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Hey Krios, We've seen a higher response rate among CHers new to this regimen when they take the Bio-Tech D3-50 50,000 IU water soluble vitamin D3. As you're still experiencing CH, this is usually an indication your 25(OH)D3 is too low. Accordingly, you need a higher maintenance dose of vitamin D3. The most effective method of elevating serum 25(OH)D3 and faster way of returning to a CH pain free state is by starting a 4-Day vitamin D3 loading schedule taking 50,000 IU/day for 4 days. There's also "Pulsed" loading where you take 200,000 IU of vitamin D3 on Day-1 then coast taking no vitamin D3 on Days 2, 3, and 4. You take all the cofactors daily. On day 5 if you're CH pain free restart your maintenance dose at least 5,000 IU/day higher. If you're not CH pain free by Day-5 continue loading or pulsed loading until you experience a CH pain free response for at least 48 hours then return to a maintenance dose 5,000 IU/day higher than previous. Either way the goal of the anti-inflammatory regimen is a CH pain free response. The latest update to this treatment protocol will included loading or pulsed loading until you experience a CH pain free response for 48 hours then drop back to a maintenance dose. Of course it's always wise to see your PCP/GP for labs of your 25(OH)D3, calcium and PTH any time you've changed your vitamin D3 dosing and at least once a year after you've reached a stable vitamin D3 dose that keeps you CH pain Free.' Take care and please keep us posted. V/R, Batch V