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As I understand 4 grams of dried mushrooms is equal to 20-25 mg active ingredient. This being the case the max dose in the Yale study would be about the same as 2 grams dried fungus. If i recall the study design included input from several folks with descent experience and influence with cluster busters. The safety studies with psilocybin done at UW Madison used an escalating weight adjusted model of doses from 23-30 mg/70 kg body weight. Basically at the top end they received the equivalent of 5 plus grams dried which is often considered a "heroic dose". I do not believe any participants had adverse physiological or psycho logic outcomes. Many have participated in group discussions about the experience and have become actively involved in the psychedelic community.

...yeah, i know, it aint gonna happen officially. we've pretty much always been on our own...or what's a Clusterbusters for? citizen science that DECADES down the line might get a mention like "yeah those alt medicine cluster folks were onto something".....................

Hmmm.....is it an un-buster? That would be a good question. I have the feeling we'd be left trying to figure that out ourselves for a good while before any psychedelic / ketanserin / CH study would be undertaken.

...thank you...fascinating....can see as an important tool in psychotherapy... but begs the question, and another study....does it also block the beneficial effects for CH? ....still, without availability of bol-148, a potential option....