Hey Snafu,
Great question. For starters, the Wuhan Corona virus is now endemic in the population like influenza. As coronavirus mutate rapidly, it's very likely healthy innate and adaptive immune systems will neutralize one mutant variant and develop the specific antibodies for that strain. However, the next mutant variant may be sufficiently different in its genetic makeup to avoid detection by the antibodies developed for the previous variant and this results in yet another infection. This is likely what you're experiencing.
There's an excellent 2019 gene activation study by Dr Holick and colleagues. This a landmark study as it shows a significant dose response in gene activation in 3 groups of healthy volunteers who took varying amounts of vitamin D daily for 6 months. The doses used in the 3 groups were 600, 4000, and 10,000 units a day. https://www.nature.com/articles/s41598-019-53864-1.
"There was a dose-dependent 25(OH)D alteration in broad gene expression with 162, 320 and 1289 genes up- or down-regulated in their white blood cells (our immune systems), respectively.” This is great science. It makes me wonder how many genes would have been activated with 20,000, 30,000 units or more a day of vitamin D3 for 6 months.
I don't have the gene activation counts for vitamin D3 doses of 20,000 to 30,000 IU/day or higher, but I do have first hand end results. Over the last 30 months, I've averaged a vitamin D3 dose around 30,000 IU/day with a few weeks as high as 80,000 IU/day to remain CH pain free during periods of high pollen and mold spore counts. This much vitamin D3 elevated my serum 25(OH)D3 concentration up to around 150 ng/mL (375 nmol/L) and at a couple points, as high as 270 ng/mL (675 nmol/L). The net results were clear. I remained CH pain free and I also remained asymptomatic to Wuhan Coronavirus infections by the alpha through omicron 2 and 3 mutant variant exposures.
This doesn't mean I wasn't infected. What was likely happening was my innate immune system's killer T-Cells were activated beating back the coronavirus infection and stopping viral replication before it reached the point of emerging symptoms (sore throat, temperature, malaise, etc.). There's a great chart by Dr. Paul Marik, MD, Chief of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, illustrating the time line from inoculation by the Wuhan Coronavirus.
As you can see, viral incubation and replication can be in progress with an innate immune system, naive to a new viral strain and not boosted by vitamin D3, for up to five days before symptoms present/become evident. In my case, its likely my T-Cell activation has been occurring within a couple days of inoculation by a new Wuhan Coronavirus variant.
Since the Wuhan Coronavirus landed in the US, I've also taken larger doses of vitamin C (8 grams/day in divided doses) as an antiviral supplement. Zinc has been part of the anti-inflammatory regimen and treatment protocol since I developed it in 2010. I added Quercetin in April of 2020. Quercetin is a zinc ionophore that enables water soluble zinc ions to pass through the fatty acids that make up cell membranes to stop viral replication. Had Ivermectin been available, I would have taken it as a prophylaxis. Accordingly, the message here should be clear. Higher vitamin D3 doses resulting in an elevated 25(OH)D3 serum concentration around 150 ng/mL, coupled with vitamin C, zinc and Quercetin have enabled my innate and adaptive immune systems to keep me asymptomatic to Wuhan Coronavirus infections.
The bottom line, see your PCP for assays of my serum 25(OH)D3, calcium and PTH. As long as your calcium serum concentration is within its normal reference range, I would load vitamin D3 for 6 days at 100,000 IU/day (2.5 mg/day) then drop back to a maintenance dose at least 5000 IU/day higher than usual. Test again in two weeks with assays for serum 25(OH)D3, calcium and PTH. You're looking for an initial target 25(OH)D3 serum concentration around 150 ng/mL (375 nmol/L) without going bust on serum calcium concentration too high or PTH serum concentration too low.
In my opinion, for what it's worth, this is a prudent course of action for CHers who have had one or more COVID-19 mRNA vaccinations. There is sufficient evidence from properly structured, peer reviewed RCTs that each mRNA vaccination results in progressively weaker immune systems as evidenced by significant increases in diseases and medical conditions normally kept in check by healthy immune systems.
Take care and please keep us posted.
V/R, Batch