Ricardo

I agree, everything about Sansert sounds horrible, but we need to remember this is a completely different drug. LSD and Bol-148 are very similar chemically too. The only thing the study I have in front of me says about the fibrosis risk is   "We are always acutely aware that drugs that interfere with the serotonergic mechanisms may be producers of fibrotic complications; so far, even though high dosages of Lisuride have been employed by several authors, no untoward side effects have been reported, which could lead us to think that Lisuride is a "safe" drug." I also find it hard to believe that this drug would be causing the same type or amount of fibrosis risk if they are giving this as a daily drug to Parkinsons patients in Canada--they wouldn't last too long. According to this Pub Med article it sounds like the drugs that cause the fibrosis risk all stimulate the 5HT-2B receptor, whereas Lisuride does the exact opposite. http://www.ncbi.nlm.nih.gov/pubmed/16614540 As far as side effects....Who knows? We'd probably need to find some parkinson patients for an accurate answer. All the Lisuride study I have says is   "The patients were aware they might have side effects such as nausea, hypotension, muscle pains, drowsiness, and cold extremities with Lisuride. No side effects were reported."  (which I find hard to believe ) -Ricardo

So I got my hands on the full article...The whole thing looks promising, very promising. Now we have to convince some researcher to pick it up and start more studies! Unless any adventurous Docs out there in Canada want to try this out... The Conclusions stated: "(1) it has beneficial effects both on episodic and chronic cases; (2) in the patients in whom we used 0.200-0.400 mg of the drug, the dosage was rapidly increased in 2-4 days, with no side-effects, which may suggest that cluster headache patients have a high treshold for nausea and hypotension; (3) for cluster headache, lisuride probably has to be administered in dosages higher than the ones we used; (4) in the three cases with associated migraine there was an amelioration instead of a worsening of migraine as may happen with lithium; (5) lisuride may interrupt a cluster; (6) there was a remarkable alleviation in the intensity and frequency of attacks in our cases even with 0.100 mg of lisuride; (7) lisuride may open the possibility of using a "safe" drug as a preventive treatment for well-timed episodic cluster headache; (8) the alleviation of attacks obtained with lisuride was very quick, comparable to prednisone; (9) the side-effects of lisuride, according to the literature, are negligible, and in the cases we studied they were non-existent." I still don't know the answer to the question--If a drug is available in Canada, but not the US, Can a US doctor prescribe it and get it from a Canadian pharmacy? Maybe I should call a pharmacy up North and ask...  -Ricardo

In a recent post Ron voiced frustration at the not knowing any info on where Bol-148 and Entheogen is presently at, saying "Doesn't anyone know Halpern?!?"  I don't know him, but after looking into him and finding he was a fellow Massachusettsian (Yes, I love making new words up, and I'm not sure how Halpern feels about the popular Masshole term that many of us have adopted ) So I looked him up, found a current email and wrote to him. Suprisingly, it got through to him and he already wrote back...(I sent out the first message less than 24 hours ago) The important info for anybody out there with loot--  If you know of any potential major investors - ah, geez, let us know! No surprise, we're pretty much waiting on money. Anyone that knows of any investors should steer them this way. I find it hard to believe that people won't be making their money back on this one. Dr. Halpern seems like a really great guy who expressed appreciation for all that WE do, and I heavily expressed how much we appreciate all he has done for us.... Baby steps, but it's getting there -Ricardo

1. 22 2. 24 or 25 3. 9 4. Yes, but I have not been able to find a definite "schedule" I have notice that the end of the summer seems to be prime time for me to be getting hit. I have noticed that when I am doing good and having mostly just shadows, they tend to hit me more in the day. 5. I have a strong painful feeling that I would call a shadow, definitely not a migraine, that seems to be there at least half of the time. Same pain as my cluster (left eye feels like it's about to be popped like a grape), just not strong enough to make me do anything about it. 6. Effective medications for aborting have been Psilocybin, DMT, triptans, high dose opiates, ketamine, nitrous oxide, probably more...I'll keep thinking. All these drugs have lost effectiveness after doing enough of them, but they all have worked again with a good break of time. (The nitrous I can not comment on in this regard, as I have had very limited experience with it) Effective preventatives have seemed to be LSD, LSA, LSH, but even when they are "preventing" it will usually only last 2-3 weeks. (Oh, but how wonderful those 3 weeks are ) 7. Right now for abortives I am taking intranasal ketamine, and triptans when that doesn't work. Strong Coffee and marijuana seem to make all my drugs work better. About once a month or so I take LSD, LSA, LSH, or Psilocybin in the hopes of getting some good preventative action. Usually calms down the intensity of the hits if nothing else. 8. Hard to say how frequent. I get hit with shadows every day. Some days they end up progressing into full blown hits, other times they peter out to nothing by evening, like the past couple weeks for me. (Thank you LSD) If I was pressed to answer I think I would say I'm getting hit somewhere between 1/2 to 3/4 of the year, with the rest just being shadows. -Ricardo

