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Heading back up for another round with this study. https://clinicaltrials.gov/ct2/show/NCT02981173 Might not help me much but it will make things a little better for the future.

Volunteering for a study like this is, knowing you may receive a placebo and be subject to some out of control attacks, is nothing short of a heroic act as far as I'm concerned, FunTimes - THANK YOU.

@FunTimesyou are a true hero! Thank you for helping the future

Great reply's to a provocative article. Its reports like these taken out of context that provide inane arguments from reimbursement decision makers and scare off those who would potentially benefit from Oxygen to treat a cluster attack. I have attached the original article which is "Hyperoxic Brain Effects Are Normalized by Addition of CO2". The OP placed a link from a PR arm of UCLA (self promotion) to bring our attention and concern. The PR department took great liberties with the content going so far as to state the info in being incorporated tin Europe to modify resuscitation. In reality the article has only been referenced 10 times (since 2007) in other literature, mostly basic science and peripheral to O2 harm. Please read the editor notes at the end of the article. Basically there is no follow up and no real concern with O2 as it applies to safety and treating a cluster attack. O2 clearly works much of the time, its not perfect and there a are a few variables that must be managed but properly delivered and used multiple studies support its efficacy and safety. It is interesting to see the study does confirm O2 affects hypothalamic activity which supports theories where clusters are propagated. It also gives support to the notion of vasoconstriction being a mechanism of action. I suspicion a change in hormonal milieu may also play a role and be an explanation for inconsistent response to therapy. oxygenandharm