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  1. Indomethacin is a powerful non steroidal, sort of a super ibuprofen, which is generally taken in a short course. It is also used by knowledgeable headache experts to distinguish between cluster headaches and another trigeminal autonomic cephalgia (TAC) called hemicranium continuum. Cephalgia is a fancy name for headache. Para tabs are tylenol (acetaminophen). Dymista is a combination of steroid and antihistamine for nasal inhalation. Sirdalud is an alpha-2 receptor blocker that can be used to treat muscle spasms. I do not think any of these medications alone would interfere with a bust. When you throw a whole bunch of supplements and medications into the mix unpredictable things can happen. Thoughtful use and proper preparation will handle most adverse side effects. As a rule its best to reduce expose by limiting non essential medications.. Once her pulmonary health is stable I believe she can consider busting with a certain degree of confidence. Again, the concern with any non traditional intervention is the unfamiliarity with the experience and potential overreaction to symptoms while in the midst of a psychedelic experience. The best way to combat or avoid this is by proper preparation by the individual and their sitter. It can not be emphasized enough the importance of proper set and setting with these molecules. Of course one does not need a full blown psychedelic experience to benefit cluster headaches in many cases. It is best to be prepared in case the individual gets more than they bargained for with a treatment. Since things like MM are very variable in content of active ingredient a person might find themselves further out there than intended. You are a good soul and friend to translate and help others, it is not an easy task.
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  2. You are presenting a fairly significant list of prescription drugs largely aimed a an individual with significant reactive airway (or COPD) lung disease. The asthma meds are a mix of bronchodilators (open up airways), inhaled steroids and a combination of the two. The medrol is a steroid (fairly equal to prednisone in potency) I would assume being indicated for the lung condition. Zolt is a proton pump inhibitor similar to protonix which blocks the production of gastric juices irreversibly. It works through an enzyme system and generally is used in short courses, it does not work right away but you dont want to use it in a sustained manner either. A beta blocker is usually used for hypertension although it has a role in migraine prevention and heart disease. The estrogen preparations are used vaginally and have little systemic absorption once used for 6-12 weeks. So if you subscribe to the belief steroids are blockers there is a concern about the medrol and some of the inhaled meds. The bronchodilators can cause feelings of anxiety and a rapid heart rate but should not block. I doubt the proton pump inhibitor is an issue. Systemic estrogen can increase drug metabolism in the liver but usually vaginal estrogen doses are insufficient to cause that. Beta blockers show up on some blocking lists but I doubt its a real issue. This is the med list of a person who has significant medical issues. Would not advise stopping any of the pulmonary drugs without close medical supervision. If she has been on steroids a long time I suspicion they are required for handling physiologic stress and weaning is probably not practical. She needs to be well prepared for the anxiety that can accompany a busting experience and a sitter needs to understand her breathing issues. Ultimately it is her decision but tread lightly Significant care and caution are urged.
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