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Understatement alert! ^^^^ I bet you do get some some days of relief @FunTimes. Feeling confident enough to go public with that prediction right here, and looking forward to having been proven right when we get your valuable report on how it has gone.

If you type DHE into the searh bar, you'll see a lot of reports. This one is from "Boston Headache Doc," (from 2014). As you may know, he is a physician who is strongly committed to patients with CH and to the ClusterBusters organization. "DHE 45 is dihydroergotamine, hence it is an ergotamine, but one with poor oral absorption. So it is given in other routes- as a nasal spray, under the skin (subcutaneous injection) or intravenously. There is even an inhalation product in late development. On occasion I admit patients to hospital for DHE intravenously every 8 hours for a few days- works in most people but often the attacks of cluster come back after the therapy. Can give patients a much needed break, emotionally useful, even if the break is only temporary. I also prescribe DHE vials, then come in packs of 10, and patients can inject under the skin- it is not that hard to do. Patients could use this as a once off abortive, or use it twice to three times a day for 48 hours to try and break the cycle. While you are on an ergotamine you should not be taking triptans however, and also not any other ergotamine derived substance (hmm). Those with known cardiac disease or peripheral vascular disease cannot use this treatment." [Back to me] From all I've read, and from what BHD says here, I think DHE is mostly effective as an abortive, but maybe it can give a short-tem break or in some cases break a cycle. I don't know how responsive BHD is to PMs, but I suppose it might be worth trying him to see what his more recent experience has been.