I think I gotta see this movie

OK, now I'm confused. How does a Unicorn hold a sword? In it's teeth? I mean I guess that would work, but you would think his Unicorn horn would work way better than taking somebody down while trying not to break a molar on ole excalibur...Or maybe it's a MAGIC sword that the unicorn just has to think about and it flies out to take some Unicorn hating schmuck down...Or maybe it's.... Wait a minute....Did I have too much coffee? Optimism is cool. So are Unicorns. Thanks for sharing -Ricardo

This is really interesting....I had never heard of this before...Came across a couple of other related articles-- http://www.sciencedebate.com/science-blog/how-headache-tree-causes-cluster-headache-and-migraine This one I found really interesting as it hits on the "Tumor Necrosis Factor" thing I was talking about. "Our results suggest that increased levels of TNF[ch945] and its receptors under pathological conditions may have considerable impact on the function of spinal cord TRPV1 receptors" http://www.jneuroinflammation.com/content/7/1/49 Seeing as how the hallucinogens lower TNF levels, you would expect the TRPV1 levels to lower too...(maybe ) Good find! I'm betting this is the tip of the iceberg... -Ricardo

The post from thebbz...(slightly edited due to a lack of cute little hearts) "I respect your choice not to discuss controversial issues, however I will scream at the top of my voice. I  [smiley=2vrolijk_08.gif]RC seeds. If I restricted my speech because of something being illegal I wouldn't be able to live with myself. I dont recall the bill of rights being completely rescinded. All that is necessary for evil to prevail is that good men do nothing. I believe that open and free speech is critical for liberty and freedom. Many have died for it.    I   [smiley=vrolijk_26.gif] mushrooms. I use them to alleviate the pain from the most painful condition known to man. Not because I am incorrigible, but because they work and legal treatments do not.  I do not mean to pick or make trouble I believe freedom of speech is a GOD given inaileable right that can be taken by none and promised by our founding documents. Backed up with the blood of our forefathers. Amen" Truer words have not been spoken-- Viva La Resistance! Ricardo

Two things I've found point to it not being a problem, but I would go carefully and slowly.... About 3/4 of the way down, in this really thick (and really awesome--think I'm going to have to post this somewhere else too...) compilation of Psilocybin studies I found this... "In a study conducted by A.M. Quetin, electrolyte levels, liver toxicity tests and blood sugar levels were shown to be unaffected by psilocybin (Passie 2002)" http://users.humboldt.edu/jmmorgan/psil_s05.htm From the Psilocybin wikipedia page... http://en.wikipedia.org/wiki/Psilocybin "In one study, administration of gradually-increasing dosages of psilocybin daily for 21 days had no measurable effect on electrolyte levels, blood sugar levels, or liver toxicity tests." Anybody out there with blood sugar problems that's busted before?

I was thinking this too...But it looks like the real problem with methysergide comes from the boosting of serotonin levels in the blood over the long term, because you are taking it every day. From what I know of Bol-148, I'm pretty sure you don't take it everyday, you just take huge doses of it every once in a while. In this way, I doubt it's doing anything different with blood serotonin levels than LSD or psilocybin. As far as Lisuride, the wikipedia page says that it is also called Dopergen, Proclacam, and Revanil and I have found it available in Canada, as Dopergen. The one thing that is throwing me off is that according to the Canadian pharmacy page I was looking at (http://static.canadadrugs.com/dopergin/index.html) it says "It is given to patients with dopamine deficiency disease or Parkinson’s disease." And from what I've heard about cluster headaches and dopamine, it's usually talking about cluster heads having TOO much dopamine.... http://www.ncbi.nlm.nih.gov/pubmed/16643552 Then again, the one very vague abstract that we have says it was at least SOMEWHAT effective for clusters.... Everything I have read about Lisuride (for migraines or parkinsons disease) imply's that you would take it everyday, and then you're right Flash, you probably would have to start worrying about fibrosis...I have to admit though, what I'm really wondering about with this drug is if you would have better results giving really really huge doses of it together WITH the BOL-148..... but maybe I just like experimentation too much -Ricardo

Nobody? I really don't want to shell out the $35....

Pretty sure Google got in trouble because people with NO prescription at all were just ordering drugs on line and having them sent to them. Wonder if it's any different if a doctor gets involved...

Anybody know anything about getting drugs that are not available in the US? Is it even legal? Can you have a doc in the US prescribe it and get it from an overseas pharmacy?

Man that sucks. One of these days SOMETHINGS gonna work...Hoping it comes sooner than later. Give Michael our best. Ricardo

Have you tried busting yet? I would encourage you to get some psychedelics and bust that beast as soon as possible--It sounds like you are kinda in a bad place right now, I think you really should try and have someone with you if you're going to though. Stick around and I bet SOMEBODY'S going to have something that can help you, hang in there, I know it's rough. Maybe you could start with what you've tried and haven't tried. O2? D3? Seeds? LSD? Mushrooms? Ketamine? Licorice? There are a lot of smart people on this board, try us. -Ricardo

