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Hey Igdc, Good comments. My experience with CH that dates back to 1994 with my first bout with CH and I've been chronic since 2005. What I've found is the severity of this disorder is compounded by vitamin D3 and magnesium deficiencies and there's a clear inverse relationship between CH frequency and serum 25(OH)D3, the serum level metabolite of vitamin D3 that's measured by lab tests. Well over 2500 CHers are now taking the anti-inflammatory regimen with 10,000 IU/day vitamin D3 and cofactors to prevent their CH. The updated version of the supplements called for in this regimen are illustrated in the following photo of what my wife and I have taken daily since October of 2010. I suggest these supplements to CHers all over the world. If you add 3 grams/day vitamin C, t.i.d. (one gram 3 times a day), you'll have an effective preventative for colds and flu... and I'm confident the COVID-19 novel coronavirus as well. The last two graphics apply. On a related note, my niece has asthma and has been taking this regimen daily for the last 9 years through two pregnancies and breastfeeding. Results: two flawless pregnancies, deliveries and two exceptionally healthy babies with T-Rex immune systems. She's taken one of the Bio-Tech D3-50 50,000 IU capsules of water soluble vitamin D3 every 3 to 4 days for the last four years since she stopped all Rx meds for asthma, to keep her asthma in remission and that has proven to be very effective. Take care and please keep us posted. V/R, Batch

...very valid question...and I wouldn't limit it to physiological...there are probably elements of emotional, mental and spiritual involved also... ....I was the caregiver for my Mother in the last 3 1/2 months of her life...it occurred right in the MIDDLE of a regular/reoccurring cycle....and I remember saying "Lord, please...I can't handle BOTH of these at the same time!"....then making plans for TRYING to do exactly that.... ...whether attributable to spiritual faith, emotional self preservation, stress hormones (def a preventive but minimally sustainable) or something else didn't matter then, but has intrigued me ever since. The cycle stopped IMMEDIATELY... and failed to reappear the expected and "normal" 2 or 3 more times for the next 6+ mos.... until I was finished with her estate. slap me for stupid, but after 20 yrs I thought they were gone forever...nope....but what a remarkable and timely window I am forever grateful for... ...there is way more to dealing with this ailment than just treating a wonky hypothalamus...we haven't even begun to tap the potential of the human mind......and I continue to believe that much of the battle simply involves the "attitude" we approach with... best jonathan