxin type-A 428 Successful treatment of cluster headache with the antihistamine terfenadine 438 Hemicrania continua-like syndrome after ipsilateral lateral medulla infarction with significant painrelief on occipital nerve stimulation 481 Diagnostic delay and misdiagnosis of cluster headache 483 Secondary headache in periodontitis (incl. CH) 500 Use of cannabis among cluster headache sufferers: frequency and effect on attacks 502 Twenty years of mid-face cluster headache diagnosed as ‘‘TMJ’’ 538 Injections of the greater occipital nerve in episodic and chronic cluster headache - efficacy and safety of 113 injections 546 Evaluation of habituation patterns in cluster headache 549 Burden of disease in cluster headache 559 Cluster headache-like headache in an eight-year-old girl: case report 585 Subcutaneous occipital nerve neurostimulation; treatment for refractory headaches ... and some more!
  10. cluster


    Best wishes for a successfull treatment! Some stuff to read: http://www.acta-clinica.kbsm.hr/arhiva/Acta2009/Acta3/15.pdf (PDF) http://www.blackwell-synergy.com/doi/abs/10.1111/j.1468-1331.2007.01738.x http://www.ncbi.nlm.nih.gov/pubmed/11595003?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/11464360?dopt=Abstract http://dx.doi.org/10.1046/j.1468-2982.2000.00046.x
  11. Springer publications for free! No registration required. No strings attached. Simply click on the links below to view or download all content from the top journals on SpringerLink, now through November 30th. * Neurological Sciences. Volume 21 / 2000 - Volume 31 / 2010 * Journal of Neurology. Volume 1 / 1891 - Volume 257 / 2010 * Virchows Archiv. Volume 1 / 1847 - Volume 457 / 2010 * More ...
  12. Jes Olesen: 5-Hydroxyptryptamine 1F (5-HT1F) receptor agonism. A possible new treatment principle for acute migraine attacks http://cep.sagepub.com/cgi/content/long/30/10/1157
  13. cluster

    sleep apnea

    Yes, me too. CH since 1999, sleep apnea diagnosed 2001, CH diagnosed 2005. The CPAP machine did not change CH but improved my wife's and my life a lot. In any case sleep apnea has to be treated, otherwise heart problems may develop. Wikipedia has tons of information: http://en.wikipedia.org/wiki/Sleep_apnea
  14. More: http://pubs.ama-assn.org/media/2010a/0906.dtl#2 http://archpsyc.ama-assn.org/cgi/content/short/archgenpsychiatry.2010.116
  15. cluster

    Insert Device

    Two examples: http://www.clusterheadaches.com/cb/cgi-bin/yabb2/YaBB.pl?num=1278639620 http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1221233650
  16. Please see http://www.petitiononline.com/headache/
  17. Health On the Net Foundation survey about the evolution of Internet use for health purposes: http://services.hon.ch/cgi-bin/Survey/Survey2010/quest.pl Wikipedia about the Health On the Net Foundation: http://en.wikipedia.org/wiki/Health_On_the_Net_Foundation
  18. cluster


    There was also some research in Munich, Germany, please see: http://dx.doi.org/10.1007/s10194-007-0400-0
  19. cluster


    http://clusterattack.com A must read! I just missed a => Table of contents of Dr. Andrew SewellÂ’s weblog
  20. Quite a while ago maalstroom translated this text: http://www.ck-wissen.de/ckwiki/index.php?title=Cluster_Headache_Triggers from our German website into English.
  21. cluster


    If you can, visit Pamukkale, gorgeous place: http://en.wikipedia.org/wiki/Pamukkale We enjoyed a couple of great days at the http://en.wikipedia.org/wiki/Turkish_Riviera Have a good time!
  22. cluster