Another really awesome documentary I just saw was made by the History channel, called "Peyote to LSD-A psychedelic odyssey" and it really impressed me. I figured it was mostly just about the drugs themselves, but it really turned out to be mostly a documentary on Richard Evan Schultes, an amazing guy with an amazing story of Psychedelic Amazon adventures before LSD was even invented. They also intersperse a good bit of info on Albert Hoffman and Timothy Leary, along with info on the drugs themselves. All in all, I thoroughly enjoyed it and recommend it highly. http://www.youtube.com/watch?v=I2ufRW7hFAc&feature=related -Ricardo

I was very surprised to find out that there already is a non-halucinogenic drug made from LSD, it's called Lisuride and it's prescribed for parkinson's disease. They have even done a study on it for clusters, but all the abstract says is "The results obtained with lisuride were quite satisfactory as compared to results with other drugs, and there were no side-effects in this small group of patients." and "Comparatively to migraine, which requires low dosages of lisuride, cluster headache seems to require a higher dosage of the drug for better results." Pretty vague, but here's the abstract...anybody have a membership with "Headache" so we can see the full article? http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.1983.hed2303117.x/abstract Supposedly it is not available in the US, but is in some of the UK and China. Anybody ever hear of this stuff?

Nice...I wonder if they're going to touch on the medical aspects of it on top of recreational use...You would think so if they go the way they did for the mushrooms. Someday when I get better internet then this slow ass satellite service (all I can get in the mountains out here, supposedly that's going to change this summer) I'll watch both of them.

Now that I think of it, the few times that I've just eaten the mushy's instead of making tea I did feel really pukey. When I make tea I crush them up as good as I can, boil some water and pour it over them (usually in a french press). I let them steep for 10 minutes and it's good to go, I usually add a bit of peppermint to try and prevent bloating or gas.

Know what's funny? I get nervous almost anytime I bust. Not from nausea...but still... I always have to talk myself into it...Have to convince myself--"I've taken this much before, I'm not going to blow my mind...Just Friggin drink it!" No matter how many times I bust, it's always there...and somehow I think it's important. It's an enjoyable state, but it's powerful medicine that should not be taken lightly. Not the first time, not the hundredth time. A couple of nausea options---scopolamine patches? I've heard very good things about it's effectiveness with psychedelics. (I personally would just eat 1-3 datura seeds, but find it hard to recommend datura to anyone ) A couple of drops of lemon essential oil in a capsule is supposed to hit the same receptors that ginger works on, but better. Heard good things from other people, gave me a bit of heartburn though. Dan--thanks so much for bringing this out for people to see...Getting people to see what we go through is important, and you may have done more in that regard than any of us have ever been able to. -Ricardo

Really awesome documentary I watched the other night while busting-- Shamans Of The Amazon - Dmt, Ayahuasca & Mckenna http://www.youtube.com/watch?v=_4RkOsLxoT4&feature=player_embedded

Damn close to every time I've taken more than 6 mg melatonin before bed I've woken up with a cluster.

Sorry, guess I wasn't really paying attention to your situation and how long you've gone pain free. Going from chronic to having more than 20 days pain free is no joke...Just getting your sleep right could do wonders--I hope this keeps up and more people try this. Who knows, maybe it would be a great addition to Batch's ant-inflammatory cocktail... -Ricardo

I just found an amazing link to an amazing research paper. It is also amazing in it's ability to make me read at 3 words a minute and getting me to say "WTF are they talking about?" I am going to slowly digest this and see what I get out of it....It is essentially a huge list of psychedelic drugs and the receptors they hit...Eventually I think this could be helpful in finding out what exactly it is about the psychedelics that is so helpful for us-- by looking at what substances are helping, and what receptors these substances hit. I'm including the link to the link, because it includes some other intelligent discussion on what this paper means. Psychedelics and the Human Receptorome- http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009019 Message board with people talking about the Psychedelics and the Human Receptorome research paper- http://www.bluelight.ru/vb/archive/index.php/t-487865.html -Ricardo

My take on this is that the authors of the article are saying that they assume BOL does not hit the same serotonin receptors LSD does, because it does not cause hallucinogen like effects. BUT...this is based on the assumption that LSD makes you hallucinate by hitting these serotonin receptors (5ht2a receptors) AND that assumption is all wrong.   This is what Dr. Sewell is pointing out, that just because LSD hits these serotonin receptors, that does not mean that hitting these receptors is the CAUSE of the hallucinogenic activity. Or in other words, LSD does lots of stuff, one small part of it is hitting the serotonin receptors--but there's a hell of a lot more going on than just that. The idea that hallucinogenic activity is caused by hitting the 5ht2a serotonin receptors has been around for a while, but has been challenged by many people. From everything I have read, I do not believe at all that hitting this serotonin receptor is what causes hallucinogenic activity--I will try and find the links to a paper Sasha Shulgin wrote where he lists a bunch of drugs that hit the 5ht2a receptor, but do not cause any sort of hallucinogenic activity.  I would post a link to a ridiculously hard to interpret paper I just found listing all sorts of hallucinogens and what receptors they hit, but it's an amazing enough article that I think it might just deserve it's own link. To sum it up in relation to TNF....It looks like no one knows, not even Halpern, if Bol-148 hits the 5ht2a receptors. I hope it does, and so does my friend---but if not, I guess we'll just keep eating acid -Ricardo