Hey Billyx,
Thank you for the reply. The 14-day loading schedule should have elevated your 25(OH)D3 up by 170 nmol/L bringing your total 25(OH)D3 serum concentration up around 300 nmol/L (121 ng/mL). That's good and it should be more than sufficient to bring about a therapeutic response with a significant reduction in CH frequency or better yet, a complete cessation of CH.
Accordingly, as you're still getting hit with CH, it's more than likely you're also experiencing an immune system response to allergens. These can be subclinical with no obvious or outward observable symptoms. Allergic reactions kick off a lot of histamine and histamine to a CHer is like Kryptonite to Superman, bad news. None of the prevents work during an allergic reaction and that includes vitamin D3.
The best course of action I take when an allergic reaction is present, is to start what I call the "Full Monty" clutch of supplements with antihistamine properties on top of the basic anti-inflammatory regimen supplements. I take 3 grams/day each of Turmeric (Curcumin), Resveratrol, Quercetin and Omega-3 fish oil. I also take 8 grams/day vitamin C in divided doses.
I buy the powdered bulk vitamin C in 1 Kg bags ( 3 cents/gram USD) and mix two level teaspoons (8 grams) in 8 oz of water and take sips throughout the day until it's all gone by bedtime. I also take 10 mg/day melatonin at bedtime.
I stay on this concoction for at least a week after cessation of CH then taper the doses. It never hurts to keep taking at least 4 grams/day vitamin C all the time. Our bodies need vitamin C to synthesize collagen. We need collagen to help prevent brittle bones, maintain healthy cartilage and elastic skin. Besides being an antihistamine, vitamin C is also an excellent antioxidant, antiviral and antibacterial agent.
Watch the following video of Linus Pauling giving a presentation on the use of vitamin C to prevent illness and disease.
Pauling was 92 when he filmed this video. He had many critics of his suggested use of vitamin C in large quantities to prevent illnesses. Most of these critics came from the Big Pharmas. When he died at 93, he still had two more individual Nobel Prizes than any of his critics and he had outlived most of them.
His first individual Nobel Prize was for Chemistry involving quantum mechanics, electron orbits and molecular shapes. (My degree was in Chemistry so quantum mechanics was a central theme throughout my studies.) Pauling's second individual Nobel Prize was for Peace. He stopped above ground nuclear warhead testing. He took 18 grams/day vitamin C. He also took 10,000 IU/day vitamin D3.
Take care and please keep us posted.
V/R, Batch