    BOL trial at the MHH

    Published online today: Matthias Karst, John H Halpern, Michael Bernateck, and Torsten Passie The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: An open, non-randomized case series Cephalalgia first published on March 26, 2010 as doi:10.1177/0333102410363490 [OnlineFirst PDF]Â Free full text until March 31st, 2010 http://cep.sagepub.com/cgi/rapidpdf/0333102410363490v1 Found here: http://cep.sagepub.com/pap.dtl
  23. Personal CH history My first cluster headache (CH) episode was in 1999. The second CH episode started summer 2000 and is still ongoing. CH was diagnosed in July 2005. I have been taking Verapamil daily since July 2005, the sustained release version 2 x 120 mg/day since June 2006. The change from normal release to sustained release Verapamil improved my situation in June 2006. Most time of the year Verapamil works quite well for me. I use oxygen for treating the remaining attacks. This works very well with the ClusterMasx™ or with an equivalent high concentration non re-breather mask. Usually the peak of the pain severity is gone after less than five minutes of oxygen inhalation. In 2008 my CH got worse; a peak of attack frequency during the summer and November / December last year was really terrible. I had the feeling as if the Verapamil didn’t work any more. Oxygen did still stop the attacks in less than ten minutes, but the CH attacks returned within 2 hours. In 2007 a cardiologist recommended NOT to increase the Verapamil dose, because of the ECG and other cardiologic examination results. This is what my feeling is too; I would find it very hard to take more than 240mg/day, due to unwanted Verapamil side effects. In December 2008 I had some success with 3 x 2.5 mg Frovatriptan per day, as an additional preventive medication. There weren't any noticeable or measurable side effects; blood pressure and ECG were OK. I stopped the Frovatriptan before the BOL trial, but continued to take Verapamil. The BOL trial Starting two weeks before the BOL trial and for four weeks after the third BOL dose all participants had to keep track of each CH attack and of all related observations, medication etc. on standardized forms, similar to these forms here: http://www.clusterbusters.com/CB.CH.GeneralDiary.pdf'>http://www.clusterbusters.com/CB.CH.GeneralDiary.pdf BOL MH Hannover, January 2009 The BOL was dissolved in distilled water. I was instructed to take 29 drops = 3.1 mg acc. to the label on the bottle for each of the three BOL doses to be taken. Some notes I wrote after the trial: Written Dec 18, 2008 Today I have had the honour and the privilege to join the BOL trial at the MH Hannover. The feeling after dosing was great: A bit like being slightly drunk but a little bit different, funny, perhaps silly, somehow I felt HAPPY!!! I had to stay there for two hours for medical observation. On the journey back from Hannover (appr. 4 hours after the BOL) I had a slight burning sensation in my head on the side were the pain usually is. Also the nose on this side was a bit congested, but there was no pain at all. Written Jan 8, 2009: Things improved a lot for me. The second and the third BOL dose were taken at home, Dec. 23rd and Dec. 28th 2008. They did not come with this feeling of "happiness", like the first dose did; I just felt a bit like being slightly drunk for a couple of hours after the BOL. After the second BOL dose I had a runny nose for a couple of hours (cluster side only), similar to the runny nose I usually have during a cluster hit coming to its end. After the third BOL dose I had a congested nose for a couple of hours (cluster side only), similar to the congested nose I usually have during the beginning of a cluster headache attack. The BOL medication does seem to have a positive effect: I have much less attacks than before the first dose and the remaining "attacks" I have are very weak and of short duration. I am not even sure, if I can call this "attacks" any more. The pain intensity is low, side symptoms are reduced and the pain goes away after 10-30 minutes without using any medication or oxygen. During the last three years I have had only very few "attacks" which such low pain intensity. Since BOL I have had "attacks" with low pain intensity only. Sometimes I still used oxygen to make the pain go away quicker. Usually when I woke up from pain (before BOL) I had to rush to get the oxygen to avoid the pain getting really bad. Since BOL it has happened twice that I woke up from CH pain, turned around and continued to sleep after a couple of minutes. Febr 12, 2009 Since Jan. 5th I am completely free from CH attacks!!!!! Febr. 2nd I woke up with a light headache on the cluster side during the night but didn't bother to get up. After about 30 minutes I slept again without taking any medication or oxygen.  Yesterday afternoon I thought an attack might come up but this feeling disappeared within 5 minutes. That’s all I have to report for the last 4 weeks. Mar 28, 2009 There was just one CH attack of low severity during a plane flight four weeks ago, nothing on the return flight. I am still taking 240mg Verapamil per day. April 26, 2009 YES, I am still pain free! Long term results CH attacks with mostly low severity started again from June to September 2009, with a peak in July 2009. Since Sept 21st 2009 I am pain free again. Sometimes I feel as if an attack is coming up, but it doesn't. I continue taking 240mg Verapamil per day. In total I had 115 CH attacks from Jan. 2006 – Oct. 2006 In total I had 105 CH attacks from Jan. 2007 – Oct. 2007 In total I had 216 CH attacks from Jan. 2008 – Oct. 2008 (+ 79 in Nov. and Dec.) Took BOL Dec. 18, Dec. 23, Dec. 28, 2008 In total I had 46 CH attacks from Jan. 2009 – Oct. 2009 Thank you VERY MUCH Bob! Thank you VERY MUCH ClusterBusters! Thank you VERY MUCH to everybody else who made this trial with BOL for CH possible! For me there is no doubt about it: We have to get BOL into the pharmacies A.S.A.P.! The first BOL results where presented at the IHS-IHC-2009. LeLimey took a picture of the poster presentation: http://community.webshots.com/photo/fullsize/2487881130074489379qMjgsL The poster presentation abstract text is available here, PDF 3.5 MB, PO88 on page 46 of the PDF: https://www.americanheadachesociety.org/assets/Abstracts_for_IHC_Website.pdf There is "Donate" button at the bottom of this page, so if you want to support further research please donate to ClusterBusters here or on http://www.clusterbusters.com
  24. Thanks Tommy! If the link in Tommy's message doesn't work, try this one: http://www.ft.com/cms/s/b396de10-180a-11df-91d2-00144feab49a,dwp_uuid=34c8a8a6-2f7b-11da-8b51-00000e2511c8,print=yes.html
  25. cluster

    "going legal" - methysergide ?

    Hello Bob, thanks for checking. Here is some more (and newer) information about lisuride: Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19937319 Free full text here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797624/ Lisuride is still available in the pharmacies in Germany and in some other countries.